Incidental Mutation 'R8359:Cenpw'
ID 645925
Institutional Source Beutler Lab
Gene Symbol Cenpw
Ensembl Gene ENSMUSG00000075266
Gene Name centromere protein W
Synonyms 2610036L11Rik
MMRRC Submission 067872-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.934) question?
Stock # R8359 (G1)
Quality Score 225.009
Status Validated
Chromosome 10
Chromosomal Location 30072005-30076599 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 30074484 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Valine at position 71 (D71V)
Ref Sequence ENSEMBL: ENSMUSP00000097565 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099985] [ENSMUST00000216853]
AlphaFold Q3URR0
Predicted Effect probably damaging
Transcript: ENSMUST00000099985
AA Change: D71V

PolyPhen 2 Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000097565
Gene: ENSMUSG00000075266
AA Change: D71V

DomainStartEndE-ValueType
Pfam:CENP-W 1 86 2.4e-52 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000216853
AA Change: D71V

PolyPhen 2 Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (55/55)
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam5 A T 8: 25,296,502 (GRCm39) V315D probably damaging Het
Adgrf1 A T 17: 43,621,286 (GRCm39) I508F probably damaging Het
Atpaf2 T C 11: 60,298,129 (GRCm39) D147G probably damaging Het
Brwd1 T C 16: 95,817,409 (GRCm39) T1368A probably damaging Het
Cacna1s A T 1: 136,043,799 (GRCm39) E1626V probably benign Het
Carm1 G A 9: 21,480,765 (GRCm39) V80I possibly damaging Het
Cit T A 5: 116,122,603 (GRCm39) probably null Het
Ckmt1 A T 2: 121,193,531 (GRCm39) T364S probably benign Het
Col6a4 T C 9: 105,945,583 (GRCm39) S844G probably benign Het
Crybg1 T C 10: 43,868,538 (GRCm39) E1380G probably benign Het
Cyp21a1 A G 17: 35,021,105 (GRCm39) probably null Het
Dhodh A C 8: 110,333,038 (GRCm39) D12E probably benign Het
Dnali1 T A 4: 124,957,460 (GRCm39) T95S probably damaging Het
Dynlrb1 A G 2: 155,091,870 (GRCm39) N93D probably benign Het
Edem1 C T 6: 108,823,774 (GRCm39) A390V probably benign Het
Enthd1 T C 15: 80,358,356 (GRCm39) D388G probably benign Het
Fam170a A G 18: 50,414,677 (GRCm39) T108A probably damaging Het
Fryl A G 5: 73,233,276 (GRCm39) S1531P probably benign Het
Golm2 A T 2: 121,697,632 (GRCm39) probably benign Het
Hspbap1 C A 16: 35,645,366 (GRCm39) N350K probably benign Het
Htr3b A C 9: 48,858,596 (GRCm39) S94R probably damaging Het
Ide A T 19: 37,307,886 (GRCm39) V42E Het
Igf2r A G 17: 12,902,748 (GRCm39) V2434A probably benign Het
Katnip T C 7: 125,468,023 (GRCm39) probably null Het
Kif16b G A 2: 142,553,777 (GRCm39) A1007V probably benign Het
Mccc1 C T 3: 36,018,493 (GRCm39) V614I probably benign Het
Mos A G 4: 3,871,097 (GRCm39) Y240H probably damaging Het
Myh11 C T 16: 14,026,095 (GRCm39) probably null Het
Nexn T A 3: 151,953,998 (GRCm39) D166V probably damaging Het
Or10h1b G A 17: 33,395,895 (GRCm39) C173Y probably damaging Het
Or2t47 G T 11: 58,443,029 (GRCm39) T12N probably benign Het
Or4p4 A T 2: 88,483,332 (GRCm39) M279L probably benign Het
Or5p81 T A 7: 108,267,518 (GRCm39) N298K probably benign Het
Pkp4 A G 2: 59,180,895 (GRCm39) Y1061C probably damaging Het
Pla2g6 T C 15: 79,171,370 (GRCm39) D740G probably damaging Het
Pla2r1 T A 2: 60,273,627 (GRCm39) I920L probably benign Het
Plekha2 A G 8: 25,578,407 (GRCm39) I31T probably damaging Het
Ppp1r16b G T 2: 158,603,295 (GRCm39) V407L probably benign Het
Prss50 A G 9: 110,691,370 (GRCm39) I225V probably damaging Het
Rmdn2 A T 17: 79,935,580 (GRCm39) E231V Het
Sema3c T C 5: 17,858,726 (GRCm39) S42P possibly damaging Het
Sh2d1b1 T A 1: 170,110,693 (GRCm39) probably null Het
Slc22a20 T C 19: 6,021,554 (GRCm39) I483V probably benign Het
Slc30a2 T C 4: 134,076,690 (GRCm39) V275A probably damaging Het
Slc6a3 T A 13: 73,693,002 (GRCm39) F207L probably benign Het
Slc9a1 A T 4: 133,147,927 (GRCm39) Q648H probably damaging Het
Slpi A T 2: 164,197,975 (GRCm39) M1K probably null Het
Smc5 A C 19: 23,211,443 (GRCm39) S564A possibly damaging Het
Smchd1 A T 17: 71,738,238 (GRCm39) F542L probably damaging Het
Sycp1 T A 3: 102,727,909 (GRCm39) K901N probably damaging Het
Synpo2l T A 14: 20,716,208 (GRCm39) T126S probably benign Het
Upp2 A G 2: 58,667,955 (GRCm39) N216S probably benign Het
Wnk1 T C 6: 119,969,408 (GRCm39) D349G probably damaging Het
Zfp180 C T 7: 23,804,337 (GRCm39) A252V probably benign Het
Zfr2 C T 10: 81,078,653 (GRCm39) T295I possibly damaging Het
Zkscan16 C T 4: 58,957,230 (GRCm39) T504I possibly damaging Het
Other mutations in Cenpw
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02207:Cenpw APN 10 30,074,577 (GRCm39) critical splice acceptor site probably null
R0139:Cenpw UTSW 10 30,076,455 (GRCm39) missense probably benign
R9036:Cenpw UTSW 10 30,074,523 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- TGTCGTGTTTCTCACTGAAGAG -3'
(R):5'- TCACAAACCTGGAAGAAGCTG -3'

Sequencing Primer
(F):5'- GTCTCATAAAAATTGCCAGGGC -3'
(R):5'- CCTGGAAGAAGCTGTGGGTTAG -3'
Posted On 2020-09-02