|Institutional Source||Beutler Lab|
|Gene Name||growth arrest and DNA-damage-inducible 45 beta|
|Is this an essential gene?||Probably essential (E-score: 0.790)|
|Stock #||R7932 (G1)|
|Chromosomal Location||80930073-80932204 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to A at 80930335 bp|
|Amino Acid Change||Valine to Glutamic Acid at position 7 (V7E)|
|Ref Sequence||ENSEMBL: ENSMUSP00000015456 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000015456] [ENSMUST00000220246]|
|Predicted Effect||possibly damaging
AA Change: V7E
PolyPhen 2 Score 0.759 (Sensitivity: 0.85; Specificity: 0.92)
AA Change: V7E
|Predicted Effect||probably benign
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous inactivation of this locus affects immune response. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Gadd45b||
(F):5'- TCATATAAACCGCTCGCAGC -3'
(R):5'- ATTCATCAGTTTGGCCGCC -3'
(F):5'- AACCCTGGGTCTGCGTTC -3'
(R):5'- AGTTTGGCCGCCTCGTAC -3'