Incidental Mutation 'R8362:Or6c211'
ID 646007
Institutional Source Beutler Lab
Gene Symbol Or6c211
Ensembl Gene ENSMUSG00000058513
Gene Name olfactory receptor family 6 subfamily C member 211
Synonyms Olfr801, GA_x6K02T2PULF-11349138-11348182, MOR110-10
MMRRC Submission 067808-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R8362 (G1)
Quality Score 225.009
Status Not validated
Chromosome 10
Chromosomal Location 129505430-129506386 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 129506100 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Glutamic Acid at position 96 (A96E)
Ref Sequence ENSEMBL: ENSMUSP00000148943 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072063] [ENSMUST00000203424] [ENSMUST00000213294] [ENSMUST00000216067]
AlphaFold Q8VEU1
Predicted Effect possibly damaging
Transcript: ENSMUST00000072063
AA Change: A96E

PolyPhen 2 Score 0.883 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000071941
Gene: ENSMUSG00000058513
AA Change: A96E

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 1.2e-51 PFAM
Pfam:7tm_1 39 288 8.8e-25 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000203424
AA Change: A59E

PolyPhen 2 Score 0.883 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000145011
Gene: ENSMUSG00000058513
AA Change: A59E

DomainStartEndE-ValueType
Pfam:7tm_4 1 96 5.9e-18 PFAM
Pfam:7tm_1 2 96 1.3e-17 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000213294
AA Change: A96E

PolyPhen 2 Score 0.883 (Sensitivity: 0.82; Specificity: 0.94)
Predicted Effect possibly damaging
Transcript: ENSMUST00000216067
AA Change: A96E

PolyPhen 2 Score 0.883 (Sensitivity: 0.82; Specificity: 0.94)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1810009A15Rik T A 19: 8,867,395 (GRCm39) S65T probably damaging Het
Abcb1b A T 5: 8,848,758 (GRCm39) N6I probably benign Het
Abr A T 11: 76,369,954 (GRCm39) I145N probably benign Het
Alcam A T 16: 52,115,387 (GRCm39) Y244N probably damaging Het
Amotl1 G A 9: 14,556,218 (GRCm39) A36V probably benign Het
Ankrd11 A T 8: 123,618,797 (GRCm39) L1685Q probably damaging Het
Ascc3 A C 10: 50,518,692 (GRCm39) Q332H possibly damaging Het
Cdc42bpa C T 1: 179,989,690 (GRCm39) L1720F probably damaging Het
Clec4b1 T C 6: 123,027,602 (GRCm39) S20P probably benign Het
Cpt1a C T 19: 3,420,744 (GRCm39) R401* probably null Het
Dnah12 T A 14: 26,576,788 (GRCm39) Y3013N probably damaging Het
Dop1a G A 9: 86,395,941 (GRCm39) R801H probably benign Het
Flywch1 G T 17: 23,975,682 (GRCm39) T520N probably damaging Het
Fndc1 A G 17: 8,001,207 (GRCm39) S190P unknown Het
Gabra1 G T 11: 42,066,831 (GRCm39) Q28K probably benign Het
Gria2 T C 3: 80,615,197 (GRCm39) M428V possibly damaging Het
H13 T A 2: 152,528,311 (GRCm39) I220N unknown Het
Hars2 T A 18: 36,923,228 (GRCm39) F412L probably benign Het
Hecw2 A T 1: 54,079,650 (GRCm39) M1K probably null Het
Homer1 T A 13: 93,502,797 (GRCm39) S192T unknown Het
Itga2b T A 11: 102,352,189 (GRCm39) D464V probably damaging Het
Ivd T A 2: 118,708,422 (GRCm39) C379S probably damaging Het
Khdc3 A T 9: 73,010,848 (GRCm39) N233Y possibly damaging Het
Lrrc37 A G 11: 103,506,163 (GRCm39) V1935A probably benign Het
Lrrfip1 T A 1: 90,981,423 (GRCm39) L15Q probably damaging Het
Megf8 C A 7: 25,039,943 (GRCm39) P986Q probably benign Het
Morc2b G T 17: 33,357,295 (GRCm39) T159K possibly damaging Het
Nudt5 A G 2: 5,858,322 (GRCm39) probably null Het
Paqr5 A T 9: 61,879,945 (GRCm39) Y116* probably null Het
Pcnx1 A C 12: 82,013,830 (GRCm39) S623R Het
Polr1a T C 6: 71,941,651 (GRCm39) V1053A probably benign Het
Ptprt A T 2: 161,393,667 (GRCm39) D1252E probably damaging Het
Qser1 A G 2: 104,620,246 (GRCm39) S189P probably damaging Het
Rasal1 C T 5: 120,813,485 (GRCm39) R620W probably damaging Het
Rbms1 C T 2: 60,793,083 (GRCm39) M9I probably benign Het
Ska3 T C 14: 58,054,105 (GRCm39) N282D probably benign Het
Slc25a24 T A 3: 109,065,878 (GRCm39) I245N possibly damaging Het
Slc26a4 C T 12: 31,594,506 (GRCm39) V281I probably benign Het
Smg8 A T 11: 86,968,881 (GRCm39) Y958* probably null Het
Spata31 A G 13: 65,070,044 (GRCm39) T731A possibly damaging Het
Spg11 G T 2: 121,948,842 (GRCm39) A3D unknown Het
Srgap1 A G 10: 121,691,383 (GRCm39) Y284H possibly damaging Het
Stt3b A G 9: 115,083,988 (GRCm39) I396T probably damaging Het
Tnxb A G 17: 34,931,946 (GRCm39) T2160A probably damaging Het
Tprg1l G C 4: 154,244,815 (GRCm39) T91S possibly damaging Het
Ush2a G A 1: 188,689,650 (GRCm39) V5071I probably damaging Het
Vmn2r60 T A 7: 41,844,954 (GRCm39) N772K probably damaging Het
Vmn2r81 T A 10: 79,103,283 (GRCm39) W159R probably benign Het
Vmn2r93 G A 17: 18,546,353 (GRCm39) V742I probably benign Het
Zc3h13 C A 14: 75,561,909 (GRCm39) H654N unknown Het
Zfp516 T C 18: 83,005,019 (GRCm39) L641P probably benign Het
Zfp623 T C 15: 75,819,488 (GRCm39) V148A probably damaging Het
Other mutations in Or6c211
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00948:Or6c211 APN 10 129,505,756 (GRCm39) missense probably damaging 1.00
IGL02400:Or6c211 APN 10 129,505,752 (GRCm39) missense probably damaging 0.99
IGL02721:Or6c211 APN 10 129,505,992 (GRCm39) missense probably benign 0.08
IGL03107:Or6c211 APN 10 129,505,809 (GRCm39) missense probably benign 0.00
R0114:Or6c211 UTSW 10 129,505,467 (GRCm39) missense probably benign
R0140:Or6c211 UTSW 10 129,505,557 (GRCm39) missense probably damaging 1.00
R0652:Or6c211 UTSW 10 129,506,248 (GRCm39) missense probably benign 0.08
R1375:Or6c211 UTSW 10 129,506,241 (GRCm39) missense probably null 0.97
R1449:Or6c211 UTSW 10 129,506,238 (GRCm39) missense probably damaging 0.99
R2026:Or6c211 UTSW 10 129,506,334 (GRCm39) missense probably damaging 1.00
R2241:Or6c211 UTSW 10 129,505,764 (GRCm39) missense probably damaging 1.00
R2516:Or6c211 UTSW 10 129,506,155 (GRCm39) missense probably damaging 1.00
R2869:Or6c211 UTSW 10 129,505,628 (GRCm39) nonsense probably null
R2869:Or6c211 UTSW 10 129,505,628 (GRCm39) nonsense probably null
R2870:Or6c211 UTSW 10 129,505,628 (GRCm39) nonsense probably null
R2870:Or6c211 UTSW 10 129,505,628 (GRCm39) nonsense probably null
R2873:Or6c211 UTSW 10 129,505,628 (GRCm39) nonsense probably null
R6562:Or6c211 UTSW 10 129,506,008 (GRCm39) missense probably damaging 1.00
R8503:Or6c211 UTSW 10 129,505,512 (GRCm39) missense probably damaging 0.99
R8867:Or6c211 UTSW 10 129,505,628 (GRCm39) nonsense probably null
R9251:Or6c211 UTSW 10 129,505,980 (GRCm39) missense possibly damaging 0.61
Z1177:Or6c211 UTSW 10 129,505,663 (GRCm39) missense probably benign 0.39
Predicted Primers PCR Primer
(F):5'- TCCAGTTTGAGTCCCAACAC -3'
(R):5'- ATTACATCTTGAGCCTGATGGG -3'

Sequencing Primer
(F):5'- TTTGAGTCCCAACACTAAAGGG -3'
(R):5'- CCTGATGGGAAACTTAGTGATCATCC -3'
Posted On 2020-09-02