Incidental Mutation 'R8349:Morc2b'
ID 645441
Institutional Source Beutler Lab
Gene Symbol Morc2b
Ensembl Gene ENSMUSG00000048602
Gene Name microrchidia 2B
Synonyms 4932411A10Rik
MMRRC Submission 067803-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.274) question?
Stock # R8349 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 33354562-33369473 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 33355775 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Lysine at position 666 (E666K)
Ref Sequence ENSEMBL: ENSMUSP00000056879 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053896] [ENSMUST00000131954]
AlphaFold Q8C5W4
Predicted Effect probably benign
Transcript: ENSMUST00000053896
AA Change: E666K

PolyPhen 2 Score 0.131 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000056879
Gene: ENSMUSG00000048602
AA Change: E666K

DomainStartEndE-ValueType
HATPase_c 24 134 5.78e0 SMART
coiled coil region 285 321 N/A INTRINSIC
Pfam:zf-CW 495 541 1.9e-16 PFAM
coiled coil region 555 584 N/A INTRINSIC
low complexity region 680 695 N/A INTRINSIC
coiled coil region 961 1001 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000131954
AA Change: E666K

PolyPhen 2 Score 0.131 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000123354
Gene: ENSMUSG00000048602
AA Change: E666K

DomainStartEndE-ValueType
HATPase_c 24 134 5.78e0 SMART
coiled coil region 285 321 N/A INTRINSIC
Pfam:zf-CW 494 543 7.7e-18 PFAM
coiled coil region 555 584 N/A INTRINSIC
low complexity region 680 695 N/A INTRINSIC
coiled coil region 961 1001 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a null mutation display male and female infertility with failure of chromosomal synapsis, double strand break repair, and recombination in meiosis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ace3 A G 11: 105,885,768 (GRCm39) E58G probably damaging Het
Ank1 T A 8: 23,629,302 (GRCm39) F4I possibly damaging Het
Arih2 T C 9: 108,488,872 (GRCm39) D282G possibly damaging Het
Atp7b C T 8: 22,503,556 (GRCm39) V733I probably damaging Het
Avil A G 10: 126,845,861 (GRCm39) D370G probably benign Het
Ccdc88b T C 19: 6,833,213 (GRCm39) E278G probably damaging Het
Cdkl3 A G 11: 51,975,260 (GRCm39) H74R Het
Clec9a C A 6: 129,387,292 (GRCm39) A49E probably damaging Het
Cntn5 A G 9: 9,666,840 (GRCm39) probably null Het
Cyp11b2 A G 15: 74,723,428 (GRCm39) M412T possibly damaging Het
Dhrs7l T C 12: 72,659,340 (GRCm39) N145D probably damaging Het
Dync1i1 A G 6: 5,966,815 (GRCm39) Q399R possibly damaging Het
Fam47e C A 5: 92,702,990 (GRCm39) R21S probably benign Het
Gimap4 A G 6: 48,667,694 (GRCm39) I150V probably damaging Het
Gm7361 T A 5: 26,465,387 (GRCm39) M128K possibly damaging Het
Gtf3c3 C T 1: 54,468,068 (GRCm39) E190K probably damaging Het
Hells T C 19: 38,940,286 (GRCm39) S396P probably damaging Het
Hrg T A 16: 22,780,286 (GRCm39) S521R unknown Het
Itih5 A G 2: 10,191,800 (GRCm39) T112A probably benign Het
Ly9 T A 1: 171,421,586 (GRCm39) N555I probably damaging Het
Mup8 C A 4: 60,222,382 (GRCm39) V30L probably benign Het
Nebl T A 2: 17,418,593 (GRCm39) E268D probably damaging Het
Nr4a3 G T 4: 48,052,170 (GRCm39) R308L probably benign Het
Or10k2 A T 8: 84,268,301 (GRCm39) H176L probably damaging Het
Or14j1 A G 17: 38,146,561 (GRCm39) R224G probably damaging Het
Or4c10 A T 2: 89,760,878 (GRCm39) I242L possibly damaging Het
Or6d14 G T 6: 116,534,289 (GRCm39) R301L probably damaging Het
Or8k33 T G 2: 86,383,980 (GRCm39) I163L probably benign Het
Plcd3 A G 11: 102,965,496 (GRCm39) Y530H probably damaging Het
Pou2af1 A T 9: 51,144,326 (GRCm39) E80V probably damaging Het
Scgb2b18 C T 7: 32,872,656 (GRCm39) D50N probably benign Het
Sis C T 3: 72,810,984 (GRCm39) G1679D probably damaging Het
Sorcs2 A T 5: 36,386,519 (GRCm39) M173K possibly damaging Het
Ston2 T C 12: 91,608,649 (GRCm39) D817G probably damaging Het
Ticrr T A 7: 79,344,428 (GRCm39) F1431Y probably benign Het
Uevld T A 7: 46,595,055 (GRCm39) N179I probably damaging Het
Utp6 G T 11: 79,836,610 (GRCm39) Q375K probably benign Het
Vmn2r68 T A 7: 84,882,785 (GRCm39) E322D probably damaging Het
Wnt5a A G 14: 28,235,108 (GRCm39) M51V probably benign Het
Zfp202 A T 9: 40,118,976 (GRCm39) R130* probably null Het
Zfp949 G T 9: 88,449,302 (GRCm39) V36L possibly damaging Het
Other mutations in Morc2b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01323:Morc2b APN 17 33,356,293 (GRCm39) missense possibly damaging 0.47
IGL01369:Morc2b APN 17 33,357,139 (GRCm39) missense probably benign 0.12
IGL01533:Morc2b APN 17 33,354,695 (GRCm39) utr 3 prime probably benign
IGL02003:Morc2b APN 17 33,357,298 (GRCm39) missense probably benign 0.07
IGL02028:Morc2b APN 17 33,356,387 (GRCm39) missense possibly damaging 0.78
IGL02152:Morc2b APN 17 33,356,917 (GRCm39) missense probably damaging 1.00
IGL02341:Morc2b APN 17 33,356,281 (GRCm39) missense probably damaging 1.00
IGL02976:Morc2b APN 17 33,356,497 (GRCm39) missense possibly damaging 0.90
IGL03293:Morc2b APN 17 33,357,337 (GRCm39) missense probably damaging 1.00
twinkle UTSW 17 33,354,906 (GRCm39) nonsense probably null
PIT4283001:Morc2b UTSW 17 33,355,042 (GRCm39) missense probably benign 0.00
R0056:Morc2b UTSW 17 33,357,733 (GRCm39) missense possibly damaging 0.78
R0116:Morc2b UTSW 17 33,356,015 (GRCm39) missense probably damaging 1.00
R0179:Morc2b UTSW 17 33,355,956 (GRCm39) nonsense probably null
R0533:Morc2b UTSW 17 33,354,906 (GRCm39) nonsense probably null
R0556:Morc2b UTSW 17 33,356,812 (GRCm39) missense probably benign 0.05
R0629:Morc2b UTSW 17 33,354,781 (GRCm39) missense probably benign 0.00
R0635:Morc2b UTSW 17 33,356,661 (GRCm39) missense possibly damaging 0.90
R0840:Morc2b UTSW 17 33,355,086 (GRCm39) missense probably benign 0.01
R1205:Morc2b UTSW 17 33,354,908 (GRCm39) missense probably damaging 1.00
R1566:Morc2b UTSW 17 33,355,948 (GRCm39) missense probably benign 0.02
R1676:Morc2b UTSW 17 33,354,955 (GRCm39) missense possibly damaging 0.82
R1892:Morc2b UTSW 17 33,354,748 (GRCm39) missense probably damaging 1.00
R1954:Morc2b UTSW 17 33,356,464 (GRCm39) missense probably damaging 1.00
R1955:Morc2b UTSW 17 33,356,464 (GRCm39) missense probably damaging 1.00
R1969:Morc2b UTSW 17 33,356,065 (GRCm39) missense probably benign 0.00
R2069:Morc2b UTSW 17 33,355,734 (GRCm39) missense probably benign 0.13
R3609:Morc2b UTSW 17 33,355,252 (GRCm39) missense probably damaging 1.00
R3610:Morc2b UTSW 17 33,355,252 (GRCm39) missense probably damaging 1.00
R3831:Morc2b UTSW 17 33,356,233 (GRCm39) missense probably benign 0.01
R4156:Morc2b UTSW 17 33,357,401 (GRCm39) missense probably benign 0.43
R4243:Morc2b UTSW 17 33,355,375 (GRCm39) missense probably benign 0.03
R4877:Morc2b UTSW 17 33,357,712 (GRCm39) missense probably benign 0.26
R4911:Morc2b UTSW 17 33,356,351 (GRCm39) missense probably damaging 1.00
R5230:Morc2b UTSW 17 33,355,226 (GRCm39) missense probably benign 0.00
R5264:Morc2b UTSW 17 33,357,353 (GRCm39) missense probably benign 0.03
R5326:Morc2b UTSW 17 33,355,907 (GRCm39) missense probably benign 0.01
R5455:Morc2b UTSW 17 33,357,584 (GRCm39) missense probably benign 0.29
R5933:Morc2b UTSW 17 33,357,583 (GRCm39) missense possibly damaging 0.84
R5973:Morc2b UTSW 17 33,356,446 (GRCm39) missense probably damaging 0.97
R6026:Morc2b UTSW 17 33,356,957 (GRCm39) missense possibly damaging 0.55
R6113:Morc2b UTSW 17 33,357,042 (GRCm39) nonsense probably null
R6393:Morc2b UTSW 17 33,356,750 (GRCm39) missense probably damaging 0.97
R7066:Morc2b UTSW 17 33,355,610 (GRCm39) missense probably benign 0.00
R7117:Morc2b UTSW 17 33,356,926 (GRCm39) missense probably benign 0.00
R7120:Morc2b UTSW 17 33,354,787 (GRCm39) missense probably damaging 1.00
R7130:Morc2b UTSW 17 33,355,262 (GRCm39) missense possibly damaging 0.68
R7498:Morc2b UTSW 17 33,356,833 (GRCm39) missense possibly damaging 0.55
R7516:Morc2b UTSW 17 33,356,435 (GRCm39) missense probably benign 0.03
R7664:Morc2b UTSW 17 33,355,376 (GRCm39) missense probably benign 0.12
R7754:Morc2b UTSW 17 33,356,218 (GRCm39) missense probably benign 0.33
R7756:Morc2b UTSW 17 33,355,981 (GRCm39) missense probably damaging 1.00
R7758:Morc2b UTSW 17 33,355,981 (GRCm39) missense probably damaging 1.00
R7766:Morc2b UTSW 17 33,357,397 (GRCm39) missense probably benign 0.19
R7957:Morc2b UTSW 17 33,354,747 (GRCm39) missense probably benign 0.39
R7965:Morc2b UTSW 17 33,354,746 (GRCm39) missense possibly damaging 0.91
R8164:Morc2b UTSW 17 33,357,014 (GRCm39) missense probably damaging 0.99
R8283:Morc2b UTSW 17 33,355,675 (GRCm39) missense probably benign 0.00
R8338:Morc2b UTSW 17 33,355,387 (GRCm39) missense probably benign
R8352:Morc2b UTSW 17 33,356,476 (GRCm39) missense probably damaging 1.00
R8362:Morc2b UTSW 17 33,357,295 (GRCm39) missense possibly damaging 0.91
R8364:Morc2b UTSW 17 33,357,214 (GRCm39) missense probably benign 0.01
R8449:Morc2b UTSW 17 33,355,775 (GRCm39) missense probably benign 0.13
R8452:Morc2b UTSW 17 33,356,476 (GRCm39) missense probably damaging 1.00
R8476:Morc2b UTSW 17 33,354,833 (GRCm39) missense possibly damaging 0.87
R8844:Morc2b UTSW 17 33,354,742 (GRCm39) missense probably damaging 1.00
R9277:Morc2b UTSW 17 33,354,997 (GRCm39) missense probably benign 0.10
R9571:Morc2b UTSW 17 33,355,178 (GRCm39) missense probably benign 0.00
Z1088:Morc2b UTSW 17 33,355,060 (GRCm39) missense possibly damaging 0.49
Z1177:Morc2b UTSW 17 33,356,376 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CAGGACTCCGCTTATGATCAC -3'
(R):5'- GAAGTGACTTCCAGACCTTTCTCC -3'

Sequencing Primer
(F):5'- GCTTATGATCACAAATCACCAGTG -3'
(R):5'- ATATCCTGCTCATATATTTCAGGGTC -3'
Posted On 2020-09-02