Incidental Mutation 'R8044:Rab24'
ID 643157
Institutional Source Beutler Lab
Gene Symbol Rab24
Ensembl Gene ENSMUSG00000034789
Gene Name RAB24, member RAS oncogene family
Synonyms 6530406O07Rik
MMRRC Submission 067481-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8044 (G1)
Quality Score 225.009
Status Validated
Chromosome 13
Chromosomal Location 55467556-55469759 bp(-) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) A to G at 55469345 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000153246 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021941] [ENSMUST00000021942] [ENSMUST00000035242] [ENSMUST00000099490] [ENSMUST00000224685]
AlphaFold P35290
Predicted Effect probably benign
Transcript: ENSMUST00000021941
SMART Domains Protein: ENSMUSP00000021941
Gene: ENSMUSG00000021485

DomainStartEndE-ValueType
low complexity region 11 26 N/A INTRINSIC
HLH 63 115 5.8e-11 SMART
low complexity region 119 138 N/A INTRINSIC
low complexity region 148 167 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000021942
SMART Domains Protein: ENSMUSP00000021942
Gene: ENSMUSG00000021486

DomainStartEndE-ValueType
Pfam:PRELI 16 172 1.9e-61 PFAM
coiled coil region 178 215 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000035242
SMART Domains Protein: ENSMUSP00000046188
Gene: ENSMUSG00000034789

DomainStartEndE-ValueType
RAB 8 175 2.39e-44 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000099490
SMART Domains Protein: ENSMUSP00000097089
Gene: ENSMUSG00000021488

DomainStartEndE-ValueType
low complexity region 177 187 N/A INTRINSIC
low complexity region 281 289 N/A INTRINSIC
PWWP 322 388 1.97e-3 SMART
low complexity region 635 644 N/A INTRINSIC
low complexity region 980 1000 N/A INTRINSIC
low complexity region 1296 1309 N/A INTRINSIC
PHD 1546 1588 4.25e-8 SMART
PHD 1593 1640 3.79e-5 SMART
RING 1594 1639 1.08e-1 SMART
PHD 1641 1694 1.09e1 SMART
PHD 1710 1750 1.02e-10 SMART
PWWP 1755 1817 8.87e-29 SMART
AWS 1891 1942 3.02e-22 SMART
SET 1943 2066 1e-45 SMART
PostSET 2067 2083 3.99e-3 SMART
PHD 2121 2164 1.08e-9 SMART
low complexity region 2224 2237 N/A INTRINSIC
low complexity region 2276 2286 N/A INTRINSIC
low complexity region 2335 2356 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000224685
Meta Mutation Damage Score 0.0846 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (36/36)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] RAB24 is a small GTPase of the Rab subfamily of Ras-related proteins that regulate intracellular protein trafficking (Olkkonen et al., 1993 [PubMed 8126105]).[supplied by OMIM, Aug 2009]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921524J17Rik T C 8: 86,138,747 (GRCm39) E114G possibly damaging Het
Abcc4 ACCAGCCC ACC 14: 118,852,682 (GRCm39) probably null Het
Adgrv1 A T 13: 81,588,344 (GRCm39) V4414E possibly damaging Het
Asb7 T C 7: 66,309,511 (GRCm39) N235S probably benign Het
Atrn A T 2: 130,777,449 (GRCm39) N166I probably damaging Het
Cd300ld2 C T 11: 114,904,545 (GRCm39) W107* probably null Het
Chl1 A T 6: 103,683,593 (GRCm39) E806D probably damaging Het
Dnajb12 A G 10: 59,732,172 (GRCm39) K337R possibly damaging Het
Dock5 T C 14: 68,062,141 (GRCm39) D409G probably damaging Het
Efhb G A 17: 53,706,143 (GRCm39) S798L probably benign Het
Gpd1 T C 15: 99,621,083 (GRCm39) F322S probably damaging Het
Gria4 A G 9: 4,456,216 (GRCm39) Y695H probably damaging Het
Ipo8 A G 6: 148,711,421 (GRCm39) F289S probably damaging Het
Jakmip1 A G 5: 37,311,988 (GRCm39) E72G unknown Het
Mettl14 T C 3: 123,163,309 (GRCm39) N366S probably benign Het
Ntrk2 A G 13: 59,274,313 (GRCm39) T730A probably damaging Het
Or5b101 T C 19: 13,004,829 (GRCm39) Y288C probably damaging Het
Otop3 T C 11: 115,237,261 (GRCm39) L575P probably damaging Het
Piwil2 T C 14: 70,628,887 (GRCm39) S710G possibly damaging Het
Pramel32 T G 4: 88,548,212 (GRCm39) E64D possibly damaging Het
Ptpra A G 2: 130,386,881 (GRCm39) K627E possibly damaging Het
Rbm20 C A 19: 53,806,402 (GRCm39) A494D probably benign Het
Rpe65 T C 3: 159,320,342 (GRCm39) F300L probably benign Het
St6gal1 G A 16: 23,176,585 (GRCm39) A393T probably benign Het
Tert A G 13: 73,783,568 (GRCm39) E590G probably damaging Het
Tlr4 C A 4: 66,746,084 (GRCm39) L6I probably benign Het
Trim3 G A 7: 105,262,465 (GRCm39) silent Het
Tubg1 G T 11: 101,014,854 (GRCm39) A199S probably benign Het
Ube3a A T 7: 58,926,320 (GRCm39) H387L possibly damaging Het
Ugt1a7c G A 1: 88,023,278 (GRCm39) V146M probably damaging Het
Upf2 T C 2: 6,034,249 (GRCm39) I974T unknown Het
Vmn1r38 A T 6: 66,753,516 (GRCm39) I200N probably benign Het
Wnt5b A G 6: 119,423,319 (GRCm39) V115A probably damaging Het
Xpo7 C A 14: 70,922,366 (GRCm39) R574L probably benign Het
Other mutations in Rab24
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0518:Rab24 UTSW 13 55,468,738 (GRCm39) critical splice donor site probably null
R0521:Rab24 UTSW 13 55,468,738 (GRCm39) critical splice donor site probably null
R3871:Rab24 UTSW 13 55,468,992 (GRCm39) missense probably damaging 1.00
R5935:Rab24 UTSW 13 55,468,343 (GRCm39) missense probably damaging 1.00
R5964:Rab24 UTSW 13 55,469,389 (GRCm39) missense probably damaging 1.00
R7528:Rab24 UTSW 13 55,468,921 (GRCm39) missense probably damaging 1.00
R7941:Rab24 UTSW 13 55,468,120 (GRCm39) splice site probably null
R9416:Rab24 UTSW 13 55,468,049 (GRCm39) missense unknown
V1024:Rab24 UTSW 13 55,468,561 (GRCm39) missense probably benign 0.09
Predicted Primers PCR Primer
(F):5'- TGCACAAGACTCTGTTCTCAAG -3'
(R):5'- CAGATTCAGTCGGTAACCCC -3'

Sequencing Primer
(F):5'- TCTACAACCAGGGAAGAG -3'
(R):5'- CTCTGCAAAGGACGGAGC -3'
Posted On 2020-08-06