Mutagenetix > Incidental Mutation

Incidental Mutation 'R8337:Or51b17'

644671

Institutional Source

Beutler Lab

Gene Symbol

Or51b17

Ensembl Gene

ENSMUSG00000063615

Gene Name

olfactory receptor family 51 subfamily B member 17

Synonyms

GA_x6K02T2PBJ9-6648196-6649143, Olfr64, 5'[b]2, MOR1-2

MMRRC Submission

067800-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.248) question?

Stock #

R8337 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

103542017-103543678 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 103542256 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glycine to Arginine at position 229 (G229R)

Ref Sequence

ENSEMBL: ENSMUSP00000080444 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000081748]

AlphaFold

F8VPZ8

Predicted Effect

probably benign
Transcript: ENSMUST00000081748
AA Change: G229R

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000080444
Gene: ENSMUSG00000063615
AA Change: G229R

Domain	Start	End	E-Value	Type
Pfam:7tm_4	29	307	2.4e-113	PFAM
Pfam:7TM_GPCR_Srsx	33	295	4.2e-6	PFAM
Pfam:7tm_1	39	290	1.1e-22	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.5%
20x: 98.2%

Validation Efficiency

100% (55/55)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2310034C09Rik	T	C	16: 88,556,151 (GRCm39)	Y122H	probably damaging	Het
Abhd14b	T	A	9: 106,327,240 (GRCm39)	H7Q	probably benign	Het
Acod1	C	T	14: 103,286,780 (GRCm39)	R28W	possibly damaging	Het
Agap2	A	G	10: 126,924,194 (GRCm39)	T803A	unknown	Het
Angptl7	T	C	4: 148,581,741 (GRCm39)	E215G	probably damaging	Het
Ankrd34c	T	A	9: 89,611,951 (GRCm39)	D130V	probably damaging	Het
BC028528	A	G	3: 95,792,298 (GRCm39)	V144A	probably benign	Het
Cab39l	T	C	14: 59,776,640 (GRCm39)	F274L	probably damaging	Het
Cdsn	T	C	17: 35,866,415 (GRCm39)	S315P	possibly damaging	Het
Celsr3	CGGGG	CGGGGG	9: 108,718,471 (GRCm39)		probably null	Het
Cep97	A	T	16: 55,735,394 (GRCm39)	L540*	probably null	Het
Chrna2	G	T	14: 66,387,017 (GRCm39)	E388*	probably null	Het
Ckap4	A	G	10: 84,364,460 (GRCm39)	V201A	probably damaging	Het
Clec4b1	A	G	6: 123,042,922 (GRCm39)	K47R	probably benign	Het
Clvs2	A	T	10: 33,404,484 (GRCm39)	I244N	possibly damaging	Het
Cmtr1	G	A	17: 29,893,151 (GRCm39)	E57K	probably benign	Het
Cxxc1	T	A	18: 74,353,910 (GRCm39)	D565E	possibly damaging	Het
Dtx3l	T	A	16: 35,754,073 (GRCm39)	M178L	probably benign	Het
Eml2	A	G	7: 18,930,161 (GRCm39)	D294G	possibly damaging	Het
Flt3	A	G	5: 147,269,698 (GRCm39)		probably null	Het
Frs3	T	A	17: 48,014,777 (GRCm39)	L490Q	probably damaging	Het
Gm6882	G	A	7: 21,161,559 (GRCm39)	T103I	possibly damaging	Het
Gsdmd	C	T	15: 75,736,270 (GRCm39)	T133I	probably benign	Het
Hhipl2	C	A	1: 183,209,540 (GRCm39)	C331*	probably null	Het
Ifnar1	C	A	16: 91,302,224 (GRCm39)	D566E	possibly damaging	Het
Ighv1-34	A	T	12: 114,814,939 (GRCm39)	N74K	probably benign	Het
Itk	T	C	11: 46,233,222 (GRCm39)		probably null	Het
Kdm7a	T	C	6: 39,122,461 (GRCm39)	D801G	probably benign	Het
Marchf1	T	C	8: 66,871,641 (GRCm39)	L139P	probably damaging	Het
Metap1d	T	C	2: 71,345,982 (GRCm39)	V181A	probably damaging	Het
Mfsd8	G	A	3: 40,789,628 (GRCm39)	R140C	probably damaging	Het
Mrps25	T	C	6: 92,152,745 (GRCm39)	T92A	probably benign	Het
Mucl3	T	C	17: 35,948,486 (GRCm39)	H371R	possibly damaging	Het
Ntng2	C	A	2: 29,138,050 (GRCm39)	M1I	probably null	Het
Or51q1	A	C	7: 103,628,581 (GRCm39)	M61L	probably damaging	Het
Or8b57	T	C	9: 40,003,695 (GRCm39)	K189R	probably benign	Het
Pla2g12a	A	G	3: 129,672,465 (GRCm39)	D33G	probably damaging	Het
Prlhr	A	G	19: 60,456,284 (GRCm39)	V94A	possibly damaging	Het
Ralgapb	T	A	2: 158,292,192 (GRCm39)	S793T	probably benign	Het
Rapgef6	T	A	11: 54,522,127 (GRCm39)	L455*	probably null	Het
Sbf2	T	C	7: 110,040,669 (GRCm39)	H386R	probably benign	Het
Sec23ip	C	A	7: 128,365,749 (GRCm39)	N539K	probably damaging	Het
Shisa4	A	G	1: 135,300,907 (GRCm39)	L121P	probably damaging	Het
Slc28a2b	C	T	2: 122,355,617 (GRCm39)	T603I	probably benign	Het
Stard9	T	A	2: 120,510,306 (GRCm39)	F296I	probably damaging	Het
Strn3	T	C	12: 51,707,955 (GRCm39)	K147E	probably damaging	Het
Taf5l	T	C	8: 124,724,841 (GRCm39)	N326S	probably benign	Het
Tfb2m	T	A	1: 179,369,914 (GRCm39)	I170L	probably benign	Het
Tfec	T	C	6: 16,845,422 (GRCm39)	N79S	possibly damaging	Het
Tnn	C	T	1: 159,946,053 (GRCm39)	G922R	probably damaging	Het
Tox3	T	C	8: 91,074,507 (GRCm39)	Y24C	probably damaging	Het
Vmn2r6	A	T	3: 64,463,526 (GRCm39)	L436*	probably null	Het
Vmn2r80	A	G	10: 78,984,707 (GRCm39)	I20V	probably benign	Het
Wdr97	T	C	15: 76,245,684 (GRCm39)	V1307A		Het

Other mutations in Or51b17

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00934:Or51b17	APN	7	103,542,071 (GRCm39)	nonsense	probably null
IGL01597:Or51b17	APN	7	103,542,303 (GRCm39)	missense	probably benign	0.01
IGL01868:Or51b17	APN	7	103,542,583 (GRCm39)	nonsense	probably null
IGL02502:Or51b17	APN	7	103,542,696 (GRCm39)	missense	probably damaging	0.99
R0294:Or51b17	UTSW	7	103,542,137 (GRCm39)	missense	probably benign	0.09
R0534:Or51b17	UTSW	7	103,542,438 (GRCm39)	missense	probably benign	0.00
R0838:Or51b17	UTSW	7	103,542,622 (GRCm39)	missense	probably benign	0.00
R1350:Or51b17	UTSW	7	103,542,937 (GRCm39)	missense	probably benign	0.01
R1733:Or51b17	UTSW	7	103,542,118 (GRCm39)	missense	probably benign	0.40
R1768:Or51b17	UTSW	7	103,542,484 (GRCm39)	missense	probably benign	0.28
R1780:Or51b17	UTSW	7	103,542,762 (GRCm39)	missense	probably damaging	1.00
R1836:Or51b17	UTSW	7	103,542,592 (GRCm39)	missense	probably damaging	0.98
R1956:Or51b17	UTSW	7	103,542,925 (GRCm39)	missense	probably benign	0.01
R2075:Or51b17	UTSW	7	103,542,127 (GRCm39)	missense	probably damaging	0.96
R4677:Or51b17	UTSW	7	103,542,615 (GRCm39)	missense	probably damaging	1.00
R4884:Or51b17	UTSW	7	103,542,862 (GRCm39)	missense	probably benign	0.04
R4899:Or51b17	UTSW	7	103,542,672 (GRCm39)	missense	possibly damaging	0.54
R5753:Or51b17	UTSW	7	103,542,408 (GRCm39)	missense	probably damaging	1.00
R6351:Or51b17	UTSW	7	103,542,342 (GRCm39)	nonsense	probably null
R6997:Or51b17	UTSW	7	103,542,238 (GRCm39)	missense	probably benign	0.00
R8319:Or51b17	UTSW	7	103,542,636 (GRCm39)	missense	probably damaging	1.00
R8984:Or51b17	UTSW	7	103,542,816 (GRCm39)	missense	probably benign	0.01
R9780:Or51b17	UTSW	7	103,542,631 (GRCm39)	missense	probably damaging	0.99
X0017:Or51b17	UTSW	7	103,542,358 (GRCm39)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- GCTCCTCTGAATTTGCTTGGT -3'
(R):5'- TCATATTGCCGTTCCCATGT -3'

Sequencing Primer
(F):5'- GCTGTAAATGATGGGGTTCATAAATG -3'
(R):5'- ATATTGCCGTTCCCATGTTCTTTC -3'

Posted On

2020-09-02