Mutagenetix > Incidental Mutation

Incidental Mutation 'R0034:Or51m1'

64587

Institutional Source

Beutler Lab

Gene Symbol

Or51m1

Ensembl Gene

ENSMUSG00000042219

Gene Name

olfactory receptor family 51 subfamily M member 1

Synonyms

Olfr631, MOR3-1, GA_x6K02T2PBJ9-6662699-6663658

MMRRC Submission

038328-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.140) question?

Stock #

R0034 (G1)

Quality Score

136

Status

Validated

Chromosome

Chromosomal Location

103578032-103578991 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 103578708 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 226 (V226A)

Ref Sequence

ENSEMBL: ENSMUSP00000102476 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000106863] [ENSMUST00000214711]

AlphaFold

F8VPJ9

Predicted Effect

probably benign
Transcript: ENSMUST00000106863
AA Change: V226A

PolyPhen 2 Score 0.042 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000102476
Gene: ENSMUSG00000042219
AA Change: V226A

Domain	Start	End	E-Value	Type
Pfam:7tm_4	32	311	2e-114	PFAM
Pfam:7TM_GPCR_Srsx	36	308	6.6e-8	PFAM
Pfam:7tm_1	42	293	4.8e-25	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000214509

Predicted Effect

probably benign
Transcript: ENSMUST00000214711

Meta Mutation Damage Score

0.1380

Coding Region Coverage

1x: 99.4%
3x: 98.9%
10x: 97.8%
20x: 96.4%

Validation Efficiency

98% (64/65)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 58 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9430038I01Rik	C	T	7: 136,989,321 (GRCm39)	R60Q	probably benign	Het
Angpt4	C	T	2: 151,771,311 (GRCm39)	T209I	probably benign	Het
Ap3b1	T	C	13: 94,616,393 (GRCm39)		probably benign	Het
Aplp1	A	C	7: 30,143,867 (GRCm39)	V56G	probably damaging	Het
Asns	G	A	6: 7,676,299 (GRCm39)	P419L	probably damaging	Het
Atxn7	A	T	14: 14,100,846 (GRCm38)	H844L	probably damaging	Het
Cd14	A	G	18: 36,859,288 (GRCm39)	Y56H	probably benign	Het
Cd300lb	C	T	11: 114,819,225 (GRCm39)	V135I	probably damaging	Het
Cep152	C	T	2: 125,425,813 (GRCm39)	A851T	probably benign	Het
Cfap74	C	T	4: 155,545,344 (GRCm39)		probably benign	Het
Col28a1	T	A	6: 8,175,708 (GRCm39)	I47L	probably benign	Het
Dnaaf9	T	C	2: 130,578,492 (GRCm39)	H664R	probably damaging	Het
Eef1d	T	C	15: 75,774,808 (GRCm39)	T200A	probably benign	Het
Exoc1l	A	G	5: 76,664,377 (GRCm39)	I155M	probably damaging	Het
Faap100	A	T	11: 120,262,973 (GRCm39)	M795K	probably benign	Het
Gabpb1	C	T	2: 126,500,454 (GRCm39)	R15Q	possibly damaging	Het
Gata4	C	A	14: 63,438,933 (GRCm39)	M381I	probably benign	Het
Gm5114	A	G	7: 39,058,282 (GRCm39)	S446P	possibly damaging	Het
Gnb1	T	A	4: 155,636,146 (GRCm39)	N155K	probably benign	Het
Haspin	G	A	11: 73,029,044 (GRCm39)	T15M	probably damaging	Het
Heatr5a	A	G	12: 51,971,955 (GRCm39)	L745P	probably damaging	Het
Kcng3	T	A	17: 83,895,812 (GRCm39)		probably benign	Het
Kif15	A	T	9: 122,828,350 (GRCm39)	N887I	possibly damaging	Het
Kif26a	T	C	12: 112,135,397 (GRCm39)		probably benign	Het
Kif9	G	A	9: 110,348,679 (GRCm39)	C738Y	probably benign	Het
Kifc2	G	T	15: 76,551,300 (GRCm39)	C613F	probably benign	Het
Klf12	A	G	14: 100,224,865 (GRCm39)		probably null	Het
Lrp1	A	T	10: 127,381,520 (GRCm39)	I3826N	probably benign	Het
Map2k4	A	G	11: 65,610,437 (GRCm39)		probably benign	Het
Myo7b	A	G	18: 32,093,913 (GRCm39)	S2006P	probably damaging	Het
Pax4	T	C	6: 28,442,448 (GRCm39)	T285A	probably benign	Het
Pcdhb5	A	G	18: 37,455,137 (GRCm39)	N506D	probably damaging	Het
Pkhd1l1	G	A	15: 44,367,405 (GRCm39)	G768S	probably benign	Het
Plb1	G	T	5: 32,430,457 (GRCm39)	G138V	probably benign	Het
Poln	A	C	5: 34,272,762 (GRCm39)	V398G	possibly damaging	Het
Poteg	A	G	8: 27,952,105 (GRCm39)		probably benign	Het
Rapgef1	C	A	2: 29,614,780 (GRCm39)		probably benign	Het
Rbm43	A	T	2: 51,815,722 (GRCm39)	D166E	probably benign	Het
Rhobtb2	T	C	14: 70,026,137 (GRCm39)	T602A	probably benign	Het
Samd3	G	A	10: 26,147,398 (GRCm39)		probably benign	Het
Sbno2	A	C	10: 79,894,174 (GRCm39)		probably benign	Het
Sec1	A	G	7: 45,328,759 (GRCm39)	V96A	probably benign	Het
Senp7	A	C	16: 55,973,933 (GRCm39)	S385R	possibly damaging	Het
Sgk3	T	C	1: 9,955,902 (GRCm39)	V301A	probably damaging	Het
Sgpl1	A	T	10: 60,938,392 (GRCm39)	M467K	probably damaging	Het
Slc22a26	A	G	19: 7,779,618 (GRCm39)	I66T	probably benign	Het
Stra6	G	A	9: 58,058,752 (GRCm39)		probably null	Het
Tfrc	T	A	16: 32,434,214 (GRCm39)		probably null	Het
Tmem30b	T	C	12: 73,592,779 (GRCm39)	Y112C	probably damaging	Het
Trap1	A	T	16: 3,886,894 (GRCm39)		probably benign	Het
Trpc1	A	G	9: 95,631,814 (GRCm39)	S43P	probably damaging	Het
Tsku	T	C	7: 98,001,870 (GRCm39)	T154A	possibly damaging	Het
Uroc1	T	C	6: 90,322,292 (GRCm39)	V272A	probably damaging	Het
Vmn1r69	T	A	7: 10,314,738 (GRCm39)		probably benign	Het
Vmn2r1	T	A	3: 63,997,435 (GRCm39)	W364R	probably damaging	Het
Wnk2	G	T	13: 49,221,556 (GRCm39)	T377K	possibly damaging	Het
Zfta	C	A	19: 7,397,724 (GRCm39)	H90Q	probably damaging	Het
Zscan20	T	C	4: 128,479,455 (GRCm39)	N1012S	probably damaging	Het

Other mutations in Or51m1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02632:Or51m1	APN	7	103,578,914 (GRCm39)	missense	possibly damaging	0.93
IGL02732:Or51m1	APN	7	103,578,336 (GRCm39)	missense	probably damaging	1.00
IGL02834:Or51m1	APN	7	103,578,601 (GRCm39)	nonsense	probably null
IGL03089:Or51m1	APN	7	103,578,329 (GRCm39)	missense	probably benign	0.01
IGL03137:Or51m1	APN	7	103,578,801 (GRCm39)	missense	probably benign
IGL03407:Or51m1	APN	7	103,578,158 (GRCm39)	missense	probably damaging	1.00
R1768:Or51m1	UTSW	7	103,578,932 (GRCm39)	nonsense	probably null
R1779:Or51m1	UTSW	7	103,578,668 (GRCm39)	missense	probably benign	0.39
R1933:Or51m1	UTSW	7	103,578,337 (GRCm39)	missense	probably damaging	0.99
R4976:Or51m1	UTSW	7	103,578,944 (GRCm39)	missense	probably benign
R5783:Or51m1	UTSW	7	103,578,149 (GRCm39)	missense	probably damaging	1.00
R5888:Or51m1	UTSW	7	103,578,239 (GRCm39)	missense	possibly damaging	0.47
R6051:Or51m1	UTSW	7	103,578,084 (GRCm39)	missense	probably damaging	0.98
R7016:Or51m1	UTSW	7	103,578,737 (GRCm39)	missense	probably benign	0.01
R7605:Or51m1	UTSW	7	103,578,075 (GRCm39)	missense	probably damaging	1.00
R8247:Or51m1	UTSW	7	103,578,783 (GRCm39)	missense	possibly damaging	0.46
R9420:Or51m1	UTSW	7	103,578,980 (GRCm39)	missense	possibly damaging	0.93
Z1176:Or51m1	UTSW	7	103,578,984 (GRCm39)	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- TGCCAAATCCAGATGTTCTGCATCC -3'
(R):5'- TGACTTGGAGGTCGAAGCTCTCAG -3'

Sequencing Primer
(F):5'- GAAGGATTTTCCCTACTGTGGACC -3'
(R):5'- TCGAAGCTCTCAGGATGCTG -3'

Posted On

2013-08-06