Incidental Mutation 'R8325:Vmn2r91'
| ID |
644079 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r91
|
| Ensembl Gene |
ENSMUSG00000091206 |
| Gene Name |
vomeronasal 2, receptor 91 |
| Synonyms |
EG665210 |
| MMRRC Submission |
067857-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.065)
|
| Stock # |
R8325 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
18305319-18356905 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to A
at 18356625 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Alanine to Aspartic acid
at position 764
(A764D)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000127465
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000172359]
|
| AlphaFold |
E9Q2U5 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000172359
AA Change: A764D
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000127465
Gene: ENSMUSG00000091206
AA Change: A764D
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
83 |
462 |
2.2e-38 |
PFAM |
|
Pfam:NCD3G
|
510 |
564 |
6.7e-20 |
PFAM |
|
Pfam:7tm_3
|
597 |
832 |
2.1e-53 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.4%
- 20x: 98.2%
|
| Validation Efficiency |
100% (51/51) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 54 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acr |
T |
C |
15: 89,453,954 (GRCm39) |
V97A |
probably benign |
Het |
| Agrn |
C |
T |
4: 156,258,119 (GRCm39) |
G1081D |
probably benign |
Het |
| Ang2 |
A |
G |
14: 51,432,960 (GRCm39) |
S141P |
probably damaging |
Het |
| Ap3b2 |
T |
C |
7: 81,134,237 (GRCm39) |
|
probably null |
Het |
| Apba2 |
A |
T |
7: 64,345,730 (GRCm39) |
T307S |
probably benign |
Het |
| Cadm2 |
T |
A |
16: 66,612,338 (GRCm39) |
N84Y |
possibly damaging |
Het |
| Camsap1 |
T |
C |
2: 25,829,375 (GRCm39) |
D783G |
probably benign |
Het |
| Ccdc62 |
T |
C |
5: 124,092,448 (GRCm39) |
C478R |
probably benign |
Het |
| Cep290 |
A |
C |
10: 100,353,670 (GRCm39) |
H801P |
probably benign |
Het |
| Chfr |
T |
A |
5: 110,310,629 (GRCm39) |
Y555* |
probably null |
Het |
| Cmas |
T |
C |
6: 142,717,065 (GRCm39) |
|
probably null |
Het |
| Cmtm7 |
T |
C |
9: 114,592,415 (GRCm39) |
I61V |
probably benign |
Het |
| Cyb5d2 |
A |
G |
11: 72,669,651 (GRCm39) |
S236P |
possibly damaging |
Het |
| Dcp1b |
C |
T |
6: 119,192,397 (GRCm39) |
Q438* |
probably null |
Het |
| Dgcr8 |
T |
C |
16: 18,076,149 (GRCm39) |
Q678R |
probably damaging |
Het |
| Emc1 |
T |
A |
4: 139,092,521 (GRCm39) |
M487K |
possibly damaging |
Het |
| Gm7361 |
T |
C |
5: 26,467,154 (GRCm39) |
S258P |
probably damaging |
Het |
| Hbs1l |
A |
G |
10: 21,183,548 (GRCm39) |
I96M |
probably benign |
Het |
| Ifi27l2a |
G |
A |
12: 103,409,144 (GRCm39) |
A49V |
unknown |
Het |
| Igkv10-96 |
T |
C |
6: 68,609,088 (GRCm39) |
Y69C |
possibly damaging |
Het |
| Igsf10 |
A |
T |
3: 59,225,954 (GRCm39) |
V2573D |
probably damaging |
Het |
| Kcng3 |
T |
C |
17: 83,939,007 (GRCm39) |
N14S |
possibly damaging |
Het |
| Kif20a |
A |
G |
18: 34,759,975 (GRCm39) |
T94A |
possibly damaging |
Het |
| Lcp2 |
T |
A |
11: 34,032,394 (GRCm39) |
V324E |
probably benign |
Het |
| Lmod3 |
T |
C |
6: 97,224,379 (GRCm39) |
K481E |
probably benign |
Het |
| Met |
A |
G |
6: 17,571,671 (GRCm39) |
E1330G |
probably damaging |
Het |
| Mroh1 |
GCCCAGGCCCC |
GCC |
15: 76,316,415 (GRCm39) |
|
probably null |
Het |
| Mss51 |
T |
C |
14: 20,534,771 (GRCm39) |
D333G |
possibly damaging |
Het |
| Nav3 |
A |
G |
10: 109,541,464 (GRCm39) |
V1933A |
probably benign |
Het |
| Nbas |
A |
G |
12: 13,338,796 (GRCm39) |
Y212C |
probably damaging |
Het |
| Nkapd1 |
T |
C |
9: 50,521,608 (GRCm39) |
I104M |
probably benign |
Het |
| Npsr1 |
C |
T |
9: 24,198,118 (GRCm39) |
|
probably benign |
Het |
| Nt5e |
A |
G |
9: 88,245,615 (GRCm39) |
E295G |
probably benign |
Het |
| Or6b1 |
T |
C |
6: 42,815,124 (GRCm39) |
F103S |
probably damaging |
Het |
| Or9m1b |
A |
T |
2: 87,836,537 (GRCm39) |
L186Q |
probably damaging |
Het |
| Papss1 |
A |
G |
3: 131,288,372 (GRCm39) |
T136A |
probably benign |
Het |
| Pcdha1 |
A |
T |
18: 37,063,867 (GRCm39) |
D177V |
possibly damaging |
Het |
| Pcolce2 |
A |
T |
9: 95,574,973 (GRCm39) |
S308C |
probably damaging |
Het |
| Pdhx |
G |
T |
2: 102,872,597 (GRCm39) |
P162T |
probably benign |
Het |
| Plin3 |
C |
T |
17: 56,593,268 (GRCm39) |
R98Q |
probably benign |
Het |
| Prr36 |
T |
C |
8: 4,262,982 (GRCm39) |
T895A |
probably benign |
Het |
| Repin1 |
G |
T |
6: 48,574,279 (GRCm39) |
E403* |
probably null |
Het |
| Rnf213 |
A |
G |
11: 119,321,271 (GRCm39) |
N1243S |
|
Het |
| Serpinb1b |
A |
T |
13: 33,277,584 (GRCm39) |
K272N |
probably benign |
Het |
| Sez6l |
A |
T |
5: 112,575,982 (GRCm39) |
|
probably null |
Het |
| Syne1 |
A |
T |
10: 5,096,257 (GRCm39) |
M739K |
probably benign |
Het |
| Tbc1d9 |
G |
A |
8: 83,966,667 (GRCm39) |
|
probably null |
Het |
| Trp53inp1 |
A |
G |
4: 11,164,561 (GRCm39) |
D35G |
probably damaging |
Het |
| Trpc7 |
A |
G |
13: 56,952,524 (GRCm39) |
V549A |
probably damaging |
Het |
| Usp18 |
T |
C |
6: 121,230,769 (GRCm39) |
L66S |
probably damaging |
Het |
| Vmn1r238 |
C |
T |
18: 3,122,529 (GRCm39) |
S295N |
probably benign |
Het |
| Vmn2r29 |
T |
C |
7: 7,244,941 (GRCm39) |
D311G |
probably damaging |
Het |
| Wdfy4 |
T |
A |
14: 32,689,444 (GRCm39) |
I3031F |
|
Het |
| Wdr7 |
A |
G |
18: 63,911,535 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Vmn2r91 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00983:Vmn2r91
|
APN |
17 |
18,325,820 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01121:Vmn2r91
|
APN |
17 |
18,356,766 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL01464:Vmn2r91
|
APN |
17 |
18,327,864 (GRCm39) |
missense |
probably null |
0.00 |
|
IGL02003:Vmn2r91
|
APN |
17 |
18,327,921 (GRCm39) |
missense |
probably benign |
|
|
IGL02709:Vmn2r91
|
APN |
17 |
18,325,711 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
IGL02795:Vmn2r91
|
APN |
17 |
18,305,539 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02813:Vmn2r91
|
APN |
17 |
18,356,348 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL02830:Vmn2r91
|
APN |
17 |
18,356,884 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03130:Vmn2r91
|
APN |
17 |
18,330,373 (GRCm39) |
splice site |
probably benign |
|
|
BB006:Vmn2r91
|
UTSW |
17 |
18,327,906 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB016:Vmn2r91
|
UTSW |
17 |
18,327,906 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0164:Vmn2r91
|
UTSW |
17 |
18,326,399 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0164:Vmn2r91
|
UTSW |
17 |
18,326,399 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0393:Vmn2r91
|
UTSW |
17 |
18,325,712 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1142:Vmn2r91
|
UTSW |
17 |
18,356,705 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1603:Vmn2r91
|
UTSW |
17 |
18,326,405 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1992:Vmn2r91
|
UTSW |
17 |
18,356,142 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2182:Vmn2r91
|
UTSW |
17 |
18,325,691 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2424:Vmn2r91
|
UTSW |
17 |
18,356,431 (GRCm39) |
nonsense |
probably null |
|
|
R2512:Vmn2r91
|
UTSW |
17 |
18,356,048 (GRCm39) |
missense |
probably benign |
|
|
R2885:Vmn2r91
|
UTSW |
17 |
18,325,628 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2909:Vmn2r91
|
UTSW |
17 |
18,356,661 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3009:Vmn2r91
|
UTSW |
17 |
18,325,717 (GRCm39) |
missense |
probably benign |
0.11 |
|
R3079:Vmn2r91
|
UTSW |
17 |
18,355,973 (GRCm39) |
splice site |
probably null |
|
|
R3080:Vmn2r91
|
UTSW |
17 |
18,355,973 (GRCm39) |
splice site |
probably null |
|
|
R3434:Vmn2r91
|
UTSW |
17 |
18,330,370 (GRCm39) |
splice site |
probably benign |
|
|
R3723:Vmn2r91
|
UTSW |
17 |
18,305,540 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3829:Vmn2r91
|
UTSW |
17 |
18,325,759 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3845:Vmn2r91
|
UTSW |
17 |
18,327,860 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3846:Vmn2r91
|
UTSW |
17 |
18,327,860 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4118:Vmn2r91
|
UTSW |
17 |
18,330,358 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4285:Vmn2r91
|
UTSW |
17 |
18,356,030 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4729:Vmn2r91
|
UTSW |
17 |
18,327,906 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4793:Vmn2r91
|
UTSW |
17 |
18,325,658 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4932:Vmn2r91
|
UTSW |
17 |
18,356,751 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R5016:Vmn2r91
|
UTSW |
17 |
18,330,322 (GRCm39) |
nonsense |
probably null |
|
|
R5018:Vmn2r91
|
UTSW |
17 |
18,356,700 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5605:Vmn2r91
|
UTSW |
17 |
18,356,763 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5815:Vmn2r91
|
UTSW |
17 |
18,326,464 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6146:Vmn2r91
|
UTSW |
17 |
18,356,518 (GRCm39) |
missense |
probably benign |
0.07 |
|
R6187:Vmn2r91
|
UTSW |
17 |
18,326,888 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6426:Vmn2r91
|
UTSW |
17 |
18,355,865 (GRCm39) |
splice site |
probably null |
|
|
R6450:Vmn2r91
|
UTSW |
17 |
18,305,527 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6767:Vmn2r91
|
UTSW |
17 |
18,327,807 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6986:Vmn2r91
|
UTSW |
17 |
18,356,271 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7112:Vmn2r91
|
UTSW |
17 |
18,325,880 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7178:Vmn2r91
|
UTSW |
17 |
18,356,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7330:Vmn2r91
|
UTSW |
17 |
18,326,429 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7368:Vmn2r91
|
UTSW |
17 |
18,356,540 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R7380:Vmn2r91
|
UTSW |
17 |
18,356,838 (GRCm39) |
nonsense |
probably null |
|
|
R7397:Vmn2r91
|
UTSW |
17 |
18,356,060 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7625:Vmn2r91
|
UTSW |
17 |
18,325,693 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7739:Vmn2r91
|
UTSW |
17 |
18,356,080 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7749:Vmn2r91
|
UTSW |
17 |
18,356,540 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R7755:Vmn2r91
|
UTSW |
17 |
18,330,311 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R7929:Vmn2r91
|
UTSW |
17 |
18,327,906 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7981:Vmn2r91
|
UTSW |
17 |
18,327,887 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8211:Vmn2r91
|
UTSW |
17 |
18,326,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8781:Vmn2r91
|
UTSW |
17 |
18,305,323 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R8974:Vmn2r91
|
UTSW |
17 |
18,325,636 (GRCm39) |
missense |
probably benign |
0.27 |
|
R9047:Vmn2r91
|
UTSW |
17 |
18,326,296 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9048:Vmn2r91
|
UTSW |
17 |
18,356,122 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9109:Vmn2r91
|
UTSW |
17 |
18,327,905 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9211:Vmn2r91
|
UTSW |
17 |
18,356,819 (GRCm39) |
nonsense |
probably null |
|
|
R9555:Vmn2r91
|
UTSW |
17 |
18,325,792 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R9616:Vmn2r91
|
UTSW |
17 |
18,356,305 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGGGTCCAAACTACATCATTCC -3'
(R):5'- CACTTGGGACCAAATATAAAGGC -3'
Sequencing Primer
(F):5'- GGTCCAAACTACATCATTCCTATCTG -3'
(R):5'- CAAGGAGTGCTGTGCTGGAAG -3'
|
| Posted On |
2020-09-02 |
Incidental Mutation