Incidental Mutation 'R8332:Zfp59'
ID 644425
Institutional Source Beutler Lab
Gene Symbol Zfp59
Ensembl Gene ENSMUSG00000078779
Gene Name zinc finger protein 59
Synonyms Mfg2, Mfg-2
MMRRC Submission 067728-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.072) question?
Stock # R8332 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 27538032-27555863 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 27552971 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 141 (D141G)
Ref Sequence ENSEMBL: ENSMUSP00000145671 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000108331] [ENSMUST00000205701] [ENSMUST00000205715]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000108331
AA Change: D141G

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000103968
Gene: ENSMUSG00000078779
AA Change: D141G

DomainStartEndE-ValueType
KRAB 14 75 1.2e-35 SMART
ZnF_C2H2 172 194 2.91e-2 SMART
ZnF_C2H2 200 222 1.95e-3 SMART
ZnF_C2H2 256 278 2.02e-1 SMART
ZnF_C2H2 284 306 3.21e-4 SMART
ZnF_C2H2 312 334 1.92e-2 SMART
ZnF_C2H2 340 362 1.22e-4 SMART
ZnF_C2H2 368 390 2.53e-2 SMART
ZnF_C2H2 396 418 6.78e-3 SMART
ZnF_C2H2 424 446 3.44e-4 SMART
ZnF_C2H2 452 474 1.38e-3 SMART
ZnF_C2H2 480 502 3.34e-2 SMART
ZnF_C2H2 508 530 2.2e-2 SMART
ZnF_C2H2 536 558 2.71e-2 SMART
ZnF_C2H2 564 586 2.4e-3 SMART
ZnF_C2H2 592 614 1.92e-2 SMART
ZnF_C2H2 620 642 2.57e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000205701
AA Change: D141G

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000205715
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
MGI Phenotype FUNCTION: The Krueppel-associated box (KRAB) is a domain of around 75 amino acids found in the N-terminal portion of about one third of eukaryotic Krueppel-type C2H2 zinc finger proteins (ZFPs). The KRAB domain functions as a transcriptional repressor when tethered to the template DNA by a DNA-binding domain. Although the function of KRAB-ZFPs is largely unknown, they appear to play important roles during cell differentiation and development. This gene encodes a protein belonging to the Krueppel family of C2H2-type zinc finger proteins and has been shown to accumulate in the nuclei of mature sperm in association with the nuclear matrix. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca14 A G 7: 119,815,436 (GRCm39) D228G probably benign Het
Adgrv1 C T 13: 81,593,462 (GRCm39) R4175H probably damaging Het
Ahdc1 A G 4: 132,791,282 (GRCm39) D841G possibly damaging Het
Alms1 G A 6: 85,597,561 (GRCm39) V796I probably benign Het
Angptl8 A T 9: 21,748,137 (GRCm39) probably null Het
Arhgap23 A T 11: 97,381,960 (GRCm39) S61T unknown Het
Bcl9 C T 3: 97,117,086 (GRCm39) G536D possibly damaging Het
Bscl2 A G 19: 8,823,594 (GRCm39) D220G probably benign Het
Ccl28 C A 13: 120,107,514 (GRCm39) C58* probably null Het
Ccr8 A T 9: 119,923,440 (GRCm39) Y185F probably damaging Het
Chsy3 T A 18: 59,542,087 (GRCm39) H408Q probably damaging Het
Cntrl A G 2: 35,016,037 (GRCm39) E351G probably damaging Het
Cog5 A T 12: 31,883,222 (GRCm39) K384* probably null Het
Cpne1 T C 2: 155,920,317 (GRCm39) T187A probably benign Het
Crat T A 2: 30,295,084 (GRCm39) I444F possibly damaging Het
Crb1 T A 1: 139,165,152 (GRCm39) M1052L probably damaging Het
Cstdc1 A G 2: 148,625,377 (GRCm39) K104E probably damaging Het
Erp44 A G 4: 48,243,475 (GRCm39) probably null Het
Flad1 G T 3: 89,314,828 (GRCm39) Q290K probably benign Het
Gata3os G A 2: 9,887,650 (GRCm39) R17H unknown Het
Gli3 G T 13: 15,888,133 (GRCm39) R516L possibly damaging Het
Gm19402 A T 10: 77,526,048 (GRCm39) C182S unknown Het
Herc2 T C 7: 55,796,343 (GRCm39) I1905T probably damaging Het
Ikbkb A T 8: 23,155,641 (GRCm39) V617D possibly damaging Het
Intu A G 3: 40,629,719 (GRCm39) I350V probably benign Het
Limd1 A G 9: 123,308,319 (GRCm39) D6G probably damaging Het
Llgl1 A G 11: 60,601,210 (GRCm39) D716G possibly damaging Het
Lrp1 G A 10: 127,407,805 (GRCm39) T1828I probably damaging Het
Or2at1 T C 7: 99,417,334 (GRCm39) *322Q probably null Het
Or6c38 A G 10: 128,929,174 (GRCm39) I223T possibly damaging Het
Piezo2 A T 18: 63,145,857 (GRCm39) I2689N possibly damaging Het
Prag1 T C 8: 36,613,457 (GRCm39) I1003T probably damaging Het
Rbm8a2 T C 1: 175,805,967 (GRCm39) D170G unknown Het
Rnf213 A C 11: 119,374,524 (GRCm39) Q5027P Het
Robo1 T C 16: 72,775,466 (GRCm39) Y664H probably damaging Het
Rrn3 T A 16: 13,616,484 (GRCm39) D287E possibly damaging Het
Slc22a16 G A 10: 40,449,741 (GRCm39) R80Q possibly damaging Het
Slc4a4 A T 5: 89,327,680 (GRCm39) T706S probably benign Het
Srek1ip1 A T 13: 104,970,757 (GRCm39) R69S possibly damaging Het
St3gal5 T A 6: 72,119,165 (GRCm39) C119* probably null Het
T2 A G 17: 8,609,784 (GRCm39) M78V probably null Het
Taok1 A T 11: 77,432,545 (GRCm39) V756D possibly damaging Het
Tecta C T 9: 42,286,310 (GRCm39) G782D probably damaging Het
Thbs2 G A 17: 14,900,032 (GRCm39) P615L probably damaging Het
Ttll11 T A 2: 35,830,721 (GRCm39) I217F possibly damaging Het
Vmn2r57 C T 7: 41,049,677 (GRCm39) V691M probably benign Het
Xkr4 T C 1: 3,492,122 (GRCm39) Y267C probably damaging Het
Zfp760 A G 17: 21,942,301 (GRCm39) E492G probably damaging Het
Other mutations in Zfp59
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02976:Zfp59 APN 7 27,552,821 (GRCm39) missense probably benign 0.00
R0689:Zfp59 UTSW 7 27,553,142 (GRCm39) missense probably benign 0.19
R0726:Zfp59 UTSW 7 27,553,513 (GRCm39) missense probably damaging 0.98
R1570:Zfp59 UTSW 7 27,553,016 (GRCm39) missense probably benign 0.03
R1587:Zfp59 UTSW 7 27,553,559 (GRCm39) missense possibly damaging 0.84
R2067:Zfp59 UTSW 7 27,552,935 (GRCm39) missense probably benign 0.01
R4880:Zfp59 UTSW 7 27,543,742 (GRCm39) missense probably damaging 0.99
R5677:Zfp59 UTSW 7 27,553,594 (GRCm39) missense probably benign 0.15
R6969:Zfp59 UTSW 7 27,552,922 (GRCm39) missense probably damaging 0.98
R7574:Zfp59 UTSW 7 27,552,863 (GRCm39) missense probably benign 0.04
R7837:Zfp59 UTSW 7 27,554,342 (GRCm39) frame shift probably null
R8891:Zfp59 UTSW 7 27,554,313 (GRCm39) missense probably benign 0.00
R9314:Zfp59 UTSW 7 27,554,029 (GRCm39) missense possibly damaging 0.86
R9583:Zfp59 UTSW 7 27,554,483 (GRCm39) missense probably benign 0.04
Predicted Primers PCR Primer
(F):5'- CCTTTTCTTTCAGATTTGGAGGCAG -3'
(R):5'- GACACTTCTGATGCCTTGTGAG -3'

Sequencing Primer
(F):5'- CAGATTTGGAGGCAGATTATGATGC -3'
(R):5'- AGTCTGAAGGCCTTCCCAC -3'
Posted On 2020-09-02