Incidental Mutation 'R8343:Nynrin'
ID 645041
Institutional Source Beutler Lab
Gene Symbol Nynrin
Ensembl Gene ENSMUSG00000075592
Gene Name NYN domain and retroviral integrase containing
Synonyms
MMRRC Submission 067866-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8343 (G1)
Quality Score 225.009
Status Validated
Chromosome 14
Chromosomal Location 56091572-56112193 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 56101248 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 306 (T306A)
Ref Sequence ENSEMBL: ENSMUSP00000098098 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000100529] [ENSMUST00000168479] [ENSMUST00000227465]
AlphaFold Q5DTZ0
Predicted Effect probably benign
Transcript: ENSMUST00000100529
AA Change: T306A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000098098
Gene: ENSMUSG00000075592
AA Change: T306A

DomainStartEndE-ValueType
low complexity region 581 606 N/A INTRINSIC
Pfam:RNase_Zc3h12a 739 890 1.6e-54 PFAM
low complexity region 938 952 N/A INTRINSIC
low complexity region 1212 1228 N/A INTRINSIC
low complexity region 1390 1397 N/A INTRINSIC
PDB:3S3O|B 1478 1706 6e-8 PDB
SCOP:d1cxqa_ 1552 1646 2e-12 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000168479
AA Change: T306A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000129557
Gene: ENSMUSG00000075592
AA Change: T306A

DomainStartEndE-ValueType
low complexity region 581 606 N/A INTRINSIC
Pfam:RNase_Zc3h12a 739 890 5.5e-54 PFAM
low complexity region 938 952 N/A INTRINSIC
low complexity region 1212 1228 N/A INTRINSIC
low complexity region 1390 1397 N/A INTRINSIC
PDB:3S3O|B 1478 1706 6e-8 PDB
SCOP:d1cxqa_ 1552 1646 2e-12 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000227465
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 97% (64/66)
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aars1 T A 8: 111,767,361 (GRCm39) W156R probably damaging Het
Acvr1 T A 2: 58,364,286 (GRCm39) probably null Het
Adamts2 G T 11: 50,494,315 (GRCm39) V130L probably damaging Het
Adcy4 C T 14: 56,012,697 (GRCm39) V541I probably benign Het
Adgrl2 C T 3: 148,552,542 (GRCm39) V654I probably damaging Het
Ago3 T A 4: 126,270,721 (GRCm39) K258* probably null Het
Akap11 A T 14: 78,749,929 (GRCm39) S819R Het
Alox5ap T C 5: 149,224,419 (GRCm39) F121L probably damaging Het
Baz2b A T 2: 59,731,858 (GRCm39) M2060K probably damaging Het
Bltp3b T C 10: 89,627,281 (GRCm39) S449P probably benign Het
C030005K15Rik T C 10: 97,561,414 (GRCm39) I106V unknown Het
Carmil2 T A 8: 106,417,716 (GRCm39) S604T probably benign Het
Ccdc121rt2 C T 5: 112,598,653 (GRCm39) T400I probably benign Het
Cdhr1 T C 14: 36,813,935 (GRCm39) T164A probably benign Het
Dhx30 T C 9: 109,914,569 (GRCm39) E976G possibly damaging Het
Dnah17 C T 11: 118,005,021 (GRCm39) G788R probably benign Het
Dus2 T C 8: 106,722,645 (GRCm39) probably benign Het
Etv6 T C 6: 134,225,717 (GRCm39) V316A possibly damaging Het
Fabp9 T G 3: 10,259,085 (GRCm39) K107T possibly damaging Het
Fmn2 CCCTCCTCTCCCTGGAATGGGAATACCTCCCCCACCTCCTCTCCCTGGAATGGGAATACCTCCCCCACCTCCTCTCCCTGGAATGGGAATATCTCCCCTACCTCCTCTCCCTGGAATGGGAATACCTCC CCCTCCTCTCCCTGGAATGGGAATACCTCCCCCACCTCCTCTCCCTGGAATGGGAATATCTCCCCTACCTCCTCTCCCTGGAATGGGAATACCTCC 1: 174,436,769 (GRCm39) probably benign Het
Gapdh A G 6: 125,140,226 (GRCm39) V92A probably benign Het
Gfy A G 7: 44,826,019 (GRCm39) L453P probably damaging Het
Gp2 C T 7: 119,042,010 (GRCm39) C505Y probably benign Het
Gtpbp8 T C 16: 44,566,676 (GRCm39) R9G probably benign Het
Hipk4 G T 7: 27,223,033 (GRCm39) R31L probably damaging Het
Htt T A 5: 35,063,068 (GRCm39) M2900K probably damaging Het
Ighv1-20 T C 12: 114,687,810 (GRCm39) I6V probably benign Het
Il17d C T 14: 57,779,937 (GRCm39) T153I probably damaging Het
Izumo3 T A 4: 92,034,581 (GRCm39) N117I probably damaging Het
Kcnh7 T C 2: 62,680,879 (GRCm39) D236G probably benign Het
Kmt2d T C 15: 98,750,478 (GRCm39) D2405G unknown Het
Map4k2 T C 19: 6,396,596 (GRCm39) W533R probably damaging Het
Matn1 C A 4: 130,673,300 (GRCm39) Y89* probably null Het
Mettl18 T A 1: 163,824,509 (GRCm39) Y277N probably damaging Het
Muc5b G A 7: 141,417,898 (GRCm39) G3615S probably benign Het
Mycbp2 A C 14: 103,398,111 (GRCm39) probably null Het
Myh4 T A 11: 67,143,390 (GRCm39) S1041T possibly damaging Het
Myl10 G C 5: 136,726,825 (GRCm39) V70L probably benign Het
Naaladl1 T C 19: 6,159,703 (GRCm39) V378A possibly damaging Het
Nars1 T C 18: 64,637,458 (GRCm39) D374G probably benign Het
Neb C T 2: 52,198,283 (GRCm39) probably null Het
Neurl1b A G 17: 26,650,965 (GRCm39) Y79C probably damaging Het
Ola1 G T 2: 73,029,745 (GRCm39) R125S probably damaging Het
Or12d15 T A 17: 37,694,122 (GRCm39) F221L probably benign Het
Or51a43 A T 7: 103,717,383 (GRCm39) V285D probably damaging Het
Pak1ip1 C A 13: 41,158,214 (GRCm39) T29K probably benign Het
Podnl1 T A 8: 84,857,402 (GRCm39) L337H Het
Rictor T G 15: 6,807,800 (GRCm39) probably null Het
Rsf1 ATGGCG ATGGCGACGGTGGCG 7: 97,229,111 (GRCm39) probably benign Het
Sel1l2 T C 2: 140,072,753 (GRCm39) I627M probably benign Het
Sh3rf2 T C 18: 42,244,493 (GRCm39) S352P probably damaging Het
Slc6a6 G A 6: 91,703,224 (GRCm39) W199* probably null Het
Smc2 T A 4: 52,450,965 (GRCm39) V261E probably benign Het
Sorcs3 G A 19: 48,692,808 (GRCm39) probably null Het
Spdye4a T A 5: 143,211,562 (GRCm39) M1L probably benign Het
Stag1 T C 9: 100,639,819 (GRCm39) I125T possibly damaging Het
Stx8 T A 11: 67,911,814 (GRCm39) D177E probably benign Het
Sun2 T C 15: 79,623,125 (GRCm39) Y71C probably damaging Het
Tmed9 T C 13: 55,742,617 (GRCm39) F129L probably benign Het
Tmem216 T A 19: 10,529,336 (GRCm39) T17S probably benign Het
Tmpo A T 10: 90,997,974 (GRCm39) N604K probably benign Het
Tmprss11f T A 5: 86,681,666 (GRCm39) I196F probably benign Het
Tnks A G 8: 35,301,738 (GRCm39) F1244L probably benign Het
Tspan2 T C 3: 102,676,226 (GRCm39) C212R probably damaging Het
Tspan4 A G 7: 141,071,718 (GRCm39) D155G probably damaging Het
Ttc6 T C 12: 57,707,282 (GRCm39) F730L possibly damaging Het
Txnrd2 G A 16: 18,245,291 (GRCm39) A33T unknown Het
Wnk1 C T 6: 119,940,454 (GRCm39) R761H probably damaging Het
Zfp217 T C 2: 169,962,024 (GRCm39) D101G probably damaging Het
Zfp281 T C 1: 136,555,620 (GRCm39) F866S probably damaging Het
Other mutations in Nynrin
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01020:Nynrin APN 14 56,105,905 (GRCm39) missense probably benign 0.38
IGL01131:Nynrin APN 14 56,110,142 (GRCm39) missense probably damaging 1.00
IGL01357:Nynrin APN 14 56,107,874 (GRCm39) missense probably benign
IGL01537:Nynrin APN 14 56,109,502 (GRCm39) missense possibly damaging 0.87
IGL01583:Nynrin APN 14 56,107,968 (GRCm39) missense probably damaging 1.00
IGL01726:Nynrin APN 14 56,101,611 (GRCm39) missense probably benign
IGL02161:Nynrin APN 14 56,101,441 (GRCm39) missense probably damaging 1.00
IGL02167:Nynrin APN 14 56,100,792 (GRCm39) missense probably damaging 1.00
IGL02247:Nynrin APN 14 56,109,167 (GRCm39) nonsense probably null
IGL02302:Nynrin APN 14 56,105,962 (GRCm39) missense probably benign 0.43
IGL02524:Nynrin APN 14 56,108,931 (GRCm39) missense possibly damaging 0.73
IGL02600:Nynrin APN 14 56,101,449 (GRCm39) missense probably benign 0.38
IGL02639:Nynrin APN 14 56,108,112 (GRCm39) missense probably damaging 1.00
IGL02654:Nynrin APN 14 56,100,716 (GRCm39) missense possibly damaging 0.95
IGL02659:Nynrin APN 14 56,103,554 (GRCm39) unclassified probably benign
IGL02736:Nynrin APN 14 56,108,366 (GRCm39) missense probably damaging 1.00
IGL02949:Nynrin APN 14 56,109,837 (GRCm39) missense probably damaging 0.99
PIT4458001:Nynrin UTSW 14 56,101,425 (GRCm39) missense probably benign 0.39
R0017:Nynrin UTSW 14 56,109,852 (GRCm39) missense probably damaging 1.00
R0078:Nynrin UTSW 14 56,100,789 (GRCm39) missense probably damaging 1.00
R0211:Nynrin UTSW 14 56,109,255 (GRCm39) missense probably benign 0.08
R0211:Nynrin UTSW 14 56,109,255 (GRCm39) missense probably benign 0.08
R0413:Nynrin UTSW 14 56,109,648 (GRCm39) missense possibly damaging 0.90
R0609:Nynrin UTSW 14 56,110,218 (GRCm39) missense probably damaging 1.00
R0626:Nynrin UTSW 14 56,105,492 (GRCm39) missense probably damaging 1.00
R1205:Nynrin UTSW 14 56,091,646 (GRCm39) intron probably benign
R1222:Nynrin UTSW 14 56,100,998 (GRCm39) missense probably benign 0.02
R1385:Nynrin UTSW 14 56,102,356 (GRCm39) missense probably benign 0.00
R1820:Nynrin UTSW 14 56,107,835 (GRCm39) missense possibly damaging 0.95
R1829:Nynrin UTSW 14 56,110,404 (GRCm39) missense possibly damaging 0.50
R1874:Nynrin UTSW 14 56,100,950 (GRCm39) missense probably benign 0.04
R1927:Nynrin UTSW 14 56,101,049 (GRCm39) missense probably benign 0.00
R2233:Nynrin UTSW 14 56,109,524 (GRCm39) missense possibly damaging 0.83
R3018:Nynrin UTSW 14 56,100,867 (GRCm39) missense probably benign 0.00
R3154:Nynrin UTSW 14 56,101,044 (GRCm39) missense possibly damaging 0.46
R3853:Nynrin UTSW 14 56,101,562 (GRCm39) missense probably benign 0.24
R4648:Nynrin UTSW 14 56,110,351 (GRCm39) nonsense probably null
R4722:Nynrin UTSW 14 56,091,852 (GRCm39) missense probably damaging 0.97
R4735:Nynrin UTSW 14 56,107,625 (GRCm39) missense probably benign 0.03
R4736:Nynrin UTSW 14 56,101,454 (GRCm39) missense probably damaging 1.00
R4780:Nynrin UTSW 14 56,100,720 (GRCm39) missense probably damaging 1.00
R4804:Nynrin UTSW 14 56,102,326 (GRCm39) missense probably benign
R4816:Nynrin UTSW 14 56,109,458 (GRCm39) missense probably damaging 1.00
R5307:Nynrin UTSW 14 56,101,263 (GRCm39) missense probably damaging 1.00
R5372:Nynrin UTSW 14 56,105,948 (GRCm39) missense probably benign 0.01
R5432:Nynrin UTSW 14 56,101,923 (GRCm39) missense possibly damaging 0.80
R5800:Nynrin UTSW 14 56,108,088 (GRCm39) missense probably damaging 1.00
R5825:Nynrin UTSW 14 56,101,683 (GRCm39) missense probably benign 0.00
R6149:Nynrin UTSW 14 56,091,780 (GRCm39) missense possibly damaging 0.83
R6244:Nynrin UTSW 14 56,105,485 (GRCm39) missense probably damaging 1.00
R6350:Nynrin UTSW 14 56,105,533 (GRCm39) missense probably benign 0.19
R6379:Nynrin UTSW 14 56,107,848 (GRCm39) missense probably damaging 1.00
R6437:Nynrin UTSW 14 56,109,227 (GRCm39) missense probably benign 0.00
R6501:Nynrin UTSW 14 56,100,989 (GRCm39) missense probably benign
R6702:Nynrin UTSW 14 56,101,935 (GRCm39) missense possibly damaging 0.80
R6703:Nynrin UTSW 14 56,101,935 (GRCm39) missense possibly damaging 0.80
R6907:Nynrin UTSW 14 56,101,335 (GRCm39) missense probably benign 0.20
R6908:Nynrin UTSW 14 56,101,335 (GRCm39) missense probably benign 0.20
R6928:Nynrin UTSW 14 56,101,335 (GRCm39) missense probably benign 0.20
R6934:Nynrin UTSW 14 56,101,335 (GRCm39) missense probably benign 0.20
R6935:Nynrin UTSW 14 56,101,335 (GRCm39) missense probably benign 0.20
R7197:Nynrin UTSW 14 56,109,380 (GRCm39) missense probably benign 0.00
R7204:Nynrin UTSW 14 56,110,190 (GRCm39) missense probably damaging 1.00
R7272:Nynrin UTSW 14 56,107,872 (GRCm39) missense probably damaging 1.00
R7335:Nynrin UTSW 14 56,101,371 (GRCm39) missense probably benign
R7361:Nynrin UTSW 14 56,107,857 (GRCm39) missense possibly damaging 0.71
R7368:Nynrin UTSW 14 56,107,968 (GRCm39) missense probably damaging 1.00
R7443:Nynrin UTSW 14 56,108,873 (GRCm39) missense probably benign 0.18
R7584:Nynrin UTSW 14 56,109,041 (GRCm39) missense probably damaging 1.00
R7677:Nynrin UTSW 14 56,107,693 (GRCm39) missense probably benign
R7723:Nynrin UTSW 14 56,109,502 (GRCm39) missense possibly damaging 0.87
R7776:Nynrin UTSW 14 56,103,420 (GRCm39) missense probably damaging 1.00
R7787:Nynrin UTSW 14 56,107,980 (GRCm39) missense probably benign
R7842:Nynrin UTSW 14 56,102,553 (GRCm39) missense probably damaging 1.00
R7852:Nynrin UTSW 14 56,108,886 (GRCm39) missense probably damaging 0.96
R8040:Nynrin UTSW 14 56,108,982 (GRCm39) missense probably benign 0.01
R8159:Nynrin UTSW 14 56,102,517 (GRCm39) missense probably benign
R8159:Nynrin UTSW 14 56,100,587 (GRCm39) missense probably damaging 0.99
R8258:Nynrin UTSW 14 56,100,815 (GRCm39) missense possibly damaging 0.95
R8259:Nynrin UTSW 14 56,100,815 (GRCm39) missense possibly damaging 0.95
R8504:Nynrin UTSW 14 56,107,703 (GRCm39) missense probably benign 0.01
R8671:Nynrin UTSW 14 56,107,899 (GRCm39) missense possibly damaging 0.52
R8691:Nynrin UTSW 14 56,110,106 (GRCm39) missense probably damaging 1.00
R8777:Nynrin UTSW 14 56,109,120 (GRCm39) missense probably benign
R8777-TAIL:Nynrin UTSW 14 56,109,120 (GRCm39) missense probably benign
R9041:Nynrin UTSW 14 56,108,753 (GRCm39) missense possibly damaging 0.83
R9346:Nynrin UTSW 14 56,100,495 (GRCm39) missense probably benign 0.01
R9366:Nynrin UTSW 14 56,100,587 (GRCm39) missense probably damaging 0.99
R9690:Nynrin UTSW 14 56,108,204 (GRCm39) missense probably benign 0.00
RF007:Nynrin UTSW 14 56,103,658 (GRCm39) splice site probably null
Predicted Primers PCR Primer
(F):5'- AGCTAGCACGGTAAGTACTGG -3'
(R):5'- CAGTTCATTGATCTTCCAGAAGG -3'

Sequencing Primer
(F):5'- CTAGCACGGTAAGTACTGGAAAAG -3'
(R):5'- TGGCAGCAATGGTCCCTG -3'
Posted On 2020-09-02