Incidental Mutation 'R8076:Dock5'
ID 643830
Institutional Source Beutler Lab
Gene Symbol Dock5
Ensembl Gene ENSMUSG00000044447
Gene Name dedicator of cytokinesis 5
Synonyms 1110060D06Rik, rlc, lr2
MMRRC Submission 067510-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.346) question?
Stock # R8076 (G1)
Quality Score 225.009
Status Validated
Chromosome 14
Chromosomal Location 67989584-68170891 bp(-) (GRCm39)
Type of Mutation splice site (6 bp from exon)
DNA Base Change (assembly) A to T at 68040426 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000036674 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039135]
AlphaFold B2RY04
Predicted Effect probably null
Transcript: ENSMUST00000039135
SMART Domains Protein: ENSMUSP00000036674
Gene: ENSMUSG00000044447

DomainStartEndE-ValueType
SH3 11 68 1.45e-13 SMART
Pfam:DOCK_N 71 434 9e-110 PFAM
Pfam:DOCK-C2 439 636 1.1e-57 PFAM
low complexity region 752 764 N/A INTRINSIC
Pfam:DHR-2 1133 1635 6.4e-99 PFAM
low complexity region 1663 1692 N/A INTRINSIC
low complexity region 1815 1824 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.8%
  • 20x: 95.1%
Validation Efficiency 98% (62/63)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family act as guanine nucleotide exchange factors for small Rho family G proteins. The protein encoded by this gene is thought to associate with adaptors CRK and CRKL, and function in regulation of intestinal epithelial cell spreading and migration on collagen IV. Similar proteins in mouse and zebrafish also function in myoblast fusion. [provided by RefSeq, Oct 2016]
PHENOTYPE: Mutations at this locus result in lens abnormalities involving cataracts and rupturing of the lens nucleus. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam9 T A 8: 25,452,938 (GRCm39) R790* probably null Het
Adamts13 C A 2: 26,880,624 (GRCm39) P736T probably benign Het
Aldh3b2 T A 19: 4,028,859 (GRCm39) F176L possibly damaging Het
Aldoart2 A G 12: 55,612,696 (GRCm39) E207G probably benign Het
Arid4b A T 13: 14,361,535 (GRCm39) E753D probably benign Het
Cd160 T A 3: 96,709,662 (GRCm39) T158S probably benign Het
Cd209g T A 8: 4,185,195 (GRCm39) M1K probably null Het
Chrm4 A G 2: 91,758,204 (GRCm39) Y204C probably damaging Het
Cyld T A 8: 89,456,346 (GRCm39) N465K probably benign Het
Dchs1 A T 7: 105,405,128 (GRCm39) H2471Q possibly damaging Het
Dchs1 A G 7: 105,411,189 (GRCm39) V1612A probably damaging Het
Ddx24 A G 12: 103,382,477 (GRCm39) V702A probably damaging Het
Dnah8 A G 17: 31,003,127 (GRCm39) T3609A possibly damaging Het
Dpy19l2 C T 9: 24,591,988 (GRCm39) R205H probably damaging Het
Eif3a A T 19: 60,762,363 (GRCm39) D473E probably damaging Het
Elapor1 G T 3: 108,399,398 (GRCm39) T64K probably benign Het
Elobl T C 11: 88,855,796 (GRCm39) E89G possibly damaging Het
Fam186a A T 15: 99,841,351 (GRCm39) I1631N possibly damaging Het
Fbn2 C T 18: 58,159,496 (GRCm39) W2411* probably null Het
Fbxl17 A G 17: 63,367,360 (GRCm39) I671T probably damaging Het
Glul C T 1: 153,782,868 (GRCm39) T193I possibly damaging Het
Grm7 A G 6: 111,543,000 (GRCm39) Y907C probably damaging Het
H4c16 A G 6: 136,781,124 (GRCm39) M85T probably benign Het
Hr A G 14: 70,795,381 (GRCm39) T309A probably benign Het
Ighg3 A G 12: 113,324,158 (GRCm39) S110P probably benign Het
Llgl2 A G 11: 115,737,755 (GRCm39) E180G possibly damaging Het
Mat2b A T 11: 40,576,092 (GRCm39) L112Q probably damaging Het
Mcoln2 T C 3: 145,896,169 (GRCm39) M497T probably damaging Het
Mmp24 C A 2: 155,649,481 (GRCm39) Y299* probably null Het
Mtor T C 4: 148,610,260 (GRCm39) probably null Het
Olig2 C A 16: 91,023,299 (GRCm39) D4E probably damaging Het
Or10ag2 A T 2: 87,248,889 (GRCm39) I164L probably benign Het
Pard3 T C 8: 128,142,077 (GRCm39) S878P probably damaging Het
Pcgf5 C T 19: 36,417,483 (GRCm39) P137L probably damaging Het
Pck1 A G 2: 172,997,071 (GRCm39) N238D probably damaging Het
Pstpip1 T C 9: 56,035,064 (GRCm39) S346P probably benign Het
Qsox2 G A 2: 26,114,897 (GRCm39) H40Y possibly damaging Het
Rbpj T C 5: 53,799,479 (GRCm39) I129T probably damaging Het
Rsf1 ATGGCG ATGGCGACGGTGGCG 7: 97,229,111 (GRCm39) probably benign Het
Saal1 G A 7: 46,360,031 (GRCm39) P9L probably benign Het
Sema3c A G 5: 17,932,362 (GRCm39) I622V probably benign Het
Sigirr C T 7: 140,671,785 (GRCm39) V333M probably benign Het
Sort1 T C 3: 108,246,183 (GRCm39) S387P probably damaging Het
Spata31h1 A C 10: 82,132,520 (GRCm39) Y163* probably null Het
Spta1 T A 1: 174,014,797 (GRCm39) S426T probably benign Het
Stag3 G A 5: 138,281,404 (GRCm39) S124N probably damaging Het
Stard10 A G 7: 100,993,176 (GRCm39) Y244C probably damaging Het
Tcea3 T A 4: 135,995,440 (GRCm39) I261N probably damaging Het
Tdrd1 A G 19: 56,832,267 (GRCm39) K395E probably damaging Het
Tenm2 T A 11: 35,918,048 (GRCm39) D1905V probably benign Het
Trim12c T C 7: 103,990,037 (GRCm39) Y480C unknown Het
Trip11 A G 12: 101,849,741 (GRCm39) V1441A probably damaging Het
Ttc21a G A 9: 119,795,392 (GRCm39) R1107Q probably benign Het
Wdr41 A G 13: 95,153,838 (GRCm39) I296V probably benign Het
Zdbf2 T A 1: 63,345,260 (GRCm39) V1213E possibly damaging Het
Zfp37 T C 4: 62,109,553 (GRCm39) N545D possibly damaging Het
Other mutations in Dock5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00504:Dock5 APN 14 68,024,338 (GRCm39) splice site probably benign
IGL00930:Dock5 APN 14 68,008,526 (GRCm39) missense probably damaging 1.00
IGL01525:Dock5 APN 14 68,043,169 (GRCm39) splice site probably benign
IGL01759:Dock5 APN 14 68,118,708 (GRCm39) nonsense probably null
IGL01941:Dock5 APN 14 68,049,681 (GRCm39) missense probably damaging 1.00
IGL02025:Dock5 APN 14 68,000,736 (GRCm39) missense probably damaging 1.00
IGL02093:Dock5 APN 14 68,076,992 (GRCm39) splice site probably benign
IGL02179:Dock5 APN 14 68,043,945 (GRCm39) splice site probably benign
IGL02208:Dock5 APN 14 68,065,899 (GRCm39) missense probably benign 0.06
IGL02605:Dock5 APN 14 68,065,887 (GRCm39) missense probably benign 0.18
IGL02608:Dock5 APN 14 68,065,888 (GRCm39) missense probably benign 0.01
IGL02938:Dock5 APN 14 67,994,667 (GRCm39) splice site probably benign
IGL02971:Dock5 APN 14 67,994,558 (GRCm39) missense probably null 1.00
IGL02983:Dock5 APN 14 68,002,119 (GRCm39) missense probably damaging 1.00
IGL03151:Dock5 APN 14 68,103,516 (GRCm39) missense probably damaging 1.00
IGL03410:Dock5 APN 14 68,083,535 (GRCm39) missense probably benign 0.04
PIT4366001:Dock5 UTSW 14 68,062,123 (GRCm39) missense possibly damaging 0.83
R0026:Dock5 UTSW 14 68,083,530 (GRCm39) missense probably benign 0.00
R0058:Dock5 UTSW 14 68,018,485 (GRCm39) missense probably benign 0.00
R0058:Dock5 UTSW 14 68,018,485 (GRCm39) missense probably benign 0.00
R0112:Dock5 UTSW 14 68,057,090 (GRCm39) missense probably benign
R0127:Dock5 UTSW 14 68,083,491 (GRCm39) missense probably benign 0.13
R0144:Dock5 UTSW 14 68,023,735 (GRCm39) missense probably benign 0.18
R0312:Dock5 UTSW 14 68,033,440 (GRCm39) missense possibly damaging 0.82
R0360:Dock5 UTSW 14 68,060,129 (GRCm39) splice site probably benign
R0364:Dock5 UTSW 14 68,060,129 (GRCm39) splice site probably benign
R0496:Dock5 UTSW 14 68,054,967 (GRCm39) missense probably damaging 1.00
R0506:Dock5 UTSW 14 68,022,241 (GRCm39) splice site probably benign
R0586:Dock5 UTSW 14 68,046,481 (GRCm39) missense probably damaging 1.00
R0597:Dock5 UTSW 14 68,022,383 (GRCm39) splice site probably null
R0625:Dock5 UTSW 14 68,078,612 (GRCm39) missense probably benign
R1109:Dock5 UTSW 14 68,043,927 (GRCm39) missense possibly damaging 0.80
R1221:Dock5 UTSW 14 67,996,610 (GRCm39) missense probably benign 0.00
R1278:Dock5 UTSW 14 68,077,015 (GRCm39) missense possibly damaging 0.80
R1927:Dock5 UTSW 14 68,083,511 (GRCm39) missense possibly damaging 0.60
R1944:Dock5 UTSW 14 67,994,584 (GRCm39) nonsense probably null
R1946:Dock5 UTSW 14 68,023,765 (GRCm39) missense probably damaging 1.00
R2046:Dock5 UTSW 14 68,049,591 (GRCm39) missense probably benign
R2101:Dock5 UTSW 14 68,031,459 (GRCm39) missense probably benign 0.02
R2252:Dock5 UTSW 14 68,022,261 (GRCm39) missense probably damaging 0.98
R2882:Dock5 UTSW 14 68,077,069 (GRCm39) missense probably damaging 0.99
R3110:Dock5 UTSW 14 68,095,371 (GRCm39) missense possibly damaging 0.72
R3112:Dock5 UTSW 14 68,095,371 (GRCm39) missense possibly damaging 0.72
R4236:Dock5 UTSW 14 67,993,941 (GRCm39) missense probably benign 0.02
R4242:Dock5 UTSW 14 68,065,939 (GRCm39) missense probably benign 0.19
R4244:Dock5 UTSW 14 68,012,031 (GRCm39) missense probably benign 0.41
R4646:Dock5 UTSW 14 68,080,228 (GRCm39) missense probably benign 0.01
R4793:Dock5 UTSW 14 68,037,803 (GRCm39) missense probably benign 0.26
R4841:Dock5 UTSW 14 68,055,012 (GRCm39) missense probably damaging 0.98
R4842:Dock5 UTSW 14 68,055,012 (GRCm39) missense probably damaging 0.98
R5159:Dock5 UTSW 14 68,029,738 (GRCm39) missense probably benign 0.04
R5164:Dock5 UTSW 14 68,055,110 (GRCm39) nonsense probably null
R5206:Dock5 UTSW 14 68,000,633 (GRCm39) missense probably benign 0.35
R5207:Dock5 UTSW 14 68,013,733 (GRCm39) missense probably benign 0.06
R5322:Dock5 UTSW 14 68,007,715 (GRCm39) missense probably benign 0.41
R5374:Dock5 UTSW 14 68,043,205 (GRCm39) missense possibly damaging 0.81
R5413:Dock5 UTSW 14 68,002,104 (GRCm39) missense probably damaging 1.00
R5476:Dock5 UTSW 14 68,051,456 (GRCm39) missense possibly damaging 0.92
R5504:Dock5 UTSW 14 68,040,535 (GRCm39) missense probably benign 0.01
R5677:Dock5 UTSW 14 68,015,052 (GRCm39) missense probably benign 0.00
R5773:Dock5 UTSW 14 68,033,507 (GRCm39) missense possibly damaging 0.95
R5845:Dock5 UTSW 14 68,078,550 (GRCm39) missense possibly damaging 0.82
R5957:Dock5 UTSW 14 68,095,443 (GRCm39) missense probably benign
R6154:Dock5 UTSW 14 68,097,361 (GRCm39) missense probably benign 0.03
R6268:Dock5 UTSW 14 68,027,724 (GRCm39) nonsense probably null
R6393:Dock5 UTSW 14 68,060,051 (GRCm39) missense probably benign 0.32
R6512:Dock5 UTSW 14 68,062,097 (GRCm39) missense possibly damaging 0.93
R6759:Dock5 UTSW 14 68,033,445 (GRCm39) missense probably benign 0.00
R7012:Dock5 UTSW 14 68,060,035 (GRCm39) missense probably damaging 1.00
R7061:Dock5 UTSW 14 68,007,703 (GRCm39) missense probably damaging 0.96
R7196:Dock5 UTSW 14 67,993,919 (GRCm39) missense probably damaging 1.00
R7200:Dock5 UTSW 14 68,009,151 (GRCm39) nonsense probably null
R7311:Dock5 UTSW 14 68,065,951 (GRCm39) missense probably benign 0.25
R7359:Dock5 UTSW 14 68,003,337 (GRCm39) missense probably benign 0.10
R7422:Dock5 UTSW 14 68,046,479 (GRCm39) missense probably benign 0.01
R7588:Dock5 UTSW 14 68,000,607 (GRCm39) critical splice donor site probably null
R7637:Dock5 UTSW 14 68,023,789 (GRCm39) missense possibly damaging 0.95
R7709:Dock5 UTSW 14 68,033,454 (GRCm39) missense probably benign 0.44
R7763:Dock5 UTSW 14 68,058,776 (GRCm39) missense probably damaging 0.97
R8044:Dock5 UTSW 14 68,062,141 (GRCm39) missense probably damaging 1.00
R8168:Dock5 UTSW 14 68,007,646 (GRCm39) splice site probably null
R8353:Dock5 UTSW 14 68,054,957 (GRCm39) splice site probably null
R8480:Dock5 UTSW 14 68,073,859 (GRCm39) missense probably benign 0.32
R8535:Dock5 UTSW 14 68,031,425 (GRCm39) missense probably benign 0.19
R8708:Dock5 UTSW 14 68,004,820 (GRCm39) missense probably benign 0.02
R8732:Dock5 UTSW 14 68,083,449 (GRCm39) missense possibly damaging 0.85
R8888:Dock5 UTSW 14 68,055,112 (GRCm39) missense possibly damaging 0.95
R8895:Dock5 UTSW 14 68,055,112 (GRCm39) missense possibly damaging 0.95
R8936:Dock5 UTSW 14 68,083,439 (GRCm39) nonsense probably null
R8962:Dock5 UTSW 14 67,994,640 (GRCm39) missense probably benign
R8972:Dock5 UTSW 14 68,013,749 (GRCm39) missense probably damaging 1.00
R9244:Dock5 UTSW 14 67,996,563 (GRCm39) missense probably damaging 0.99
R9345:Dock5 UTSW 14 68,060,071 (GRCm39) missense possibly damaging 0.74
R9679:Dock5 UTSW 14 68,018,450 (GRCm39) missense probably damaging 1.00
X0023:Dock5 UTSW 14 68,008,537 (GRCm39) missense probably benign 0.15
Z1177:Dock5 UTSW 14 68,051,382 (GRCm39) missense possibly damaging 0.90
Predicted Primers PCR Primer
(F):5'- ATTCGGGCCCTCACACTAAG -3'
(R):5'- CTGCAGAGTGTTTAGAGCAAGTG -3'

Sequencing Primer
(F):5'- GGCCCTCACACTAAGCCATTTG -3'
(R):5'- CAGGTAGCCATGTGTGAGC -3'
Posted On 2020-08-27