Incidental Mutation 'R7926:Vmn2r125'
ID |
643321 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r125
|
Ensembl Gene |
ENSMUSG00000096042 |
Gene Name |
vomeronasal 2, receptor 125 |
Synonyms |
Gm20782 |
MMRRC Submission |
045973-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.078)
|
Stock # |
R7926 (G1)
|
Quality Score |
227.241 |
Status
|
Not validated
|
Chromosome |
4 |
Chromosomal Location |
156696567-156708037 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 156702988 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Aspartic acid to Glycine
at position 122
(D122G)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000094556
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000096794]
|
AlphaFold |
no structure available at present |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000096794
AA Change: D122G
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000094556 Gene: ENSMUSG00000096042 AA Change: D122G
Domain | Start | End | E-Value | Type |
Pfam:ANF_receptor
|
9 |
355 |
7e-32 |
PFAM |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.9%
- 20x: 99.6%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 46 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Adprhl1 |
C |
T |
8: 13,298,682 (GRCm39) |
V83I |
probably damaging |
Het |
BC016579 |
C |
A |
16: 45,449,825 (GRCm39) |
D198Y |
probably damaging |
Het |
Cep170 |
A |
G |
1: 176,588,979 (GRCm39) |
S549P |
probably damaging |
Het |
Cnih3 |
T |
C |
1: 181,277,566 (GRCm39) |
L96P |
probably damaging |
Het |
Cnn2 |
T |
A |
10: 79,829,160 (GRCm39) |
L168Q |
probably damaging |
Het |
Cnot1 |
ACG |
A |
8: 96,472,275 (GRCm39) |
|
probably null |
Het |
Cnot10 |
A |
G |
9: 114,446,883 (GRCm39) |
C398R |
probably damaging |
Het |
Dcaf4 |
C |
A |
12: 83,580,703 (GRCm39) |
Y212* |
probably null |
Het |
Dmxl2 |
T |
C |
9: 54,335,326 (GRCm39) |
T665A |
probably benign |
Het |
Dnmt1 |
C |
A |
9: 20,818,855 (GRCm39) |
A1609S |
unknown |
Het |
Dzip1 |
T |
C |
14: 119,120,911 (GRCm39) |
D682G |
probably benign |
Het |
Fam76a |
A |
G |
4: 132,629,405 (GRCm39) |
L249P |
probably damaging |
Het |
Fgf10 |
T |
C |
13: 118,925,752 (GRCm39) |
M177T |
probably damaging |
Het |
G530012D18Rik |
C |
G |
1: 85,504,935 (GRCm39) |
D113E |
unknown |
Het |
Hoxa13 |
CG |
CGAG |
6: 52,237,619 (GRCm39) |
|
probably null |
Het |
Itln1 |
G |
A |
1: 171,359,261 (GRCm39) |
T73I |
probably benign |
Het |
Jkamp |
T |
C |
12: 72,141,590 (GRCm39) |
Y197H |
probably damaging |
Het |
Kti12 |
A |
C |
4: 108,705,443 (GRCm39) |
E119A |
probably benign |
Het |
Kti12 |
G |
T |
4: 108,705,444 (GRCm39) |
E119D |
probably benign |
Het |
Lcor |
T |
C |
19: 41,571,008 (GRCm39) |
F67S |
probably benign |
Het |
Lmf2 |
G |
A |
15: 89,236,624 (GRCm39) |
P514L |
probably damaging |
Het |
Lmntd2 |
G |
T |
7: 140,790,258 (GRCm39) |
P610Q |
probably damaging |
Het |
Map3k3 |
T |
C |
11: 106,036,548 (GRCm39) |
S225P |
probably damaging |
Het |
Mbd5 |
T |
C |
2: 49,146,335 (GRCm39) |
Y182H |
probably damaging |
Het |
Mki67 |
A |
G |
7: 135,298,869 (GRCm39) |
V2055A |
possibly damaging |
Het |
Mtmr7 |
G |
A |
8: 41,059,927 (GRCm39) |
A62V |
possibly damaging |
Het |
Myh8 |
C |
T |
11: 67,169,732 (GRCm39) |
P17L |
possibly damaging |
Het |
Myt1l |
T |
A |
12: 29,861,651 (GRCm39) |
D144E |
unknown |
Het |
Nfatc1 |
T |
C |
18: 80,740,881 (GRCm39) |
Y373C |
probably damaging |
Het |
Pacs2 |
C |
T |
12: 113,024,372 (GRCm39) |
L418F |
probably damaging |
Het |
Paxip1 |
A |
G |
5: 27,996,207 (GRCm39) |
I24T |
unknown |
Het |
Pdcl |
C |
T |
2: 37,242,249 (GRCm39) |
G167E |
probably damaging |
Het |
Pdcl |
A |
C |
2: 37,242,251 (GRCm39) |
S166R |
probably damaging |
Het |
Pigt |
CCAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGATCTGTAACCACAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGATCTGTAACCACAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGAT |
CCAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGATCTGTAACCACAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGAT |
2: 164,341,589 (GRCm39) |
|
probably null |
Het |
Qsox1 |
C |
T |
1: 155,688,533 (GRCm39) |
G5S |
unknown |
Het |
Rftn1 |
G |
T |
17: 50,354,408 (GRCm39) |
A318D |
probably damaging |
Het |
Sass6 |
T |
A |
3: 116,422,419 (GRCm39) |
S641T |
possibly damaging |
Het |
Six1 |
T |
C |
12: 73,090,583 (GRCm39) |
N194S |
probably benign |
Het |
Tagap |
T |
C |
17: 8,145,770 (GRCm39) |
|
probably null |
Het |
Tiparp |
T |
C |
3: 65,460,946 (GRCm39) |
V645A |
possibly damaging |
Het |
Tm2d2 |
T |
C |
8: 25,510,480 (GRCm39) |
V113A |
probably damaging |
Het |
Tmprss6 |
C |
A |
15: 78,337,050 (GRCm39) |
R352L |
probably benign |
Het |
Tslp |
A |
G |
18: 32,950,246 (GRCm39) |
E105G |
possibly damaging |
Het |
Ttc41 |
A |
G |
10: 86,611,911 (GRCm39) |
E1093G |
probably benign |
Het |
Ush2a |
G |
A |
1: 188,460,797 (GRCm39) |
R2686H |
probably benign |
Het |
Usp54 |
A |
T |
14: 20,627,036 (GRCm39) |
Y541N |
probably damaging |
Het |
|
Other mutations in Vmn2r125 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00990:Vmn2r125
|
APN |
4 |
156,703,194 (GRCm39) |
missense |
probably benign |
|
IGL00990:Vmn2r125
|
APN |
4 |
156,703,333 (GRCm39) |
missense |
probably benign |
0.06 |
IGL00990:Vmn2r125
|
APN |
4 |
156,703,332 (GRCm39) |
missense |
probably benign |
0.16 |
IGL00990:Vmn2r125
|
APN |
4 |
156,703,521 (GRCm39) |
missense |
probably benign |
|
IGL00990:Vmn2r125
|
APN |
4 |
156,703,678 (GRCm39) |
missense |
probably benign |
0.00 |
IGL00990:Vmn2r125
|
APN |
4 |
156,703,261 (GRCm39) |
missense |
probably benign |
0.01 |
IGL00990:Vmn2r125
|
APN |
4 |
156,703,195 (GRCm39) |
missense |
probably benign |
0.35 |
IGL01018:Vmn2r125
|
APN |
4 |
156,703,333 (GRCm39) |
missense |
probably benign |
0.06 |
IGL01018:Vmn2r125
|
APN |
4 |
156,703,332 (GRCm39) |
missense |
probably benign |
0.16 |
IGL01018:Vmn2r125
|
APN |
4 |
156,703,521 (GRCm39) |
missense |
probably benign |
|
IGL01018:Vmn2r125
|
APN |
4 |
156,703,195 (GRCm39) |
missense |
probably benign |
0.35 |
IGL01018:Vmn2r125
|
APN |
4 |
156,703,194 (GRCm39) |
missense |
probably benign |
|
IGL01018:Vmn2r125
|
APN |
4 |
156,703,140 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01018:Vmn2r125
|
APN |
4 |
156,702,907 (GRCm39) |
splice site |
probably benign |
|
IGL02644:Vmn2r125
|
APN |
4 |
156,703,294 (GRCm39) |
missense |
probably benign |
0.01 |
IGL03144:Vmn2r125
|
APN |
4 |
156,702,314 (GRCm39) |
missense |
possibly damaging |
0.76 |
BB013:Vmn2r125
|
UTSW |
4 |
156,702,988 (GRCm39) |
missense |
probably damaging |
1.00 |
FR4342:Vmn2r125
|
UTSW |
4 |
156,703,260 (GRCm39) |
missense |
probably benign |
0.01 |
R0408:Vmn2r125
|
UTSW |
4 |
156,703,153 (GRCm39) |
missense |
probably damaging |
0.99 |
R0785:Vmn2r125
|
UTSW |
4 |
156,703,396 (GRCm39) |
missense |
probably benign |
|
R1185:Vmn2r125
|
UTSW |
4 |
156,703,396 (GRCm39) |
missense |
probably benign |
|
R1185:Vmn2r125
|
UTSW |
4 |
156,703,396 (GRCm39) |
missense |
probably benign |
|
R1530:Vmn2r125
|
UTSW |
4 |
156,703,447 (GRCm39) |
missense |
probably damaging |
1.00 |
R1698:Vmn2r125
|
UTSW |
4 |
156,703,333 (GRCm39) |
missense |
probably benign |
0.06 |
R1780:Vmn2r125
|
UTSW |
4 |
156,703,668 (GRCm39) |
missense |
probably damaging |
1.00 |
R1977:Vmn2r125
|
UTSW |
4 |
156,707,162 (GRCm39) |
splice site |
probably null |
|
R2917:Vmn2r125
|
UTSW |
4 |
156,703,564 (GRCm39) |
missense |
probably benign |
0.01 |
R3428:Vmn2r125
|
UTSW |
4 |
156,702,436 (GRCm39) |
missense |
probably benign |
0.34 |
R3712:Vmn2r125
|
UTSW |
4 |
156,702,419 (GRCm39) |
nonsense |
probably null |
|
R4274:Vmn2r125
|
UTSW |
4 |
156,702,382 (GRCm39) |
missense |
probably benign |
0.00 |
R4575:Vmn2r125
|
UTSW |
4 |
156,702,272 (GRCm39) |
missense |
probably null |
0.30 |
R4707:Vmn2r125
|
UTSW |
4 |
156,702,276 (GRCm39) |
missense |
probably damaging |
1.00 |
R5229:Vmn2r125
|
UTSW |
4 |
156,703,333 (GRCm39) |
missense |
probably benign |
0.06 |
R5504:Vmn2r125
|
UTSW |
4 |
156,703,456 (GRCm39) |
missense |
possibly damaging |
0.81 |
R5587:Vmn2r125
|
UTSW |
4 |
156,702,433 (GRCm39) |
missense |
probably damaging |
1.00 |
R5987:Vmn2r125
|
UTSW |
4 |
156,702,292 (GRCm39) |
missense |
probably damaging |
1.00 |
R6037:Vmn2r125
|
UTSW |
4 |
156,703,396 (GRCm39) |
missense |
probably benign |
|
R6183:Vmn2r125
|
UTSW |
4 |
156,702,364 (GRCm39) |
missense |
probably damaging |
0.97 |
R6456:Vmn2r125
|
UTSW |
4 |
156,703,357 (GRCm39) |
missense |
probably benign |
0.41 |
R7342:Vmn2r125
|
UTSW |
4 |
156,703,138 (GRCm39) |
missense |
probably damaging |
1.00 |
R8113:Vmn2r125
|
UTSW |
4 |
156,703,642 (GRCm39) |
missense |
probably damaging |
1.00 |
R8191:Vmn2r125
|
UTSW |
4 |
156,703,709 (GRCm39) |
missense |
probably damaging |
1.00 |
R8272:Vmn2r125
|
UTSW |
4 |
156,702,373 (GRCm39) |
missense |
probably damaging |
1.00 |
R8962:Vmn2r125
|
UTSW |
4 |
156,703,186 (GRCm39) |
missense |
possibly damaging |
0.50 |
R9187:Vmn2r125
|
UTSW |
4 |
156,703,554 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- TCTGGAAGGTGGGTAGCATTAC -3'
(R):5'- ACTTCTAGAGTAGAGTTCATGTCACC -3'
Sequencing Primer
(F):5'- GGGTAGCATTACTTGTATATGAGTCC -3'
(R):5'- AACAACCTTTGCTGAAGATGTC -3'
|
Posted On |
2020-08-07 |