Incidental Mutation 'R8332:Ccl28'
ID 644448
Institutional Source Beutler Lab
Gene Symbol Ccl28
Ensembl Gene ENSMUSG00000074715
Gene Name C-C motif chemokine ligand 28
Synonyms Scya28, CCK1
MMRRC Submission 067728-MU
Accession Numbers
Essential gene? Not available question?
Stock # R8332 (G1)
Quality Score 225.009
Status Not validated
Chromosome 13
Chromosomal Location 120085355-120115895 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to A at 120107514 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Stop codon at position 58 (C58*)
Ref Sequence ENSEMBL: ENSMUSP00000096847 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099241]
AlphaFold Q9JIL2
Predicted Effect probably null
Transcript: ENSMUST00000099241
AA Change: C58*
SMART Domains Protein: ENSMUSP00000096847
Gene: ENSMUSG00000074715
AA Change: C58*

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
SCY 27 88 1.65e-1 SMART
low complexity region 110 126 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for resting CD4 or CD8 T cells and eosinophils. The product of this gene binds to chemokine receptors CCR3 and CCR10. This chemokine may play a role in the physiology of extracutaneous epithelial tissues, including diverse mucosal organs. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca14 A G 7: 119,815,436 (GRCm39) D228G probably benign Het
Adgrv1 C T 13: 81,593,462 (GRCm39) R4175H probably damaging Het
Ahdc1 A G 4: 132,791,282 (GRCm39) D841G possibly damaging Het
Alms1 G A 6: 85,597,561 (GRCm39) V796I probably benign Het
Angptl8 A T 9: 21,748,137 (GRCm39) probably null Het
Arhgap23 A T 11: 97,381,960 (GRCm39) S61T unknown Het
Bcl9 C T 3: 97,117,086 (GRCm39) G536D possibly damaging Het
Bscl2 A G 19: 8,823,594 (GRCm39) D220G probably benign Het
Ccr8 A T 9: 119,923,440 (GRCm39) Y185F probably damaging Het
Chsy3 T A 18: 59,542,087 (GRCm39) H408Q probably damaging Het
Cntrl A G 2: 35,016,037 (GRCm39) E351G probably damaging Het
Cog5 A T 12: 31,883,222 (GRCm39) K384* probably null Het
Cpne1 T C 2: 155,920,317 (GRCm39) T187A probably benign Het
Crat T A 2: 30,295,084 (GRCm39) I444F possibly damaging Het
Crb1 T A 1: 139,165,152 (GRCm39) M1052L probably damaging Het
Cstdc1 A G 2: 148,625,377 (GRCm39) K104E probably damaging Het
Erp44 A G 4: 48,243,475 (GRCm39) probably null Het
Flad1 G T 3: 89,314,828 (GRCm39) Q290K probably benign Het
Gata3os G A 2: 9,887,650 (GRCm39) R17H unknown Het
Gli3 G T 13: 15,888,133 (GRCm39) R516L possibly damaging Het
Gm19402 A T 10: 77,526,048 (GRCm39) C182S unknown Het
Herc2 T C 7: 55,796,343 (GRCm39) I1905T probably damaging Het
Ikbkb A T 8: 23,155,641 (GRCm39) V617D possibly damaging Het
Intu A G 3: 40,629,719 (GRCm39) I350V probably benign Het
Limd1 A G 9: 123,308,319 (GRCm39) D6G probably damaging Het
Llgl1 A G 11: 60,601,210 (GRCm39) D716G possibly damaging Het
Lrp1 G A 10: 127,407,805 (GRCm39) T1828I probably damaging Het
Or2at1 T C 7: 99,417,334 (GRCm39) *322Q probably null Het
Or6c38 A G 10: 128,929,174 (GRCm39) I223T possibly damaging Het
Piezo2 A T 18: 63,145,857 (GRCm39) I2689N possibly damaging Het
Prag1 T C 8: 36,613,457 (GRCm39) I1003T probably damaging Het
Rbm8a2 T C 1: 175,805,967 (GRCm39) D170G unknown Het
Rnf213 A C 11: 119,374,524 (GRCm39) Q5027P Het
Robo1 T C 16: 72,775,466 (GRCm39) Y664H probably damaging Het
Rrn3 T A 16: 13,616,484 (GRCm39) D287E possibly damaging Het
Slc22a16 G A 10: 40,449,741 (GRCm39) R80Q possibly damaging Het
Slc4a4 A T 5: 89,327,680 (GRCm39) T706S probably benign Het
Srek1ip1 A T 13: 104,970,757 (GRCm39) R69S possibly damaging Het
St3gal5 T A 6: 72,119,165 (GRCm39) C119* probably null Het
T2 A G 17: 8,609,784 (GRCm39) M78V probably null Het
Taok1 A T 11: 77,432,545 (GRCm39) V756D possibly damaging Het
Tecta C T 9: 42,286,310 (GRCm39) G782D probably damaging Het
Thbs2 G A 17: 14,900,032 (GRCm39) P615L probably damaging Het
Ttll11 T A 2: 35,830,721 (GRCm39) I217F possibly damaging Het
Vmn2r57 C T 7: 41,049,677 (GRCm39) V691M probably benign Het
Xkr4 T C 1: 3,492,122 (GRCm39) Y267C probably damaging Het
Zfp59 A G 7: 27,552,971 (GRCm39) D141G probably benign Het
Zfp760 A G 17: 21,942,301 (GRCm39) E492G probably damaging Het
Other mutations in Ccl28
AlleleSourceChrCoordTypePredicted EffectPPH Score
R2908:Ccl28 UTSW 13 120,112,398 (GRCm39) splice site probably null
R7096:Ccl28 UTSW 13 120,112,429 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- ATCTGTTTCCCCGGAACCTG -3'
(R):5'- GTAGGACTTGAGGCATTCCTG -3'

Sequencing Primer
(F):5'- TTTCCCCGGAACCTGGAAGATG -3'
(R):5'- ACAGAGATTGTGTGTTTACTCCAG -3'
Posted On 2020-09-02