Incidental Mutation 'R8337:Vmn2r6'
ID 644660
Institutional Source Beutler Lab
Gene Symbol Vmn2r6
Ensembl Gene ENSMUSG00000090581
Gene Name vomeronasal 2, receptor 6
Synonyms EG667069, EG620718
MMRRC Submission 067800-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.198) question?
Stock # R8337 (G1)
Quality Score 225.009
Status Validated
Chromosome 3
Chromosomal Location 64444916-64472855 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 64463526 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Stop codon at position 436 (L436*)
Ref Sequence ENSEMBL: ENSMUSP00000135148 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000165012] [ENSMUST00000176481]
AlphaFold H3BK29
Predicted Effect probably null
Transcript: ENSMUST00000165012
AA Change: L347*
SMART Domains Protein: ENSMUSP00000131831
Gene: ENSMUSG00000090581
AA Change: L347*

DomainStartEndE-ValueType
Pfam:ANF_receptor 1 416 1.4e-72 PFAM
Pfam:Peripla_BP_6 58 244 1.2e-10 PFAM
Pfam:NCD3G 458 511 1.8e-17 PFAM
Pfam:7tm_3 542 779 3.9e-76 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000176481
AA Change: L436*
SMART Domains Protein: ENSMUSP00000135148
Gene: ENSMUSG00000090581
AA Change: L436*

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:ANF_receptor 88 505 9.8e-77 PFAM
Pfam:Peripla_BP_6 142 331 3.4e-10 PFAM
Pfam:NCD3G 547 600 5.4e-17 PFAM
Pfam:7tm_3 633 867 3.9e-47 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.2%
Validation Efficiency 100% (55/55)
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310034C09Rik T C 16: 88,556,151 (GRCm39) Y122H probably damaging Het
Abhd14b T A 9: 106,327,240 (GRCm39) H7Q probably benign Het
Acod1 C T 14: 103,286,780 (GRCm39) R28W possibly damaging Het
Agap2 A G 10: 126,924,194 (GRCm39) T803A unknown Het
Angptl7 T C 4: 148,581,741 (GRCm39) E215G probably damaging Het
Ankrd34c T A 9: 89,611,951 (GRCm39) D130V probably damaging Het
BC028528 A G 3: 95,792,298 (GRCm39) V144A probably benign Het
Cab39l T C 14: 59,776,640 (GRCm39) F274L probably damaging Het
Cdsn T C 17: 35,866,415 (GRCm39) S315P possibly damaging Het
Celsr3 CGGGG CGGGGG 9: 108,718,471 (GRCm39) probably null Het
Cep97 A T 16: 55,735,394 (GRCm39) L540* probably null Het
Chrna2 G T 14: 66,387,017 (GRCm39) E388* probably null Het
Ckap4 A G 10: 84,364,460 (GRCm39) V201A probably damaging Het
Clec4b1 A G 6: 123,042,922 (GRCm39) K47R probably benign Het
Clvs2 A T 10: 33,404,484 (GRCm39) I244N possibly damaging Het
Cmtr1 G A 17: 29,893,151 (GRCm39) E57K probably benign Het
Cxxc1 T A 18: 74,353,910 (GRCm39) D565E possibly damaging Het
Dtx3l T A 16: 35,754,073 (GRCm39) M178L probably benign Het
Eml2 A G 7: 18,930,161 (GRCm39) D294G possibly damaging Het
Flt3 A G 5: 147,269,698 (GRCm39) probably null Het
Frs3 T A 17: 48,014,777 (GRCm39) L490Q probably damaging Het
Gm6882 G A 7: 21,161,559 (GRCm39) T103I possibly damaging Het
Gsdmd C T 15: 75,736,270 (GRCm39) T133I probably benign Het
Hhipl2 C A 1: 183,209,540 (GRCm39) C331* probably null Het
Ifnar1 C A 16: 91,302,224 (GRCm39) D566E possibly damaging Het
Ighv1-34 A T 12: 114,814,939 (GRCm39) N74K probably benign Het
Itk T C 11: 46,233,222 (GRCm39) probably null Het
Kdm7a T C 6: 39,122,461 (GRCm39) D801G probably benign Het
Marchf1 T C 8: 66,871,641 (GRCm39) L139P probably damaging Het
Metap1d T C 2: 71,345,982 (GRCm39) V181A probably damaging Het
Mfsd8 G A 3: 40,789,628 (GRCm39) R140C probably damaging Het
Mrps25 T C 6: 92,152,745 (GRCm39) T92A probably benign Het
Mucl3 T C 17: 35,948,486 (GRCm39) H371R possibly damaging Het
Ntng2 C A 2: 29,138,050 (GRCm39) M1I probably null Het
Or51b17 C T 7: 103,542,256 (GRCm39) G229R probably benign Het
Or51q1 A C 7: 103,628,581 (GRCm39) M61L probably damaging Het
Or8b57 T C 9: 40,003,695 (GRCm39) K189R probably benign Het
Pla2g12a A G 3: 129,672,465 (GRCm39) D33G probably damaging Het
Prlhr A G 19: 60,456,284 (GRCm39) V94A possibly damaging Het
Ralgapb T A 2: 158,292,192 (GRCm39) S793T probably benign Het
Rapgef6 T A 11: 54,522,127 (GRCm39) L455* probably null Het
Sbf2 T C 7: 110,040,669 (GRCm39) H386R probably benign Het
Sec23ip C A 7: 128,365,749 (GRCm39) N539K probably damaging Het
Shisa4 A G 1: 135,300,907 (GRCm39) L121P probably damaging Het
Slc28a2b C T 2: 122,355,617 (GRCm39) T603I probably benign Het
Stard9 T A 2: 120,510,306 (GRCm39) F296I probably damaging Het
Strn3 T C 12: 51,707,955 (GRCm39) K147E probably damaging Het
Taf5l T C 8: 124,724,841 (GRCm39) N326S probably benign Het
Tfb2m T A 1: 179,369,914 (GRCm39) I170L probably benign Het
Tfec T C 6: 16,845,422 (GRCm39) N79S possibly damaging Het
Tnn C T 1: 159,946,053 (GRCm39) G922R probably damaging Het
Tox3 T C 8: 91,074,507 (GRCm39) Y24C probably damaging Het
Vmn2r80 A G 10: 78,984,707 (GRCm39) I20V probably benign Het
Wdr97 T C 15: 76,245,684 (GRCm39) V1307A Het
Other mutations in Vmn2r6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01547:Vmn2r6 APN 3 64,445,525 (GRCm39) missense probably damaging 1.00
IGL01968:Vmn2r6 APN 3 64,463,766 (GRCm39) missense possibly damaging 0.94
IGL02009:Vmn2r6 APN 3 64,445,323 (GRCm39) missense possibly damaging 0.61
IGL02039:Vmn2r6 APN 3 64,463,610 (GRCm39) missense probably damaging 1.00
IGL02652:Vmn2r6 APN 3 64,463,749 (GRCm39) missense probably benign 0.24
IGL02737:Vmn2r6 APN 3 64,463,911 (GRCm39) missense possibly damaging 0.55
IGL02808:Vmn2r6 APN 3 64,463,917 (GRCm39) missense probably damaging 1.00
IGL03066:Vmn2r6 APN 3 64,472,574 (GRCm39) missense probably damaging 0.99
IGL03331:Vmn2r6 APN 3 64,445,428 (GRCm39) missense probably damaging 1.00
BB010:Vmn2r6 UTSW 3 64,467,224 (GRCm39) missense probably benign 0.02
BB020:Vmn2r6 UTSW 3 64,467,224 (GRCm39) missense probably benign 0.02
R0010:Vmn2r6 UTSW 3 64,466,966 (GRCm39) nonsense probably null
R0206:Vmn2r6 UTSW 3 64,447,333 (GRCm39) missense probably benign
R0206:Vmn2r6 UTSW 3 64,447,333 (GRCm39) missense probably benign
R0208:Vmn2r6 UTSW 3 64,447,333 (GRCm39) missense probably benign
R0427:Vmn2r6 UTSW 3 64,467,008 (GRCm39) missense probably damaging 1.00
R0466:Vmn2r6 UTSW 3 64,463,723 (GRCm39) missense probably damaging 1.00
R1018:Vmn2r6 UTSW 3 64,464,261 (GRCm39) missense probably benign 0.00
R1104:Vmn2r6 UTSW 3 64,445,487 (GRCm39) missense possibly damaging 0.93
R1186:Vmn2r6 UTSW 3 64,472,488 (GRCm39) missense probably benign 0.01
R1245:Vmn2r6 UTSW 3 64,464,211 (GRCm39) missense possibly damaging 0.53
R1295:Vmn2r6 UTSW 3 64,445,694 (GRCm39) missense probably damaging 1.00
R1473:Vmn2r6 UTSW 3 64,445,579 (GRCm39) nonsense probably null
R1498:Vmn2r6 UTSW 3 64,463,890 (GRCm39) missense probably damaging 1.00
R1925:Vmn2r6 UTSW 3 64,463,698 (GRCm39) missense possibly damaging 0.87
R2044:Vmn2r6 UTSW 3 64,445,262 (GRCm39) missense probably damaging 0.96
R2069:Vmn2r6 UTSW 3 64,463,519 (GRCm39) missense possibly damaging 0.89
R2253:Vmn2r6 UTSW 3 64,467,139 (GRCm39) missense probably damaging 1.00
R2261:Vmn2r6 UTSW 3 64,464,090 (GRCm39) missense probably benign 0.24
R2262:Vmn2r6 UTSW 3 64,464,090 (GRCm39) missense probably benign 0.24
R2350:Vmn2r6 UTSW 3 64,463,773 (GRCm39) missense probably benign 0.01
R2680:Vmn2r6 UTSW 3 64,445,707 (GRCm39) missense possibly damaging 0.91
R2846:Vmn2r6 UTSW 3 64,464,211 (GRCm39) missense possibly damaging 0.53
R2860:Vmn2r6 UTSW 3 64,454,760 (GRCm39) missense probably benign 0.00
R2861:Vmn2r6 UTSW 3 64,454,760 (GRCm39) missense probably benign 0.00
R3766:Vmn2r6 UTSW 3 64,463,929 (GRCm39) missense probably benign 0.19
R3870:Vmn2r6 UTSW 3 64,464,042 (GRCm39) missense probably damaging 0.96
R4018:Vmn2r6 UTSW 3 64,463,893 (GRCm39) missense probably benign 0.05
R4024:Vmn2r6 UTSW 3 64,445,671 (GRCm39) missense possibly damaging 0.73
R4026:Vmn2r6 UTSW 3 64,445,671 (GRCm39) missense possibly damaging 0.73
R4227:Vmn2r6 UTSW 3 64,445,369 (GRCm39) missense probably damaging 0.99
R4526:Vmn2r6 UTSW 3 64,445,145 (GRCm39) missense probably benign 0.32
R4570:Vmn2r6 UTSW 3 64,467,068 (GRCm39) missense probably benign 0.31
R4894:Vmn2r6 UTSW 3 64,454,829 (GRCm39) missense probably benign
R4934:Vmn2r6 UTSW 3 64,463,766 (GRCm39) missense probably damaging 0.99
R5057:Vmn2r6 UTSW 3 64,445,207 (GRCm39) missense probably damaging 1.00
R5059:Vmn2r6 UTSW 3 64,445,044 (GRCm39) missense possibly damaging 0.89
R5148:Vmn2r6 UTSW 3 64,464,015 (GRCm39) missense probably damaging 0.99
R5155:Vmn2r6 UTSW 3 64,445,935 (GRCm39) missense probably benign 0.44
R5179:Vmn2r6 UTSW 3 64,445,411 (GRCm39) missense probably benign 0.00
R5256:Vmn2r6 UTSW 3 64,464,263 (GRCm39) missense probably benign 0.33
R5861:Vmn2r6 UTSW 3 64,463,454 (GRCm39) missense probably benign 0.00
R5950:Vmn2r6 UTSW 3 64,472,652 (GRCm39) missense probably benign 0.05
R6081:Vmn2r6 UTSW 3 64,463,953 (GRCm39) missense probably benign 0.25
R6173:Vmn2r6 UTSW 3 64,467,176 (GRCm39) missense probably damaging 1.00
R6190:Vmn2r6 UTSW 3 64,445,424 (GRCm39) missense probably benign 0.04
R6240:Vmn2r6 UTSW 3 64,464,226 (GRCm39) missense probably damaging 1.00
R6433:Vmn2r6 UTSW 3 64,454,801 (GRCm39) nonsense probably null
R6645:Vmn2r6 UTSW 3 64,464,297 (GRCm39) missense probably damaging 1.00
R6791:Vmn2r6 UTSW 3 64,445,580 (GRCm39) missense probably damaging 1.00
R7265:Vmn2r6 UTSW 3 64,464,195 (GRCm39) missense probably benign 0.00
R7503:Vmn2r6 UTSW 3 64,447,372 (GRCm39) nonsense probably null
R7562:Vmn2r6 UTSW 3 64,463,941 (GRCm39) missense probably benign 0.00
R7584:Vmn2r6 UTSW 3 64,472,683 (GRCm39) missense probably benign 0.07
R7611:Vmn2r6 UTSW 3 64,472,563 (GRCm39) missense probably damaging 0.98
R7759:Vmn2r6 UTSW 3 64,463,991 (GRCm39) missense probably damaging 1.00
R7834:Vmn2r6 UTSW 3 64,445,443 (GRCm39) missense probably damaging 1.00
R7933:Vmn2r6 UTSW 3 64,467,224 (GRCm39) missense probably benign 0.02
R7982:Vmn2r6 UTSW 3 64,467,241 (GRCm39) missense probably damaging 1.00
R8024:Vmn2r6 UTSW 3 64,467,245 (GRCm39) missense probably benign 0.40
R8074:Vmn2r6 UTSW 3 64,455,064 (GRCm39) intron probably benign
R8169:Vmn2r6 UTSW 3 64,447,310 (GRCm39) missense probably benign 0.01
R8736:Vmn2r6 UTSW 3 64,467,221 (GRCm39) missense probably damaging 1.00
R8962:Vmn2r6 UTSW 3 64,463,576 (GRCm39) missense probably damaging 1.00
R9139:Vmn2r6 UTSW 3 64,464,277 (GRCm39) missense probably benign 0.12
R9206:Vmn2r6 UTSW 3 64,467,032 (GRCm39) missense probably damaging 0.97
R9295:Vmn2r6 UTSW 3 64,463,484 (GRCm39) missense probably benign 0.00
R9332:Vmn2r6 UTSW 3 64,454,671 (GRCm39) missense probably benign 0.01
R9616:Vmn2r6 UTSW 3 64,445,724 (GRCm39) missense probably damaging 1.00
R9663:Vmn2r6 UTSW 3 64,463,549 (GRCm39) missense possibly damaging 0.90
R9685:Vmn2r6 UTSW 3 64,464,081 (GRCm39) missense probably benign 0.19
X0020:Vmn2r6 UTSW 3 64,445,871 (GRCm39) missense probably benign
X0066:Vmn2r6 UTSW 3 64,454,799 (GRCm39) missense probably damaging 1.00
Z1176:Vmn2r6 UTSW 3 64,463,746 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- GTCACCCAGACATGTTTTGATG -3'
(R):5'- AGCACTGTGCCATACAATGTG -3'

Sequencing Primer
(F):5'- CACATGGAAGCAAATTAGCAGTTTC -3'
(R):5'- TGTGCCATACAATGTGGACCAC -3'
Posted On 2020-09-02