Incidental Mutation 'R8330:S1pr3'
ID 644321
Institutional Source Beutler Lab
Gene Symbol S1pr3
Ensembl Gene ENSMUSG00000067586
Gene Name sphingosine-1-phosphate receptor 3
Synonyms LPb3, S1P3, Edg3
MMRRC Submission 067799-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8330 (G1)
Quality Score 225.009
Status Not validated
Chromosome 13
Chromosomal Location 51562675-51576833 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 51573173 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Asparagine at position 118 (S118N)
Ref Sequence ENSEMBL: ENSMUSP00000085293 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087978]
AlphaFold Q9Z0U9
Predicted Effect probably damaging
Transcript: ENSMUST00000087978
AA Change: S118N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000085293
Gene: ENSMUSG00000067586
AA Change: S118N

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 51 313 1.8e-12 PFAM
Pfam:7tm_1 57 298 8.8e-39 PFAM
low complexity region 334 350 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for the lysophospholipid sphingosine 1-phosphate. The gene product functions in endothelial cells and is involved in vascular and heart development. The gene product mediates HDL and HDL-associated lysophospholipid-induced vasorelaxation, and it coordinates with other lysophospholipid receptors in the process of angiogenesis. [provided by RefSeq, Jan 2010]
PHENOTYPE: Mice homozygous for disruptions in this gene display an essentially normal phenotype although litter sizes are reduced. Susceptibility to pulmonary edema is also reduced. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3425401B19Rik T A 14: 32,381,750 (GRCm39) D1405V probably damaging Het
Acsl6 A G 11: 54,236,034 (GRCm39) I514V probably benign Het
Adgrv1 C T 13: 81,593,462 (GRCm39) R4175H probably damaging Het
Ahnak T C 19: 8,987,026 (GRCm39) V2770A possibly damaging Het
B4galt1 A G 4: 40,812,787 (GRCm39) V246A probably damaging Het
Cdr2l T C 11: 115,284,939 (GRCm39) V425A probably benign Het
Celsr1 T A 15: 85,816,501 (GRCm39) D1814V probably damaging Het
Exoc2 A G 13: 31,061,556 (GRCm39) V495A probably benign Het
Ifi47 A G 11: 48,986,637 (GRCm39) T135A possibly damaging Het
Klhl23 T C 2: 69,654,496 (GRCm39) V122A probably damaging Het
Klri2 T A 6: 129,710,694 (GRCm39) N142Y probably damaging Het
Kmt2c A T 5: 25,509,692 (GRCm39) F3161L probably null Het
Mgl2 A G 11: 70,026,785 (GRCm39) T144A probably benign Het
Mpp3 T C 11: 101,899,453 (GRCm39) E356G probably benign Het
Neb T G 2: 52,117,420 (GRCm39) T872P Het
Nek9 A G 12: 85,376,727 (GRCm39) M218T probably damaging Het
Or10a49 A T 7: 108,468,046 (GRCm39) L105H probably damaging Het
Or4f14 A G 2: 111,742,724 (GRCm39) F184L probably benign Het
Or51k2 T G 7: 103,596,610 (GRCm39) I279S possibly damaging Het
Pabpc1l G A 2: 163,869,568 (GRCm39) G123R probably damaging Het
Parp3 T C 9: 106,352,069 (GRCm39) probably null Het
Pcdhga1 A T 18: 37,796,376 (GRCm39) Y460F probably benign Het
Pclo A G 5: 14,725,311 (GRCm39) T1390A unknown Het
Peg10 GC GCTCC 6: 4,756,452 (GRCm39) probably benign Het
Pex6 T C 17: 47,023,060 (GRCm39) L212P possibly damaging Het
Pigt CCAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGATCTGTAACCACAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGATCTGTAACCACAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGAT CCAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGATCTGTAACCACAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGAT 2: 164,341,589 (GRCm39) probably null Het
Ppib T C 9: 65,968,755 (GRCm39) F48L probably damaging Het
Psme4 A G 11: 30,793,583 (GRCm39) E1228G probably benign Het
Ptpdc1 G T 13: 48,751,390 (GRCm39) H37N probably benign Het
Rab31 A T 17: 66,003,269 (GRCm39) I126N possibly damaging Het
Rsad2 A T 12: 26,506,405 (GRCm39) V5E probably benign Het
Sbsn T A 7: 30,451,366 (GRCm39) I127N possibly damaging Het
Scart2 C T 7: 139,876,231 (GRCm39) Q568* probably null Het
Selenoh G T 2: 84,500,691 (GRCm39) Q50K probably damaging Het
Simc1 GCAGTCACTAAGAAGTGTAATGCAGTCATCAGGAGGTGTGACACAGTCACTAAGAAGTGTGATGCAGTCACCAGGAGGTGTGA GCAGTCACTAAGAAGTGTGATGCAGTCACCAGGAGGTGTGA 13: 54,673,177 (GRCm39) probably benign Het
Stkld1 A T 2: 26,841,515 (GRCm39) I487L probably benign Het
Tep1 T A 14: 51,085,162 (GRCm39) I874F possibly damaging Het
Tmem43 T C 6: 91,455,746 (GRCm39) V119A possibly damaging Het
Vmn2r80 T A 10: 79,007,550 (GRCm39) W509R probably damaging Het
Xpr1 A C 1: 155,189,001 (GRCm39) Y290* probably null Het
Zfp160 T C 17: 21,246,313 (GRCm39) C288R probably damaging Het
Zfp955a C T 17: 33,463,087 (GRCm39) V15M probably damaging Het
Other mutations in S1pr3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01759:S1pr3 APN 13 51,573,548 (GRCm39) missense probably damaging 1.00
IGL01997:S1pr3 APN 13 51,573,751 (GRCm39) missense probably damaging 1.00
IGL02270:S1pr3 APN 13 51,573,092 (GRCm39) missense probably benign 0.03
R0242:S1pr3 UTSW 13 51,572,938 (GRCm39) missense probably benign 0.00
R0242:S1pr3 UTSW 13 51,572,938 (GRCm39) missense probably benign 0.00
R0584:S1pr3 UTSW 13 51,573,697 (GRCm39) missense probably benign 0.00
R1869:S1pr3 UTSW 13 51,573,952 (GRCm39) missense probably benign 0.01
R1870:S1pr3 UTSW 13 51,573,952 (GRCm39) missense probably benign 0.01
R2338:S1pr3 UTSW 13 51,573,614 (GRCm39) missense possibly damaging 0.76
R5472:S1pr3 UTSW 13 51,573,683 (GRCm39) missense probably damaging 1.00
R6006:S1pr3 UTSW 13 51,573,731 (GRCm39) missense probably damaging 1.00
R6345:S1pr3 UTSW 13 51,573,068 (GRCm39) missense probably damaging 1.00
R6345:S1pr3 UTSW 13 51,573,067 (GRCm39) missense probably damaging 1.00
R6702:S1pr3 UTSW 13 51,573,475 (GRCm39) missense probably damaging 1.00
R6703:S1pr3 UTSW 13 51,573,475 (GRCm39) missense probably damaging 1.00
R8066:S1pr3 UTSW 13 51,573,955 (GRCm39) makesense probably null
R8964:S1pr3 UTSW 13 51,573,248 (GRCm39) missense probably damaging 0.96
R9341:S1pr3 UTSW 13 51,573,553 (GRCm39) missense probably damaging 1.00
R9343:S1pr3 UTSW 13 51,573,553 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATCGTCTTGGAGAACCTGATGG -3'
(R):5'- AGCAGTCGGGAAAGTTCTCC -3'

Sequencing Primer
(F):5'- GGTTTTGATTGCCATCTGGAAAAAC -3'
(R):5'- GAAAGTTCTCCAGGCAGTTCCAG -3'
Posted On 2020-09-02