Incidental Mutation 'R8342:Vmn2r60'
| ID |
644950 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r60
|
| Ensembl Gene |
ENSMUSG00000090619 |
| Gene Name |
vomeronasal 2, receptor 60 |
| Synonyms |
Casr-rs3, EG637898, Gprc2a-rs3 |
| MMRRC Submission |
067731-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.112)
|
| Stock # |
R8342 (G1)
|
| Quality Score |
156.008 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
41765895-41845200 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 41790494 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Cysteine
at position 494
(S494C)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000128493
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000166447]
|
| AlphaFold |
A0A3B2WBC8 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000166447
AA Change: S494C
PolyPhen 2
Score 0.627 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000128493
Gene: ENSMUSG00000090619
AA Change: S494C
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
78 |
471 |
1.2e-44 |
PFAM |
|
Pfam:NCD3G
|
514 |
567 |
5.1e-23 |
PFAM |
|
Pfam:7tm_3
|
600 |
835 |
1.4e-51 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.6%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 62 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aak1 |
A |
G |
6: 86,963,321 (GRCm39) |
D917G |
unknown |
Het |
| Adad1 |
T |
C |
3: 37,134,050 (GRCm39) |
S322P |
probably damaging |
Het |
| Agbl4 |
C |
T |
4: 110,976,224 (GRCm39) |
L194F |
probably damaging |
Het |
| Ahr |
C |
T |
12: 35,558,271 (GRCm39) |
G250R |
probably damaging |
Het |
| AI987944 |
A |
T |
7: 41,024,310 (GRCm39) |
I226N |
probably benign |
Het |
| Ankar |
A |
G |
1: 72,691,619 (GRCm39) |
V1114A |
probably damaging |
Het |
| Ankrd49 |
C |
A |
9: 14,692,823 (GRCm39) |
A114S |
probably damaging |
Het |
| Arl6 |
C |
T |
16: 59,442,802 (GRCm39) |
G140D |
unknown |
Het |
| Arrdc3 |
A |
G |
13: 81,031,790 (GRCm39) |
S8G |
probably benign |
Het |
| Ate1 |
A |
T |
7: 130,105,495 (GRCm39) |
V298E |
probably benign |
Het |
| Atp6v1b2 |
A |
G |
8: 69,554,035 (GRCm39) |
I71V |
probably benign |
Het |
| Bin1 |
A |
G |
18: 32,546,166 (GRCm39) |
M112V |
probably benign |
Het |
| Camk2b |
C |
T |
11: 5,940,383 (GRCm39) |
A152T |
probably benign |
Het |
| Cars2 |
A |
C |
8: 11,579,706 (GRCm39) |
F251V |
probably damaging |
Het |
| Cdkl1 |
A |
T |
12: 69,800,952 (GRCm39) |
F229I |
probably damaging |
Het |
| Ceacam5 |
A |
T |
7: 17,486,171 (GRCm39) |
Y556F |
possibly damaging |
Het |
| Chst15 |
T |
C |
7: 131,849,615 (GRCm39) |
N442S |
probably benign |
Het |
| Ckap5 |
T |
A |
2: 91,436,707 (GRCm39) |
D1602E |
possibly damaging |
Het |
| Col9a3 |
A |
T |
2: 180,245,183 (GRCm39) |
I131F |
unknown |
Het |
| Cyp4f15 |
A |
T |
17: 32,909,733 (GRCm39) |
D110V |
possibly damaging |
Het |
| Dlec1 |
A |
G |
9: 118,968,457 (GRCm39) |
I1258V |
probably benign |
Het |
| Dpyd |
A |
G |
3: 119,108,452 (GRCm39) |
T832A |
possibly damaging |
Het |
| Eno1 |
A |
G |
4: 150,329,693 (GRCm39) |
Y189C |
probably damaging |
Het |
| Gnat3 |
A |
G |
5: 18,208,838 (GRCm39) |
T181A |
|
Het |
| Kif1b |
T |
C |
4: 149,306,805 (GRCm39) |
M852V |
probably damaging |
Het |
| Klk1b26 |
A |
T |
7: 43,665,508 (GRCm39) |
I139F |
probably damaging |
Het |
| Loxhd1 |
G |
A |
18: 77,493,681 (GRCm39) |
V1547M |
possibly damaging |
Het |
| Lrp4 |
A |
G |
2: 91,318,790 (GRCm39) |
T876A |
probably damaging |
Het |
| Malrd1 |
G |
T |
2: 15,638,035 (GRCm39) |
W451L |
unknown |
Het |
| Marchf6 |
A |
T |
15: 31,494,262 (GRCm39) |
N261K |
possibly damaging |
Het |
| Mcpt2 |
T |
C |
14: 56,280,250 (GRCm39) |
C50R |
probably damaging |
Het |
| Muc16 |
A |
G |
9: 18,569,981 (GRCm39) |
V846A |
unknown |
Het |
| Muc5b |
A |
T |
7: 141,414,602 (GRCm39) |
D2516V |
unknown |
Het |
| Myh15 |
T |
C |
16: 48,913,120 (GRCm39) |
L359P |
probably benign |
Het |
| Nemp1 |
G |
A |
10: 127,528,898 (GRCm39) |
V201I |
probably benign |
Het |
| Nr2e1 |
A |
T |
10: 42,444,425 (GRCm39) |
L228Q |
probably damaging |
Het |
| Nrg1 |
C |
A |
8: 32,312,334 (GRCm39) |
V388L |
probably benign |
Het |
| Nrg3 |
T |
A |
14: 38,734,053 (GRCm39) |
T278S |
probably damaging |
Het |
| Numb |
T |
C |
12: 83,854,990 (GRCm39) |
E112G |
probably benign |
Het |
| Or1l4b |
T |
C |
2: 37,036,778 (GRCm39) |
S185P |
probably damaging |
Het |
| Or8g2b |
A |
C |
9: 39,751,612 (GRCm39) |
N294T |
probably damaging |
Het |
| Pdlim2 |
C |
A |
14: 70,403,563 (GRCm39) |
C283F |
probably damaging |
Het |
| Potegl |
T |
A |
2: 23,147,017 (GRCm39) |
|
probably null |
Het |
| Ppm1a |
G |
A |
12: 72,830,909 (GRCm39) |
G145R |
probably damaging |
Het |
| Pramel14 |
T |
A |
4: 143,720,809 (GRCm39) |
D44V |
probably benign |
Het |
| Pramel18 |
A |
T |
4: 101,767,581 (GRCm39) |
M277L |
probably benign |
Het |
| Prune2 |
C |
A |
19: 17,103,027 (GRCm39) |
Q2729K |
probably benign |
Het |
| Repin1 |
G |
T |
6: 48,574,279 (GRCm39) |
E403* |
probably null |
Het |
| Scn9a |
G |
T |
2: 66,366,626 (GRCm39) |
T719K |
probably benign |
Het |
| Slc12a7 |
T |
C |
13: 73,933,281 (GRCm39) |
V113A |
probably benign |
Het |
| Slc23a1 |
C |
T |
18: 35,755,588 (GRCm39) |
G436E |
probably damaging |
Het |
| Slc37a2 |
A |
T |
9: 37,149,510 (GRCm39) |
|
probably null |
Het |
| Steap1 |
G |
A |
5: 5,790,816 (GRCm39) |
S44L |
probably benign |
Het |
| Sucnr1 |
C |
T |
3: 59,994,155 (GRCm39) |
R228C |
probably damaging |
Het |
| Sult3a1 |
G |
A |
10: 33,742,517 (GRCm39) |
G48D |
probably damaging |
Het |
| Syn3 |
A |
T |
10: 86,302,891 (GRCm39) |
V88D |
probably damaging |
Het |
| Syne1 |
T |
C |
10: 5,058,622 (GRCm39) |
D7297G |
probably benign |
Het |
| Tmco5 |
T |
C |
2: 116,710,734 (GRCm39) |
I18T |
probably damaging |
Het |
| Trpc1 |
A |
G |
9: 95,608,601 (GRCm39) |
L230P |
probably damaging |
Het |
| Ttn |
T |
C |
2: 76,719,785 (GRCm39) |
N7108S |
unknown |
Het |
| Ubr5 |
A |
G |
15: 38,025,081 (GRCm39) |
V559A |
|
Het |
| Ugt1a7c |
T |
C |
1: 88,022,973 (GRCm39) |
V44A |
possibly damaging |
Het |
|
| Other mutations in Vmn2r60 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01622:Vmn2r60
|
APN |
7 |
41,785,910 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL01623:Vmn2r60
|
APN |
7 |
41,785,910 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02363:Vmn2r60
|
APN |
7 |
41,844,578 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02485:Vmn2r60
|
APN |
7 |
41,844,890 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
IGL02651:Vmn2r60
|
APN |
7 |
41,845,010 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02660:Vmn2r60
|
APN |
7 |
41,791,720 (GRCm39) |
nonsense |
probably null |
|
|
IGL03135:Vmn2r60
|
APN |
7 |
41,786,018 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL03307:Vmn2r60
|
APN |
7 |
41,765,971 (GRCm39) |
missense |
probably benign |
0.14 |
|
R0310:Vmn2r60
|
UTSW |
7 |
41,844,564 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R0314:Vmn2r60
|
UTSW |
7 |
41,784,985 (GRCm39) |
splice site |
probably benign |
|
|
R0328:Vmn2r60
|
UTSW |
7 |
41,791,744 (GRCm39) |
splice site |
probably benign |
|
|
R0464:Vmn2r60
|
UTSW |
7 |
41,785,255 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0755:Vmn2r60
|
UTSW |
7 |
41,844,869 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1119:Vmn2r60
|
UTSW |
7 |
41,844,365 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1162:Vmn2r60
|
UTSW |
7 |
41,845,195 (GRCm39) |
missense |
probably benign |
0.29 |
|
R1241:Vmn2r60
|
UTSW |
7 |
41,786,476 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1404:Vmn2r60
|
UTSW |
7 |
41,786,211 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1404:Vmn2r60
|
UTSW |
7 |
41,786,211 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1488:Vmn2r60
|
UTSW |
7 |
41,786,137 (GRCm39) |
missense |
probably benign |
0.17 |
|
R1623:Vmn2r60
|
UTSW |
7 |
41,785,279 (GRCm39) |
nonsense |
probably null |
|
|
R1628:Vmn2r60
|
UTSW |
7 |
41,785,830 (GRCm39) |
nonsense |
probably null |
|
|
R1883:Vmn2r60
|
UTSW |
7 |
41,786,094 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1884:Vmn2r60
|
UTSW |
7 |
41,786,094 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2182:Vmn2r60
|
UTSW |
7 |
41,844,931 (GRCm39) |
missense |
probably benign |
0.06 |
|
R2275:Vmn2r60
|
UTSW |
7 |
41,786,251 (GRCm39) |
nonsense |
probably null |
|
|
R2847:Vmn2r60
|
UTSW |
7 |
41,785,857 (GRCm39) |
missense |
probably benign |
0.07 |
|
R2885:Vmn2r60
|
UTSW |
7 |
41,790,403 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R2894:Vmn2r60
|
UTSW |
7 |
41,785,220 (GRCm39) |
missense |
probably benign |
|
|
R2921:Vmn2r60
|
UTSW |
7 |
41,790,459 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2922:Vmn2r60
|
UTSW |
7 |
41,790,459 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3772:Vmn2r60
|
UTSW |
7 |
41,765,980 (GRCm39) |
missense |
probably benign |
0.35 |
|
R3820:Vmn2r60
|
UTSW |
7 |
41,785,125 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3822:Vmn2r60
|
UTSW |
7 |
41,785,125 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3872:Vmn2r60
|
UTSW |
7 |
41,785,878 (GRCm39) |
missense |
probably benign |
0.19 |
|
R4222:Vmn2r60
|
UTSW |
7 |
41,765,952 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4223:Vmn2r60
|
UTSW |
7 |
41,765,952 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4224:Vmn2r60
|
UTSW |
7 |
41,765,952 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4526:Vmn2r60
|
UTSW |
7 |
41,844,667 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4547:Vmn2r60
|
UTSW |
7 |
41,785,087 (GRCm39) |
missense |
probably null |
0.54 |
|
R4840:Vmn2r60
|
UTSW |
7 |
41,785,285 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5173:Vmn2r60
|
UTSW |
7 |
41,844,935 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5231:Vmn2r60
|
UTSW |
7 |
41,786,448 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5480:Vmn2r60
|
UTSW |
7 |
41,785,154 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5521:Vmn2r60
|
UTSW |
7 |
41,845,049 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5834:Vmn2r60
|
UTSW |
7 |
41,765,932 (GRCm39) |
missense |
probably benign |
0.17 |
|
R6038:Vmn2r60
|
UTSW |
7 |
41,844,386 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6038:Vmn2r60
|
UTSW |
7 |
41,844,386 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6112:Vmn2r60
|
UTSW |
7 |
41,844,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6149:Vmn2r60
|
UTSW |
7 |
41,786,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6170:Vmn2r60
|
UTSW |
7 |
41,785,045 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6383:Vmn2r60
|
UTSW |
7 |
41,765,895 (GRCm39) |
start codon destroyed |
probably null |
0.04 |
|
R6811:Vmn2r60
|
UTSW |
7 |
41,844,310 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6876:Vmn2r60
|
UTSW |
7 |
41,785,087 (GRCm39) |
missense |
probably null |
0.54 |
|
R6997:Vmn2r60
|
UTSW |
7 |
41,791,716 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7040:Vmn2r60
|
UTSW |
7 |
41,791,666 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7116:Vmn2r60
|
UTSW |
7 |
41,786,487 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7128:Vmn2r60
|
UTSW |
7 |
41,844,536 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7232:Vmn2r60
|
UTSW |
7 |
41,786,166 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7296:Vmn2r60
|
UTSW |
7 |
41,785,826 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7376:Vmn2r60
|
UTSW |
7 |
41,844,631 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7526:Vmn2r60
|
UTSW |
7 |
41,845,158 (GRCm39) |
frame shift |
probably null |
|
|
R7527:Vmn2r60
|
UTSW |
7 |
41,845,158 (GRCm39) |
frame shift |
probably null |
|
|
R7528:Vmn2r60
|
UTSW |
7 |
41,845,158 (GRCm39) |
frame shift |
probably null |
|
|
R7764:Vmn2r60
|
UTSW |
7 |
41,844,535 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7843:Vmn2r60
|
UTSW |
7 |
41,844,511 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8080:Vmn2r60
|
UTSW |
7 |
41,790,521 (GRCm39) |
missense |
probably benign |
0.30 |
|
R8290:Vmn2r60
|
UTSW |
7 |
41,791,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8362:Vmn2r60
|
UTSW |
7 |
41,844,954 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8418:Vmn2r60
|
UTSW |
7 |
41,844,850 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8848:Vmn2r60
|
UTSW |
7 |
41,786,169 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8860:Vmn2r60
|
UTSW |
7 |
41,791,654 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8882:Vmn2r60
|
UTSW |
7 |
41,790,518 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8913:Vmn2r60
|
UTSW |
7 |
41,785,778 (GRCm39) |
missense |
probably benign |
0.27 |
|
R9190:Vmn2r60
|
UTSW |
7 |
41,844,935 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9229:Vmn2r60
|
UTSW |
7 |
41,791,723 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9295:Vmn2r60
|
UTSW |
7 |
41,785,955 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9335:Vmn2r60
|
UTSW |
7 |
41,844,332 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9796:Vmn2r60
|
UTSW |
7 |
41,785,172 (GRCm39) |
missense |
probably benign |
|
|
RF024:Vmn2r60
|
UTSW |
7 |
41,790,363 (GRCm39) |
missense |
probably benign |
0.01 |
|
X0023:Vmn2r60
|
UTSW |
7 |
41,790,538 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCTTCACCCTTTCCTAAAGAAC -3'
(R):5'- TCCGAGGCAGTAACTAATAGACAC -3'
Sequencing Primer
(F):5'- CCCTTTCCTAAAGAACACGATAATG -3'
(R):5'- TGATCACAGTCAGAAATGAA -3'
|
| Posted On |
2020-09-02 |
Incidental Mutation