Incidental Mutation 'R8340:Or14j3'
ID 644864
Institutional Source Beutler Lab
Gene Symbol Or14j3
Ensembl Gene ENSMUSG00000062629
Gene Name olfactory receptor family 14 subfamily J member 3
Synonyms MOR218-10, GA_x6K02T2PSCP-2049802-2048870, Olfr114
MMRRC Submission 067864-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.055) question?
Stock # R8340 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 37900304-37901242 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 37901034 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 70 (D70G)
Ref Sequence ENSEMBL: ENSMUSP00000151201 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076914] [ENSMUST00000214871] [ENSMUST00000216249]
AlphaFold Q923Q8
Predicted Effect probably damaging
Transcript: ENSMUST00000076914
AA Change: D70G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000076181
Gene: ENSMUSG00000062629
AA Change: D70G

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 2e-43 PFAM
Pfam:7TM_GPCR_Srsx 35 305 3.7e-6 PFAM
Pfam:7tm_1 41 290 3e-19 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214871
AA Change: D70G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000216249
AA Change: D70G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3110040N11Rik C T 7: 81,435,839 (GRCm39) V91M probably damaging Het
Actr2 A G 11: 20,044,435 (GRCm39) V57A possibly damaging Het
Aoah A G 13: 21,184,112 (GRCm39) Y392C probably damaging Het
Armc6 T G 8: 70,673,502 (GRCm39) N407T probably damaging Het
BC024139 A G 15: 76,005,670 (GRCm39) V484A probably benign Het
Bdp1 A G 13: 100,202,476 (GRCm39) V716A possibly damaging Het
C2cd2 T C 16: 97,670,013 (GRCm39) E550G probably benign Het
Cbl A G 9: 44,070,297 (GRCm39) S512P possibly damaging Het
Chac2 C G 11: 30,927,511 (GRCm39) G136A probably damaging Het
Crhr2 C T 6: 55,079,831 (GRCm39) V170M probably damaging Het
Cyp2c54 T A 19: 40,060,831 (GRCm39) D104V possibly damaging Het
Dhtkd1 T A 2: 5,924,408 (GRCm39) S402C probably damaging Het
Efcab3 A G 11: 104,876,856 (GRCm39) I4099V unknown Het
Etv3 A G 3: 87,443,856 (GRCm39) D480G possibly damaging Het
Fam186b A T 15: 99,177,595 (GRCm39) I577K probably benign Het
Foxe1 T C 4: 46,344,437 (GRCm39) Y82H possibly damaging Het
Gsdma T A 11: 98,557,421 (GRCm39) V120E probably benign Het
Insig2 A T 1: 121,234,946 (GRCm39) S153R probably damaging Het
Isx T A 8: 75,616,688 (GRCm39) I105N probably damaging Het
Klra4 T A 6: 130,042,257 (GRCm39) E3D probably benign Het
Mkln1 G T 6: 31,409,878 (GRCm39) R172L possibly damaging Het
Myrf A T 19: 10,192,705 (GRCm39) S605T probably benign Het
Nell1 T A 7: 49,870,021 (GRCm39) D232E probably damaging Het
Nemf T G 12: 69,400,659 (GRCm39) T139P possibly damaging Het
Nrdc A C 4: 108,858,351 (GRCm39) K108Q probably damaging Het
Or10c1 G T 17: 37,522,075 (GRCm39) T223N possibly damaging Het
Or3a10 G T 11: 73,935,851 (GRCm39) P83Q probably damaging Het
Pcnx4 T C 12: 72,613,851 (GRCm39) S599P probably damaging Het
Plscr2 A G 9: 92,173,130 (GRCm39) N224S probably benign Het
Poln A G 5: 34,307,118 (GRCm39) S28P probably damaging Het
Prr36 A G 8: 4,264,224 (GRCm39) S481P unknown Het
Scrn1 G A 6: 54,511,518 (GRCm39) A74V possibly damaging Het
Slc22a22 T A 15: 57,127,086 (GRCm39) probably null Het
Srpra A G 9: 35,127,102 (GRCm39) D592G probably damaging Het
Tnc T C 4: 63,926,036 (GRCm39) N915D probably damaging Het
Trpm2 T A 10: 77,759,458 (GRCm39) K1109* probably null Het
Tsks C T 7: 44,602,144 (GRCm39) R287W probably damaging Het
Ush1c T G 7: 45,860,630 (GRCm39) M456L probably benign Het
Usp38 A G 8: 81,712,031 (GRCm39) V668A probably benign Het
Vmn2r117 T A 17: 23,679,511 (GRCm39) Q571L probably benign Het
Vmn2r13 A T 5: 109,322,006 (GRCm39) D230E probably benign Het
Vmn2r25 C T 6: 123,829,972 (GRCm39) G60S probably benign Het
Vmn2r82 A G 10: 79,217,036 (GRCm39) D456G probably benign Het
Zfp738 A C 13: 67,819,231 (GRCm39) H253Q probably damaging Het
Other mutations in Or14j3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01534:Or14j3 APN 17 37,900,963 (GRCm39) missense possibly damaging 0.93
IGL01624:Or14j3 APN 17 37,900,816 (GRCm39) missense probably benign 0.00
IGL02026:Or14j3 APN 17 37,900,298 (GRCm39) utr 3 prime probably benign
IGL02608:Or14j3 APN 17 37,901,110 (GRCm39) missense probably damaging 1.00
IGL02632:Or14j3 APN 17 37,901,232 (GRCm39) missense probably benign 0.00
IGL02990:Or14j3 APN 17 37,900,559 (GRCm39) missense probably benign 0.00
R0114:Or14j3 UTSW 17 37,900,306 (GRCm39) makesense probably null
R1156:Or14j3 UTSW 17 37,900,408 (GRCm39) missense possibly damaging 0.93
R1366:Or14j3 UTSW 17 37,900,655 (GRCm39) missense probably benign 0.03
R3413:Or14j3 UTSW 17 37,900,587 (GRCm39) missense probably benign 0.00
R3701:Or14j3 UTSW 17 37,900,717 (GRCm39) nonsense probably null
R6122:Or14j3 UTSW 17 37,900,817 (GRCm39) missense probably benign 0.12
R6639:Or14j3 UTSW 17 37,900,822 (GRCm39) missense probably damaging 1.00
R7066:Or14j3 UTSW 17 37,901,034 (GRCm39) missense probably damaging 1.00
R7316:Or14j3 UTSW 17 37,901,026 (GRCm39) missense probably damaging 0.99
R8483:Or14j3 UTSW 17 37,900,866 (GRCm39) missense possibly damaging 0.52
R8555:Or14j3 UTSW 17 37,900,540 (GRCm39) missense possibly damaging 0.95
R9442:Or14j3 UTSW 17 37,900,633 (GRCm39) missense possibly damaging 0.95
R9617:Or14j3 UTSW 17 37,901,053 (GRCm39) nonsense probably null
R9718:Or14j3 UTSW 17 37,900,914 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CCTACACTTTCTGGGACACATG -3'
(R):5'- GAGTGGATTCCTCCTCATGG -3'

Sequencing Primer
(F):5'- CTGGGACACATGATGATCTCATAGTG -3'
(R):5'- GGATTCTCTGACAACCATGAGCTG -3'
Posted On 2020-09-02