Incidental Mutation 'R8325:Mroh1'
ID 644075
Institutional Source Beutler Lab
Gene Symbol Mroh1
Ensembl Gene ENSMUSG00000022558
Gene Name maestro heat-like repeat family member 1
Synonyms Heatr7a, D330001F17Rik
MMRRC Submission 067857-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # R8325 (G1)
Quality Score 217.468
Status Validated
Chromosome 15
Chromosomal Location 76264638-76337239 bp(+) (GRCm39)
Type of Mutation frame shift
DNA Base Change (assembly) GCCCAGGCCCC to GCC at 76316415 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000094115 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000092595] [ENSMUST00000096385] [ENSMUST00000161305]
AlphaFold E0CZ22
Predicted Effect probably null
Transcript: ENSMUST00000092595
SMART Domains Protein: ENSMUSP00000090256
Gene: ENSMUSG00000022558

DomainStartEndE-ValueType
SCOP:d1gw5a_ 4 435 4e-10 SMART
low complexity region 442 455 N/A INTRINSIC
low complexity region 594 607 N/A INTRINSIC
low complexity region 790 801 N/A INTRINSIC
low complexity region 926 937 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000096385
SMART Domains Protein: ENSMUSP00000094115
Gene: ENSMUSG00000022558

DomainStartEndE-ValueType
low complexity region 442 455 N/A INTRINSIC
low complexity region 594 607 N/A INTRINSIC
low complexity region 799 810 N/A INTRINSIC
low complexity region 935 946 N/A INTRINSIC
low complexity region 1191 1202 N/A INTRINSIC
low complexity region 1355 1367 N/A INTRINSIC
low complexity region 1488 1502 N/A INTRINSIC
Pfam:HEAT 1610 1640 2.2e-5 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000161305
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.2%
Validation Efficiency 100% (51/51)
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acr T C 15: 89,453,954 (GRCm39) V97A probably benign Het
Agrn C T 4: 156,258,119 (GRCm39) G1081D probably benign Het
Ang2 A G 14: 51,432,960 (GRCm39) S141P probably damaging Het
Ap3b2 T C 7: 81,134,237 (GRCm39) probably null Het
Apba2 A T 7: 64,345,730 (GRCm39) T307S probably benign Het
Cadm2 T A 16: 66,612,338 (GRCm39) N84Y possibly damaging Het
Camsap1 T C 2: 25,829,375 (GRCm39) D783G probably benign Het
Ccdc62 T C 5: 124,092,448 (GRCm39) C478R probably benign Het
Cep290 A C 10: 100,353,670 (GRCm39) H801P probably benign Het
Chfr T A 5: 110,310,629 (GRCm39) Y555* probably null Het
Cmas T C 6: 142,717,065 (GRCm39) probably null Het
Cmtm7 T C 9: 114,592,415 (GRCm39) I61V probably benign Het
Cyb5d2 A G 11: 72,669,651 (GRCm39) S236P possibly damaging Het
Dcp1b C T 6: 119,192,397 (GRCm39) Q438* probably null Het
Dgcr8 T C 16: 18,076,149 (GRCm39) Q678R probably damaging Het
Emc1 T A 4: 139,092,521 (GRCm39) M487K possibly damaging Het
Gm7361 T C 5: 26,467,154 (GRCm39) S258P probably damaging Het
Hbs1l A G 10: 21,183,548 (GRCm39) I96M probably benign Het
Ifi27l2a G A 12: 103,409,144 (GRCm39) A49V unknown Het
Igkv10-96 T C 6: 68,609,088 (GRCm39) Y69C possibly damaging Het
Igsf10 A T 3: 59,225,954 (GRCm39) V2573D probably damaging Het
Kcng3 T C 17: 83,939,007 (GRCm39) N14S possibly damaging Het
Kif20a A G 18: 34,759,975 (GRCm39) T94A possibly damaging Het
Lcp2 T A 11: 34,032,394 (GRCm39) V324E probably benign Het
Lmod3 T C 6: 97,224,379 (GRCm39) K481E probably benign Het
Met A G 6: 17,571,671 (GRCm39) E1330G probably damaging Het
Mss51 T C 14: 20,534,771 (GRCm39) D333G possibly damaging Het
Nav3 A G 10: 109,541,464 (GRCm39) V1933A probably benign Het
Nbas A G 12: 13,338,796 (GRCm39) Y212C probably damaging Het
Nkapd1 T C 9: 50,521,608 (GRCm39) I104M probably benign Het
Npsr1 C T 9: 24,198,118 (GRCm39) probably benign Het
Nt5e A G 9: 88,245,615 (GRCm39) E295G probably benign Het
Or6b1 T C 6: 42,815,124 (GRCm39) F103S probably damaging Het
Or9m1b A T 2: 87,836,537 (GRCm39) L186Q probably damaging Het
Papss1 A G 3: 131,288,372 (GRCm39) T136A probably benign Het
Pcdha1 A T 18: 37,063,867 (GRCm39) D177V possibly damaging Het
Pcolce2 A T 9: 95,574,973 (GRCm39) S308C probably damaging Het
Pdhx G T 2: 102,872,597 (GRCm39) P162T probably benign Het
Plin3 C T 17: 56,593,268 (GRCm39) R98Q probably benign Het
Prr36 T C 8: 4,262,982 (GRCm39) T895A probably benign Het
Repin1 G T 6: 48,574,279 (GRCm39) E403* probably null Het
Rnf213 A G 11: 119,321,271 (GRCm39) N1243S Het
Serpinb1b A T 13: 33,277,584 (GRCm39) K272N probably benign Het
Sez6l A T 5: 112,575,982 (GRCm39) probably null Het
Syne1 A T 10: 5,096,257 (GRCm39) M739K probably benign Het
Tbc1d9 G A 8: 83,966,667 (GRCm39) probably null Het
Trp53inp1 A G 4: 11,164,561 (GRCm39) D35G probably damaging Het
Trpc7 A G 13: 56,952,524 (GRCm39) V549A probably damaging Het
Usp18 T C 6: 121,230,769 (GRCm39) L66S probably damaging Het
Vmn1r238 C T 18: 3,122,529 (GRCm39) S295N probably benign Het
Vmn2r29 T C 7: 7,244,941 (GRCm39) D311G probably damaging Het
Vmn2r91 C A 17: 18,356,625 (GRCm39) A764D probably damaging Het
Wdfy4 T A 14: 32,689,444 (GRCm39) I3031F Het
Wdr7 A G 18: 63,911,535 (GRCm39) probably null Het
Other mutations in Mroh1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01574:Mroh1 APN 15 76,316,488 (GRCm39) missense probably benign 0.01
IGL02141:Mroh1 APN 15 76,330,799 (GRCm39) missense possibly damaging 0.47
IGL02146:Mroh1 APN 15 76,318,879 (GRCm39) splice site probably benign
IGL02205:Mroh1 APN 15 76,321,439 (GRCm39) missense possibly damaging 0.81
IGL02261:Mroh1 APN 15 76,313,360 (GRCm39) missense probably benign 0.03
IGL02818:Mroh1 APN 15 76,316,601 (GRCm39) splice site probably null
IGL02949:Mroh1 APN 15 76,293,168 (GRCm39) missense probably damaging 0.97
IGL02951:Mroh1 APN 15 76,311,836 (GRCm39) missense probably damaging 1.00
IGL03154:Mroh1 APN 15 76,337,038 (GRCm39) missense probably damaging 1.00
IGL02799:Mroh1 UTSW 15 76,276,661 (GRCm39) critical splice donor site probably null
R0068:Mroh1 UTSW 15 76,330,892 (GRCm39) splice site probably benign
R0068:Mroh1 UTSW 15 76,330,892 (GRCm39) splice site probably benign
R0076:Mroh1 UTSW 15 76,335,340 (GRCm39) missense probably benign 0.00
R0180:Mroh1 UTSW 15 76,312,450 (GRCm39) missense probably damaging 0.99
R0315:Mroh1 UTSW 15 76,311,800 (GRCm39) missense possibly damaging 0.94
R0350:Mroh1 UTSW 15 76,316,449 (GRCm39) missense probably damaging 0.98
R0399:Mroh1 UTSW 15 76,336,299 (GRCm39) missense probably benign 0.44
R0835:Mroh1 UTSW 15 76,336,083 (GRCm39) missense probably damaging 0.96
R0893:Mroh1 UTSW 15 76,293,138 (GRCm39) missense possibly damaging 0.62
R1109:Mroh1 UTSW 15 76,330,709 (GRCm39) splice site probably benign
R1527:Mroh1 UTSW 15 76,336,463 (GRCm39) missense probably benign 0.03
R1595:Mroh1 UTSW 15 76,317,730 (GRCm39) splice site probably benign
R1900:Mroh1 UTSW 15 76,317,585 (GRCm39) missense probably benign 0.00
R1901:Mroh1 UTSW 15 76,320,249 (GRCm39) missense probably benign
R2223:Mroh1 UTSW 15 76,292,245 (GRCm39) critical splice donor site probably null
R2415:Mroh1 UTSW 15 76,305,411 (GRCm39) missense probably damaging 0.99
R3113:Mroh1 UTSW 15 76,292,736 (GRCm39) splice site probably benign
R3437:Mroh1 UTSW 15 76,317,808 (GRCm39) missense possibly damaging 0.92
R3618:Mroh1 UTSW 15 76,336,546 (GRCm39) missense possibly damaging 0.55
R3833:Mroh1 UTSW 15 76,285,819 (GRCm39) missense probably benign 0.08
R4073:Mroh1 UTSW 15 76,292,185 (GRCm39) missense probably benign 0.13
R4156:Mroh1 UTSW 15 76,286,326 (GRCm39) splice site probably null
R4276:Mroh1 UTSW 15 76,278,051 (GRCm39) missense probably damaging 1.00
R4745:Mroh1 UTSW 15 76,292,730 (GRCm39) critical splice donor site probably null
R5450:Mroh1 UTSW 15 76,316,547 (GRCm39) intron probably benign
R5574:Mroh1 UTSW 15 76,318,131 (GRCm39) missense probably benign
R5673:Mroh1 UTSW 15 76,314,381 (GRCm39) missense probably damaging 1.00
R5970:Mroh1 UTSW 15 76,335,691 (GRCm39) missense probably benign 0.24
R5993:Mroh1 UTSW 15 76,330,880 (GRCm39) missense probably damaging 0.99
R6008:Mroh1 UTSW 15 76,335,557 (GRCm39) missense possibly damaging 0.50
R6082:Mroh1 UTSW 15 76,314,423 (GRCm39) missense probably benign 0.06
R6302:Mroh1 UTSW 15 76,320,319 (GRCm39) critical splice donor site probably null
R7030:Mroh1 UTSW 15 76,321,517 (GRCm39) missense probably benign 0.01
R7098:Mroh1 UTSW 15 76,292,657 (GRCm39) nonsense probably null
R7334:Mroh1 UTSW 15 76,311,838 (GRCm39) missense probably benign 0.00
R7337:Mroh1 UTSW 15 76,335,676 (GRCm39) missense probably benign 0.00
R7352:Mroh1 UTSW 15 76,335,674 (GRCm39) missense probably benign 0.06
R7446:Mroh1 UTSW 15 76,336,472 (GRCm39) missense possibly damaging 0.93
R7453:Mroh1 UTSW 15 76,317,745 (GRCm39) missense probably damaging 1.00
R7669:Mroh1 UTSW 15 76,336,048 (GRCm39) missense possibly damaging 0.88
R7753:Mroh1 UTSW 15 76,317,475 (GRCm39) missense possibly damaging 0.62
R7860:Mroh1 UTSW 15 76,331,532 (GRCm39) missense probably benign 0.00
R7990:Mroh1 UTSW 15 76,336,475 (GRCm39) missense probably damaging 1.00
R8140:Mroh1 UTSW 15 76,318,073 (GRCm39) missense probably benign 0.00
R8334:Mroh1 UTSW 15 76,330,756 (GRCm39) missense probably benign
R8529:Mroh1 UTSW 15 76,311,832 (GRCm39) missense probably benign 0.00
R8544:Mroh1 UTSW 15 76,327,558 (GRCm39) nonsense probably null
R8688:Mroh1 UTSW 15 76,312,550 (GRCm39) missense probably benign 0.00
R8769:Mroh1 UTSW 15 76,297,126 (GRCm39) missense probably benign 0.00
R8782:Mroh1 UTSW 15 76,298,496 (GRCm39) missense possibly damaging 0.74
R8887:Mroh1 UTSW 15 76,331,474 (GRCm39) missense probably benign 0.43
R8934:Mroh1 UTSW 15 76,334,386 (GRCm39) missense probably benign 0.03
R9254:Mroh1 UTSW 15 76,292,215 (GRCm39) missense probably benign 0.16
R9400:Mroh1 UTSW 15 76,336,093 (GRCm39) missense possibly damaging 0.93
R9443:Mroh1 UTSW 15 76,318,964 (GRCm39) missense probably damaging 1.00
Z1177:Mroh1 UTSW 15 76,307,961 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTAGCTGGCTCTGGCTATTC -3'
(R):5'- CATAGTTCACACATGGTCGGTC -3'

Sequencing Primer
(F):5'- TCCAGGAGTTTTAGGGTATAGAAAGC -3'
(R):5'- ATGGTCGGTCGCCATACACTATAC -3'
Posted On 2020-09-02