Incidental Mutation 'R8327:Or51s1'
ID 644157
Institutional Source Beutler Lab
Gene Symbol Or51s1
Ensembl Gene ENSMUSG00000043310
Gene Name olfactory receptor family 51 subfamily S member 1
Synonyms Olfr571, MOR21-1, GA_x6K02T2PBJ9-5620890-5619922
MMRRC Submission 067858-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.227) question?
Stock # R8327 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 102558076-102559044 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 102558926 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 40 (I40N)
Ref Sequence ENSEMBL: ENSMUSP00000148964 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061738] [ENSMUST00000214160] [ENSMUST00000215773]
AlphaFold E9Q407
Predicted Effect probably damaging
Transcript: ENSMUST00000061738
AA Change: I40N

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000062385
Gene: ENSMUSG00000043310
AA Change: I40N

DomainStartEndE-ValueType
Pfam:7tm_4 39 318 8.9e-91 PFAM
Pfam:7TM_GPCR_Srsx 43 177 3.1e-8 PFAM
Pfam:7tm_1 49 299 1.6e-17 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214160
AA Change: I40N

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
Predicted Effect probably damaging
Transcript: ENSMUST00000215773
AA Change: I40N

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2900026A02Rik T A 5: 113,331,685 (GRCm39) D843V possibly damaging Het
6330409D20Rik T A 2: 32,627,623 (GRCm39) Q111L unknown Het
Abcc5 C A 16: 20,241,068 (GRCm39) R39L probably benign Het
Acbd3 C A 1: 180,566,158 (GRCm39) Q284K probably damaging Het
Adgrv1 C T 13: 81,593,462 (GRCm39) R4175H probably damaging Het
Ankrd27 T C 7: 35,300,985 (GRCm39) L95P probably damaging Het
Apc2 T G 10: 80,137,764 (GRCm39) D68E probably damaging Het
Apob A T 12: 8,051,015 (GRCm39) I1093F possibly damaging Het
Arid2 T A 15: 96,260,485 (GRCm39) D411E probably damaging Het
Astn1 T A 1: 158,436,850 (GRCm39) Y811N probably damaging Het
Calhm5 A C 10: 33,972,064 (GRCm39) F124V probably damaging Het
Ccdc187 T C 2: 26,170,630 (GRCm39) H616R probably benign Het
Ccdc198 C T 14: 49,470,356 (GRCm39) G197S possibly damaging Het
Clca4b T C 3: 144,627,762 (GRCm39) Y403C possibly damaging Het
Dagla C T 19: 10,228,451 (GRCm39) V656I probably benign Het
Dguok A C 6: 83,464,061 (GRCm39) W166G probably damaging Het
Dlg5 G A 14: 24,196,388 (GRCm39) A1603V probably damaging Het
Fanca G A 8: 124,039,984 (GRCm39) Q138* probably null Het
Fbxl19 T A 7: 127,347,520 (GRCm39) C25* probably null Het
Gm49383 C A 12: 69,243,643 (GRCm39) E79* probably null Het
Lcor C T 19: 41,570,996 (GRCm39) S63L probably damaging Het
Lrp2 T C 2: 69,322,268 (GRCm39) Y1887C probably damaging Het
Mast3 T C 8: 71,232,062 (GRCm39) D1305G probably damaging Het
Mreg C A 1: 72,203,257 (GRCm39) R107L possibly damaging Het
Nbn T A 4: 15,981,470 (GRCm39) S521T probably benign Het
Nxpe2 C A 9: 48,231,059 (GRCm39) V437L probably benign Het
Or2t49 T C 11: 58,392,942 (GRCm39) M153V probably benign Het
Or8c13 T C 9: 38,091,186 (GRCm39) E311G possibly damaging Het
Pcdhb5 A C 18: 37,453,953 (GRCm39) K111T probably benign Het
Pi4kb A G 3: 94,906,192 (GRCm39) I580V probably benign Het
Plaat3 T C 19: 7,556,514 (GRCm39) L105P probably benign Het
Rbm15b A G 9: 106,761,646 (GRCm39) S841P probably benign Het
Reep2 A G 18: 34,975,566 (GRCm39) N31S probably damaging Het
Scmh1 C T 4: 120,379,699 (GRCm39) H505Y probably benign Het
Setd1a T A 7: 127,390,669 (GRCm39) L1115H unknown Het
Slc26a3 A G 12: 31,516,430 (GRCm39) D596G possibly damaging Het
Smg5 G T 3: 88,252,714 (GRCm39) A167S probably damaging Het
Supv3l1 T C 10: 62,277,004 (GRCm39) T255A probably damaging Het
Synrg G A 11: 83,899,731 (GRCm39) A568T probably benign Het
Tmem132a G T 19: 10,836,311 (GRCm39) P740T probably benign Het
Tmem181a T C 17: 6,351,680 (GRCm39) L353P probably damaging Het
Tubgcp3 T C 8: 12,704,343 (GRCm39) E242G probably benign Het
Vmn2r77 A T 7: 86,450,680 (GRCm39) T189S probably benign Het
Zfp638 T G 6: 83,905,679 (GRCm39) L44W probably damaging Het
Zfp715 G A 7: 42,947,482 (GRCm39) T826I possibly damaging Het
Zfp865 G A 7: 5,034,058 (GRCm39) S681N probably benign Het
Zscan5b C T 7: 6,236,946 (GRCm39) P232S possibly damaging Het
Other mutations in Or51s1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00236:Or51s1 APN 7 102,558,479 (GRCm39) missense probably damaging 1.00
IGL01457:Or51s1 APN 7 102,558,926 (GRCm39) missense possibly damaging 0.74
IGL01962:Or51s1 APN 7 102,559,054 (GRCm39) utr 5 prime probably benign
IGL02110:Or51s1 APN 7 102,558,402 (GRCm39) missense probably benign 0.13
R0306:Or51s1 UTSW 7 102,559,010 (GRCm39) missense probably benign
R0790:Or51s1 UTSW 7 102,558,843 (GRCm39) missense probably benign 0.02
R3791:Or51s1 UTSW 7 102,558,239 (GRCm39) missense probably benign 0.14
R6461:Or51s1 UTSW 7 102,558,235 (GRCm39) missense possibly damaging 0.62
R6793:Or51s1 UTSW 7 102,558,935 (GRCm39) missense probably benign 0.00
R8860:Or51s1 UTSW 7 102,558,336 (GRCm39) missense probably benign 0.19
R9532:Or51s1 UTSW 7 102,558,746 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- TGTGAGCATCAGCAAAGGC -3'
(R):5'- TGAGTCTGTGCCTAAAGGGGAG -3'

Sequencing Primer
(F):5'- GCATCAGCAAAGGCCAGGC -3'
(R):5'- GGCAGGTTGTGGTAAAATATATCTTC -3'
Posted On 2020-09-02