Incidental Mutation 'R8093:Rev1'
ID 643763
Institutional Source Beutler Lab
Gene Symbol Rev1
Ensembl Gene ENSMUSG00000026082
Gene Name REV1, DNA directed polymerase
Synonyms 1110027I23Rik, Rev1l, REV1
MMRRC Submission 067525-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.921) question?
Stock # R8093 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 38091867-38168882 bp(-) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) T to C at 38114097 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000027251]
AlphaFold Q920Q2
Predicted Effect probably benign
Transcript: ENSMUST00000027251
SMART Domains Protein: ENSMUSP00000027251
Gene: ENSMUSG00000026082

DomainStartEndE-ValueType
BRCT 46 121 3.99e-13 SMART
low complexity region 320 342 N/A INTRINSIC
Pfam:IMS 420 620 1.9e-43 PFAM
Pfam:IMS_C 700 831 5.8e-20 PFAM
low complexity region 888 901 N/A INTRINSIC
Pfam:DUF4414 938 1071 9.7e-11 PFAM
Pfam:REV1_C 1127 1248 1.2e-43 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000193472
Predicted Effect
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 99.2%
  • 20x: 98.3%
Validation Efficiency 100% (60/60)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. [provided by RefSeq, Mar 2016]
PHENOTYPE: Mice homozygous for a knock-in allele exhibit abnormal somatic hypermutation frequency of the Ig gene. Mice homozygous for a knock-out allele exhibit background-sensitive prenatal lethality and abnormal somatic hypermutation frequency. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930562C15Rik A T 16: 4,669,368 (GRCm39) T745S possibly damaging Het
Abca12 T C 1: 71,319,552 (GRCm39) I1777V probably benign Het
Abhd6 T C 14: 8,028,353 (GRCm38) L28P probably damaging Het
Angpt1 T A 15: 42,339,873 (GRCm39) E279D probably benign Het
Arfgef2 A G 2: 166,736,577 (GRCm39) M1750V probably benign Het
Atrn T C 2: 130,817,908 (GRCm39) F821L probably benign Het
Cbx3 A G 6: 51,458,748 (GRCm39) E71G possibly damaging Het
Ccdc14 G A 16: 34,530,022 (GRCm39) A482T probably damaging Het
Cdh15 G T 8: 123,593,574 (GRCm39) A723S probably damaging Het
Cyp2a12 A G 7: 26,736,054 (GRCm39) S488G probably damaging Het
Ddx55 C A 5: 124,694,883 (GRCm39) H104N possibly damaging Het
Det1 G T 7: 78,493,257 (GRCm39) T249N possibly damaging Het
Disp3 A G 4: 148,354,973 (GRCm39) S348P possibly damaging Het
Dnah6 T G 6: 73,137,896 (GRCm39) N936T probably damaging Het
Dnajc11 A T 4: 152,054,357 (GRCm39) N188Y probably damaging Het
Etaa1 G A 11: 17,897,559 (GRCm39) T186I possibly damaging Het
Fhip1a T C 3: 85,580,111 (GRCm39) D698G probably benign Het
Ftl1-ps1 T A 13: 74,555,138 (GRCm39) V139E probably benign Het
Fzd10 A G 5: 128,679,303 (GRCm39) K341R probably benign Het
Galnt7 A G 8: 57,985,739 (GRCm39) Y544H probably benign Het
Gm21190 T A 5: 15,730,814 (GRCm39) I181F possibly damaging Het
Gm3604 T C 13: 62,517,363 (GRCm39) N332D probably damaging Het
Gm47996 G T 1: 151,086,055 (GRCm39) E45D possibly damaging Het
Gm5475 T A 15: 100,321,893 (GRCm39) L14Q unknown Het
Gmcl1 G T 6: 86,698,408 (GRCm39) A163E probably damaging Het
Gpr137b T C 13: 13,533,991 (GRCm39) Y355C Het
Gpr182 T C 10: 127,586,783 (GRCm39) Y56C probably damaging Het
Gxylt2 T A 6: 100,710,188 (GRCm39) W110R probably damaging Het
Hivep3 G T 4: 119,952,632 (GRCm39) R316L possibly damaging Het
Hnf1a T C 5: 115,093,336 (GRCm39) T310A probably benign Het
Igkv6-32 A G 6: 70,051,547 (GRCm39) F8L probably benign Het
Kcnq1 A G 7: 142,916,389 (GRCm39) N550D probably damaging Het
Lrrc40 T G 3: 157,757,419 (GRCm39) Y249* probably null Het
Lrrc43 T A 5: 123,639,192 (GRCm39) M407K probably benign Het
Map2k6 A C 11: 110,373,411 (GRCm39) E21D probably benign Het
Mcoln1 T A 8: 3,558,740 (GRCm39) I246N possibly damaging Het
Msantd5f6 A T 4: 73,321,759 (GRCm39) V92E probably damaging Het
Myh2 A G 11: 67,079,536 (GRCm39) K998E probably damaging Het
Myo1b C T 1: 51,797,034 (GRCm39) probably null Het
Numbl T A 7: 26,980,461 (GRCm39) M481K possibly damaging Het
Nxpe4 G T 9: 48,307,852 (GRCm39) V319F probably benign Het
Pam C A 1: 97,813,357 (GRCm39) D358Y probably damaging Het
Papola A G 12: 105,775,836 (GRCm39) M251V probably damaging Het
Pcnx1 C T 12: 81,965,593 (GRCm39) R59* probably null Het
Prelid2 A G 18: 42,065,700 (GRCm39) S112P probably damaging Het
Ptgfrn T C 3: 100,963,753 (GRCm39) T620A probably benign Het
Ptgfrn C T 3: 100,980,257 (GRCm39) R361Q probably benign Het
Pygm T A 19: 6,436,072 (GRCm39) M148K probably damaging Het
Ren1 T A 1: 133,287,812 (GRCm39) I382N probably damaging Het
Sdsl T C 5: 120,598,017 (GRCm39) K159E probably benign Het
Serinc4 T C 2: 121,285,434 (GRCm39) N203S possibly damaging Het
Slc12a2 A G 18: 58,012,423 (GRCm39) H182R probably benign Het
Sned1 C A 1: 93,202,387 (GRCm39) T677K possibly damaging Het
Ston2 G A 12: 91,710,460 (GRCm39) T3I probably damaging Het
Tnf T C 17: 35,420,072 (GRCm39) T77A probably benign Het
Trav6-2 G A 14: 52,905,126 (GRCm39) G49E probably benign Het
Trav7-4 A T 14: 53,699,140 (GRCm39) I96F probably damaging Het
Trmu T A 15: 85,766,921 (GRCm39) D43E probably benign Het
Uggt1 T A 1: 36,266,566 (GRCm39) Q136L probably damaging Het
Ugt1a5 T A 1: 88,094,304 (GRCm39) Y177* probably null Het
Vmn1r126 T C 7: 21,034,516 (GRCm39) R293G probably damaging Het
Vmn2r89 A G 14: 51,693,699 (GRCm39) I350V probably benign Het
Vps11 A T 9: 44,267,529 (GRCm39) L361Q probably damaging Het
Zfp467 A G 6: 48,420,366 (GRCm39) L5P possibly damaging Het
Zfp652 A G 11: 95,640,288 (GRCm39) H71R probably damaging Het
Zfp804b T C 5: 6,820,082 (GRCm39) K994E probably benign Het
Other mutations in Rev1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00896:Rev1 APN 1 38,138,021 (GRCm39) missense probably damaging 1.00
IGL01065:Rev1 APN 1 38,138,090 (GRCm39) missense possibly damaging 0.89
IGL01393:Rev1 APN 1 38,131,144 (GRCm39) missense probably damaging 1.00
IGL03003:Rev1 APN 1 38,127,154 (GRCm39) missense possibly damaging 0.77
H8562:Rev1 UTSW 1 38,095,848 (GRCm39) missense probably damaging 0.96
PIT1430001:Rev1 UTSW 1 38,095,337 (GRCm39) unclassified probably benign
R0409:Rev1 UTSW 1 38,113,449 (GRCm39) nonsense probably null
R0606:Rev1 UTSW 1 38,098,204 (GRCm39) missense probably null 1.00
R1134:Rev1 UTSW 1 38,096,768 (GRCm39) missense probably benign 0.04
R1171:Rev1 UTSW 1 38,127,581 (GRCm39) missense possibly damaging 0.89
R1208:Rev1 UTSW 1 38,098,199 (GRCm39) unclassified probably benign
R1440:Rev1 UTSW 1 38,127,286 (GRCm39) missense probably damaging 1.00
R1485:Rev1 UTSW 1 38,127,653 (GRCm39) missense probably benign 0.00
R1627:Rev1 UTSW 1 38,094,571 (GRCm39) missense probably damaging 0.99
R3845:Rev1 UTSW 1 38,138,069 (GRCm39) missense probably damaging 0.99
R3948:Rev1 UTSW 1 38,113,414 (GRCm39) missense possibly damaging 0.69
R4074:Rev1 UTSW 1 38,093,319 (GRCm39) missense possibly damaging 0.50
R4075:Rev1 UTSW 1 38,093,319 (GRCm39) missense possibly damaging 0.50
R4076:Rev1 UTSW 1 38,093,319 (GRCm39) missense possibly damaging 0.50
R4248:Rev1 UTSW 1 38,146,729 (GRCm39) missense possibly damaging 0.87
R4293:Rev1 UTSW 1 38,147,500 (GRCm39) missense possibly damaging 0.89
R4548:Rev1 UTSW 1 38,098,275 (GRCm39) missense possibly damaging 0.72
R4610:Rev1 UTSW 1 38,092,730 (GRCm39) missense probably damaging 1.00
R4654:Rev1 UTSW 1 38,118,337 (GRCm39) intron probably benign
R5032:Rev1 UTSW 1 38,113,570 (GRCm39) intron probably benign
R5286:Rev1 UTSW 1 38,094,407 (GRCm39) nonsense probably null
R5311:Rev1 UTSW 1 38,118,474 (GRCm39) missense probably benign 0.00
R5327:Rev1 UTSW 1 38,147,532 (GRCm39) nonsense probably null
R6363:Rev1 UTSW 1 38,110,570 (GRCm39) missense probably damaging 1.00
R7050:Rev1 UTSW 1 38,093,352 (GRCm39) missense probably damaging 1.00
R7072:Rev1 UTSW 1 38,106,626 (GRCm39) nonsense probably null
R7132:Rev1 UTSW 1 38,110,530 (GRCm39) missense possibly damaging 0.95
R7264:Rev1 UTSW 1 38,124,682 (GRCm39) missense probably damaging 1.00
R7298:Rev1 UTSW 1 38,092,185 (GRCm39) missense probably damaging 1.00
R7367:Rev1 UTSW 1 38,113,488 (GRCm39) nonsense probably null
R7395:Rev1 UTSW 1 38,127,146 (GRCm39) missense possibly damaging 0.69
R7829:Rev1 UTSW 1 38,095,526 (GRCm39) missense probably damaging 0.98
R8053:Rev1 UTSW 1 38,102,222 (GRCm39) missense possibly damaging 0.67
R8356:Rev1 UTSW 1 38,098,324 (GRCm39) nonsense probably null
R8456:Rev1 UTSW 1 38,098,324 (GRCm39) nonsense probably null
R8461:Rev1 UTSW 1 38,122,868 (GRCm39) missense possibly damaging 0.56
R8724:Rev1 UTSW 1 38,127,150 (GRCm39) missense probably damaging 1.00
R8757:Rev1 UTSW 1 38,098,353 (GRCm39) missense probably damaging 1.00
R8759:Rev1 UTSW 1 38,098,353 (GRCm39) missense probably damaging 1.00
R8945:Rev1 UTSW 1 38,122,824 (GRCm39) missense probably damaging 0.98
R9309:Rev1 UTSW 1 38,093,945 (GRCm39) missense probably damaging 1.00
R9433:Rev1 UTSW 1 38,092,173 (GRCm39) missense probably damaging 1.00
R9500:Rev1 UTSW 1 38,102,214 (GRCm39) nonsense probably null
X0017:Rev1 UTSW 1 38,092,742 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACACAGAACAGTGCTATGTGAC -3'
(R):5'- ACCATGGTCATCCTGCACAG -3'

Sequencing Primer
(F):5'- CAGTGCTATGTGACAGACAGAC -3'
(R):5'- CATGGTCATCCTGCACAGTATTATG -3'
Posted On 2020-08-13