|Institutional Source||Beutler Lab|
|Gene Name||decapping mRNA 2|
|Is this an essential gene?||Probably essential (E-score: 0.967)|
|Stock #||R0051 (G1)|
|Chromosomal Location||44380502-44424969 bp(+) (GRCm38)|
|Type of Mutation||splice site|
|DNA Base Change (assembly)||T to A at 44405374 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000025350 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000025350]|
|Predicted Effect||probably benign
|Meta Mutation Damage Score||0.0898|
|Coding Region Coverage||
|Validation Efficiency||100% (64/64)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structure from mRNA, prior to its degradation from the 5' end. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]
PHENOTYPE: Mice homozygous for a gene trapped allele are viable and fertile. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Dcp2||
(F):5'- AGCATAAGAAGGGGCTTGGTCCTA -3'
(R):5'- GCAGCAGTGAGGCCAGTTTTACAG -3'
(F):5'- AAGAAGGGGCTTGGTCCTAATTATC -3'
(R):5'- GGCCATAAAAAACTTATTAGGTGC -3'