Mutagenetix > Incidental Mutation

Incidental Mutation 'R8325:Vmn1r238'

644081

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r238

Ensembl Gene

ENSMUSG00000091539

Gene Name

vomeronasal 1 receptor, 238

Synonyms

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.056) question?

Stock #

R8325 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

3122492-3123412 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 3122529 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Asparagine at position 295 (S295N)

Ref Sequence

ENSEMBL: ENSMUSP00000129804 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000165255]

AlphaFold

E9Q373

Predicted Effect

probably benign
Transcript: ENSMUST00000165255
AA Change: S295N

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)

SMART Domains

Protein: ENSMUSP00000129804
Gene: ENSMUSG00000091539
AA Change: S295N

Domain	Start	End	E-Value	Type
Pfam:TAS2R	7	302	5.3e-8	PFAM
Pfam:7tm_1	27	292	8.8e-7	PFAM
Pfam:V1R	34	298	1.9e-33	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.4%
20x: 98.2%

Validation Efficiency

100% (51/51)

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acr	T	C	15: 89,569,751	V97A	probably benign	Het
Agrn	C	T	4: 156,173,662	G1081D	probably benign	Het
Ang2	A	G	14: 51,195,503	S141P	probably damaging	Het
Ap3b2	T	C	7: 81,484,489		probably null	Het
Apba2	A	T	7: 64,695,982	T307S	probably benign	Het
AU019823	T	C	9: 50,610,308	I104M	probably benign	Het
Cadm2	T	A	16: 66,815,450	N84Y	possibly damaging	Het
Camsap1	T	C	2: 25,939,363	D783G	probably benign	Het
Ccdc62	T	C	5: 123,954,385	C478R	probably benign	Het
Cep290	A	C	10: 100,517,808	H801P	probably benign	Het
Chfr	T	A	5: 110,162,763	Y555*	probably null	Het
Cmas	T	C	6: 142,771,339		probably null	Het
Cmtm7	T	C	9: 114,763,347	I61V	probably benign	Het
Cyb5d2	A	G	11: 72,778,825	S236P	possibly damaging	Het
Dcp1b	C	T	6: 119,215,436	Q438*	probably null	Het
Dgcr8	T	C	16: 18,258,285	Q678R	probably damaging	Het
Emc1	T	A	4: 139,365,210	M487K	possibly damaging	Het
Gm7361	T	C	5: 26,262,156	S258P	probably damaging	Het
Hbs1l	A	G	10: 21,307,649	I96M	probably benign	Het
Ifi27l2a	G	A	12: 103,442,885	A49V	unknown	Het
Igkv10-96	T	C	6: 68,632,104	Y69C	possibly damaging	Het
Igsf10	A	T	3: 59,318,533	V2573D	probably damaging	Het
Kcng3	T	C	17: 83,631,578	N14S	possibly damaging	Het
Kif20a	A	G	18: 34,626,922	T94A	possibly damaging	Het
Lcp2	T	A	11: 34,082,394	V324E	probably benign	Het
Lmod3	T	C	6: 97,247,418	K481E	probably benign	Het
Met	A	G	6: 17,571,672	E1330G	probably damaging	Het
Mroh1	GCCCAGGCCCC	GCC	15: 76,432,215		probably null	Het
Mss51	T	C	14: 20,484,703	D333G	possibly damaging	Het
Nav3	A	G	10: 109,705,603	V1933A	probably benign	Het
Nbas	A	G	12: 13,288,795	Y212C	probably damaging	Het
Npsr1	C	T	9: 24,286,822		probably benign	Het
Nt5e	A	G	9: 88,363,562	E295G	probably benign	Het
Olfr1160	A	T	2: 88,006,193	L186Q	probably damaging	Het
Olfr449	T	C	6: 42,838,190	F103S	probably damaging	Het
Papss1	A	G	3: 131,582,611	T136A	probably benign	Het
Pcdha1	A	T	18: 36,930,814	D177V	possibly damaging	Het
Pcolce2	A	T	9: 95,692,920	S308C	probably damaging	Het
Pdhx	G	T	2: 103,042,252	P162T	probably benign	Het
Plin3	C	T	17: 56,286,268	R98Q	probably benign	Het
Prr36	T	C	8: 4,212,982	T895A	probably benign	Het
Repin1	G	T	6: 48,597,345	E403*	probably null	Het
Rnf213	A	G	11: 119,430,445	N1243S		Het
Serpinb1b	A	T	13: 33,093,601	K272N	probably benign	Het
Sez6l	A	T	5: 112,428,116		probably null	Het
Syne1	A	T	10: 5,146,257	M739K	probably benign	Het
Tbc1d9	G	A	8: 83,240,038		probably null	Het
Trp53inp1	A	G	4: 11,164,561	D35G	probably damaging	Het
Trpc7	A	G	13: 56,804,711	V549A	probably damaging	Het
Usp18	T	C	6: 121,253,810	L66S	probably damaging	Het
Vmn2r29	T	C	7: 7,241,942	D311G	probably damaging	Het
Vmn2r91	C	A	17: 18,136,363	A764D	probably damaging	Het
Wdfy4	T	A	14: 32,967,487	I3031F		Het
Wdr7	A	G	18: 63,778,464		probably null	Het

Other mutations in Vmn1r238

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00427:Vmn1r238	APN	18	3123243	missense	probably benign	0.01
IGL01385:Vmn1r238	APN	18	3122770	missense	possibly damaging	0.83
IGL02716:Vmn1r238	APN	18	3123124	missense	probably damaging	1.00
R1219:Vmn1r238	UTSW	18	3123135	missense	possibly damaging	0.81
R1568:Vmn1r238	UTSW	18	3123358	missense	probably benign	0.00
R1864:Vmn1r238	UTSW	18	3123040	nonsense	probably null
R3024:Vmn1r238	UTSW	18	3123305	missense	probably benign	0.13
R4291:Vmn1r238	UTSW	18	3123214	nonsense	probably null
R4304:Vmn1r238	UTSW	18	3123040	nonsense	probably null
R4586:Vmn1r238	UTSW	18	3123294	missense	probably damaging	1.00
R4664:Vmn1r238	UTSW	18	3123300	missense	probably damaging	0.99
R5123:Vmn1r238	UTSW	18	3123243	missense	probably benign
R5430:Vmn1r238	UTSW	18	3122521	missense	possibly damaging	0.63
R5834:Vmn1r238	UTSW	18	3123168	missense	probably benign
R7186:Vmn1r238	UTSW	18	3122661	missense	probably damaging	0.99
R7206:Vmn1r238	UTSW	18	3122623	missense	possibly damaging	0.94
R7308:Vmn1r238	UTSW	18	3122875	missense	probably benign	0.09
R7346:Vmn1r238	UTSW	18	3123151	missense	probably damaging	1.00
R7467:Vmn1r238	UTSW	18	3123393	missense	probably benign	0.10
R7571:Vmn1r238	UTSW	18	3122721	missense	probably damaging	1.00
R7808:Vmn1r238	UTSW	18	3123033	missense	probably benign	0.03
R8085:Vmn1r238	UTSW	18	3123151	missense	probably damaging	1.00
R8086:Vmn1r238	UTSW	18	3123250	missense	probably damaging	1.00
R8423:Vmn1r238	UTSW	18	3123365	nonsense	probably null
R8747:Vmn1r238	UTSW	18	3123232	missense	possibly damaging	0.87
R8930:Vmn1r238	UTSW	18	3123127	missense	probably benign	0.03
R8932:Vmn1r238	UTSW	18	3123127	missense	probably benign	0.03
R9279:Vmn1r238	UTSW	18	3122994	missense	probably damaging	0.99
R9382:Vmn1r238	UTSW	18	3122676	missense	probably damaging	0.99
R9644:Vmn1r238	UTSW	18	3122635	missense	probably benign	0.10
R9725:Vmn1r238	UTSW	18	3122577	missense	probably benign	0.00
Z1177:Vmn1r238	UTSW	18	3122505	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- GTCACAAAATTTTCTACTGATCATTCC -3'
(R):5'- CTTTCTGAAAGTCTCACCTGAAGAC -3'

Sequencing Primer
(F):5'- GTTTTAGCATTGTGTAACAGA -3'
(R):5'- GTCTCACCTGAAGACAGAGC -3'

Posted On

2020-09-02