Incidental Mutation 'R8347:Vmn2r69'
ID |
645299 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r69
|
Ensembl Gene |
ENSMUSG00000091006 |
Gene Name |
vomeronasal 2, receptor 69 |
Synonyms |
|
MMRRC Submission |
067867-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.088)
|
Stock # |
R8347 (G1)
|
Quality Score |
225.009 |
Status
|
Not validated
|
Chromosome |
7 |
Chromosomal Location |
85055584-85064884 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to T
at 85064838 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Methionine to Lysine
at position 16
(M16K)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000132726
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000171213]
|
AlphaFold |
G3XA45 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000171213
AA Change: M16K
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
SMART Domains |
Protein: ENSMUSP00000132726 Gene: ENSMUSG00000091006 AA Change: M16K
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
77 |
465 |
1.3e-28 |
PFAM |
Pfam:NCD3G
|
507 |
559 |
1.8e-20 |
PFAM |
Pfam:7tm_3
|
592 |
827 |
3.2e-54 |
PFAM |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 98.9%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 69 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
1700123K08Rik |
T |
A |
5: 138,561,153 (GRCm39) |
I170L |
probably benign |
Het |
Adamts15 |
C |
T |
9: 30,813,846 (GRCm39) |
R773Q |
probably benign |
Het |
Ankib1 |
A |
G |
5: 3,797,065 (GRCm39) |
L249P |
probably damaging |
Het |
Cabin1 |
A |
G |
10: 75,578,201 (GRCm39) |
F499L |
probably damaging |
Het |
Cdhr17 |
G |
A |
5: 17,006,572 (GRCm39) |
M96I |
probably benign |
Het |
Clec12b |
C |
T |
6: 129,357,450 (GRCm39) |
|
probably null |
Het |
Col23a1 |
G |
A |
11: 51,462,083 (GRCm39) |
G373D |
probably damaging |
Het |
Cse1l |
C |
T |
2: 166,769,505 (GRCm39) |
T304I |
possibly damaging |
Het |
D6Wsu163e |
T |
A |
6: 126,932,251 (GRCm39) |
L330* |
probably null |
Het |
Dbi |
A |
C |
1: 120,048,550 (GRCm39) |
L32R |
possibly damaging |
Het |
Dennd2c |
A |
G |
3: 103,065,025 (GRCm39) |
Y716C |
probably damaging |
Het |
Dnah5 |
G |
A |
15: 28,236,812 (GRCm39) |
M379I |
possibly damaging |
Het |
Dpys |
T |
C |
15: 39,720,709 (GRCm39) |
D17G |
probably benign |
Het |
Dync2h1 |
C |
T |
9: 7,116,578 (GRCm39) |
S2319N |
possibly damaging |
Het |
Dyrk2 |
T |
C |
10: 118,695,888 (GRCm39) |
K457E |
probably damaging |
Het |
Efs |
A |
G |
14: 55,157,241 (GRCm39) |
C357R |
probably benign |
Het |
Egfr |
T |
A |
11: 16,828,174 (GRCm39) |
W516R |
probably damaging |
Het |
Folh1 |
T |
A |
7: 86,378,326 (GRCm39) |
R529* |
probably null |
Het |
Fsip2 |
A |
C |
2: 82,818,198 (GRCm39) |
I4644L |
probably benign |
Het |
Garnl3 |
T |
C |
2: 32,975,903 (GRCm39) |
Y66C |
probably damaging |
Het |
Gli3 |
T |
C |
13: 15,898,110 (GRCm39) |
L730P |
probably damaging |
Het |
Gm19668 |
T |
C |
10: 77,634,221 (GRCm39) |
*249W |
probably null |
Het |
Ighv2-6-8 |
T |
C |
12: 113,759,947 (GRCm39) |
D54G |
probably benign |
Het |
Irs2 |
C |
A |
8: 11,058,000 (GRCm39) |
S144I |
possibly damaging |
Het |
Itgb5 |
T |
C |
16: 33,761,048 (GRCm39) |
C628R |
probably damaging |
Het |
Kcnh4 |
A |
T |
11: 100,648,575 (GRCm39) |
V43D |
probably damaging |
Het |
Krtap16-3 |
A |
T |
16: 88,759,507 (GRCm39) |
Y69N |
unknown |
Het |
Lcn12 |
A |
C |
2: 25,382,045 (GRCm39) |
D176E |
possibly damaging |
Het |
Lilrb4b |
T |
A |
10: 51,357,850 (GRCm39) |
F181L |
probably damaging |
Het |
Med13l |
T |
A |
5: 118,880,662 (GRCm39) |
H1251Q |
probably benign |
Het |
Nppb |
C |
A |
4: 148,070,756 (GRCm39) |
L44M |
probably damaging |
Het |
Nutm2 |
T |
C |
13: 50,626,373 (GRCm39) |
V320A |
probably benign |
Het |
Or4b1b |
A |
T |
2: 90,112,020 (GRCm39) |
W300R |
probably benign |
Het |
Or52a24 |
A |
G |
7: 103,381,150 (GRCm39) |
S6G |
probably benign |
Het |
Or5ae2 |
C |
T |
7: 84,505,963 (GRCm39) |
P131S |
probably damaging |
Het |
Or5ak4 |
T |
A |
2: 85,162,047 (GRCm39) |
H65L |
probably damaging |
Het |
Padi6 |
T |
C |
4: 140,462,719 (GRCm39) |
M301V |
probably benign |
Het |
Pappa |
G |
A |
4: 65,245,302 (GRCm39) |
R1530Q |
probably damaging |
Het |
Pcgf6 |
C |
T |
19: 47,034,277 (GRCm39) |
D255N |
possibly damaging |
Het |
Pgap3 |
TCAGCAGCAGCAGCAGCAG |
TCAGCAGCAGCAGCAG |
11: 98,281,575 (GRCm39) |
|
probably benign |
Het |
Phip |
A |
G |
9: 82,790,816 (GRCm39) |
I710T |
probably benign |
Het |
Pla2r1 |
A |
T |
2: 60,365,247 (GRCm39) |
Y108N |
probably damaging |
Het |
Plat |
G |
T |
8: 23,262,248 (GRCm39) |
G91W |
probably damaging |
Het |
Rint1 |
C |
G |
5: 24,016,770 (GRCm39) |
L512V |
probably damaging |
Het |
Sdad1 |
A |
C |
5: 92,446,088 (GRCm39) |
F282L |
probably benign |
Het |
Sirt5 |
G |
T |
13: 43,533,977 (GRCm39) |
A189S |
probably benign |
Het |
Slc14a1 |
T |
C |
18: 78,154,646 (GRCm39) |
T247A |
probably benign |
Het |
Slc22a6 |
C |
G |
19: 8,599,169 (GRCm39) |
R267G |
probably damaging |
Het |
Slfn3 |
A |
G |
11: 83,104,415 (GRCm39) |
K429E |
possibly damaging |
Het |
Spag17 |
T |
C |
3: 99,934,957 (GRCm39) |
F721S |
probably benign |
Het |
Spata31d1e |
T |
A |
13: 59,890,050 (GRCm39) |
D590V |
possibly damaging |
Het |
St3gal1 |
G |
A |
15: 66,985,511 (GRCm39) |
R48C |
probably damaging |
Het |
Sult2a6 |
A |
G |
7: 13,959,883 (GRCm39) |
Y217H |
probably benign |
Het |
Synj2 |
A |
G |
17: 6,060,060 (GRCm39) |
N394S |
probably damaging |
Het |
Telo2 |
A |
T |
17: 25,323,611 (GRCm39) |
Y605* |
probably null |
Het |
Trank1 |
T |
A |
9: 111,196,317 (GRCm39) |
L1447Q |
probably damaging |
Het |
Trim56 |
A |
G |
5: 137,141,446 (GRCm39) |
L690P |
probably damaging |
Het |
Trmt13 |
T |
C |
3: 116,376,417 (GRCm39) |
T325A |
probably benign |
Het |
Ttn |
T |
A |
2: 76,539,811 (GRCm39) |
T34392S |
probably benign |
Het |
Uncx |
A |
G |
5: 139,532,571 (GRCm39) |
E212G |
probably damaging |
Het |
Ush2a |
A |
G |
1: 188,679,281 (GRCm39) |
T4830A |
probably benign |
Het |
Usp34 |
C |
A |
11: 23,362,345 (GRCm39) |
T1616N |
|
Het |
Vars1 |
C |
T |
17: 35,234,953 (GRCm39) |
L1261F |
possibly damaging |
Het |
Vmn1r223 |
T |
C |
13: 23,434,020 (GRCm39) |
S205P |
probably damaging |
Het |
Vmn2r118 |
A |
T |
17: 55,917,423 (GRCm39) |
I363K |
possibly damaging |
Het |
Wdr62 |
G |
A |
7: 29,962,128 (GRCm39) |
T428I |
possibly damaging |
Het |
Yeats4 |
A |
T |
10: 117,053,374 (GRCm39) |
L129Q |
probably benign |
Het |
Zfp423 |
T |
C |
8: 88,509,784 (GRCm39) |
R187G |
probably damaging |
Het |
Zfp853 |
A |
T |
5: 143,274,702 (GRCm39) |
L321Q |
unknown |
Het |
|
Other mutations in Vmn2r69 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01019:Vmn2r69
|
APN |
7 |
85,055,739 (GRCm39) |
missense |
probably benign |
|
IGL01457:Vmn2r69
|
APN |
7 |
85,055,836 (GRCm39) |
missense |
possibly damaging |
0.87 |
IGL01760:Vmn2r69
|
APN |
7 |
85,056,072 (GRCm39) |
missense |
possibly damaging |
0.90 |
IGL01834:Vmn2r69
|
APN |
7 |
85,061,576 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02001:Vmn2r69
|
APN |
7 |
85,056,434 (GRCm39) |
missense |
probably benign |
0.05 |
IGL02057:Vmn2r69
|
APN |
7 |
85,060,990 (GRCm39) |
missense |
possibly damaging |
0.93 |
IGL02289:Vmn2r69
|
APN |
7 |
85,056,054 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02472:Vmn2r69
|
APN |
7 |
85,058,960 (GRCm39) |
missense |
probably benign |
0.01 |
IGL02478:Vmn2r69
|
APN |
7 |
85,055,889 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02554:Vmn2r69
|
APN |
7 |
85,059,014 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02723:Vmn2r69
|
APN |
7 |
85,059,416 (GRCm39) |
missense |
probably damaging |
1.00 |
R0526:Vmn2r69
|
UTSW |
7 |
85,060,711 (GRCm39) |
missense |
probably damaging |
1.00 |
R0560:Vmn2r69
|
UTSW |
7 |
85,058,922 (GRCm39) |
critical splice donor site |
probably null |
|
R0909:Vmn2r69
|
UTSW |
7 |
85,055,873 (GRCm39) |
missense |
probably benign |
0.00 |
R0976:Vmn2r69
|
UTSW |
7 |
85,056,108 (GRCm39) |
missense |
probably damaging |
1.00 |
R1158:Vmn2r69
|
UTSW |
7 |
85,059,058 (GRCm39) |
splice site |
probably benign |
|
R1459:Vmn2r69
|
UTSW |
7 |
85,055,908 (GRCm39) |
nonsense |
probably null |
|
R1482:Vmn2r69
|
UTSW |
7 |
85,056,082 (GRCm39) |
missense |
probably damaging |
1.00 |
R1917:Vmn2r69
|
UTSW |
7 |
85,060,891 (GRCm39) |
missense |
probably damaging |
1.00 |
R2016:Vmn2r69
|
UTSW |
7 |
85,056,493 (GRCm39) |
missense |
probably damaging |
0.98 |
R2108:Vmn2r69
|
UTSW |
7 |
85,059,404 (GRCm39) |
missense |
probably benign |
|
R2571:Vmn2r69
|
UTSW |
7 |
85,064,764 (GRCm39) |
missense |
probably benign |
|
R2910:Vmn2r69
|
UTSW |
7 |
85,055,918 (GRCm39) |
missense |
probably damaging |
1.00 |
R2920:Vmn2r69
|
UTSW |
7 |
85,060,973 (GRCm39) |
missense |
probably benign |
0.08 |
R3708:Vmn2r69
|
UTSW |
7 |
85,061,029 (GRCm39) |
missense |
probably damaging |
0.98 |
R3710:Vmn2r69
|
UTSW |
7 |
85,055,601 (GRCm39) |
missense |
probably benign |
|
R4757:Vmn2r69
|
UTSW |
7 |
85,061,575 (GRCm39) |
missense |
probably damaging |
0.99 |
R4823:Vmn2r69
|
UTSW |
7 |
85,060,508 (GRCm39) |
missense |
probably benign |
0.21 |
R4870:Vmn2r69
|
UTSW |
7 |
85,060,793 (GRCm39) |
missense |
possibly damaging |
0.93 |
R4918:Vmn2r69
|
UTSW |
7 |
85,055,967 (GRCm39) |
missense |
probably benign |
0.06 |
R5022:Vmn2r69
|
UTSW |
7 |
85,060,367 (GRCm39) |
missense |
possibly damaging |
0.72 |
R5174:Vmn2r69
|
UTSW |
7 |
85,064,739 (GRCm39) |
missense |
possibly damaging |
0.92 |
R5200:Vmn2r69
|
UTSW |
7 |
85,055,717 (GRCm39) |
missense |
probably damaging |
1.00 |
R5278:Vmn2r69
|
UTSW |
7 |
85,060,991 (GRCm39) |
missense |
probably benign |
0.02 |
R5643:Vmn2r69
|
UTSW |
7 |
85,056,404 (GRCm39) |
missense |
probably damaging |
0.98 |
R5996:Vmn2r69
|
UTSW |
7 |
85,061,117 (GRCm39) |
splice site |
probably null |
|
R6083:Vmn2r69
|
UTSW |
7 |
85,055,711 (GRCm39) |
missense |
probably damaging |
1.00 |
R6140:Vmn2r69
|
UTSW |
7 |
85,060,657 (GRCm39) |
missense |
probably damaging |
0.99 |
R6306:Vmn2r69
|
UTSW |
7 |
85,064,799 (GRCm39) |
missense |
probably benign |
0.04 |
R6330:Vmn2r69
|
UTSW |
7 |
85,060,835 (GRCm39) |
missense |
probably benign |
|
R6380:Vmn2r69
|
UTSW |
7 |
85,061,067 (GRCm39) |
missense |
probably benign |
|
R6466:Vmn2r69
|
UTSW |
7 |
85,056,378 (GRCm39) |
missense |
probably benign |
0.01 |
R6542:Vmn2r69
|
UTSW |
7 |
85,060,413 (GRCm39) |
nonsense |
probably null |
|
R6583:Vmn2r69
|
UTSW |
7 |
85,059,017 (GRCm39) |
missense |
probably benign |
|
R6623:Vmn2r69
|
UTSW |
7 |
85,056,309 (GRCm39) |
missense |
possibly damaging |
0.84 |
R6709:Vmn2r69
|
UTSW |
7 |
85,061,069 (GRCm39) |
missense |
probably benign |
0.03 |
R6732:Vmn2r69
|
UTSW |
7 |
85,060,351 (GRCm39) |
missense |
probably benign |
0.00 |
R6741:Vmn2r69
|
UTSW |
7 |
85,061,724 (GRCm39) |
missense |
probably benign |
0.01 |
R7070:Vmn2r69
|
UTSW |
7 |
85,060,688 (GRCm39) |
missense |
probably damaging |
0.98 |
R7234:Vmn2r69
|
UTSW |
7 |
85,056,315 (GRCm39) |
missense |
probably benign |
0.22 |
R7323:Vmn2r69
|
UTSW |
7 |
85,060,972 (GRCm39) |
missense |
possibly damaging |
0.95 |
R7427:Vmn2r69
|
UTSW |
7 |
85,060,467 (GRCm39) |
missense |
probably benign |
0.28 |
R7428:Vmn2r69
|
UTSW |
7 |
85,060,467 (GRCm39) |
missense |
probably benign |
0.28 |
R7453:Vmn2r69
|
UTSW |
7 |
85,060,768 (GRCm39) |
frame shift |
probably null |
|
R7532:Vmn2r69
|
UTSW |
7 |
85,059,622 (GRCm39) |
missense |
probably benign |
0.36 |
R7556:Vmn2r69
|
UTSW |
7 |
85,060,768 (GRCm39) |
frame shift |
probably null |
|
R7562:Vmn2r69
|
UTSW |
7 |
85,056,420 (GRCm39) |
missense |
probably benign |
|
R7592:Vmn2r69
|
UTSW |
7 |
85,060,768 (GRCm39) |
frame shift |
probably null |
|
R7708:Vmn2r69
|
UTSW |
7 |
85,061,755 (GRCm39) |
missense |
possibly damaging |
0.87 |
R7803:Vmn2r69
|
UTSW |
7 |
85,056,324 (GRCm39) |
missense |
probably benign |
0.00 |
R7960:Vmn2r69
|
UTSW |
7 |
85,055,973 (GRCm39) |
missense |
probably benign |
|
R7966:Vmn2r69
|
UTSW |
7 |
85,060,762 (GRCm39) |
missense |
possibly damaging |
0.81 |
R8071:Vmn2r69
|
UTSW |
7 |
85,055,713 (GRCm39) |
nonsense |
probably null |
|
R8237:Vmn2r69
|
UTSW |
7 |
85,060,340 (GRCm39) |
missense |
probably benign |
0.02 |
R8737:Vmn2r69
|
UTSW |
7 |
85,055,783 (GRCm39) |
missense |
probably damaging |
1.00 |
R8795:Vmn2r69
|
UTSW |
7 |
85,064,883 (GRCm39) |
start codon destroyed |
probably null |
0.94 |
R8831:Vmn2r69
|
UTSW |
7 |
85,059,018 (GRCm39) |
nonsense |
probably null |
|
R8856:Vmn2r69
|
UTSW |
7 |
85,061,663 (GRCm39) |
missense |
probably benign |
0.00 |
R8998:Vmn2r69
|
UTSW |
7 |
85,060,307 (GRCm39) |
missense |
probably benign |
0.33 |
R8999:Vmn2r69
|
UTSW |
7 |
85,060,307 (GRCm39) |
missense |
probably benign |
0.33 |
R9161:Vmn2r69
|
UTSW |
7 |
85,056,177 (GRCm39) |
missense |
possibly damaging |
0.88 |
R9228:Vmn2r69
|
UTSW |
7 |
85,064,697 (GRCm39) |
missense |
probably benign |
0.01 |
R9494:Vmn2r69
|
UTSW |
7 |
85,060,768 (GRCm39) |
missense |
probably damaging |
1.00 |
R9494:Vmn2r69
|
UTSW |
7 |
85,056,084 (GRCm39) |
missense |
probably benign |
0.08 |
R9541:Vmn2r69
|
UTSW |
7 |
85,056,209 (GRCm39) |
missense |
probably benign |
|
R9620:Vmn2r69
|
UTSW |
7 |
85,061,504 (GRCm39) |
missense |
probably benign |
0.10 |
Z1176:Vmn2r69
|
UTSW |
7 |
85,055,696 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- ATGGTCTACATCCCAGCATTTC -3'
(R):5'- TCCAGAGGCAAACGTAGAAC -3'
Sequencing Primer
(F):5'- GTCTACATCCCAGCATTTCTAGAATG -3'
(R):5'- CATTTGTCCTTTAGTAGTGAGTACAG -3'
|
Posted On |
2020-09-02 |