Mutagenetix > Incidental Mutation

Incidental Mutation 'BB018:Vmn1r157'

643011

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r157

Ensembl Gene

ENSMUSG00000095619

Gene Name

vomeronasal 1 receptor 157

Synonyms

Gm8699, Vmn1r109, Gm4517

Accession Numbers

Essential gene?

Not available question?

Stock #

BB018

Quality Score

166.009

Status

Not validated

Chromosome

Chromosomal Location

22461122-22462015 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 22461210 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Alanine to Valine at position 30 (A30V)

Ref Sequence

ENSEMBL: ENSMUSP00000137271 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000178215]

AlphaFold

E9Q069

Predicted Effect

probably damaging
Transcript: ENSMUST00000178215
AA Change: A30V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000137271
Gene: ENSMUSG00000095619
AA Change: A30V

Domain	Start	End	E-Value	Type
transmembrane domain	13	35	N/A	INTRINSIC
transmembrane domain	50	72	N/A	INTRINSIC
transmembrane domain	175	192	N/A	INTRINSIC
transmembrane domain	196	214	N/A	INTRINSIC
transmembrane domain	235	257	N/A	INTRINSIC
transmembrane domain	262	284	N/A	INTRINSIC

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.8%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acp2	A	T	2: 91,037,060 (GRCm39)		probably null	Het
Aire	G	A	10: 77,866,130 (GRCm39)	A536V	probably damaging	Het
Aox4	A	G	1: 58,294,645 (GRCm39)	I951M	probably benign	Het
Ash1l	G	T	3: 88,950,848 (GRCm39)	C2190F	probably damaging	Het
C1s1	C	T	6: 124,510,359 (GRCm39)	V363M	probably damaging	Het
Diaph3	A	T	14: 87,352,456 (GRCm39)	D48E	possibly damaging	Het
Dnajc13	A	G	9: 104,095,763 (GRCm39)	V559A	probably benign	Het
Dzank1	T	C	2: 144,323,614 (GRCm39)	I610V	probably benign	Het
F7	A	G	8: 13,085,209 (GRCm39)	I412V	probably benign	Het
Flt1	A	G	5: 147,525,382 (GRCm39)	S919P	probably damaging	Het
Igkv4-70	C	A	6: 69,244,975 (GRCm39)	R82L	probably damaging	Het
Lnp1	T	A	16: 56,748,281 (GRCm39)	R4*	probably null	Het
Lrrc3b	T	C	14: 15,358,018 (GRCm38)	N196S	probably benign	Het
Mlxip	A	G	5: 123,588,558 (GRCm39)	D816G	probably damaging	Het
Myh7	C	T	14: 55,221,119 (GRCm39)	E935K	possibly damaging	Het
Myom3	A	T	4: 135,516,947 (GRCm39)	H839L	probably benign	Het
Nebl	C	T	2: 17,381,433 (GRCm39)		probably null	Het
Ninj1	T	C	13: 49,347,432 (GRCm39)	I99T	probably damaging	Het
Or11g1	A	C	14: 50,651,786 (GRCm39)	M262L	probably damaging	Het
Or2l5	A	G	16: 19,334,258 (GRCm39)	S43P	possibly damaging	Het
Or4a76	T	A	2: 89,460,448 (GRCm39)	I265F	possibly damaging	Het
Or8g55	A	T	9: 39,785,146 (GRCm39)	T192S	possibly damaging	Het
Otop1	A	G	5: 38,445,364 (GRCm39)	H174R	probably damaging	Het
Pcdhb16	A	G	18: 37,611,510 (GRCm39)	N157D	possibly damaging	Het
Prss44	A	C	9: 110,643,746 (GRCm39)	Q130P	probably damaging	Het
Ptpn4	T	A	1: 119,607,925 (GRCm39)	M712L	probably damaging	Het
Ptprh	C	A	7: 4,574,987 (GRCm39)	S344I	probably benign	Het
Rps6kl1	T	C	12: 85,196,566 (GRCm39)	I33V	possibly damaging	Het
Rsf1	G	GACGGCGGCT	7: 97,229,116 (GRCm39)		probably benign	Het
Scn1a	T	C	2: 66,148,156 (GRCm39)	S110G	probably damaging	Het
Sdk2	C	A	11: 113,784,267 (GRCm39)	K157N	possibly damaging	Het
Serpina1d	A	T	12: 103,733,815 (GRCm39)	V163D	probably damaging	Het
Serpina3g	T	C	12: 104,205,428 (GRCm39)	S56P	probably benign	Het
Slc4a4	T	C	5: 89,318,640 (GRCm39)	L636P	probably benign	Het
Slc6a1	T	C	6: 114,288,863 (GRCm39)	F474S	probably benign	Het
Slco6d1	A	G	1: 98,356,141 (GRCm39)	D235G	probably damaging	Het
Srgn	A	T	10: 62,330,763 (GRCm39)	M114K	possibly damaging	Het
Syne3	A	T	12: 104,929,491 (GRCm39)	V243E	probably damaging	Het
Tcf19	A	G	17: 35,825,804 (GRCm39)	F118L	probably damaging	Het
Tln2	A	T	9: 67,165,742 (GRCm39)		probably null	Het
Tnxb	A	G	17: 34,907,672 (GRCm39)	T1239A	probably damaging	Het
Traip	A	G	9: 107,848,241 (GRCm39)	I453M	probably benign	Het
Vmn1r233	G	A	17: 21,214,125 (GRCm39)	A275V	probably benign	Het
Vps13d	G	A	4: 144,822,854 (GRCm39)	R2976*	probably null	Het
Wdr75	T	C	1: 45,858,795 (GRCm39)	F655L	probably benign	Het
Wwp1	A	G	4: 19,650,114 (GRCm39)		probably null	Het
Zc3h4	T	C	7: 16,166,909 (GRCm39)	L747P	unknown	Het
Zfp268	G	A	4: 145,349,126 (GRCm39)	D188N	possibly damaging	Het

Other mutations in Vmn1r157

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
BB008:Vmn1r157	UTSW	7	22,461,210 (GRCm39)	missense	probably damaging	1.00
R5253:Vmn1r157	UTSW	7	22,461,183 (GRCm39)	missense	probably damaging	1.00
R6016:Vmn1r157	UTSW	7	22,461,272 (GRCm39)	missense	possibly damaging	0.89
R7249:Vmn1r157	UTSW	7	22,461,125 (GRCm39)	missense	probably benign	0.03
R7931:Vmn1r157	UTSW	7	22,461,210 (GRCm39)	missense	probably damaging	1.00
R9233:Vmn1r157	UTSW	7	22,461,381 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- CTCAAATCAATTGGTAAGTGTGGAC -3'
(R):5'- AAATTTGTGCTTCTTGCCACCATG -3'

Sequencing Primer
(F):5'- TGTGGACAATAAAACAGAGACCC -3'
(R):5'- TTGCCACCATGTGACTGAAG -3'

Posted On

2020-08-01