Incidental Mutation 'BB015:Rassf3'
ID 642857
Institutional Source Beutler Lab
Gene Symbol Rassf3
Ensembl Gene ENSMUSG00000025795
Gene Name Ras association (RalGDS/AF-6) domain family member 3
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.118) question?
Stock # BB015
Quality Score 225.009
Status Not validated
Chromosome 10
Chromosomal Location 121246255-121312220 bp(-) (GRCm39)
Type of Mutation splice site (6 bp from exon)
DNA Base Change (assembly) A to G at 121252984 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000026902 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026902]
AlphaFold Q99P51
Predicted Effect probably null
Transcript: ENSMUST00000026902
SMART Domains Protein: ENSMUSP00000026902
Gene: ENSMUSG00000025795

DomainStartEndE-ValueType
low complexity region 14 26 N/A INTRINSIC
RA 78 181 1.98e-3 SMART
Pfam:Nore1-SARAH 186 225 1e-20 PFAM
Meta Mutation Damage Score 0.9756 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The RAS oncogene (MIM 190020) is mutated in nearly one-third of all human cancers. Members of the RAS superfamily are plasma membrane GTP-binding proteins that modulate intracellular signal transduction pathways. A subfamily of RAS effectors, including RASSF3, share a RAS association (RA) domain.[supplied by OMIM, Jul 2003]
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrb1 T A 15: 74,410,170 (GRCm39) W270R probably damaging Het
Adprhl1 C T 8: 13,298,682 (GRCm39) V83I probably damaging Het
App A T 16: 84,775,134 (GRCm39) V501D probably benign Het
Cnot6l A G 5: 96,278,927 (GRCm39) V97A possibly damaging Het
Cntrob A G 11: 69,191,121 (GRCm39) L831P probably damaging Het
Dmbt1 T C 7: 130,639,620 (GRCm39) S53P probably benign Het
Dnah2 T C 11: 69,321,661 (GRCm39) D3833G probably damaging Het
Dock4 T C 12: 40,838,302 (GRCm39) L1081P probably damaging Het
Dock7 T C 4: 98,889,335 (GRCm39) N185D Het
Dsn1 T C 2: 156,847,932 (GRCm39) probably benign Het
Evpl T C 11: 116,113,359 (GRCm39) T1444A possibly damaging Het
Fanci T C 7: 79,094,459 (GRCm39) L1130P probably benign Het
Fancm A G 12: 65,152,898 (GRCm39) D1118G unknown Het
G530012D18Rik C G 1: 85,504,935 (GRCm39) D113E unknown Het
Gm11596 A G 11: 99,683,622 (GRCm39) V166A unknown Het
Gm2696 A T 10: 77,650,723 (GRCm39) T70S unknown Het
Gm5773 A G 3: 93,680,997 (GRCm39) E223G probably damaging Het
Madd T A 2: 91,007,233 (GRCm39) D293V probably damaging Het
Odam A G 5: 88,035,269 (GRCm39) T78A possibly damaging Het
Or52ae9 T A 7: 103,390,397 (GRCm39) I17F probably damaging Het
Rftn1 G T 17: 50,354,408 (GRCm39) A318D probably damaging Het
Rhbdf1 T C 11: 32,159,898 (GRCm39) Y826C possibly damaging Het
Rnf13 C A 3: 57,671,729 (GRCm39) Q14K probably benign Het
Sec13 A G 6: 113,706,601 (GRCm39) S271P probably damaging Het
Sema6c T C 3: 95,079,620 (GRCm39) L638P probably damaging Het
Sgsh T G 11: 119,238,561 (GRCm39) H301P probably benign Het
Shh T C 5: 28,666,404 (GRCm39) M161V possibly damaging Het
Stil C T 4: 114,887,198 (GRCm39) H764Y probably damaging Het
Vmn1r203 C T 13: 22,708,705 (GRCm39) T162I probably benign Het
Zzef1 T C 11: 72,712,722 (GRCm39) M214T probably damaging Het
Other mutations in Rassf3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00783:Rassf3 APN 10 121,251,985 (GRCm39) missense probably benign 0.00
IGL01955:Rassf3 APN 10 121,253,027 (GRCm39) missense probably damaging 1.00
BB005:Rassf3 UTSW 10 121,252,984 (GRCm39) splice site probably null
R0418:Rassf3 UTSW 10 121,253,075 (GRCm39) missense probably benign 0.42
R0467:Rassf3 UTSW 10 121,253,109 (GRCm39) splice site probably benign
R1167:Rassf3 UTSW 10 121,252,159 (GRCm39) missense probably damaging 1.00
R2906:Rassf3 UTSW 10 121,250,297 (GRCm39) missense probably damaging 1.00
R3801:Rassf3 UTSW 10 121,250,271 (GRCm39) missense possibly damaging 0.76
R7146:Rassf3 UTSW 10 121,252,052 (GRCm39) missense probably benign 0.06
R7257:Rassf3 UTSW 10 121,248,924 (GRCm39) nonsense probably null
R7579:Rassf3 UTSW 10 121,312,103 (GRCm39) start gained probably benign
R7928:Rassf3 UTSW 10 121,252,984 (GRCm39) splice site probably null
R8783:Rassf3 UTSW 10 121,253,069 (GRCm39) missense probably benign
R9010:Rassf3 UTSW 10 121,311,991 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- CAGGCTACCAGTCCTGAAAG -3'
(R):5'- AGAATCCTGGCTTATCTGCAC -3'

Sequencing Primer
(F):5'- AGTCCTGAAAGCCCCTGC -3'
(R):5'- TGGCTTATCTGCACGCTTG -3'
Posted On 2020-08-01