Incidental Mutation 'R8359:Or5p81'
ID 645916
Institutional Source Beutler Lab
Gene Symbol Or5p81
Ensembl Gene ENSMUSG00000096209
Gene Name olfactory receptor family 5 subfamily P member 81
Synonyms MOR204-34, GA_x6K02T2PBJ9-10997715-10998659, Olfr510
MMRRC Submission 067872-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.082) question?
Stock # R8359 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 108265625-108267569 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 108267518 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 298 (N298K)
Ref Sequence ENSEMBL: ENSMUSP00000149237 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076289] [ENSMUST00000213979] [ENSMUST00000216331] [ENSMUST00000217170]
AlphaFold Q8VEW6
Predicted Effect probably benign
Transcript: ENSMUST00000076289
AA Change: N298K

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000075637
Gene: ENSMUSG00000096209
AA Change: N298K

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 3e-50 PFAM
Pfam:7tm_1 44 293 4e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213979
AA Change: N298K

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000216331
AA Change: N298K

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000217170
AA Change: N298K

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (55/55)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam5 A T 8: 25,296,502 (GRCm39) V315D probably damaging Het
Adgrf1 A T 17: 43,621,286 (GRCm39) I508F probably damaging Het
Atpaf2 T C 11: 60,298,129 (GRCm39) D147G probably damaging Het
Brwd1 T C 16: 95,817,409 (GRCm39) T1368A probably damaging Het
Cacna1s A T 1: 136,043,799 (GRCm39) E1626V probably benign Het
Carm1 G A 9: 21,480,765 (GRCm39) V80I possibly damaging Het
Cenpw T A 10: 30,074,484 (GRCm39) D71V probably damaging Het
Cit T A 5: 116,122,603 (GRCm39) probably null Het
Ckmt1 A T 2: 121,193,531 (GRCm39) T364S probably benign Het
Col6a4 T C 9: 105,945,583 (GRCm39) S844G probably benign Het
Crybg1 T C 10: 43,868,538 (GRCm39) E1380G probably benign Het
Cyp21a1 A G 17: 35,021,105 (GRCm39) probably null Het
Dhodh A C 8: 110,333,038 (GRCm39) D12E probably benign Het
Dnali1 T A 4: 124,957,460 (GRCm39) T95S probably damaging Het
Dynlrb1 A G 2: 155,091,870 (GRCm39) N93D probably benign Het
Edem1 C T 6: 108,823,774 (GRCm39) A390V probably benign Het
Enthd1 T C 15: 80,358,356 (GRCm39) D388G probably benign Het
Fam170a A G 18: 50,414,677 (GRCm39) T108A probably damaging Het
Fryl A G 5: 73,233,276 (GRCm39) S1531P probably benign Het
Golm2 A T 2: 121,697,632 (GRCm39) probably benign Het
Hspbap1 C A 16: 35,645,366 (GRCm39) N350K probably benign Het
Htr3b A C 9: 48,858,596 (GRCm39) S94R probably damaging Het
Ide A T 19: 37,307,886 (GRCm39) V42E Het
Igf2r A G 17: 12,902,748 (GRCm39) V2434A probably benign Het
Katnip T C 7: 125,468,023 (GRCm39) probably null Het
Kif16b G A 2: 142,553,777 (GRCm39) A1007V probably benign Het
Mccc1 C T 3: 36,018,493 (GRCm39) V614I probably benign Het
Mos A G 4: 3,871,097 (GRCm39) Y240H probably damaging Het
Myh11 C T 16: 14,026,095 (GRCm39) probably null Het
Nexn T A 3: 151,953,998 (GRCm39) D166V probably damaging Het
Or10h1b G A 17: 33,395,895 (GRCm39) C173Y probably damaging Het
Or2t47 G T 11: 58,443,029 (GRCm39) T12N probably benign Het
Or4p4 A T 2: 88,483,332 (GRCm39) M279L probably benign Het
Pkp4 A G 2: 59,180,895 (GRCm39) Y1061C probably damaging Het
Pla2g6 T C 15: 79,171,370 (GRCm39) D740G probably damaging Het
Pla2r1 T A 2: 60,273,627 (GRCm39) I920L probably benign Het
Plekha2 A G 8: 25,578,407 (GRCm39) I31T probably damaging Het
Ppp1r16b G T 2: 158,603,295 (GRCm39) V407L probably benign Het
Prss50 A G 9: 110,691,370 (GRCm39) I225V probably damaging Het
Rmdn2 A T 17: 79,935,580 (GRCm39) E231V Het
Sema3c T C 5: 17,858,726 (GRCm39) S42P possibly damaging Het
Sh2d1b1 T A 1: 170,110,693 (GRCm39) probably null Het
Slc22a20 T C 19: 6,021,554 (GRCm39) I483V probably benign Het
Slc30a2 T C 4: 134,076,690 (GRCm39) V275A probably damaging Het
Slc6a3 T A 13: 73,693,002 (GRCm39) F207L probably benign Het
Slc9a1 A T 4: 133,147,927 (GRCm39) Q648H probably damaging Het
Slpi A T 2: 164,197,975 (GRCm39) M1K probably null Het
Smc5 A C 19: 23,211,443 (GRCm39) S564A possibly damaging Het
Smchd1 A T 17: 71,738,238 (GRCm39) F542L probably damaging Het
Sycp1 T A 3: 102,727,909 (GRCm39) K901N probably damaging Het
Synpo2l T A 14: 20,716,208 (GRCm39) T126S probably benign Het
Upp2 A G 2: 58,667,955 (GRCm39) N216S probably benign Het
Wnk1 T C 6: 119,969,408 (GRCm39) D349G probably damaging Het
Zfp180 C T 7: 23,804,337 (GRCm39) A252V probably benign Het
Zfr2 C T 10: 81,078,653 (GRCm39) T295I possibly damaging Het
Zkscan16 C T 4: 58,957,230 (GRCm39) T504I possibly damaging Het
Other mutations in Or5p81
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00909:Or5p81 APN 7 108,266,907 (GRCm39) missense possibly damaging 0.61
IGL00952:Or5p81 APN 7 108,267,445 (GRCm39) missense possibly damaging 0.89
IGL01358:Or5p81 APN 7 108,266,869 (GRCm39) missense possibly damaging 0.90
IGL01663:Or5p81 APN 7 108,267,098 (GRCm39) missense probably benign 0.01
IGL02686:Or5p81 APN 7 108,267,093 (GRCm39) missense probably benign 0.00
PIT4466001:Or5p81 UTSW 7 108,266,743 (GRCm39) missense possibly damaging 0.52
R0095:Or5p81 UTSW 7 108,267,252 (GRCm39) missense probably benign 0.00
R0095:Or5p81 UTSW 7 108,267,252 (GRCm39) missense probably benign 0.00
R0792:Or5p81 UTSW 7 108,267,364 (GRCm39) missense probably damaging 1.00
R0925:Or5p81 UTSW 7 108,267,400 (GRCm39) missense probably benign 0.00
R1829:Or5p81 UTSW 7 108,266,851 (GRCm39) missense probably benign 0.24
R2092:Or5p81 UTSW 7 108,266,869 (GRCm39) frame shift probably null
R2483:Or5p81 UTSW 7 108,266,869 (GRCm39) frame shift probably null
R3619:Or5p81 UTSW 7 108,267,057 (GRCm39) missense probably benign 0.00
R4386:Or5p81 UTSW 7 108,267,460 (GRCm39) missense probably damaging 0.99
R5298:Or5p81 UTSW 7 108,267,279 (GRCm39) missense probably benign 0.00
R5622:Or5p81 UTSW 7 108,267,289 (GRCm39) missense probably benign
R6079:Or5p81 UTSW 7 108,267,412 (GRCm39) missense probably damaging 0.97
R6138:Or5p81 UTSW 7 108,267,412 (GRCm39) missense probably damaging 0.97
R8848:Or5p81 UTSW 7 108,266,929 (GRCm39) missense probably benign 0.03
R8994:Or5p81 UTSW 7 108,267,169 (GRCm39) missense probably damaging 0.96
R9360:Or5p81 UTSW 7 108,266,977 (GRCm39) missense probably damaging 1.00
R9439:Or5p81 UTSW 7 108,266,626 (GRCm39) start codon destroyed probably null 0.97
R9641:Or5p81 UTSW 7 108,267,516 (GRCm39) missense probably damaging 0.98
U15987:Or5p81 UTSW 7 108,267,412 (GRCm39) missense probably damaging 0.97
Z1177:Or5p81 UTSW 7 108,267,043 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GACACAAGGCTTTCTCTACCTG -3'
(R):5'- CCAGGATCTTGCCAATTATACATGAC -3'

Sequencing Primer
(F):5'- GCACCTCCCACCTCACTGTAG -3'
(R):5'- TGTAACATGAAATTTGAACCCCC -3'
Posted On 2020-09-02