Incidental Mutation 'R8355:Lpo'
ID 645738
Institutional Source Beutler Lab
Gene Symbol Lpo
Ensembl Gene ENSMUSG00000009356
Gene Name lactoperoxidase
Synonyms 5830499B15Rik
MMRRC Submission 067869-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8355 (G1)
Quality Score 225.009
Status Not validated
Chromosome 11
Chromosomal Location 87697254-87716750 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 87705114 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Phenylalanine at position 407 (L407F)
Ref Sequence ENSEMBL: ENSMUSP00000099466 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103177] [ENSMUST00000136446]
AlphaFold Q5SW46
Predicted Effect probably damaging
Transcript: ENSMUST00000103177
AA Change: L407F

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000099466
Gene: ENSMUSG00000009356
AA Change: L407F

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Pfam:An_peroxidase 136 682 1.8e-180 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000136446
SMART Domains Protein: ENSMUSP00000117763
Gene: ENSMUSG00000009356

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
PDB:4OEK|A 116 145 4e-7 PDB
SCOP:g1cxp.1 130 145 1e-4 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.6%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the peroxidase family of proteins. The encoded preproprotein is proteolytically processed to generate the mature enzyme. Following its secretion from salivary, mammary, and other mucosal glands, this enzyme catalyzes the generation of the antimicrobial substance hypothiocyanous acid. This gene is present in a gene cluster on chromosome 17. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acp3 A G 9: 104,204,174 (GRCm39) V40A possibly damaging Het
Adgra1 T A 7: 139,455,567 (GRCm39) C398* probably null Het
Amy2a1 T A 3: 113,324,045 (GRCm39) D165V probably benign Het
Atf6b A G 17: 34,867,197 (GRCm39) D63G probably benign Het
BC024139 T C 15: 76,004,007 (GRCm39) D753G probably benign Het
Dnah3 T G 7: 119,551,431 (GRCm39) T2963P probably damaging Het
Fanci G T 7: 79,085,029 (GRCm39) L818F probably damaging Het
Gm40460 CACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG CACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG 7: 141,794,554 (GRCm39) probably benign Het
Gm4559 C A 7: 141,827,694 (GRCm39) C136F unknown Het
Gm45844 G A 7: 7,281,221 (GRCm39) probably benign Het
Kmt2c T A 5: 25,559,499 (GRCm39) probably null Het
Mus81 T C 19: 5,534,220 (GRCm39) Y366C probably damaging Het
Nipbl T C 15: 8,364,528 (GRCm39) D1292G probably damaging Het
Nox3 A G 17: 3,736,198 (GRCm39) S143P probably damaging Het
Npepps A T 11: 97,132,800 (GRCm39) I309N probably damaging Het
Nufip2 C T 11: 77,583,259 (GRCm39) T391I probably damaging Het
Or5g25 T A 2: 85,478,485 (GRCm39) Y60F probably damaging Het
Or7e177 A G 9: 20,211,715 (GRCm39) Y74C probably damaging Het
Piezo2 A T 18: 63,224,069 (GRCm39) V935E probably damaging Het
Rusc2 A G 4: 43,422,846 (GRCm39) I994M probably benign Het
Sgcz T C 8: 38,190,239 (GRCm39) I96V probably benign Het
Tmem108 A G 9: 103,377,069 (GRCm39) S127P possibly damaging Het
Tmem178b G A 6: 40,231,869 (GRCm39) V168I unknown Het
Tut1 T C 19: 8,936,626 (GRCm39) V150A probably benign Het
Txnl4a T A 18: 80,250,539 (GRCm39) L45Q probably damaging Het
V1ra8 C T 6: 90,180,447 (GRCm39) R217W probably damaging Het
Vmn2r95 A G 17: 18,660,352 (GRCm39) T255A probably benign Het
Zfp605 A G 5: 110,259,848 (GRCm39) probably benign Het
Other mutations in Lpo
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01483:Lpo APN 11 87,711,964 (GRCm39) missense probably benign 0.43
IGL01833:Lpo APN 11 87,698,159 (GRCm39) missense possibly damaging 0.81
IGL02413:Lpo APN 11 87,697,732 (GRCm39) missense possibly damaging 0.87
IGL02706:Lpo APN 11 87,708,599 (GRCm39) missense probably benign 0.02
IGL02865:Lpo APN 11 87,697,803 (GRCm39) missense possibly damaging 0.80
IGL02939:Lpo APN 11 87,706,004 (GRCm39) missense possibly damaging 0.85
R1072:Lpo UTSW 11 87,709,260 (GRCm39) missense probably damaging 1.00
R1169:Lpo UTSW 11 87,708,143 (GRCm39) missense possibly damaging 0.58
R1667:Lpo UTSW 11 87,698,067 (GRCm39) unclassified probably benign
R1719:Lpo UTSW 11 87,700,018 (GRCm39) splice site probably null
R2133:Lpo UTSW 11 87,711,956 (GRCm39) missense probably benign 0.17
R2871:Lpo UTSW 11 87,707,350 (GRCm39) missense possibly damaging 0.51
R2871:Lpo UTSW 11 87,707,350 (GRCm39) missense possibly damaging 0.51
R4382:Lpo UTSW 11 87,713,027 (GRCm39) missense probably benign 0.14
R4657:Lpo UTSW 11 87,705,173 (GRCm39) missense probably damaging 1.00
R4936:Lpo UTSW 11 87,701,166 (GRCm39) missense probably benign 0.02
R4969:Lpo UTSW 11 87,697,751 (GRCm39) missense probably benign 0.09
R5368:Lpo UTSW 11 87,711,895 (GRCm39) missense possibly damaging 0.61
R5536:Lpo UTSW 11 87,707,389 (GRCm39) missense probably damaging 1.00
R6246:Lpo UTSW 11 87,713,058 (GRCm39) missense unknown
R6556:Lpo UTSW 11 87,708,589 (GRCm39) nonsense probably null
R6817:Lpo UTSW 11 87,700,067 (GRCm39) missense probably benign
R7024:Lpo UTSW 11 87,707,269 (GRCm39) missense probably damaging 1.00
R7203:Lpo UTSW 11 87,700,077 (GRCm39) missense possibly damaging 0.75
R7206:Lpo UTSW 11 87,698,249 (GRCm39) missense probably damaging 1.00
R8455:Lpo UTSW 11 87,705,114 (GRCm39) missense probably damaging 1.00
R8693:Lpo UTSW 11 87,700,066 (GRCm39) missense probably benign 0.04
R8848:Lpo UTSW 11 87,708,603 (GRCm39) missense probably benign 0.00
R8891:Lpo UTSW 11 87,697,848 (GRCm39) missense probably benign 0.08
R8989:Lpo UTSW 11 87,708,660 (GRCm39) missense probably benign 0.00
RF010:Lpo UTSW 11 87,711,928 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CTCCCCACATTCAGAACATGGG -3'
(R):5'- ATCACCTTTCTCTGTGCAGG -3'

Sequencing Primer
(F):5'- CCACATTCAGAACATGGGGATAC -3'
(R):5'- TCTCTGTGCAGGTCTCCGG -3'
Posted On 2020-09-02