Incidental Mutation 'R8325:Or9m1b'
ID 644034
Institutional Source Beutler Lab
Gene Symbol Or9m1b
Ensembl Gene ENSMUSG00000075141
Gene Name olfactory receptor family 9 subfamily M member 1B
Synonyms Olfr1160, MOR173-1, GA_x6K02T2Q125-49498697-49497765
MMRRC Submission 067857-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.125) question?
Stock # R8325 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 87836161-87837120 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 87836537 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Glutamine at position 186 (L186Q)
Ref Sequence ENSEMBL: ENSMUSP00000148857 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099839] [ENSMUST00000215457]
AlphaFold A2AVT0
Predicted Effect probably damaging
Transcript: ENSMUST00000099839
AA Change: L195Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000097427
Gene: ENSMUSG00000075141
AA Change: L195Q

DomainStartEndE-ValueType
Pfam:7tm_4 40 316 1.2e-46 PFAM
Pfam:7tm_1 50 298 2e-17 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000215457
AA Change: L186Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.2%
Validation Efficiency 100% (51/51)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acr T C 15: 89,453,954 (GRCm39) V97A probably benign Het
Agrn C T 4: 156,258,119 (GRCm39) G1081D probably benign Het
Ang2 A G 14: 51,432,960 (GRCm39) S141P probably damaging Het
Ap3b2 T C 7: 81,134,237 (GRCm39) probably null Het
Apba2 A T 7: 64,345,730 (GRCm39) T307S probably benign Het
Cadm2 T A 16: 66,612,338 (GRCm39) N84Y possibly damaging Het
Camsap1 T C 2: 25,829,375 (GRCm39) D783G probably benign Het
Ccdc62 T C 5: 124,092,448 (GRCm39) C478R probably benign Het
Cep290 A C 10: 100,353,670 (GRCm39) H801P probably benign Het
Chfr T A 5: 110,310,629 (GRCm39) Y555* probably null Het
Cmas T C 6: 142,717,065 (GRCm39) probably null Het
Cmtm7 T C 9: 114,592,415 (GRCm39) I61V probably benign Het
Cyb5d2 A G 11: 72,669,651 (GRCm39) S236P possibly damaging Het
Dcp1b C T 6: 119,192,397 (GRCm39) Q438* probably null Het
Dgcr8 T C 16: 18,076,149 (GRCm39) Q678R probably damaging Het
Emc1 T A 4: 139,092,521 (GRCm39) M487K possibly damaging Het
Gm7361 T C 5: 26,467,154 (GRCm39) S258P probably damaging Het
Hbs1l A G 10: 21,183,548 (GRCm39) I96M probably benign Het
Ifi27l2a G A 12: 103,409,144 (GRCm39) A49V unknown Het
Igkv10-96 T C 6: 68,609,088 (GRCm39) Y69C possibly damaging Het
Igsf10 A T 3: 59,225,954 (GRCm39) V2573D probably damaging Het
Kcng3 T C 17: 83,939,007 (GRCm39) N14S possibly damaging Het
Kif20a A G 18: 34,759,975 (GRCm39) T94A possibly damaging Het
Lcp2 T A 11: 34,032,394 (GRCm39) V324E probably benign Het
Lmod3 T C 6: 97,224,379 (GRCm39) K481E probably benign Het
Met A G 6: 17,571,671 (GRCm39) E1330G probably damaging Het
Mroh1 GCCCAGGCCCC GCC 15: 76,316,415 (GRCm39) probably null Het
Mss51 T C 14: 20,534,771 (GRCm39) D333G possibly damaging Het
Nav3 A G 10: 109,541,464 (GRCm39) V1933A probably benign Het
Nbas A G 12: 13,338,796 (GRCm39) Y212C probably damaging Het
Nkapd1 T C 9: 50,521,608 (GRCm39) I104M probably benign Het
Npsr1 C T 9: 24,198,118 (GRCm39) probably benign Het
Nt5e A G 9: 88,245,615 (GRCm39) E295G probably benign Het
Or6b1 T C 6: 42,815,124 (GRCm39) F103S probably damaging Het
Papss1 A G 3: 131,288,372 (GRCm39) T136A probably benign Het
Pcdha1 A T 18: 37,063,867 (GRCm39) D177V possibly damaging Het
Pcolce2 A T 9: 95,574,973 (GRCm39) S308C probably damaging Het
Pdhx G T 2: 102,872,597 (GRCm39) P162T probably benign Het
Plin3 C T 17: 56,593,268 (GRCm39) R98Q probably benign Het
Prr36 T C 8: 4,262,982 (GRCm39) T895A probably benign Het
Repin1 G T 6: 48,574,279 (GRCm39) E403* probably null Het
Rnf213 A G 11: 119,321,271 (GRCm39) N1243S Het
Serpinb1b A T 13: 33,277,584 (GRCm39) K272N probably benign Het
Sez6l A T 5: 112,575,982 (GRCm39) probably null Het
Syne1 A T 10: 5,096,257 (GRCm39) M739K probably benign Het
Tbc1d9 G A 8: 83,966,667 (GRCm39) probably null Het
Trp53inp1 A G 4: 11,164,561 (GRCm39) D35G probably damaging Het
Trpc7 A G 13: 56,952,524 (GRCm39) V549A probably damaging Het
Usp18 T C 6: 121,230,769 (GRCm39) L66S probably damaging Het
Vmn1r238 C T 18: 3,122,529 (GRCm39) S295N probably benign Het
Vmn2r29 T C 7: 7,244,941 (GRCm39) D311G probably damaging Het
Vmn2r91 C A 17: 18,356,625 (GRCm39) A764D probably damaging Het
Wdfy4 T A 14: 32,689,444 (GRCm39) I3031F Het
Wdr7 A G 18: 63,911,535 (GRCm39) probably null Het
Other mutations in Or9m1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00272:Or9m1b APN 2 87,836,988 (GRCm39) missense probably damaging 1.00
IGL01321:Or9m1b APN 2 87,836,589 (GRCm39) missense probably damaging 0.97
IGL02009:Or9m1b APN 2 87,837,117 (GRCm39) missense probably benign
IGL03409:Or9m1b APN 2 87,836,239 (GRCm39) missense probably damaging 1.00
R0089:Or9m1b UTSW 2 87,836,331 (GRCm39) missense probably damaging 1.00
R0685:Or9m1b UTSW 2 87,836,762 (GRCm39) missense probably damaging 1.00
R1416:Or9m1b UTSW 2 87,836,915 (GRCm39) missense probably damaging 1.00
R1852:Or9m1b UTSW 2 87,836,865 (GRCm39) missense probably damaging 1.00
R1965:Or9m1b UTSW 2 87,836,648 (GRCm39) missense probably damaging 1.00
R2206:Or9m1b UTSW 2 87,836,579 (GRCm39) missense probably benign 0.00
R4853:Or9m1b UTSW 2 87,836,448 (GRCm39) missense probably damaging 1.00
R5599:Or9m1b UTSW 2 87,836,349 (GRCm39) missense probably benign 0.44
R6851:Or9m1b UTSW 2 87,836,300 (GRCm39) missense probably damaging 0.98
R6995:Or9m1b UTSW 2 87,836,529 (GRCm39) missense probably benign 0.00
R7817:Or9m1b UTSW 2 87,836,355 (GRCm39) missense probably benign
R7970:Or9m1b UTSW 2 87,836,169 (GRCm39) missense probably benign 0.02
R7984:Or9m1b UTSW 2 87,836,969 (GRCm39) missense probably damaging 1.00
R8912:Or9m1b UTSW 2 87,836,661 (GRCm39) missense possibly damaging 0.93
Z1176:Or9m1b UTSW 2 87,836,781 (GRCm39) missense probably damaging 0.98
Z31818:Or9m1b UTSW 2 87,836,234 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- AGATGGTGATTACGGCCAGG -3'
(R):5'- TGCAATGGCTTATGACAGGTAC -3'

Sequencing Primer
(F):5'- TTACGGCCAGGTGAGAAGCAC -3'
(R):5'- GGTACATTGCAATCTGTAACCC -3'
Posted On 2020-09-02