Incidental Mutation 'R8332:Or2at1'
ID 644428
Institutional Source Beutler Lab
Gene Symbol Or2at1
Ensembl Gene ENSMUSG00000073997
Gene Name olfactory receptor family 2 subfamily AT member 1
Synonyms MOR101-2, Olfr521, GA_x6K02T2PBJ9-2443810-2444775
MMRRC Submission 067728-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.099) question?
Stock # R8332 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 99416371-99417337 bp(+) (GRCm39)
Type of Mutation makesense
DNA Base Change (assembly) T to C at 99417334 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Stop codon to Glutamine at position 322 (*322Q)
Ref Sequence ENSEMBL: ENSMUSP00000151473 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098263] [ENSMUST00000219663] [ENSMUST00000220001]
AlphaFold E9Q519
Predicted Effect probably null
Transcript: ENSMUST00000098263
AA Change: *322Q
SMART Domains Protein: ENSMUSP00000095863
Gene: ENSMUSG00000073997
AA Change: *322Q

DomainStartEndE-ValueType
Pfam:7tm_4 36 313 1.4e-63 PFAM
Pfam:7TM_GPCR_Srsx 40 310 7.4e-6 PFAM
Pfam:7tm_1 46 309 2e-28 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000219663
AA Change: *322Q
Predicted Effect probably null
Transcript: ENSMUST00000220001
AA Change: *322Q
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca14 A G 7: 119,815,436 (GRCm39) D228G probably benign Het
Adgrv1 C T 13: 81,593,462 (GRCm39) R4175H probably damaging Het
Ahdc1 A G 4: 132,791,282 (GRCm39) D841G possibly damaging Het
Alms1 G A 6: 85,597,561 (GRCm39) V796I probably benign Het
Angptl8 A T 9: 21,748,137 (GRCm39) probably null Het
Arhgap23 A T 11: 97,381,960 (GRCm39) S61T unknown Het
Bcl9 C T 3: 97,117,086 (GRCm39) G536D possibly damaging Het
Bscl2 A G 19: 8,823,594 (GRCm39) D220G probably benign Het
Ccl28 C A 13: 120,107,514 (GRCm39) C58* probably null Het
Ccr8 A T 9: 119,923,440 (GRCm39) Y185F probably damaging Het
Chsy3 T A 18: 59,542,087 (GRCm39) H408Q probably damaging Het
Cntrl A G 2: 35,016,037 (GRCm39) E351G probably damaging Het
Cog5 A T 12: 31,883,222 (GRCm39) K384* probably null Het
Cpne1 T C 2: 155,920,317 (GRCm39) T187A probably benign Het
Crat T A 2: 30,295,084 (GRCm39) I444F possibly damaging Het
Crb1 T A 1: 139,165,152 (GRCm39) M1052L probably damaging Het
Cstdc1 A G 2: 148,625,377 (GRCm39) K104E probably damaging Het
Erp44 A G 4: 48,243,475 (GRCm39) probably null Het
Flad1 G T 3: 89,314,828 (GRCm39) Q290K probably benign Het
Gata3os G A 2: 9,887,650 (GRCm39) R17H unknown Het
Gli3 G T 13: 15,888,133 (GRCm39) R516L possibly damaging Het
Gm19402 A T 10: 77,526,048 (GRCm39) C182S unknown Het
Herc2 T C 7: 55,796,343 (GRCm39) I1905T probably damaging Het
Ikbkb A T 8: 23,155,641 (GRCm39) V617D possibly damaging Het
Intu A G 3: 40,629,719 (GRCm39) I350V probably benign Het
Limd1 A G 9: 123,308,319 (GRCm39) D6G probably damaging Het
Llgl1 A G 11: 60,601,210 (GRCm39) D716G possibly damaging Het
Lrp1 G A 10: 127,407,805 (GRCm39) T1828I probably damaging Het
Or6c38 A G 10: 128,929,174 (GRCm39) I223T possibly damaging Het
Piezo2 A T 18: 63,145,857 (GRCm39) I2689N possibly damaging Het
Prag1 T C 8: 36,613,457 (GRCm39) I1003T probably damaging Het
Rbm8a2 T C 1: 175,805,967 (GRCm39) D170G unknown Het
Rnf213 A C 11: 119,374,524 (GRCm39) Q5027P Het
Robo1 T C 16: 72,775,466 (GRCm39) Y664H probably damaging Het
Rrn3 T A 16: 13,616,484 (GRCm39) D287E possibly damaging Het
Slc22a16 G A 10: 40,449,741 (GRCm39) R80Q possibly damaging Het
Slc4a4 A T 5: 89,327,680 (GRCm39) T706S probably benign Het
Srek1ip1 A T 13: 104,970,757 (GRCm39) R69S possibly damaging Het
St3gal5 T A 6: 72,119,165 (GRCm39) C119* probably null Het
T2 A G 17: 8,609,784 (GRCm39) M78V probably null Het
Taok1 A T 11: 77,432,545 (GRCm39) V756D possibly damaging Het
Tecta C T 9: 42,286,310 (GRCm39) G782D probably damaging Het
Thbs2 G A 17: 14,900,032 (GRCm39) P615L probably damaging Het
Ttll11 T A 2: 35,830,721 (GRCm39) I217F possibly damaging Het
Vmn2r57 C T 7: 41,049,677 (GRCm39) V691M probably benign Het
Xkr4 T C 1: 3,492,122 (GRCm39) Y267C probably damaging Het
Zfp59 A G 7: 27,552,971 (GRCm39) D141G probably benign Het
Zfp760 A G 17: 21,942,301 (GRCm39) E492G probably damaging Het
Other mutations in Or2at1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02303:Or2at1 APN 7 99,417,179 (GRCm39) missense possibly damaging 0.73
IGL02491:Or2at1 APN 7 99,416,540 (GRCm39) missense possibly damaging 0.85
BB007:Or2at1 UTSW 7 99,416,803 (GRCm39) missense probably benign 0.37
BB017:Or2at1 UTSW 7 99,416,803 (GRCm39) missense probably benign 0.37
R0544:Or2at1 UTSW 7 99,416,867 (GRCm39) missense probably benign
R1029:Or2at1 UTSW 7 99,416,431 (GRCm39) missense probably benign 0.01
R1840:Or2at1 UTSW 7 99,416,803 (GRCm39) missense probably benign 0.37
R4709:Or2at1 UTSW 7 99,416,989 (GRCm39) missense probably damaging 1.00
R5215:Or2at1 UTSW 7 99,416,717 (GRCm39) missense probably damaging 1.00
R5752:Or2at1 UTSW 7 99,417,155 (GRCm39) missense probably benign 0.00
R5934:Or2at1 UTSW 7 99,416,596 (GRCm39) missense probably damaging 1.00
R6913:Or2at1 UTSW 7 99,416,924 (GRCm39) missense probably damaging 1.00
R7394:Or2at1 UTSW 7 99,416,553 (GRCm39) missense probably damaging 1.00
R7554:Or2at1 UTSW 7 99,417,210 (GRCm39) missense possibly damaging 0.62
R7930:Or2at1 UTSW 7 99,416,803 (GRCm39) missense probably benign 0.37
R9613:Or2at1 UTSW 7 99,416,536 (GRCm39) missense probably benign
Z1177:Or2at1 UTSW 7 99,417,121 (GRCm39) missense possibly damaging 0.92
Predicted Primers PCR Primer
(F):5'- TCCATCGCCATAGCCTATGTGG -3'
(R):5'- ATTCATGGGACTGTGACCCC -3'

Sequencing Primer
(F):5'- CTATGTGGCTTACCGGGCTGAC -3'
(R):5'- CTTAAGAGTGACTCTGAACAAGTG -3'
Posted On 2020-09-02