Incidental Mutation 'R8326:Vmn2r87'
| ID |
644120 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r87
|
| Ensembl Gene |
ENSMUSG00000091511 |
| Gene Name |
vomeronasal 2, receptor 87 |
| Synonyms |
EG625131 |
| MMRRC Submission |
067726-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.067)
|
| Stock # |
R8326 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
10 |
| Chromosomal Location |
130307690-130333248 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 130308180 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Lysine
at position 686
(M686K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129215
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000164227]
|
| AlphaFold |
E9PZX4 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000164227
AA Change: M686K
PolyPhen 2
Score 0.671 (Sensitivity: 0.86; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000129215
Gene: ENSMUSG00000091511
AA Change: M686K
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
422 |
1.8e-27 |
PFAM |
|
Pfam:NCD3G
|
508 |
562 |
1.8e-19 |
PFAM |
|
Pfam:7tm_3
|
595 |
829 |
8.8e-55 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.4%
- 20x: 98.2%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 53 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adgrl2 |
T |
C |
3: 148,533,190 (GRCm39) |
T35A |
|
Het |
| Adgrv1 |
C |
T |
13: 81,593,462 (GRCm39) |
R4175H |
probably damaging |
Het |
| Akt3 |
T |
C |
1: 176,877,611 (GRCm39) |
N386D |
possibly damaging |
Het |
| Aox1 |
A |
T |
1: 58,335,046 (GRCm39) |
H282L |
probably benign |
Het |
| Asb7 |
G |
T |
7: 66,309,675 (GRCm39) |
N180K |
possibly damaging |
Het |
| Cdh23 |
T |
C |
10: 60,274,591 (GRCm39) |
S500G |
possibly damaging |
Het |
| Cubn |
C |
T |
2: 13,311,274 (GRCm39) |
E3084K |
probably benign |
Het |
| Cyp2r1 |
G |
A |
7: 114,152,405 (GRCm39) |
T184I |
probably damaging |
Het |
| Dclk3 |
A |
G |
9: 111,296,602 (GRCm39) |
R49G |
probably damaging |
Het |
| Dcp1a |
C |
T |
14: 30,241,527 (GRCm39) |
Q446* |
probably null |
Het |
| Dnah9 |
A |
G |
11: 66,008,452 (GRCm39) |
I791T |
probably benign |
Het |
| Dock10 |
A |
T |
1: 80,583,892 (GRCm39) |
V189D |
possibly damaging |
Het |
| Dsg4 |
A |
G |
18: 20,582,788 (GRCm39) |
E142G |
probably benign |
Het |
| Dsp |
A |
T |
13: 38,375,611 (GRCm39) |
D1132V |
probably damaging |
Het |
| Dync2h1 |
A |
G |
9: 7,147,771 (GRCm39) |
M953T |
probably benign |
Het |
| Ecpas |
G |
T |
4: 58,847,093 (GRCm39) |
Q490K |
probably damaging |
Het |
| Ero1a |
T |
C |
14: 45,531,805 (GRCm39) |
H251R |
probably damaging |
Het |
| Fer1l5 |
A |
G |
1: 36,415,841 (GRCm39) |
Y124C |
probably benign |
Het |
| Frmpd2 |
C |
A |
14: 33,232,992 (GRCm39) |
P404Q |
probably damaging |
Het |
| Gpr87 |
G |
T |
3: 59,102,395 (GRCm39) |
|
probably benign |
Het |
| Gse1 |
T |
C |
8: 121,305,319 (GRCm39) |
Y1217H |
unknown |
Het |
| Heatr5a |
AGCACACTGCAGGAAGCTCACACAGCACAGCATACCTTCAGGAGTGCACACTGCAGGAAGCTCACACAGCACAGCATACCTTCAGGAGAGCACACTGCAGGAAGCTCA |
AGCACACTGCAGGAAGCTCACACAGCACAGCATACCTTCAGGAGAGCACACTGCAGGAAGCTCA |
12: 51,934,702 (GRCm39) |
|
probably benign |
Het |
| Irf9 |
T |
A |
14: 55,843,210 (GRCm39) |
D137E |
probably benign |
Het |
| Jup |
G |
T |
11: 100,272,571 (GRCm39) |
N280K |
probably benign |
Het |
| Kcna7 |
T |
C |
7: 45,058,765 (GRCm39) |
F351L |
probably damaging |
Het |
| Klk13 |
A |
T |
7: 43,376,136 (GRCm39) |
R270S |
probably benign |
Het |
| Msh6 |
C |
T |
17: 88,294,340 (GRCm39) |
R1032C |
probably damaging |
Het |
| Myo5a |
T |
C |
9: 75,125,271 (GRCm39) |
V1855A |
probably damaging |
Het |
| Neb |
T |
C |
2: 52,111,714 (GRCm39) |
T138A |
probably damaging |
Het |
| Nfkbie |
C |
A |
17: 45,870,234 (GRCm39) |
T193K |
probably damaging |
Het |
| Nlrp4b |
A |
G |
7: 10,452,471 (GRCm39) |
K613E |
probably benign |
Het |
| Obox6 |
T |
C |
7: 15,567,481 (GRCm39) |
E322G |
possibly damaging |
Het |
| Or51ai2 |
A |
G |
7: 103,586,809 (GRCm39) |
D74G |
probably damaging |
Het |
| Or5v1b |
T |
G |
17: 37,841,470 (GRCm39) |
S201A |
probably benign |
Het |
| Or8b36 |
T |
C |
9: 37,938,014 (GRCm39) |
M304T |
probably benign |
Het |
| Parn |
A |
T |
16: 13,483,835 (GRCm39) |
N36K |
probably benign |
Het |
| Ppp6r2 |
A |
G |
15: 89,164,650 (GRCm39) |
E618G |
probably benign |
Het |
| Prdm13 |
A |
G |
4: 21,679,557 (GRCm39) |
L311P |
unknown |
Het |
| Prkaa2 |
T |
C |
4: 104,893,495 (GRCm39) |
T485A |
possibly damaging |
Het |
| Prmt2 |
G |
T |
10: 76,053,247 (GRCm39) |
T256K |
probably benign |
Het |
| Rspry1 |
T |
C |
8: 95,366,217 (GRCm39) |
Y362H |
probably damaging |
Het |
| Slc16a14 |
A |
T |
1: 84,890,066 (GRCm39) |
I413N |
possibly damaging |
Het |
| Slc8a1 |
T |
C |
17: 81,715,535 (GRCm39) |
T821A |
probably damaging |
Het |
| Spock2 |
A |
T |
10: 59,962,777 (GRCm39) |
K276N |
probably damaging |
Het |
| Synj1 |
A |
T |
16: 90,785,084 (GRCm39) |
N257K |
probably benign |
Het |
| Taar7f |
T |
C |
10: 23,925,811 (GRCm39) |
L135P |
possibly damaging |
Het |
| Tmem132b |
T |
C |
5: 125,864,618 (GRCm39) |
F908S |
probably damaging |
Het |
| Tmem202 |
A |
T |
9: 59,426,500 (GRCm39) |
V222D |
probably benign |
Het |
| Trim33 |
T |
A |
3: 103,218,770 (GRCm39) |
C302* |
probably null |
Het |
| Tuba4a |
G |
A |
1: 75,195,265 (GRCm39) |
S1L |
|
Het |
| Tyrp1 |
G |
A |
4: 80,768,921 (GRCm39) |
E472K |
probably benign |
Het |
| V1ra8 |
A |
G |
6: 90,180,246 (GRCm39) |
I150V |
possibly damaging |
Het |
| Zscan5b |
C |
T |
7: 6,236,946 (GRCm39) |
P232S |
possibly damaging |
Het |
|
| Other mutations in Vmn2r87 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01090:Vmn2r87
|
APN |
10 |
130,333,247 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
|
IGL01295:Vmn2r87
|
APN |
10 |
130,307,878 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01411:Vmn2r87
|
APN |
10 |
130,308,429 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01680:Vmn2r87
|
APN |
10 |
130,315,586 (GRCm39) |
nonsense |
probably null |
|
|
IGL01822:Vmn2r87
|
APN |
10 |
130,307,991 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01835:Vmn2r87
|
APN |
10 |
130,314,978 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01965:Vmn2r87
|
APN |
10 |
130,314,924 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL02562:Vmn2r87
|
APN |
10 |
130,314,513 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02665:Vmn2r87
|
APN |
10 |
130,333,049 (GRCm39) |
missense |
probably benign |
0.16 |
|
IGL03202:Vmn2r87
|
APN |
10 |
130,333,091 (GRCm39) |
missense |
probably benign |
|
|
FR4304:Vmn2r87
|
UTSW |
10 |
130,314,583 (GRCm39) |
missense |
probably benign |
0.01 |
|
FR4340:Vmn2r87
|
UTSW |
10 |
130,314,583 (GRCm39) |
missense |
probably benign |
0.01 |
|
FR4342:Vmn2r87
|
UTSW |
10 |
130,314,583 (GRCm39) |
missense |
probably benign |
0.01 |
|
FR4589:Vmn2r87
|
UTSW |
10 |
130,314,583 (GRCm39) |
missense |
probably benign |
0.01 |
|
LCD18:Vmn2r87
|
UTSW |
10 |
130,314,583 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0344:Vmn2r87
|
UTSW |
10 |
130,315,806 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0374:Vmn2r87
|
UTSW |
10 |
130,307,848 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0384:Vmn2r87
|
UTSW |
10 |
130,307,712 (GRCm39) |
missense |
probably benign |
|
|
R1144:Vmn2r87
|
UTSW |
10 |
130,312,098 (GRCm39) |
splice site |
probably benign |
|
|
R1172:Vmn2r87
|
UTSW |
10 |
130,313,453 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1860:Vmn2r87
|
UTSW |
10 |
130,315,755 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1866:Vmn2r87
|
UTSW |
10 |
130,308,441 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R1897:Vmn2r87
|
UTSW |
10 |
130,307,829 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2360:Vmn2r87
|
UTSW |
10 |
130,315,631 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2909:Vmn2r87
|
UTSW |
10 |
130,314,865 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3874:Vmn2r87
|
UTSW |
10 |
130,315,856 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R4113:Vmn2r87
|
UTSW |
10 |
130,315,691 (GRCm39) |
missense |
probably benign |
|
|
R4190:Vmn2r87
|
UTSW |
10 |
130,308,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4197:Vmn2r87
|
UTSW |
10 |
130,315,779 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R4201:Vmn2r87
|
UTSW |
10 |
130,308,448 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4202:Vmn2r87
|
UTSW |
10 |
130,308,448 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4368:Vmn2r87
|
UTSW |
10 |
130,315,676 (GRCm39) |
missense |
probably benign |
0.44 |
|
R4485:Vmn2r87
|
UTSW |
10 |
130,315,678 (GRCm39) |
nonsense |
probably null |
|
|
R4537:Vmn2r87
|
UTSW |
10 |
130,308,054 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4590:Vmn2r87
|
UTSW |
10 |
130,315,014 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R4752:Vmn2r87
|
UTSW |
10 |
130,314,336 (GRCm39) |
nonsense |
probably null |
|
|
R4873:Vmn2r87
|
UTSW |
10 |
130,308,367 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4875:Vmn2r87
|
UTSW |
10 |
130,308,367 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4923:Vmn2r87
|
UTSW |
10 |
130,314,435 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4970:Vmn2r87
|
UTSW |
10 |
130,314,422 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5049:Vmn2r87
|
UTSW |
10 |
130,308,298 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5112:Vmn2r87
|
UTSW |
10 |
130,314,422 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5187:Vmn2r87
|
UTSW |
10 |
130,333,208 (GRCm39) |
missense |
probably null |
0.99 |
|
R5618:Vmn2r87
|
UTSW |
10 |
130,315,817 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6057:Vmn2r87
|
UTSW |
10 |
130,308,226 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6220:Vmn2r87
|
UTSW |
10 |
130,315,807 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6287:Vmn2r87
|
UTSW |
10 |
130,314,291 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6383:Vmn2r87
|
UTSW |
10 |
130,314,869 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6576:Vmn2r87
|
UTSW |
10 |
130,314,654 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6742:Vmn2r87
|
UTSW |
10 |
130,308,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7086:Vmn2r87
|
UTSW |
10 |
130,333,178 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7162:Vmn2r87
|
UTSW |
10 |
130,313,416 (GRCm39) |
missense |
probably benign |
0.08 |
|
R7419:Vmn2r87
|
UTSW |
10 |
130,307,992 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7425:Vmn2r87
|
UTSW |
10 |
130,314,761 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7443:Vmn2r87
|
UTSW |
10 |
130,308,588 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7571:Vmn2r87
|
UTSW |
10 |
130,314,940 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7663:Vmn2r87
|
UTSW |
10 |
130,308,054 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7716:Vmn2r87
|
UTSW |
10 |
130,308,018 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7793:Vmn2r87
|
UTSW |
10 |
130,313,413 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7806:Vmn2r87
|
UTSW |
10 |
130,315,679 (GRCm39) |
missense |
probably benign |
|
|
R7841:Vmn2r87
|
UTSW |
10 |
130,333,095 (GRCm39) |
missense |
probably benign |
0.31 |
|
R8411:Vmn2r87
|
UTSW |
10 |
130,308,126 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8445:Vmn2r87
|
UTSW |
10 |
130,313,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8540:Vmn2r87
|
UTSW |
10 |
130,314,762 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R8892:Vmn2r87
|
UTSW |
10 |
130,308,105 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9093:Vmn2r87
|
UTSW |
10 |
130,308,165 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9623:Vmn2r87
|
UTSW |
10 |
130,315,794 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9667:Vmn2r87
|
UTSW |
10 |
130,314,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9797:Vmn2r87
|
UTSW |
10 |
130,312,064 (GRCm39) |
missense |
probably benign |
0.44 |
|
R9797:Vmn2r87
|
UTSW |
10 |
130,308,138 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1088:Vmn2r87
|
UTSW |
10 |
130,308,183 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Z1176:Vmn2r87
|
UTSW |
10 |
130,307,713 (GRCm39) |
missense |
probably benign |
0.04 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGGAACCCAAGTATCCCAGG -3'
(R):5'- GCCAATAACTGCATTCTCAGC -3'
Sequencing Primer
(F):5'- AAGTATCCCAGGACAACATGG -3'
(R):5'- ATAACTGCATTCTCAGCTACATCC -3'
|
| Posted On |
2020-09-02 |
Incidental Mutation