Incidental Mutation 'BB013:Vmn2r125'
| ID |
642749 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r125
|
| Ensembl Gene |
ENSMUSG00000096042 |
| Gene Name |
vomeronasal 2, receptor 125 |
| Synonyms |
Gm20782 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.078)
|
| Stock # |
BB013
|
| Quality Score |
138.008 |
|
Status
|
Not validated
|
| Chromosome |
4 |
| Chromosomal Location |
156696567-156708037 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 156702988 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 122
(D122G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000094556
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000096794]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000096794
AA Change: D122G
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000094556
Gene: ENSMUSG00000096042
AA Change: D122G
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ANF_receptor
|
9 |
355 |
7e-32 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 98.9%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 44 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adprhl1 |
C |
T |
8: 13,298,682 (GRCm39) |
V83I |
probably damaging |
Het |
| BC016579 |
C |
A |
16: 45,449,825 (GRCm39) |
D198Y |
probably damaging |
Het |
| Cep170 |
A |
G |
1: 176,588,979 (GRCm39) |
S549P |
probably damaging |
Het |
| Cnih3 |
T |
C |
1: 181,277,566 (GRCm39) |
L96P |
probably damaging |
Het |
| Cnn2 |
T |
A |
10: 79,829,160 (GRCm39) |
L168Q |
probably damaging |
Het |
| Cnot1 |
ACG |
A |
8: 96,472,275 (GRCm39) |
|
probably null |
Het |
| Cnot10 |
A |
G |
9: 114,446,883 (GRCm39) |
C398R |
probably damaging |
Het |
| Dcaf4 |
C |
A |
12: 83,580,703 (GRCm39) |
Y212* |
probably null |
Het |
| Dmxl2 |
T |
C |
9: 54,335,326 (GRCm39) |
T665A |
probably benign |
Het |
| Dnmt1 |
C |
A |
9: 20,818,855 (GRCm39) |
A1609S |
unknown |
Het |
| Dzip1 |
T |
C |
14: 119,120,911 (GRCm39) |
D682G |
probably benign |
Het |
| Fam76a |
A |
G |
4: 132,629,405 (GRCm39) |
L249P |
probably damaging |
Het |
| Fgf10 |
T |
C |
13: 118,925,752 (GRCm39) |
M177T |
probably damaging |
Het |
| G530012D18Rik |
C |
G |
1: 85,504,935 (GRCm39) |
D113E |
unknown |
Het |
| Itln1 |
G |
A |
1: 171,359,261 (GRCm39) |
T73I |
probably benign |
Het |
| Jkamp |
T |
C |
12: 72,141,590 (GRCm39) |
Y197H |
probably damaging |
Het |
| Kti12 |
A |
C |
4: 108,705,443 (GRCm39) |
E119A |
probably benign |
Het |
| Kti12 |
G |
T |
4: 108,705,444 (GRCm39) |
E119D |
probably benign |
Het |
| Lcor |
T |
C |
19: 41,571,008 (GRCm39) |
F67S |
probably benign |
Het |
| Lmf2 |
G |
A |
15: 89,236,624 (GRCm39) |
P514L |
probably damaging |
Het |
| Lmntd2 |
G |
T |
7: 140,790,258 (GRCm39) |
P610Q |
probably damaging |
Het |
| Map3k3 |
T |
C |
11: 106,036,548 (GRCm39) |
S225P |
probably damaging |
Het |
| Mbd5 |
T |
C |
2: 49,146,335 (GRCm39) |
Y182H |
probably damaging |
Het |
| Mki67 |
A |
G |
7: 135,298,869 (GRCm39) |
V2055A |
possibly damaging |
Het |
| Mtmr7 |
G |
A |
8: 41,059,927 (GRCm39) |
A62V |
possibly damaging |
Het |
| Myh8 |
C |
T |
11: 67,169,732 (GRCm39) |
P17L |
possibly damaging |
Het |
| Myt1l |
T |
A |
12: 29,861,651 (GRCm39) |
D144E |
unknown |
Het |
| Nfatc1 |
T |
C |
18: 80,740,881 (GRCm39) |
Y373C |
probably damaging |
Het |
| Pacs2 |
C |
T |
12: 113,024,372 (GRCm39) |
L418F |
probably damaging |
Het |
| Paxip1 |
A |
G |
5: 27,996,207 (GRCm39) |
I24T |
unknown |
Het |
| Pdcl |
C |
T |
2: 37,242,249 (GRCm39) |
G167E |
probably damaging |
Het |
| Pdcl |
A |
C |
2: 37,242,251 (GRCm39) |
S166R |
probably damaging |
Het |
| Qsox1 |
C |
T |
1: 155,688,533 (GRCm39) |
G5S |
unknown |
Het |
| Rftn1 |
G |
T |
17: 50,354,408 (GRCm39) |
A318D |
probably damaging |
Het |
| Sass6 |
T |
A |
3: 116,422,419 (GRCm39) |
S641T |
possibly damaging |
Het |
| Six1 |
T |
C |
12: 73,090,583 (GRCm39) |
N194S |
probably benign |
Het |
| Tagap |
T |
C |
17: 8,145,770 (GRCm39) |
|
probably null |
Het |
| Tiparp |
T |
C |
3: 65,460,946 (GRCm39) |
V645A |
possibly damaging |
Het |
| Tm2d2 |
T |
C |
8: 25,510,480 (GRCm39) |
V113A |
probably damaging |
Het |
| Tmprss6 |
C |
A |
15: 78,337,050 (GRCm39) |
R352L |
probably benign |
Het |
| Tslp |
A |
G |
18: 32,950,246 (GRCm39) |
E105G |
possibly damaging |
Het |
| Ttc41 |
A |
G |
10: 86,611,911 (GRCm39) |
E1093G |
probably benign |
Het |
| Ush2a |
G |
A |
1: 188,460,797 (GRCm39) |
R2686H |
probably benign |
Het |
| Usp54 |
A |
T |
14: 20,627,036 (GRCm39) |
Y541N |
probably damaging |
Het |
|
| Other mutations in Vmn2r125 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00990:Vmn2r125
|
APN |
4 |
156,703,194 (GRCm39) |
missense |
probably benign |
|
|
IGL00990:Vmn2r125
|
APN |
4 |
156,703,333 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL00990:Vmn2r125
|
APN |
4 |
156,703,332 (GRCm39) |
missense |
probably benign |
0.16 |
|
IGL00990:Vmn2r125
|
APN |
4 |
156,703,521 (GRCm39) |
missense |
probably benign |
|
|
IGL00990:Vmn2r125
|
APN |
4 |
156,703,678 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00990:Vmn2r125
|
APN |
4 |
156,703,261 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL00990:Vmn2r125
|
APN |
4 |
156,703,195 (GRCm39) |
missense |
probably benign |
0.35 |
|
IGL01018:Vmn2r125
|
APN |
4 |
156,703,521 (GRCm39) |
missense |
probably benign |
|
|
IGL01018:Vmn2r125
|
APN |
4 |
156,703,333 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01018:Vmn2r125
|
APN |
4 |
156,703,332 (GRCm39) |
missense |
probably benign |
0.16 |
|
IGL01018:Vmn2r125
|
APN |
4 |
156,703,195 (GRCm39) |
missense |
probably benign |
0.35 |
|
IGL01018:Vmn2r125
|
APN |
4 |
156,703,194 (GRCm39) |
missense |
probably benign |
|
|
IGL01018:Vmn2r125
|
APN |
4 |
156,703,140 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01018:Vmn2r125
|
APN |
4 |
156,702,907 (GRCm39) |
splice site |
probably benign |
|
|
IGL02644:Vmn2r125
|
APN |
4 |
156,703,294 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03144:Vmn2r125
|
APN |
4 |
156,702,314 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
FR4342:Vmn2r125
|
UTSW |
4 |
156,703,260 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0408:Vmn2r125
|
UTSW |
4 |
156,703,153 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0785:Vmn2r125
|
UTSW |
4 |
156,703,396 (GRCm39) |
missense |
probably benign |
|
|
R1185:Vmn2r125
|
UTSW |
4 |
156,703,396 (GRCm39) |
missense |
probably benign |
|
|
R1185:Vmn2r125
|
UTSW |
4 |
156,703,396 (GRCm39) |
missense |
probably benign |
|
|
R1530:Vmn2r125
|
UTSW |
4 |
156,703,447 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1698:Vmn2r125
|
UTSW |
4 |
156,703,333 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1780:Vmn2r125
|
UTSW |
4 |
156,703,668 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1977:Vmn2r125
|
UTSW |
4 |
156,707,162 (GRCm39) |
splice site |
probably null |
|
|
R2917:Vmn2r125
|
UTSW |
4 |
156,703,564 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3428:Vmn2r125
|
UTSW |
4 |
156,702,436 (GRCm39) |
missense |
probably benign |
0.34 |
|
R3712:Vmn2r125
|
UTSW |
4 |
156,702,419 (GRCm39) |
nonsense |
probably null |
|
|
R4274:Vmn2r125
|
UTSW |
4 |
156,702,382 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4575:Vmn2r125
|
UTSW |
4 |
156,702,272 (GRCm39) |
missense |
probably null |
0.30 |
|
R4707:Vmn2r125
|
UTSW |
4 |
156,702,276 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5229:Vmn2r125
|
UTSW |
4 |
156,703,333 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5504:Vmn2r125
|
UTSW |
4 |
156,703,456 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R5587:Vmn2r125
|
UTSW |
4 |
156,702,433 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5987:Vmn2r125
|
UTSW |
4 |
156,702,292 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6037:Vmn2r125
|
UTSW |
4 |
156,703,396 (GRCm39) |
missense |
probably benign |
|
|
R6183:Vmn2r125
|
UTSW |
4 |
156,702,364 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6456:Vmn2r125
|
UTSW |
4 |
156,703,357 (GRCm39) |
missense |
probably benign |
0.41 |
|
R7342:Vmn2r125
|
UTSW |
4 |
156,703,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7926:Vmn2r125
|
UTSW |
4 |
156,702,988 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8113:Vmn2r125
|
UTSW |
4 |
156,703,642 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8191:Vmn2r125
|
UTSW |
4 |
156,703,709 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8272:Vmn2r125
|
UTSW |
4 |
156,702,373 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8962:Vmn2r125
|
UTSW |
4 |
156,703,186 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R9187:Vmn2r125
|
UTSW |
4 |
156,703,554 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCTGGAAGGTGGGTAGCATTAC -3'
(R):5'- GATTCTCCGAGCACCTAACTC -3'
Sequencing Primer
(F):5'- GGGTAGCATTACTTGTATATGAGTCC -3'
(R):5'- CTTCTAGAGTAGAGTTCATGTCACC -3'
|
| Posted On |
2020-08-01 |
Incidental Mutation