Incidental Mutation 'R8329:Wnk2'
ID 644276
Institutional Source Beutler Lab
Gene Symbol Wnk2
Ensembl Gene ENSMUSG00000037989
Gene Name WNK lysine deficient protein kinase 2
Synonyms X83337, ESTM15, 1810073P09Rik
MMRRC Submission 067859-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.287) question?
Stock # R8329 (G1)
Quality Score 225.009
Status Validated
Chromosome 13
Chromosomal Location 49189779-49301490 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 49248914 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Aspartic acid at position 379 (V379D)
Ref Sequence ENSEMBL: ENSMUSP00000047231 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035538] [ENSMUST00000049265] [ENSMUST00000091623] [ENSMUST00000110096] [ENSMUST00000110097] [ENSMUST00000159559] [ENSMUST00000162403] [ENSMUST00000162581]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000035538
AA Change: V379D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000047231
Gene: ENSMUSG00000037989
AA Change: V379D

DomainStartEndE-ValueType
low complexity region 2 9 N/A INTRINSIC
low complexity region 66 78 N/A INTRINSIC
low complexity region 88 116 N/A INTRINSIC
low complexity region 124 136 N/A INTRINSIC
low complexity region 171 182 N/A INTRINSIC
Pfam:Pkinase_Tyr 195 451 4.5e-42 PFAM
Pfam:Pkinase 195 453 1.7e-56 PFAM
Pfam:OSR1_C 474 511 5.6e-22 PFAM
low complexity region 582 593 N/A INTRINSIC
low complexity region 626 642 N/A INTRINSIC
low complexity region 678 693 N/A INTRINSIC
low complexity region 707 724 N/A INTRINSIC
low complexity region 771 803 N/A INTRINSIC
low complexity region 821 831 N/A INTRINSIC
low complexity region 840 854 N/A INTRINSIC
low complexity region 875 890 N/A INTRINSIC
low complexity region 938 954 N/A INTRINSIC
low complexity region 983 1014 N/A INTRINSIC
low complexity region 1021 1048 N/A INTRINSIC
low complexity region 1113 1136 N/A INTRINSIC
internal_repeat_1 1162 1185 6.72e-6 PROSPERO
low complexity region 1275 1292 N/A INTRINSIC
low complexity region 1317 1353 N/A INTRINSIC
low complexity region 1429 1441 N/A INTRINSIC
low complexity region 1449 1457 N/A INTRINSIC
low complexity region 1464 1489 N/A INTRINSIC
low complexity region 1587 1597 N/A INTRINSIC
low complexity region 1820 1831 N/A INTRINSIC
coiled coil region 1836 1867 N/A INTRINSIC
low complexity region 2033 2053 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000049265
AA Change: V379D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000049327
Gene: ENSMUSG00000037989
AA Change: V379D

DomainStartEndE-ValueType
low complexity region 2 9 N/A INTRINSIC
low complexity region 66 78 N/A INTRINSIC
low complexity region 88 116 N/A INTRINSIC
low complexity region 124 136 N/A INTRINSIC
low complexity region 171 182 N/A INTRINSIC
S_TKc 195 453 3.3e-19 SMART
Pfam:OSR1_C 474 511 5.6e-19 PFAM
low complexity region 582 593 N/A INTRINSIC
low complexity region 626 642 N/A INTRINSIC
low complexity region 678 693 N/A INTRINSIC
low complexity region 707 724 N/A INTRINSIC
low complexity region 771 803 N/A INTRINSIC
low complexity region 821 831 N/A INTRINSIC
low complexity region 840 854 N/A INTRINSIC
low complexity region 875 890 N/A INTRINSIC
low complexity region 938 954 N/A INTRINSIC
low complexity region 983 1014 N/A INTRINSIC
low complexity region 1021 1048 N/A INTRINSIC
low complexity region 1113 1136 N/A INTRINSIC
internal_repeat_1 1162 1185 9.51e-6 PROSPERO
low complexity region 1275 1292 N/A INTRINSIC
low complexity region 1317 1353 N/A INTRINSIC
low complexity region 1429 1441 N/A INTRINSIC
low complexity region 1449 1457 N/A INTRINSIC
low complexity region 1464 1489 N/A INTRINSIC
low complexity region 1587 1597 N/A INTRINSIC
internal_repeat_2 1611 1703 2.12e-5 PROSPERO
low complexity region 1820 1831 N/A INTRINSIC
coiled coil region 1836 1867 N/A INTRINSIC
internal_repeat_2 1923 2023 2.12e-5 PROSPERO
low complexity region 2069 2089 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000091623
AA Change: V379D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000089212
Gene: ENSMUSG00000037989
AA Change: V379D

DomainStartEndE-ValueType
low complexity region 2 9 N/A INTRINSIC
low complexity region 66 78 N/A INTRINSIC
low complexity region 88 116 N/A INTRINSIC
low complexity region 124 136 N/A INTRINSIC
low complexity region 171 182 N/A INTRINSIC
Pfam:Pkinase_Tyr 195 451 1.6e-41 PFAM
Pfam:Pkinase 195 453 1e-54 PFAM
Pfam:OSR1_C 474 511 4e-22 PFAM
low complexity region 582 593 N/A INTRINSIC
low complexity region 626 642 N/A INTRINSIC
low complexity region 678 693 N/A INTRINSIC
low complexity region 707 724 N/A INTRINSIC
low complexity region 771 803 N/A INTRINSIC
low complexity region 821 831 N/A INTRINSIC
low complexity region 840 854 N/A INTRINSIC
low complexity region 875 890 N/A INTRINSIC
low complexity region 938 954 N/A INTRINSIC
low complexity region 983 1014 N/A INTRINSIC
low complexity region 1021 1048 N/A INTRINSIC
low complexity region 1113 1136 N/A INTRINSIC
internal_repeat_1 1162 1185 1.52e-5 PROSPERO
low complexity region 1275 1292 N/A INTRINSIC
low complexity region 1317 1353 N/A INTRINSIC
low complexity region 1429 1441 N/A INTRINSIC
low complexity region 1449 1457 N/A INTRINSIC
low complexity region 1464 1489 N/A INTRINSIC
low complexity region 1587 1597 N/A INTRINSIC
internal_repeat_2 1611 1713 7.41e-5 PROSPERO
low complexity region 1820 1831 N/A INTRINSIC
coiled coil region 1836 1867 N/A INTRINSIC
internal_repeat_2 1923 2027 7.41e-5 PROSPERO
low complexity region 2117 2137 N/A INTRINSIC
low complexity region 2191 2202 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000110096
AA Change: V379D
SMART Domains Protein: ENSMUSP00000105723
Gene: ENSMUSG00000037989
AA Change: V379D

DomainStartEndE-ValueType
low complexity region 2 9 N/A INTRINSIC
low complexity region 66 78 N/A INTRINSIC
low complexity region 88 116 N/A INTRINSIC
low complexity region 124 136 N/A INTRINSIC
low complexity region 171 182 N/A INTRINSIC
Pfam:Pkinase_Tyr 195 451 4.6e-42 PFAM
Pfam:Pkinase 195 453 1.7e-56 PFAM
Pfam:OSR1_C 474 511 5.6e-22 PFAM
low complexity region 582 593 N/A INTRINSIC
low complexity region 626 642 N/A INTRINSIC
low complexity region 678 693 N/A INTRINSIC
low complexity region 707 724 N/A INTRINSIC
low complexity region 771 803 N/A INTRINSIC
low complexity region 821 831 N/A INTRINSIC
low complexity region 840 854 N/A INTRINSIC
low complexity region 875 890 N/A INTRINSIC
low complexity region 938 954 N/A INTRINSIC
low complexity region 1015 1038 N/A INTRINSIC
internal_repeat_1 1064 1087 2.89e-5 PROSPERO
low complexity region 1177 1194 N/A INTRINSIC
low complexity region 1219 1255 N/A INTRINSIC
low complexity region 1331 1343 N/A INTRINSIC
low complexity region 1351 1359 N/A INTRINSIC
low complexity region 1366 1391 N/A INTRINSIC
low complexity region 1489 1498 N/A INTRINSIC
low complexity region 1721 1732 N/A INTRINSIC
coiled coil region 1737 1768 N/A INTRINSIC
low complexity region 2018 2038 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000110097
AA Change: V379D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000105724
Gene: ENSMUSG00000037989
AA Change: V379D

DomainStartEndE-ValueType
low complexity region 2 9 N/A INTRINSIC
low complexity region 66 78 N/A INTRINSIC
low complexity region 88 116 N/A INTRINSIC
low complexity region 124 136 N/A INTRINSIC
low complexity region 171 182 N/A INTRINSIC
Pfam:Pkinase_Tyr 195 451 4.7e-42 PFAM
Pfam:Pkinase 195 453 1.7e-56 PFAM
Pfam:OSR1_C 474 511 5.8e-22 PFAM
low complexity region 582 593 N/A INTRINSIC
low complexity region 626 642 N/A INTRINSIC
low complexity region 678 693 N/A INTRINSIC
low complexity region 707 724 N/A INTRINSIC
low complexity region 771 803 N/A INTRINSIC
low complexity region 821 831 N/A INTRINSIC
low complexity region 840 854 N/A INTRINSIC
low complexity region 875 890 N/A INTRINSIC
low complexity region 938 954 N/A INTRINSIC
low complexity region 983 1014 N/A INTRINSIC
low complexity region 1021 1048 N/A INTRINSIC
low complexity region 1113 1136 N/A INTRINSIC
internal_repeat_1 1162 1185 1.16e-5 PROSPERO
low complexity region 1275 1292 N/A INTRINSIC
low complexity region 1317 1353 N/A INTRINSIC
low complexity region 1429 1441 N/A INTRINSIC
low complexity region 1449 1457 N/A INTRINSIC
low complexity region 1464 1489 N/A INTRINSIC
low complexity region 1587 1597 N/A INTRINSIC
internal_repeat_2 1611 1713 5.74e-5 PROSPERO
low complexity region 1820 1831 N/A INTRINSIC
coiled coil region 1836 1867 N/A INTRINSIC
internal_repeat_2 1923 2027 5.74e-5 PROSPERO
low complexity region 2117 2137 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000159559
AA Change: V379D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000123915
Gene: ENSMUSG00000037989
AA Change: V379D

DomainStartEndE-ValueType
low complexity region 2 9 N/A INTRINSIC
low complexity region 66 78 N/A INTRINSIC
low complexity region 88 116 N/A INTRINSIC
low complexity region 124 136 N/A INTRINSIC
low complexity region 171 182 N/A INTRINSIC
Pfam:Pkinase_Tyr 195 451 4.7e-42 PFAM
Pfam:Pkinase 195 453 1.7e-56 PFAM
Pfam:OSR1_C 474 511 5.8e-22 PFAM
low complexity region 582 593 N/A INTRINSIC
low complexity region 626 642 N/A INTRINSIC
low complexity region 678 693 N/A INTRINSIC
low complexity region 707 736 N/A INTRINSIC
low complexity region 759 791 N/A INTRINSIC
low complexity region 809 819 N/A INTRINSIC
low complexity region 828 842 N/A INTRINSIC
low complexity region 863 878 N/A INTRINSIC
low complexity region 926 942 N/A INTRINSIC
low complexity region 971 1002 N/A INTRINSIC
low complexity region 1009 1036 N/A INTRINSIC
low complexity region 1101 1124 N/A INTRINSIC
internal_repeat_1 1150 1173 7.19e-6 PROSPERO
low complexity region 1263 1280 N/A INTRINSIC
low complexity region 1305 1341 N/A INTRINSIC
low complexity region 1417 1429 N/A INTRINSIC
low complexity region 1437 1445 N/A INTRINSIC
low complexity region 1452 1477 N/A INTRINSIC
low complexity region 1575 1585 N/A INTRINSIC
internal_repeat_2 1599 1701 3.66e-5 PROSPERO
low complexity region 1808 1819 N/A INTRINSIC
coiled coil region 1824 1855 N/A INTRINSIC
internal_repeat_2 1911 2015 3.66e-5 PROSPERO
low complexity region 2105 2125 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000162403
AA Change: V379D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000125539
Gene: ENSMUSG00000037989
AA Change: V379D

DomainStartEndE-ValueType
low complexity region 2 9 N/A INTRINSIC
low complexity region 66 78 N/A INTRINSIC
low complexity region 88 116 N/A INTRINSIC
low complexity region 124 136 N/A INTRINSIC
low complexity region 171 182 N/A INTRINSIC
Pfam:Pkinase_Tyr 195 451 4.3e-42 PFAM
Pfam:Pkinase 195 453 1.6e-56 PFAM
Pfam:OSR1_C 474 511 5.3e-22 PFAM
low complexity region 582 593 N/A INTRINSIC
low complexity region 626 642 N/A INTRINSIC
low complexity region 678 693 N/A INTRINSIC
low complexity region 707 736 N/A INTRINSIC
low complexity region 759 791 N/A INTRINSIC
low complexity region 809 819 N/A INTRINSIC
low complexity region 828 842 N/A INTRINSIC
low complexity region 863 878 N/A INTRINSIC
low complexity region 926 942 N/A INTRINSIC
low complexity region 1003 1026 N/A INTRINSIC
internal_repeat_1 1052 1075 1.05e-5 PROSPERO
low complexity region 1165 1182 N/A INTRINSIC
low complexity region 1207 1243 N/A INTRINSIC
low complexity region 1319 1331 N/A INTRINSIC
low complexity region 1339 1347 N/A INTRINSIC
low complexity region 1354 1379 N/A INTRINSIC
low complexity region 1477 1487 N/A INTRINSIC
internal_repeat_2 1501 1593 2.32e-5 PROSPERO
low complexity region 1710 1721 N/A INTRINSIC
coiled coil region 1726 1757 N/A INTRINSIC
internal_repeat_2 1813 1913 2.32e-5 PROSPERO
low complexity region 1959 1979 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000162581
AA Change: V379D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000125448
Gene: ENSMUSG00000037989
AA Change: V379D

DomainStartEndE-ValueType
low complexity region 2 9 N/A INTRINSIC
low complexity region 66 78 N/A INTRINSIC
low complexity region 88 116 N/A INTRINSIC
low complexity region 124 136 N/A INTRINSIC
low complexity region 171 182 N/A INTRINSIC
Pfam:Pkinase_Tyr 195 451 4.5e-42 PFAM
Pfam:Pkinase 195 453 1.7e-56 PFAM
Pfam:OSR1_C 474 511 5.6e-22 PFAM
low complexity region 582 593 N/A INTRINSIC
low complexity region 626 642 N/A INTRINSIC
low complexity region 678 693 N/A INTRINSIC
low complexity region 707 724 N/A INTRINSIC
low complexity region 771 803 N/A INTRINSIC
low complexity region 821 831 N/A INTRINSIC
low complexity region 840 854 N/A INTRINSIC
low complexity region 875 890 N/A INTRINSIC
low complexity region 938 954 N/A INTRINSIC
low complexity region 983 1014 N/A INTRINSIC
low complexity region 1021 1048 N/A INTRINSIC
low complexity region 1113 1136 N/A INTRINSIC
internal_repeat_1 1162 1185 6.72e-6 PROSPERO
low complexity region 1275 1292 N/A INTRINSIC
low complexity region 1317 1353 N/A INTRINSIC
low complexity region 1429 1441 N/A INTRINSIC
low complexity region 1449 1457 N/A INTRINSIC
low complexity region 1464 1489 N/A INTRINSIC
low complexity region 1587 1597 N/A INTRINSIC
low complexity region 1820 1831 N/A INTRINSIC
coiled coil region 1836 1867 N/A INTRINSIC
low complexity region 2033 2053 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.9%
Validation Efficiency 100% (62/62)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a cytoplasmic serine-threonine kinase that belongs to the protein kinase superfamily. The protein plays an important role in the regulation of electrolyte homeostasis, cell signaling survival, and proliferation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933430I17Rik T A 4: 62,461,978 (GRCm39) probably null Het
Ackr4 A G 9: 103,976,660 (GRCm39) F96L possibly damaging Het
Aco1 T C 4: 40,186,376 (GRCm39) I596T possibly damaging Het
Aff3 G A 1: 38,244,135 (GRCm39) R879W probably benign Het
Apob A G 12: 8,061,135 (GRCm39) R3206G probably damaging Het
Atg7 T A 6: 114,663,057 (GRCm39) D224E possibly damaging Het
Capn12 T C 7: 28,582,626 (GRCm39) F167S probably damaging Het
Ccdc3 T G 2: 5,233,848 (GRCm39) V224G probably damaging Het
Ces4a G A 8: 105,874,714 (GRCm39) V452I probably damaging Het
Cherp G A 8: 73,215,852 (GRCm39) R834C Het
Clptm1l T A 13: 73,760,547 (GRCm39) I310N probably damaging Het
Cog3 A T 14: 75,978,003 (GRCm39) D230E probably damaging Het
Crb1 T A 1: 139,165,005 (GRCm39) I1101F probably damaging Het
Cts6 A T 13: 61,343,282 (GRCm39) M313K probably damaging Het
Cyp2c66 T A 19: 39,174,906 (GRCm39) C435* probably null Het
Defb13 A G 8: 22,438,562 (GRCm39) E40G probably benign Het
Dis3l T C 9: 64,219,112 (GRCm39) D606G possibly damaging Het
Dop1b T C 16: 93,568,675 (GRCm39) L1579P probably damaging Het
Foxa3 A G 7: 18,748,109 (GRCm39) V339A probably benign Het
Gcn1 G A 5: 115,747,921 (GRCm39) G1776E probably damaging Het
Gls2 A G 10: 128,037,154 (GRCm39) T232A probably benign Het
Gprc6a A T 10: 51,503,355 (GRCm39) Y169* probably null Het
Guca2b T C 4: 119,516,001 (GRCm39) S18G unknown Het
Hars2 A G 18: 36,922,288 (GRCm39) D301G possibly damaging Het
Haus5 T A 7: 30,358,984 (GRCm39) Q226L possibly damaging Het
Hc G A 2: 34,902,910 (GRCm39) probably null Het
Hivep2 T C 10: 14,004,011 (GRCm39) V203A probably damaging Het
Hoxc8 A G 15: 102,899,543 (GRCm39) Y111C probably damaging Het
Hoxd13 G T 2: 74,498,661 (GRCm39) R3L probably benign Het
Hspa8 T G 9: 40,713,897 (GRCm39) I130S probably damaging Het
Ier5l C A 2: 30,362,861 (GRCm39) C388F possibly damaging Het
Ldc1 C T 4: 130,109,156 (GRCm39) V295M possibly damaging Het
Lmx1a A G 1: 167,517,372 (GRCm39) N10S probably benign Het
Map2 T C 1: 66,454,272 (GRCm39) I1054T probably benign Het
Me1 C T 9: 86,501,790 (GRCm39) D268N probably damaging Het
Muc6 G A 7: 141,226,525 (GRCm39) P1501S unknown Het
Myo1d T C 11: 80,528,900 (GRCm39) M641V probably benign Het
Nuggc G A 14: 65,878,731 (GRCm39) R667K probably benign Het
Oprl1 T A 2: 181,360,717 (GRCm39) C231S probably damaging Het
Or11g26 T C 14: 50,753,015 (GRCm39) F118S probably damaging Het
Or13p10 A C 4: 118,523,604 (GRCm39) N297H probably damaging Het
Pard3b C A 1: 62,676,957 (GRCm39) Q1163K probably benign Het
Pik3c2a T C 7: 116,017,283 (GRCm39) Y158C probably damaging Het
Prune2 T G 19: 17,098,629 (GRCm39) S1378A probably benign Het
Ralgps2 G T 1: 156,712,110 (GRCm39) T158K probably damaging Het
Rbm42 T A 7: 30,344,582 (GRCm39) E227V unknown Het
Ripor3 T C 2: 167,825,119 (GRCm39) R797G possibly damaging Het
Ryr3 T A 2: 112,492,855 (GRCm39) H3764L possibly damaging Het
Sbno2 T C 10: 79,900,221 (GRCm39) Y541C probably damaging Het
Scn5a A G 9: 119,365,030 (GRCm39) V396A probably damaging Het
Slc36a3 A G 11: 55,039,409 (GRCm39) L73P probably damaging Het
Spag16 T C 1: 69,934,407 (GRCm39) I278T probably benign Het
Stx18 T A 5: 38,285,450 (GRCm39) L274* probably null Het
Terb1 A T 8: 105,211,003 (GRCm39) N341K probably damaging Het
Timm29 A G 9: 21,505,001 (GRCm39) Y223C probably damaging Het
Tmprss2 T A 16: 97,369,665 (GRCm39) M370L probably benign Het
Tmtc3 T A 10: 100,283,296 (GRCm39) N753I probably damaging Het
Tnpo3 A T 6: 29,558,832 (GRCm39) C699* probably null Het
Trav5d-4 G A 14: 53,239,208 (GRCm39) W13* probably null Het
Trdn A G 10: 33,320,074 (GRCm39) probably null Het
Tsg101 A T 7: 46,558,808 (GRCm39) Y68N probably damaging Het
Ttn A G 2: 76,664,062 (GRCm39) V11649A unknown Het
Xpnpep1 A G 19: 52,990,903 (GRCm39) probably null Het
Yme1l1 C T 2: 23,054,597 (GRCm39) Q139* probably null Het
Other mutations in Wnk2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01518:Wnk2 APN 13 49,221,668 (GRCm39) missense possibly damaging 0.89
IGL01575:Wnk2 APN 13 49,300,152 (GRCm39) missense probably damaging 1.00
IGL01601:Wnk2 APN 13 49,230,038 (GRCm39) missense probably damaging 1.00
IGL01775:Wnk2 APN 13 49,224,586 (GRCm39) missense probably damaging 1.00
IGL02013:Wnk2 APN 13 49,235,510 (GRCm39) missense possibly damaging 0.46
IGL02016:Wnk2 APN 13 49,210,381 (GRCm39) missense probably damaging 1.00
IGL02167:Wnk2 APN 13 49,224,601 (GRCm39) critical splice acceptor site probably null
IGL02174:Wnk2 APN 13 49,210,643 (GRCm39) missense probably damaging 1.00
IGL02210:Wnk2 APN 13 49,244,345 (GRCm39) missense probably damaging 0.98
IGL02228:Wnk2 APN 13 49,210,416 (GRCm39) missense probably damaging 1.00
IGL02282:Wnk2 APN 13 49,221,601 (GRCm39) missense probably damaging 1.00
IGL02319:Wnk2 APN 13 49,214,914 (GRCm39) missense possibly damaging 0.73
IGL02394:Wnk2 APN 13 49,235,375 (GRCm39) splice site probably null
IGL02624:Wnk2 APN 13 49,256,278 (GRCm39) missense probably damaging 1.00
IGL02743:Wnk2 APN 13 49,248,920 (GRCm39) missense probably damaging 1.00
IGL03012:Wnk2 APN 13 49,197,865 (GRCm39) missense probably damaging 0.99
IGL03166:Wnk2 APN 13 49,224,520 (GRCm39) nonsense probably null
R0034:Wnk2 UTSW 13 49,221,556 (GRCm39) missense possibly damaging 0.64
R0385:Wnk2 UTSW 13 49,221,604 (GRCm39) missense probably damaging 1.00
R0423:Wnk2 UTSW 13 49,248,894 (GRCm39) missense possibly damaging 0.91
R0504:Wnk2 UTSW 13 49,238,872 (GRCm39) missense probably damaging 1.00
R0504:Wnk2 UTSW 13 49,238,870 (GRCm39) missense possibly damaging 0.92
R0653:Wnk2 UTSW 13 49,210,492 (GRCm39) missense possibly damaging 0.85
R1135:Wnk2 UTSW 13 49,230,034 (GRCm39) missense probably damaging 1.00
R1445:Wnk2 UTSW 13 49,224,586 (GRCm39) missense probably damaging 1.00
R1464:Wnk2 UTSW 13 49,235,451 (GRCm39) missense probably damaging 1.00
R1464:Wnk2 UTSW 13 49,235,451 (GRCm39) missense probably damaging 1.00
R1468:Wnk2 UTSW 13 49,235,571 (GRCm39) missense probably damaging 0.99
R1468:Wnk2 UTSW 13 49,235,571 (GRCm39) missense probably damaging 0.99
R1480:Wnk2 UTSW 13 49,210,708 (GRCm39) missense probably damaging 1.00
R1605:Wnk2 UTSW 13 49,214,370 (GRCm39) missense probably damaging 1.00
R1719:Wnk2 UTSW 13 49,214,202 (GRCm39) missense possibly damaging 0.76
R1891:Wnk2 UTSW 13 49,206,200 (GRCm39) nonsense probably null
R1966:Wnk2 UTSW 13 49,192,487 (GRCm39) missense probably damaging 0.96
R2001:Wnk2 UTSW 13 49,232,158 (GRCm39) missense possibly damaging 0.61
R2310:Wnk2 UTSW 13 49,204,053 (GRCm39) missense probably damaging 0.97
R2356:Wnk2 UTSW 13 49,192,644 (GRCm39) nonsense probably null
R2406:Wnk2 UTSW 13 49,214,964 (GRCm39) missense possibly damaging 0.86
R2519:Wnk2 UTSW 13 49,224,505 (GRCm39) missense probably damaging 0.99
R3962:Wnk2 UTSW 13 49,224,453 (GRCm39) missense probably damaging 1.00
R4160:Wnk2 UTSW 13 49,244,313 (GRCm39) missense probably damaging 1.00
R4161:Wnk2 UTSW 13 49,244,313 (GRCm39) missense probably damaging 1.00
R4226:Wnk2 UTSW 13 49,244,313 (GRCm39) missense probably damaging 1.00
R4227:Wnk2 UTSW 13 49,244,313 (GRCm39) missense probably damaging 1.00
R4234:Wnk2 UTSW 13 49,214,604 (GRCm39) missense probably benign 0.33
R4304:Wnk2 UTSW 13 49,244,313 (GRCm39) missense probably damaging 1.00
R4308:Wnk2 UTSW 13 49,244,313 (GRCm39) missense probably damaging 1.00
R4584:Wnk2 UTSW 13 49,244,313 (GRCm39) missense probably damaging 1.00
R4655:Wnk2 UTSW 13 49,210,359 (GRCm39) missense probably damaging 1.00
R4715:Wnk2 UTSW 13 49,300,708 (GRCm39) start codon destroyed unknown
R4887:Wnk2 UTSW 13 49,224,478 (GRCm39) missense probably damaging 1.00
R4888:Wnk2 UTSW 13 49,224,478 (GRCm39) missense probably damaging 1.00
R4945:Wnk2 UTSW 13 49,210,722 (GRCm39) missense probably damaging 1.00
R5182:Wnk2 UTSW 13 49,214,637 (GRCm39) missense possibly damaging 0.92
R5243:Wnk2 UTSW 13 49,226,054 (GRCm39) missense possibly damaging 0.51
R5370:Wnk2 UTSW 13 49,256,437 (GRCm39) missense probably damaging 1.00
R5771:Wnk2 UTSW 13 49,256,276 (GRCm39) missense probably damaging 1.00
R5877:Wnk2 UTSW 13 49,220,782 (GRCm39) missense probably damaging 0.98
R5900:Wnk2 UTSW 13 49,256,308 (GRCm39) missense probably damaging 1.00
R5905:Wnk2 UTSW 13 49,229,821 (GRCm39) missense probably damaging 0.99
R5912:Wnk2 UTSW 13 49,214,250 (GRCm39) missense probably damaging 1.00
R5915:Wnk2 UTSW 13 49,231,561 (GRCm39) missense probably damaging 0.99
R6028:Wnk2 UTSW 13 49,229,821 (GRCm39) missense probably damaging 0.99
R6074:Wnk2 UTSW 13 49,204,875 (GRCm39) missense probably damaging 1.00
R6171:Wnk2 UTSW 13 49,214,308 (GRCm39) missense probably damaging 1.00
R6368:Wnk2 UTSW 13 49,214,814 (GRCm39) missense probably damaging 0.99
R6467:Wnk2 UTSW 13 49,300,081 (GRCm39) missense probably damaging 1.00
R6501:Wnk2 UTSW 13 49,300,159 (GRCm39) missense probably damaging 1.00
R6849:Wnk2 UTSW 13 49,220,834 (GRCm39) missense probably damaging 1.00
R6898:Wnk2 UTSW 13 49,224,557 (GRCm39) missense probably damaging 1.00
R6949:Wnk2 UTSW 13 49,254,616 (GRCm39) missense probably damaging 1.00
R7011:Wnk2 UTSW 13 49,224,567 (GRCm39) missense probably damaging 0.99
R7097:Wnk2 UTSW 13 49,256,314 (GRCm39) missense possibly damaging 0.86
R7121:Wnk2 UTSW 13 49,300,653 (GRCm39) missense probably benign 0.26
R7123:Wnk2 UTSW 13 49,235,462 (GRCm39) missense possibly damaging 0.90
R7423:Wnk2 UTSW 13 49,191,608 (GRCm39) missense probably benign 0.07
R7502:Wnk2 UTSW 13 49,300,720 (GRCm39) splice site probably null
R7529:Wnk2 UTSW 13 49,254,457 (GRCm39) missense possibly damaging 0.50
R7751:Wnk2 UTSW 13 49,231,493 (GRCm39) missense unknown
R7979:Wnk2 UTSW 13 49,248,884 (GRCm39) missense probably damaging 1.00
R8118:Wnk2 UTSW 13 49,244,459 (GRCm39) missense probably damaging 0.99
R8121:Wnk2 UTSW 13 49,214,415 (GRCm39) nonsense probably null
R8155:Wnk2 UTSW 13 49,192,577 (GRCm39) missense unknown
R8334:Wnk2 UTSW 13 49,203,958 (GRCm39) critical splice donor site probably null
R8872:Wnk2 UTSW 13 49,210,960 (GRCm39) missense probably benign 0.00
R8919:Wnk2 UTSW 13 49,221,711 (GRCm39) missense possibly damaging 0.86
R9091:Wnk2 UTSW 13 49,224,505 (GRCm39) missense probably benign 0.41
R9234:Wnk2 UTSW 13 49,224,274 (GRCm39) missense probably damaging 0.99
R9262:Wnk2 UTSW 13 49,221,430 (GRCm39) missense probably benign 0.12
R9268:Wnk2 UTSW 13 49,235,507 (GRCm39) missense possibly damaging 0.82
R9270:Wnk2 UTSW 13 49,224,505 (GRCm39) missense probably benign 0.41
R9386:Wnk2 UTSW 13 49,220,822 (GRCm39) missense probably damaging 0.98
R9582:Wnk2 UTSW 13 49,210,975 (GRCm39) missense probably benign 0.01
R9617:Wnk2 UTSW 13 49,192,453 (GRCm39) missense unknown
R9625:Wnk2 UTSW 13 49,254,445 (GRCm39) missense probably benign 0.20
R9794:Wnk2 UTSW 13 49,229,674 (GRCm39) missense probably benign 0.02
RF023:Wnk2 UTSW 13 49,300,255 (GRCm39) missense probably benign 0.00
X0025:Wnk2 UTSW 13 49,214,418 (GRCm39) missense probably damaging 0.99
X0063:Wnk2 UTSW 13 49,192,453 (GRCm39) missense unknown
Z1176:Wnk2 UTSW 13 49,191,537 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- TCTTGCACAGCTGCCCAAAG -3'
(R):5'- TGGAGCCATAAGGTAAGGTTTG -3'

Sequencing Primer
(F):5'- AAGGACTAACCAAGGCTGTTTGTTG -3'
(R):5'- AAACCCTGGGATCTGTTGAC -3'
Posted On 2020-09-02