Incidental Mutation 'R8333:Gpr182'
ID 644482
Institutional Source Beutler Lab
Gene Symbol Gpr182
Ensembl Gene ENSMUSG00000058396
Gene Name G protein-coupled receptor 182
Synonyms Gpcr17, NOW, G10-D, Admr, AM-R, Gpcr22
MMRRC Submission 067861-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8333 (G1)
Quality Score 225.009
Status Validated
Chromosome 10
Chromosomal Location 127585471-127587667 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 127585790 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 387 (N387S)
Ref Sequence ENSEMBL: ENSMUSP00000100882 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054287] [ENSMUST00000079692]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000054287
SMART Domains Protein: ENSMUSP00000052717
Gene: ENSMUSG00000044617

DomainStartEndE-ValueType
BTB 30 126 9.15e-24 SMART
low complexity region 197 206 N/A INTRINSIC
low complexity region 213 229 N/A INTRINSIC
ZnF_C2H2 372 394 6.4e0 SMART
ZnF_C2H2 400 420 3.21e1 SMART
ZnF_C2H2 451 474 9.31e1 SMART
ZnF_C2H2 480 502 6.92e0 SMART
ZnF_C2H2 508 530 1.79e-2 SMART
ZnF_C2H2 538 560 1.18e-2 SMART
ZnF_C2H2 605 627 2.57e-3 SMART
ZnF_C2H2 633 655 3.78e-1 SMART
ZnF_C2H2 661 683 2.49e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000079692
AA Change: N387S

PolyPhen 2 Score 0.081 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000100882
Gene: ENSMUSG00000058396
AA Change: N387S

DomainStartEndE-ValueType
Pfam:7tm_1 66 316 1.2e-40 PFAM
low complexity region 340 352 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 100% (39/39)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Adrenomedullin is a potent vasodilator peptide that exerts major effects on cardiovascular function. This gene encodes a seven-transmembrane protein that belongs to the family 1 of G-protein coupled receptors. Studies of the rat counterpart suggest that the encoded protein may function as a receptor for adrenomedullin. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Amigo2 T C 15: 97,143,166 (GRCm39) T419A probably damaging Het
Baiap2l1 A C 5: 144,217,691 (GRCm39) I298M possibly damaging Het
BC005624 G T 2: 30,863,748 (GRCm39) A245D probably benign Het
Cdh23 T A 10: 60,150,390 (GRCm39) I2527F probably damaging Het
Celsr1 T C 15: 85,915,615 (GRCm39) H786R possibly damaging Het
Cerkl A G 2: 79,168,922 (GRCm39) V427A possibly damaging Het
Cfap43 G T 19: 47,885,765 (GRCm39) C283* probably null Het
Chfr G A 5: 110,302,803 (GRCm39) A455T probably benign Het
Cldn13 T A 5: 134,943,850 (GRCm39) I112F possibly damaging Het
Cyb5rl T A 4: 106,925,875 (GRCm39) V19E probably benign Het
Dcp1a A G 14: 30,244,883 (GRCm39) T570A possibly damaging Het
Dlgap2 T A 8: 14,828,295 (GRCm39) C568S probably benign Het
Ecm2 T C 13: 49,671,859 (GRCm39) L120P probably damaging Het
Gpr156 T C 16: 37,812,416 (GRCm39) S251P probably damaging Het
Grid1 T C 14: 35,291,595 (GRCm39) V834A possibly damaging Het
Igkv8-34 T C 6: 70,021,337 (GRCm39) S42G probably benign Het
Kctd17 CAGCTGGAGGAGC CAGC 15: 78,321,113 (GRCm39) probably benign Het
Lrrc19 T A 4: 94,527,587 (GRCm39) D208V probably benign Het
Lrrc9 C T 12: 72,528,317 (GRCm39) T872I probably benign Het
Macf1 T C 4: 123,279,245 (GRCm39) probably null Het
Mrpl13 A G 15: 55,420,679 (GRCm39) M1T probably null Het
Ncapg C T 5: 45,831,805 (GRCm39) T217I probably damaging Het
Nim1k G A 13: 120,174,022 (GRCm39) P291S probably damaging Het
Or8c11 G A 9: 38,289,912 (GRCm39) G239D probably damaging Het
Or8k31-ps1 A T 2: 86,356,415 (GRCm39) Y35* probably null Het
Padi6 T C 4: 140,464,687 (GRCm39) M181V probably damaging Het
Pax7 T A 4: 139,557,514 (GRCm39) I86F probably damaging Het
Pbk T A 14: 66,054,680 (GRCm39) Y271N probably benign Het
Rabgap1 C T 2: 37,385,710 (GRCm39) P492L probably benign Het
Rhno1 G T 6: 128,334,728 (GRCm39) D198E probably damaging Het
Scn2a A C 2: 65,514,191 (GRCm39) I292L probably benign Het
Slc40a1 T C 1: 45,950,439 (GRCm39) S338G probably damaging Het
Slc45a3 A G 1: 131,905,928 (GRCm39) Y317C probably damaging Het
Stard9 T A 2: 120,532,270 (GRCm39) S2842R probably benign Het
Tle2 C T 10: 81,413,518 (GRCm39) T119I probably damaging Het
Ttn C T 2: 76,553,938 (GRCm39) V30922I possibly damaging Het
Usp33 C T 3: 152,080,297 (GRCm39) P476L probably damaging Het
Wdr38 T C 2: 38,889,361 (GRCm39) Y51H probably damaging Het
Other mutations in Gpr182
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00961:Gpr182 APN 10 127,586,559 (GRCm39) missense probably benign 0.09
IGL00983:Gpr182 APN 10 127,586,657 (GRCm39) missense possibly damaging 0.89
IGL01337:Gpr182 APN 10 127,586,655 (GRCm39) missense possibly damaging 0.95
IGL01810:Gpr182 APN 10 127,586,733 (GRCm39) missense probably damaging 1.00
R0449:Gpr182 UTSW 10 127,586,565 (GRCm39) missense probably damaging 1.00
R0554:Gpr182 UTSW 10 127,586,940 (GRCm39) missense probably benign 0.00
R2229:Gpr182 UTSW 10 127,586,010 (GRCm39) missense possibly damaging 0.91
R2292:Gpr182 UTSW 10 127,586,051 (GRCm39) missense possibly damaging 0.89
R2349:Gpr182 UTSW 10 127,586,806 (GRCm39) missense probably damaging 1.00
R2445:Gpr182 UTSW 10 127,586,496 (GRCm39) missense probably benign 0.01
R5977:Gpr182 UTSW 10 127,586,748 (GRCm39) missense possibly damaging 0.79
R6290:Gpr182 UTSW 10 127,586,893 (GRCm39) missense probably benign 0.00
R6415:Gpr182 UTSW 10 127,586,375 (GRCm39) missense possibly damaging 0.88
R8014:Gpr182 UTSW 10 127,586,874 (GRCm39) missense possibly damaging 0.59
R8093:Gpr182 UTSW 10 127,586,783 (GRCm39) missense probably damaging 1.00
R8543:Gpr182 UTSW 10 127,586,861 (GRCm39) missense probably benign 0.43
R8788:Gpr182 UTSW 10 127,586,529 (GRCm39) missense probably benign 0.00
R9047:Gpr182 UTSW 10 127,586,517 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GCTCCCTTAGACATCAGTACC -3'
(R):5'- TGAGCCTTGTGGTCCGTTAC -3'

Sequencing Primer
(F):5'- GGAAAGATCCATTCTCTGTCCTTC -3'
(R):5'- GGTCCGTTACCTTCCCAAG -3'
Posted On 2020-09-02