Incidental Mutation 'R8344:Or4c11c'
ID 645063
Institutional Source Beutler Lab
Gene Symbol Or4c11c
Ensembl Gene ENSMUSG00000057447
Gene Name olfactory receptor family 4 subfamily C member 11C
Synonyms GA_x6K02T2Q125-50336588-50337313, MOR230-1, MOR230-3, Olfr1205, GA_x6K02T2Q125-50304328-50305251, Olfr1203
Accession Numbers
Essential gene? Probably non essential (E-score: 0.050) question?
Stock # R8344 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 88660101-88662386 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 88661727 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 89 (I89V)
Ref Sequence ENSEMBL: ENSMUSP00000150206 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076438] [ENSMUST00000215929]
AlphaFold A2ATJ7
Predicted Effect probably benign
Transcript: ENSMUST00000076438
AA Change: I89V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000075769
Gene: ENSMUSG00000057447
AA Change: I89V

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 5e-45 PFAM
Pfam:7tm_1 39 285 9.1e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215929
AA Change: I89V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A1cf A T 19: 31,888,519 (GRCm39) Y83F possibly damaging Het
Adgre1 C G 17: 57,715,459 (GRCm39) Q260E probably benign Het
Adgrf4 T A 17: 42,977,799 (GRCm39) M515L probably benign Het
Adgrl2 A T 3: 148,565,161 (GRCm39) C140S probably damaging Het
Ago3 T A 4: 126,270,721 (GRCm39) K258* probably null Het
Ampd1 A T 3: 103,003,002 (GRCm39) E573V possibly damaging Het
Atxn7l3b T A 10: 112,764,567 (GRCm39) I21F possibly damaging Het
Bckdha C T 7: 25,330,872 (GRCm39) R298H probably damaging Het
Cacng3 A C 7: 122,367,569 (GRCm39) I150L possibly damaging Het
Ccdc18 A T 5: 108,309,369 (GRCm39) K321N possibly damaging Het
Ccl11 A T 11: 81,952,568 (GRCm39) K47M possibly damaging Het
Cdkn2a T C 4: 89,194,987 (GRCm39) I142M probably benign Het
Cfap65 C T 1: 74,967,203 (GRCm39) G249R probably benign Het
Chrna1 C A 2: 73,400,953 (GRCm39) E192D probably benign Het
Clasp1 A G 1: 118,431,629 (GRCm39) N420D probably damaging Het
Clca3a2 T A 3: 144,511,703 (GRCm39) probably null Het
Cntn2 T C 1: 132,449,512 (GRCm39) Y643C probably damaging Het
Dcun1d1 G A 3: 35,951,703 (GRCm39) H204Y probably benign Het
Dlg2 A T 7: 92,087,222 (GRCm39) Q767L possibly damaging Het
Dnah11 A G 12: 118,049,466 (GRCm39) S1653P probably benign Het
Dvl3 T A 16: 20,342,513 (GRCm39) probably null Het
Egf T C 3: 129,548,592 (GRCm39) T8A unknown Het
Eln G T 5: 134,757,246 (GRCm39) T219K unknown Het
Evc T C 5: 37,471,872 (GRCm39) D536G possibly damaging Het
Fbxo3 A G 2: 103,881,553 (GRCm39) E295G possibly damaging Het
Gp2 C T 7: 119,042,010 (GRCm39) C505Y probably benign Het
Gpr37 A G 6: 25,669,530 (GRCm39) F438S probably damaging Het
Gsk3b T C 16: 38,011,987 (GRCm39) S236P probably benign Het
Kdm5d A G Y: 942,477 (GRCm39) T1381A probably benign Het
Klhl12 T C 1: 134,413,460 (GRCm39) I315T possibly damaging Het
Ltb T A 17: 35,414,169 (GRCm39) N102K probably benign Het
Macf1 T C 4: 123,420,649 (GRCm39) T202A probably benign Het
Macf1 C A 4: 123,278,476 (GRCm39) D5993Y probably damaging Het
Mak T A 13: 41,199,679 (GRCm39) D320V probably benign Het
Map2 G A 1: 66,460,872 (GRCm39) R1556H probably damaging Het
Mgat4d G T 8: 84,094,762 (GRCm39) M266I probably benign Het
Mmp24 G T 2: 155,652,223 (GRCm39) R310S possibly damaging Het
Myh6 A T 14: 55,190,891 (GRCm39) L928Q probably damaging Het
Npnt A G 3: 132,614,217 (GRCm39) L179P probably damaging Het
Or2f1b A G 6: 42,739,499 (GRCm39) N171S probably benign Het
Or8g55 T G 9: 39,785,231 (GRCm39) F220C probably benign Het
Parp4 A T 14: 56,886,186 (GRCm39) Y1755F unknown Het
Phactr1 A G 13: 42,863,297 (GRCm39) E74G possibly damaging Het
Pira12 T A 7: 3,899,954 (GRCm39) E216V possibly damaging Het
Plcg1 G A 2: 160,589,816 (GRCm39) M113I probably benign Het
Plekhh2 T G 17: 84,879,189 (GRCm39) S638A possibly damaging Het
Ppp2r3d T A 9: 101,088,985 (GRCm39) H446L probably benign Het
Prkcg G T 7: 3,378,686 (GRCm39) D644Y probably damaging Het
Rbbp8nl G T 2: 179,921,506 (GRCm39) R293S probably benign Het
Rbl2 A T 8: 91,842,387 (GRCm39) H1057L possibly damaging Het
Rpgrip1 A T 14: 52,387,819 (GRCm39) H1076L possibly damaging Het
Scn11a A C 9: 119,611,036 (GRCm39) D938E probably benign Het
Sec24b T C 3: 129,798,650 (GRCm39) D573G probably damaging Het
Serpinf1 T G 11: 75,306,397 (GRCm39) Q147P unknown Het
Skint6 C T 4: 113,093,642 (GRCm39) G167D probably damaging Het
Slc15a5 A G 6: 138,056,898 (GRCm39) F6S probably damaging Het
Smc2 T A 4: 52,449,376 (GRCm39) I179K probably benign Het
Smpdl3a A G 10: 57,677,073 (GRCm39) K57R possibly damaging Het
Smpdl3b T A 4: 132,473,990 (GRCm39) H25L probably damaging Het
Srpk1 T C 17: 28,839,398 (GRCm39) D35G unknown Het
Strn A G 17: 78,980,076 (GRCm39) V324A probably damaging Het
Sult6b2 T C 6: 142,736,022 (GRCm39) K191E probably benign Het
Tmem168 A G 6: 13,583,324 (GRCm39) I519T probably benign Het
Tmem41a T C 16: 21,756,784 (GRCm39) T112A probably benign Het
Tmem67 A G 4: 12,058,576 (GRCm39) I507T probably benign Het
Tns1 T C 1: 74,024,201 (GRCm39) E454G probably damaging Het
Trim26 C A 17: 37,168,602 (GRCm39) D422E unknown Het
Triobp C A 15: 78,842,475 (GRCm39) R58S possibly damaging Het
Trp53 T C 11: 69,478,409 (GRCm39) F106S probably damaging Het
Tshz3 C A 7: 36,470,962 (GRCm39) Q984K probably damaging Het
Ttll3 A G 6: 113,371,959 (GRCm39) E73G probably damaging Het
Vmn1r194 A G 13: 22,429,247 (GRCm39) N288S probably benign Het
Other mutations in Or4c11c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00923:Or4c11c APN 2 88,661,456 (GRCm39) splice site probably null
IGL02079:Or4c11c APN 2 88,661,991 (GRCm39) missense probably damaging 1.00
IGL02183:Or4c11c APN 2 88,662,372 (GRCm39) missense probably benign
IGL02813:Or4c11c APN 2 88,661,495 (GRCm39) missense probably benign 0.34
IGL02839:Or4c11c APN 2 88,661,992 (GRCm39) missense probably damaging 1.00
IGL02895:Or4c11c APN 2 88,661,986 (GRCm39) missense probably damaging 1.00
R0680:Or4c11c UTSW 2 88,662,124 (GRCm39) missense probably benign
R2029:Or4c11c UTSW 2 88,661,749 (GRCm39) missense possibly damaging 0.88
R2095:Or4c11c UTSW 2 88,661,634 (GRCm39) missense probably damaging 1.00
R6158:Or4c11c UTSW 2 88,661,490 (GRCm39) missense probably damaging 1.00
R6216:Or4c11c UTSW 2 88,661,655 (GRCm39) missense probably damaging 1.00
R6240:Or4c11c UTSW 2 88,661,707 (GRCm39) missense probably benign 0.22
R6377:Or4c11c UTSW 2 88,661,613 (GRCm39) nonsense probably null
R6429:Or4c11c UTSW 2 88,661,869 (GRCm39) missense probably benign 0.01
R6521:Or4c11c UTSW 2 88,661,700 (GRCm39) missense probably benign 0.03
R7065:Or4c11c UTSW 2 88,661,730 (GRCm39) missense probably damaging 1.00
R7343:Or4c11c UTSW 2 88,662,190 (GRCm39) missense probably damaging 1.00
R7476:Or4c11c UTSW 2 88,661,932 (GRCm39) missense probably benign 0.07
R7570:Or4c11c UTSW 2 88,661,472 (GRCm39) missense possibly damaging 0.82
R8303:Or4c11c UTSW 2 88,661,633 (GRCm39) missense possibly damaging 0.90
R8306:Or4c11c UTSW 2 88,661,633 (GRCm39) missense possibly damaging 0.90
R8307:Or4c11c UTSW 2 88,661,633 (GRCm39) missense possibly damaging 0.90
R8308:Or4c11c UTSW 2 88,661,633 (GRCm39) missense possibly damaging 0.90
R8386:Or4c11c UTSW 2 88,661,633 (GRCm39) missense possibly damaging 0.90
R8387:Or4c11c UTSW 2 88,661,633 (GRCm39) missense possibly damaging 0.90
R8809:Or4c11c UTSW 2 88,662,256 (GRCm39) missense probably benign 0.01
R8894:Or4c11c UTSW 2 88,661,809 (GRCm39) missense probably benign 0.12
Z1176:Or4c11c UTSW 2 88,661,922 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TCCCCTGAAGCAGAAAATGG -3'
(R):5'- TGTAGAAAAGACCCTATCCAGGC -3'

Sequencing Primer
(F):5'- CTTCTTAGTTTTCTATATGGGGACTG -3'
(R):5'- GGCAACTATAATCAAGATGACACAG -3'
Posted On 2020-09-02