Incidental Mutation 'R0070:Ifna11'
ID 64445
Institutional Source Beutler Lab
Gene Symbol Ifna11
Ensembl Gene ENSMUSG00000100549
Gene Name interferon alpha 11
Synonyms IFN-[a]11
MMRRC Submission 038361-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R0070 (G1)
Quality Score 225
Status Validated
Chromosome 4
Chromosomal Location 88738196-88738768 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 88738512 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 106 (D106G)
Ref Sequence ENSEMBL: ENSMUSP00000127921 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000105143] [ENSMUST00000170428]
AlphaFold Q61716
Predicted Effect probably benign
Transcript: ENSMUST00000105143
SMART Domains Protein: ENSMUSP00000100774
Gene: ENSMUSG00000100713

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
IFabd 58 175 2.32e-70 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000170428
AA Change: D106G

PolyPhen 2 Score 0.914 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000127921
Gene: ENSMUSG00000100549
AA Change: D106G

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
IFabd 58 175 5.54e-68 SMART
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.9%
  • 10x: 97.7%
  • 20x: 96.1%
Validation Efficiency 97% (68/70)
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgre4 T C 17: 56,109,154 (GRCm39) I387T probably damaging Het
Alpi A G 1: 87,028,881 (GRCm39) probably benign Het
Ankfn1 A T 11: 89,283,128 (GRCm39) L173Q probably damaging Het
Atp2a1 T C 7: 126,046,624 (GRCm39) E892G probably benign Het
AU018091 T C 7: 3,208,738 (GRCm39) probably null Het
Capn12 T C 7: 28,588,551 (GRCm39) probably benign Het
Capn2 C A 1: 182,301,434 (GRCm39) probably benign Het
Cd79b A G 11: 106,202,744 (GRCm39) probably benign Het
Cdh20 C T 1: 110,026,102 (GRCm39) A446V probably benign Het
Ciapin1 T C 8: 95,551,847 (GRCm39) N246S possibly damaging Het
Cmip T A 8: 118,153,293 (GRCm39) I270N probably damaging Het
Cyp2d40 A G 15: 82,644,975 (GRCm39) V225A unknown Het
Dnah9 A G 11: 66,050,866 (GRCm39) V142A probably benign Het
Dnai4 A T 4: 102,917,131 (GRCm39) I571K probably damaging Het
Flt3 A G 5: 147,309,536 (GRCm39) probably benign Het
Gm10238 A G 15: 75,109,434 (GRCm39) noncoding transcript Het
Gm4787 T A 12: 81,425,840 (GRCm39) D106V probably damaging Het
Hipk2 G A 6: 38,795,919 (GRCm39) R117* probably null Het
Hycc1 T C 5: 24,169,997 (GRCm39) S451G probably damaging Het
Igkv1-115 G A 6: 68,138,402 (GRCm39) V2I probably benign Het
Itga6 T C 2: 71,657,060 (GRCm39) probably benign Het
Kcnj6 C A 16: 94,742,056 (GRCm39) K5N probably benign Het
Kcnt1 T C 2: 25,782,374 (GRCm39) V191A probably benign Het
Lcorl G A 5: 45,891,043 (GRCm39) R437C probably damaging Het
Man2a1 G A 17: 64,966,074 (GRCm39) probably null Het
Map3k14 T A 11: 103,130,380 (GRCm39) probably null Het
Mtch1 T A 17: 29,559,033 (GRCm39) probably benign Het
Myo1c A G 11: 75,551,076 (GRCm39) N217S probably benign Het
Or2h15 A G 17: 38,441,780 (GRCm39) L101P probably damaging Het
Or2w4 T C 13: 21,795,431 (GRCm39) K236R possibly damaging Het
Orm3 A G 4: 63,274,883 (GRCm39) T64A probably benign Het
Phf20l1 T G 15: 66,511,840 (GRCm39) W940G probably damaging Het
Phldb1 C T 9: 44,619,201 (GRCm39) R844H probably damaging Het
Piezo2 T C 18: 63,235,155 (GRCm39) D814G probably damaging Het
Pkd2 T C 5: 104,614,856 (GRCm39) C233R probably damaging Het
Prkd3 A G 17: 79,261,939 (GRCm39) Y792H probably damaging Het
Pth1r A T 9: 110,556,618 (GRCm39) probably null Het
Pxdn T C 12: 30,032,726 (GRCm39) L146S probably damaging Het
Rnf32 A G 5: 29,430,125 (GRCm39) T315A probably benign Het
Rpl5 T C 5: 108,049,766 (GRCm39) Y12H probably benign Het
Serpinh1 A T 7: 98,998,521 (GRCm39) S36R probably damaging Het
Setx A T 2: 29,051,537 (GRCm39) T2030S probably benign Het
Sf3a3 G A 4: 124,608,748 (GRCm39) V21I probably benign Het
Sin3b T A 8: 73,452,210 (GRCm39) H105Q probably damaging Het
Slitrk1 T C 14: 109,150,749 (GRCm39) probably benign Het
Slx4 A T 16: 3,805,880 (GRCm39) D557E possibly damaging Het
Sprr3 C T 3: 92,364,609 (GRCm39) M78I probably benign Het
Ssmem1 A G 6: 30,519,420 (GRCm39) E35G possibly damaging Het
Stag1 C T 9: 100,838,461 (GRCm39) P1238S probably null Het
Stra6 C T 9: 58,059,898 (GRCm39) probably benign Het
Tmem127 T C 2: 127,098,979 (GRCm39) V171A probably damaging Het
Tmem150a A G 6: 72,335,742 (GRCm39) probably null Het
Top2a C G 11: 98,905,886 (GRCm39) probably null Het
Ttn T C 2: 76,644,771 (GRCm39) probably null Het
Tusc3 G A 8: 39,530,421 (GRCm39) G129R possibly damaging Het
Uspl1 A G 5: 149,146,515 (GRCm39) Y422C probably damaging Het
Vmn2r88 A T 14: 51,651,597 (GRCm39) T312S probably benign Het
Zc3hav1l A T 6: 38,272,125 (GRCm39) S215T probably damaging Het
Zfp947 T A 17: 22,365,165 (GRCm39) T170S probably benign Het
Other mutations in Ifna11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01396:Ifna11 APN 4 88,738,314 (GRCm39) missense probably benign 0.09
IGL03371:Ifna11 APN 4 88,738,412 (GRCm39) missense probably benign 0.00
R1715:Ifna11 UTSW 4 88,738,473 (GRCm39) missense probably damaging 1.00
R2938:Ifna11 UTSW 4 88,738,530 (GRCm39) missense probably damaging 1.00
R3113:Ifna11 UTSW 4 88,738,220 (GRCm39) missense probably benign
R4788:Ifna11 UTSW 4 88,738,245 (GRCm39) nonsense probably null
R4967:Ifna11 UTSW 4 88,738,287 (GRCm39) missense probably null 0.11
R5038:Ifna11 UTSW 4 88,738,314 (GRCm39) missense probably benign 0.09
R5412:Ifna11 UTSW 4 88,738,380 (GRCm39) missense probably damaging 0.99
R6010:Ifna11 UTSW 4 88,738,278 (GRCm39) missense probably benign 0.00
R6385:Ifna11 UTSW 4 88,738,386 (GRCm39) missense probably damaging 0.96
R7297:Ifna11 UTSW 4 88,738,662 (GRCm39) missense possibly damaging 0.86
R8922:Ifna11 UTSW 4 88,738,431 (GRCm39) missense probably benign 0.16
Predicted Primers PCR Primer
(F):5'- TCCTGCCTAAAGGACAGGAAGGAC -3'
(R):5'- TTCCCAGCACATTGGCAGAGGAAG -3'

Sequencing Primer
(F):5'- CAGGAAGGACTTTGGATTCCC -3'
(R):5'- GGGCTCTCCAGACTTCTGC -3'
Posted On 2013-08-06