Mutagenetix > Incidental Mutation

Incidental Mutation 'R8331:Vmn2r26'

644363

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r26

Ensembl Gene

ENSMUSG00000096630

Gene Name

vomeronasal 2, receptor 26

Synonyms

V2r1b

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.089) question?

Stock #

R8331 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

124024758-124062035 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 124061928 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Threonine at position 821 (S821T)

Ref Sequence

ENSEMBL: ENSMUSP00000032238 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000032238]

AlphaFold

Q6TAC4

Predicted Effect

probably benign
Transcript: ENSMUST00000032238
AA Change: S821T

PolyPhen 2 Score 0.221 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000032238
Gene: ENSMUSG00000096630
AA Change: S821T

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	82	471	1.5e-31	PFAM
Pfam:NCD3G	519	572	4.6e-25	PFAM
Pfam:7tm_3	603	840	1.5e-55	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.8%

Validation Efficiency

100% (75/75)

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele exhibit abnormal vomeronasal sensory neuron physiology and avnosmia. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 76 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcd4	C	A	12: 84,603,952	A545S	probably damaging	Het
Alox12e	A	T	11: 70,321,097	S195R	probably benign	Het
Angpt1	T	C	15: 42,676,257	R69G	probably damaging	Het
Apob	A	G	12: 8,001,882	Q1149R	probably benign	Het
Arntl	C	A	7: 113,313,496	N586K	probably benign	Het
As3mt	A	T	19: 46,709,006	E71V	probably damaging	Het
Atp9a	A	T	2: 168,675,297	V372E	probably benign	Het
Bmp2k	T	C	5: 97,045,069	F259S	probably damaging	Het
Cacna1c	T	C	6: 118,630,329	T1364A		Het
Casp7	T	A	19: 56,440,965	I261N	probably damaging	Het
Ccdc151	C	T	9: 21,991,711	R441H	probably damaging	Het
Ccdc154	A	G	17: 25,167,953	K319E	probably benign	Het
Cdc42bpg	C	A	19: 6,313,447	L446I	probably benign	Het
Cdkl3	A	T	11: 52,026,877	T334S	probably benign	Het
Cep250	T	A	2: 155,990,253	L1366Q	probably damaging	Het
Chp2	G	A	7: 122,221,910	D165N	probably damaging	Het
Ckap5	T	A	2: 91,576,200	M782K	probably damaging	Het
Col20a1	T	A	2: 180,996,766	I433N	possibly damaging	Het
Col4a2	A	T	8: 11,413,985	R320*	probably null	Het
Ctsc	A	G	7: 88,297,120	H119R	possibly damaging	Het
Cubn	T	C	2: 13,340,242	H2121R	probably damaging	Het
Cyp4v3	G	A	8: 45,315,708	R272*	probably null	Het
D630045J12Rik	T	C	6: 38,148,474	E1535G	probably damaging	Het
Dido1	A	T	2: 180,660,449	D1887E	probably benign	Het
Dnah6	T	C	6: 73,025,000	E3903G	probably benign	Het
Ep300	T	C	15: 81,601,210	S133P	unknown	Het
Ercc3	T	C	18: 32,240,818	S73P	probably damaging	Het
Fis1	T	C	5: 136,963,133		probably null	Het
Fscb	T	A	12: 64,473,468	D408V	probably benign	Het
Gm17087	A	G	17: 8,566,707	W55R	probably damaging	Het
Gm3404	A	T	5: 146,525,949	S41C	probably damaging	Het
Gm5580	T	C	6: 116,552,362	I400T	probably damaging	Het
Greb1l	T	C	18: 10,458,706	S96P	possibly damaging	Het
Irf3	C	T	7: 45,000,959	P300S	probably damaging	Het
Klk1b4	G	A	7: 44,211,575	C214Y	probably damaging	Het
Krtap5-3	T	A	7: 142,201,826	C133*	probably null	Het
Map3k12	T	A	15: 102,502,331	R448*	probably null	Het
Map4k2	C	G	19: 6,352,823	A738G	probably damaging	Het
Matn2	A	T	15: 34,428,681	K730N	probably damaging	Het
Mpp3	C	T	11: 102,011,715		probably null	Het
N4bp2	T	A	5: 65,807,600	D997E	probably damaging	Het
Nav2	C	T	7: 49,452,623	P390S	probably benign	Het
Nme8	A	G	13: 19,658,866	S380P	probably damaging	Het
Nup210	C	T	6: 91,053,666	D878N	possibly damaging	Het
Olfr1299	A	G	2: 111,664,382	D52G	possibly damaging	Het
Olfr896-ps1	A	G	9: 38,292,085	I47V	possibly damaging	Het
Osbpl9	C	A	4: 109,066,181	W427L	probably damaging	Het
Pcdhb12	T	C	18: 37,437,289	V496A	probably damaging	Het
Pdlim1	G	A	19: 40,230,551	T212I	possibly damaging	Het
Phc2	C	T	4: 128,712,194	Q270*	probably null	Het
Pi4kb	G	A	3: 94,996,684	R527Q	probably null	Het
Platr25	G	T	13: 62,700,903	H48Q	probably benign	Het
Polr1a	C	T	6: 71,976,179	T1577M	probably damaging	Het
Ptprf	C	T	4: 118,226,066	V915M	probably benign	Het
Ptprh	A	G	7: 4,549,481	L928S	probably damaging	Het
Qrsl1	T	C	10: 43,876,525	N434S	probably damaging	Het
Slc44a4	T	A	17: 34,921,569	L246H	probably damaging	Het
Steap3	A	T	1: 120,241,488	C360S	possibly damaging	Het
Stk10	A	G	11: 32,588,928	T256A		Het
Tatdn3	A	T	1: 191,046,211	L261Q	probably damaging	Het
Thnsl1	T	A	2: 21,212,174	F246L	probably benign	Het
Thsd7a	A	G	6: 12,471,158	V487A		Het
Tmem41a	A	C	16: 21,947,366		probably null	Het
Togaram2	G	A	17: 71,729,226	V924M	probably damaging	Het
Trabd	T	C	15: 89,084,928	F185S	probably damaging	Het
Traf1	T	C	2: 34,948,358	D156G	probably damaging	Het
Ttn	T	C	2: 76,880,138	E8513G	unknown	Het
Txlna	C	A	4: 129,639,486	S83I	probably damaging	Het
Utrn	T	G	10: 12,614,619	T6P	probably benign	Het
Wdhd1	A	T	14: 47,272,245		probably null	Het
Wnk1	T	C	6: 119,953,833	I917V	probably benign	Het
Wscd2	A	G	5: 113,550,935	M1V	probably null	Het
Xkr6	A	G	14: 63,818,943	H357R	unknown	Het
Zfhx2	G	T	14: 55,071,987	T885K	probably benign	Het
Zfp583	C	T	7: 6,317,555	E153K	probably benign	Het
Zmynd11	A	G	13: 9,695,154	M243T	probably benign	Het

Other mutations in Vmn2r26

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01070:Vmn2r26	APN	6	124061607	missense	probably benign	0.00
IGL01370:Vmn2r26	APN	6	124061756	missense	probably benign	0.08
IGL01603:Vmn2r26	APN	6	124053874	missense	probably damaging	1.00
IGL01651:Vmn2r26	APN	6	124050673	missense	probably benign	0.01
IGL02282:Vmn2r26	APN	6	124061625	missense	probably damaging	1.00
IGL02425:Vmn2r26	APN	6	124061818	missense	probably damaging	1.00
IGL02551:Vmn2r26	APN	6	124026141	missense	probably benign	0.11
IGL02690:Vmn2r26	APN	6	124026132	missense	probably benign	0.14
IGL03002:Vmn2r26	APN	6	124039795	missense	possibly damaging	0.78
IGL03270:Vmn2r26	APN	6	124050819	missense	probably benign	0.16
R0032:Vmn2r26	UTSW	6	124039899	missense	possibly damaging	0.72
R0052:Vmn2r26	UTSW	6	124062033	makesense	probably null
R0083:Vmn2r26	UTSW	6	124053981	splice site	probably null
R0682:Vmn2r26	UTSW	6	124061170	missense	probably damaging	0.97
R1061:Vmn2r26	UTSW	6	124061644	missense	probably benign	0.12
R1077:Vmn2r26	UTSW	6	124053913	missense	probably benign	0.00
R1263:Vmn2r26	UTSW	6	124050708	missense	probably benign
R1579:Vmn2r26	UTSW	6	124039747	missense	probably benign	0.00
R1741:Vmn2r26	UTSW	6	124061472	missense	probably damaging	1.00
R1834:Vmn2r26	UTSW	6	124061410	missense	possibly damaging	0.54
R1838:Vmn2r26	UTSW	6	124024771	missense	probably benign
R1956:Vmn2r26	UTSW	6	124053887	missense	probably damaging	1.00
R1996:Vmn2r26	UTSW	6	124061185	missense	probably damaging	1.00
R2140:Vmn2r26	UTSW	6	124061237	missense	probably benign	0.01
R2327:Vmn2r26	UTSW	6	124039749	missense	probably benign	0.07
R2417:Vmn2r26	UTSW	6	124061350	missense	probably damaging	1.00
R3930:Vmn2r26	UTSW	6	124025979	missense	probably benign
R4490:Vmn2r26	UTSW	6	124050738	missense	possibly damaging	0.47
R4629:Vmn2r26	UTSW	6	124061191	missense	possibly damaging	0.50
R4655:Vmn2r26	UTSW	6	124061416	missense	probably damaging	1.00
R4709:Vmn2r26	UTSW	6	124053965	missense	probably damaging	1.00
R4992:Vmn2r26	UTSW	6	124026111	missense	probably benign	0.00
R5297:Vmn2r26	UTSW	6	124061873	missense	probably damaging	1.00
R5482:Vmn2r26	UTSW	6	124061326	missense	possibly damaging	0.88
R5517:Vmn2r26	UTSW	6	124050717	missense	probably damaging	1.00
R5737:Vmn2r26	UTSW	6	124039449	missense	probably benign	0.00
R5739:Vmn2r26	UTSW	6	124025966	missense	probably benign	0.00
R5873:Vmn2r26	UTSW	6	124061674	missense	probably benign	0.01
R5907:Vmn2r26	UTSW	6	124039871	missense	probably benign	0.00
R6086:Vmn2r26	UTSW	6	124039560	missense	possibly damaging	0.48
R6134:Vmn2r26	UTSW	6	124061485	missense	probably damaging	0.97
R6391:Vmn2r26	UTSW	6	124061389	missense	probably damaging	1.00
R6428:Vmn2r26	UTSW	6	124026080	missense	probably benign	0.17
R6637:Vmn2r26	UTSW	6	124061691	missense	probably damaging	1.00
R6927:Vmn2r26	UTSW	6	124039098	missense	possibly damaging	0.93
R6953:Vmn2r26	UTSW	6	124039782	missense	probably benign	0.00
R7173:Vmn2r26	UTSW	6	124061296	missense	probably benign	0.16
R7206:Vmn2r26	UTSW	6	124039768	missense	probably benign	0.17
R7208:Vmn2r26	UTSW	6	124061989	missense	probably damaging	1.00
R7283:Vmn2r26	UTSW	6	124025955	missense	probably damaging	0.97
R7506:Vmn2r26	UTSW	6	124039741	missense	probably benign	0.00
R7672:Vmn2r26	UTSW	6	124039647	missense	probably benign	0.25
R7674:Vmn2r26	UTSW	6	124039362	missense	probably benign
R7696:Vmn2r26	UTSW	6	124061535	missense	possibly damaging	0.94
R7716:Vmn2r26	UTSW	6	124061745	missense	probably damaging	1.00
R7831:Vmn2r26	UTSW	6	124039799	nonsense	probably null
R8063:Vmn2r26	UTSW	6	124024955	missense	probably benign	0.00
R8352:Vmn2r26	UTSW	6	124039618	missense	probably benign	0.09
R8445:Vmn2r26	UTSW	6	124026036	missense	probably damaging	0.97
R8452:Vmn2r26	UTSW	6	124039618	missense	probably benign	0.09
R8681:Vmn2r26	UTSW	6	124024918	missense	probably benign	0.00
R8914:Vmn2r26	UTSW	6	124062024	missense	probably benign
R9333:Vmn2r26	UTSW	6	124026050	missense	probably benign	0.13
R9351:Vmn2r26	UTSW	6	124039374	missense	probably benign
R9436:Vmn2r26	UTSW	6	124025867	missense	probably damaging	1.00
R9515:Vmn2r26	UTSW	6	124061178	missense	probably damaging	1.00
RF010:Vmn2r26	UTSW	6	124039489	missense	possibly damaging	0.90

Predicted Primers

PCR Primer
(F):5'- GCCAGTCTCAGCTTGCTTATTG -3'
(R):5'- AAGGTGATTAAGTTGCAGATGC -3'

Sequencing Primer
(F):5'- GCTTTTCTGGCTAGAAGGCTACC -3'
(R):5'- TTGACTACACATGACACGTTTG -3'

Posted On

2020-09-02