|Institutional Source||Beutler Lab|
|Gene Name||fibrinogen-like protein 1|
|Essential gene?||Probably non essential (E-score: 0.093)|
|Stock #||R8140 (G1)|
|Chromosomal Location||41191434-41215156 bp(-) (GRCm38)|
|Type of Mutation||splice site|
|DNA Base Change (assembly)||T to C at 41200609 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000034003 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000034003] [ENSMUST00000034003]|
|AlphaFold||no structure available at present|
|Coding Region Coverage||
|Validation Efficiency||97% (64/66)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas. Four alternatively spliced transcript variants encoding the same protein exist for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased body weight, decreased circulating cholesterol and free fatty acid, hyperglycemia, impaired glucose tolerance, increased gluconeogenesis, increased white adipose tissue and decreased respiratory quotient. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Fgl1||
(F):5'- GCAGTTACCTGTTAAAGTTCTCAC -3'
(R):5'- GGCAGCTAAGTTTCACTGTGC -3'
(F):5'- TAAAGTTCTCACTGCCATCAGATCG -3'
(R):5'- GCATGTACACCTGCATGTCAG -3'