|Institutional Source||Beutler Lab|
|Gene Name||teneurin transmembrane protein 4|
|Synonyms||Doc4, l7Rn3, Ten-m4, ELM2, l(7)-3Rn, Odz4|
|Is this an essential gene?||Essential (E-score: 1.000)|
|Stock #||R8054 (G1)|
|Chromosomal Location||96171246-96911093 bp(+) (GRCm38)|
|Type of Mutation||splice site|
|DNA Base Change (assembly)||C to A at 96729346 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000102784 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000107162] [ENSMUST00000107165] [ENSMUST00000107166]|
|AlphaFold||no structure available at present|
|Coding Region Coverage||
|Validation Efficiency||100% (75/75)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene plays a role in establishing proper neuronal connectivity during development. Defects in this gene have been associated with hereditary essential tremor-5. [provided by RefSeq, Oct 2016]
PHENOTYPE: Various ENU-induced alleles cause prenatal lethality associated with impaired mesoderm development and lead to pleiotropic phenotypes. The most severe alleles cause failure of gastrulation and somitogenesis while the least severe one allows survival to adulthood with runting of variable penetrance. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Tenm4||
(F):5'- TCAAGACCTCCTGAAACTGTG -3'
(R):5'- TCCGTTCAAAGGCAGACAC -3'
(F):5'- GGTCCAAAACCTTGATTATCACTGTG -3'
(R):5'- AGCAACCCTACCTTCTGCGG -3'