Incidental Mutation 'R8336:Sstr3'
ID 644640
Institutional Source Beutler Lab
Gene Symbol Sstr3
Ensembl Gene ENSMUSG00000044933
Gene Name somatostatin receptor 3
Synonyms Smstr-3, Smstr3, sst3
MMRRC Submission 067729-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8336 (G1)
Quality Score 225.009
Status Not validated
Chromosome 15
Chromosomal Location 78421208-78428885 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 78424693 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 18 (N18S)
Ref Sequence ENSEMBL: ENSMUSP00000058040 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053239] [ENSMUST00000230400]
AlphaFold P30935
Predicted Effect probably damaging
Transcript: ENSMUST00000053239
AA Change: N18S

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000058040
Gene: ENSMUSG00000044933
AA Change: N18S

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 53 291 1.9e-8 PFAM
Pfam:7TM_GPCR_Srsx 56 337 3.5e-15 PFAM
Pfam:7tm_1 62 322 6.3e-60 PFAM
Pfam:7TM_GPCR_Srv 121 337 9.5e-8 PFAM
coiled coil region 355 388 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000230400
AA Change: N18S

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the somatostatin receptor protein family. Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This protein is functionally coupled to adenylyl cyclase. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930578I06Rik T C 14: 64,223,545 (GRCm39) K77R probably benign Het
Acta1 C T 8: 124,619,310 (GRCm39) E261K possibly damaging Het
Adamts19 A T 18: 59,140,444 (GRCm39) I848L possibly damaging Het
Adck1 C A 12: 88,335,249 (GRCm39) T45K probably damaging Het
Agl A G 3: 116,566,495 (GRCm39) F291S Het
BC048671 T C 6: 90,279,849 (GRCm39) V24A probably benign Het
Brsk2 C T 7: 141,538,211 (GRCm39) A119V probably damaging Het
Cacnb1 A G 11: 97,894,119 (GRCm39) Y468H probably benign Het
Cep89 A T 7: 35,127,141 (GRCm39) K501* probably null Het
Ces2a T A 8: 105,465,665 (GRCm39) F306I probably damaging Het
Col6a4 T A 9: 105,952,528 (GRCm39) I457F possibly damaging Het
Cts7 A G 13: 61,504,723 (GRCm39) probably null Het
Dnah12 C A 14: 26,432,220 (GRCm39) T444K probably benign Het
Dusp5 T C 19: 53,529,406 (GRCm39) S270P probably damaging Het
Eppk1 T TCAC 15: 75,992,152 (GRCm39) probably null Het
Esam T A 9: 37,448,362 (GRCm39) I267K probably benign Het
Fastkd1 A G 2: 69,542,489 (GRCm39) V106A probably damaging Het
Fsip2 A G 2: 82,821,099 (GRCm39) T5611A possibly damaging Het
Gcc2 A G 10: 58,108,189 (GRCm39) D933G probably damaging Het
Gm16506 T A 14: 43,964,825 (GRCm39) H39L Het
Gm5145 A T 17: 20,790,687 (GRCm39) N22Y probably damaging Het
Gm6465 A T 5: 11,896,780 (GRCm39) R50W probably damaging Het
Hivep1 C A 13: 42,309,405 (GRCm39) D548E probably benign Het
Hnrnpl C A 7: 28,513,462 (GRCm39) S178R possibly damaging Het
Hsp90b1 A G 10: 86,526,968 (GRCm39) *803Q probably null Het
Kdm5a A G 6: 120,396,407 (GRCm39) N1088S probably benign Het
Klk1b11 C T 7: 43,425,865 (GRCm39) probably benign Het
Kmt5b T C 19: 3,865,531 (GRCm39) I865T probably damaging Het
Map3k10 C A 7: 27,372,884 (GRCm39) R189L probably benign Het
Nav3 A G 10: 109,603,430 (GRCm39) S1040P probably damaging Het
Neb T C 2: 52,163,902 (GRCm39) S2019G probably damaging Het
Nfrkb T C 9: 31,314,815 (GRCm39) V545A possibly damaging Het
Nkd2 G T 13: 73,969,192 (GRCm39) P425T probably damaging Het
Or5h26 T C 16: 58,987,918 (GRCm39) Y196C possibly damaging Het
Ostm1 A G 10: 42,572,334 (GRCm39) Y239C probably damaging Het
Pabpc1l A G 2: 163,874,204 (GRCm39) D203G probably benign Het
Pcdhb21 T A 18: 37,648,942 (GRCm39) Y690* probably null Het
Pla2r1 C A 2: 60,253,027 (GRCm39) V1355F possibly damaging Het
Pms1 C T 1: 53,245,985 (GRCm39) S518N probably benign Het
Rab44 A T 17: 29,367,249 (GRCm39) *726C probably null Het
Rin1 A T 19: 5,105,013 (GRCm39) H691L possibly damaging Het
Slc30a9 T A 5: 67,473,058 (GRCm39) Y47* probably null Het
Sp9 T A 2: 73,104,796 (GRCm39) V450D possibly damaging Het
Sugct T A 13: 17,032,504 (GRCm39) Y416F probably benign Het
Tcf3 T C 10: 80,257,000 (GRCm39) T75A probably benign Het
Tenm3 A G 8: 48,746,808 (GRCm39) V999A probably damaging Het
Tfap2c T A 2: 172,399,112 (GRCm39) L453* probably null Het
Trip12 A T 1: 84,743,762 (GRCm39) M515K probably benign Het
Vstm2a G A 11: 16,207,801 (GRCm39) probably benign Het
Other mutations in Sstr3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00337:Sstr3 APN 15 78,424,667 (GRCm39) missense probably benign 0.00
R0442:Sstr3 UTSW 15 78,424,597 (GRCm39) missense probably damaging 0.99
R1714:Sstr3 UTSW 15 78,424,473 (GRCm39) missense probably damaging 1.00
R1865:Sstr3 UTSW 15 78,424,168 (GRCm39) missense probably damaging 1.00
R2008:Sstr3 UTSW 15 78,424,711 (GRCm39) missense probably benign 0.14
R2351:Sstr3 UTSW 15 78,424,121 (GRCm39) missense probably benign 0.01
R3023:Sstr3 UTSW 15 78,424,187 (GRCm39) missense probably damaging 0.99
R3024:Sstr3 UTSW 15 78,424,187 (GRCm39) missense probably damaging 0.99
R3770:Sstr3 UTSW 15 78,424,577 (GRCm39) missense probably damaging 1.00
R4399:Sstr3 UTSW 15 78,424,324 (GRCm39) missense probably damaging 1.00
R4724:Sstr3 UTSW 15 78,423,897 (GRCm39) nonsense probably null
R6181:Sstr3 UTSW 15 78,423,661 (GRCm39) missense probably benign
R6247:Sstr3 UTSW 15 78,423,788 (GRCm39) missense probably damaging 0.99
R7450:Sstr3 UTSW 15 78,424,043 (GRCm39) missense probably damaging 1.00
R7578:Sstr3 UTSW 15 78,424,717 (GRCm39) missense probably benign
R7793:Sstr3 UTSW 15 78,424,588 (GRCm39) missense probably damaging 1.00
R9263:Sstr3 UTSW 15 78,423,792 (GRCm39) missense probably damaging 1.00
R9264:Sstr3 UTSW 15 78,423,792 (GRCm39) missense probably damaging 1.00
R9265:Sstr3 UTSW 15 78,423,792 (GRCm39) missense probably damaging 1.00
X0026:Sstr3 UTSW 15 78,423,574 (GRCm39) missense possibly damaging 0.57
Z1177:Sstr3 UTSW 15 78,423,503 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- CCTAGCATGAAGAGCTCATCAGC -3'
(R):5'- TTCAAAGTGGCAGTGGTGTC -3'

Sequencing Primer
(F):5'- TATAGACACTGGTCACTGATGGGC -3'
(R):5'- CAGTGGTGTCCAGTGTAGCAC -3'
Posted On 2020-09-02