|Institutional Source||Beutler Lab|
|Gene Name||deoxyribonuclease 1-like 3|
|Is this an essential gene?||Probably non essential (E-score: 0.054)|
|Stock #||R8165 (G1)|
|Chromosomal Location||7964533-7994573 bp(-) (GRCm38)|
|Type of Mutation||start gained|
|DNA Base Change (assembly)||T to C at 7994299 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000026315 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000026315]|
|Predicted Effect||probably benign
|Coding Region Coverage||
|Validation Efficiency||100% (65/65)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the deoxyribonuclease I family. The encoded protein hydrolyzes DNA, is not inhibited by actin, and mediates the breakdown of DNA during apoptosis. Mutations in this gene are a cause of systemic lupus erythematosus-16. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired necrosis-associated internucleosomal DNA fragmentation. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Dnase1l3||
(F):5'- ACGCGTTTCAATCCCCAAGG -3'
(R):5'- CACCTTCCTCAGATGCCAAG -3'
(F):5'- TCCCCAAGGAAATGAAGGTAATG -3'
(R):5'- TCCTCAGATGCCAAGGTATCC -3'