Incidental Mutation 'R8365:Vmn1r167'
ID 646140
Institutional Source Beutler Lab
Gene Symbol Vmn1r167
Ensembl Gene ENSMUSG00000090715
Gene Name vomeronasal 1 receptor 167
Synonyms Gm6279
MMRRC Submission 067736-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.052) question?
Stock # R8365 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 23204067-23205014 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 23204200 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 272 (I272N)
Ref Sequence ENSEMBL: ENSMUSP00000129193 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000164527] [ENSMUST00000227713]
AlphaFold G3UW71
Predicted Effect probably benign
Transcript: ENSMUST00000164527
AA Change: I272N

PolyPhen 2 Score 0.033 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000129193
Gene: ENSMUSG00000090715
AA Change: I272N

DomainStartEndE-ValueType
Pfam:TAS2R 19 307 1.5e-13 PFAM
Pfam:7tm_1 41 299 3.8e-6 PFAM
Pfam:V1R 52 306 2.1e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000227713
AA Change: I272N

PolyPhen 2 Score 0.033 (Sensitivity: 0.95; Specificity: 0.82)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2ml1 A T 6: 128,557,918 (GRCm39) C79* probably null Het
Abcc9 A T 6: 142,544,798 (GRCm39) S1430T probably benign Het
Akap9 C G 5: 4,018,745 (GRCm39) H1109D probably benign Het
Ankrd17 T C 5: 90,398,378 (GRCm39) K1724R possibly damaging Het
Brf2 A G 8: 27,618,566 (GRCm39) S13P possibly damaging Het
Cfap46 T A 7: 139,263,000 (GRCm39) K18* probably null Het
Cym T G 3: 107,120,182 (GRCm39) I306L probably benign Het
Cyp2c66 A T 19: 39,165,048 (GRCm39) H343L probably benign Het
Cyp2d34 T C 15: 82,504,874 (GRCm39) Y62C probably damaging Het
D630045J12Rik A G 6: 38,172,570 (GRCm39) S533P probably benign Het
Dnajc10 A G 2: 80,176,902 (GRCm39) Y619C probably damaging Het
Dnal1 T A 12: 84,178,163 (GRCm39) probably null Het
Eif4g1 T A 16: 20,502,277 (GRCm39) M914K probably damaging Het
Epb41l2 C A 10: 25,317,584 (GRCm39) Q34K probably benign Het
Esyt1 T G 10: 128,352,422 (GRCm39) N730H possibly damaging Het
Fbxo15 T G 18: 84,980,739 (GRCm39) I238S probably damaging Het
Foxn3 T C 12: 99,307,727 (GRCm39) K204E probably damaging Het
Gtf2i G A 5: 134,303,434 (GRCm39) S279L probably benign Het
Hhatl A G 9: 121,618,931 (GRCm39) M67T probably damaging Het
Itpkc C A 7: 26,911,777 (GRCm39) R598L probably damaging Het
Itprid2 T C 2: 79,492,689 (GRCm39) S1079P probably damaging Het
Jkampl A T 6: 73,446,329 (GRCm39) N73K probably benign Het
Kctd18 A T 1: 57,998,311 (GRCm39) I263N probably damaging Het
Map1a T A 2: 121,138,528 (GRCm39) M3002K probably damaging Het
Med13l T A 5: 118,866,709 (GRCm39) S588T possibly damaging Het
Pcdh8 T A 14: 80,008,426 (GRCm39) I46F probably damaging Het
Prdm6 T C 18: 53,685,137 (GRCm39) V392A probably benign Het
Ptprt T A 2: 161,743,451 (GRCm39) I497F probably benign Het
Rorc A G 3: 94,282,366 (GRCm39) H22R probably benign Het
Scaf8 A G 17: 3,246,241 (GRCm39) I777V possibly damaging Het
Shroom1 A T 11: 53,356,468 (GRCm39) R444* probably null Het
Srcap C T 7: 127,148,869 (GRCm39) T2030I probably damaging Het
Srgap3 A G 6: 112,793,695 (GRCm39) S94P probably damaging Het
Srsf12 C G 4: 33,226,070 (GRCm39) P111R probably damaging Het
Ttc27 C T 17: 75,054,669 (GRCm39) T325I probably damaging Het
Ucp1 A C 8: 84,020,628 (GRCm39) H146P probably damaging Het
Vmn2r1 T C 3: 63,994,034 (GRCm39) S127P possibly damaging Het
Vtcn1 A G 3: 100,791,145 (GRCm39) D61G probably benign Het
Zfp994 A T 17: 22,420,227 (GRCm39) C241S probably damaging Het
Other mutations in Vmn1r167
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02137:Vmn1r167 APN 7 23,204,864 (GRCm39) missense probably damaging 0.98
IGL02261:Vmn1r167 APN 7 23,204,261 (GRCm39) missense probably benign 0.17
IGL02963:Vmn1r167 APN 7 23,204,975 (GRCm39) missense possibly damaging 0.60
R0054:Vmn1r167 UTSW 7 23,204,334 (GRCm39) missense possibly damaging 0.89
R0555:Vmn1r167 UTSW 7 23,204,512 (GRCm39) missense probably damaging 1.00
R0766:Vmn1r167 UTSW 7 23,204,548 (GRCm39) missense probably benign 0.01
R1312:Vmn1r167 UTSW 7 23,204,548 (GRCm39) missense probably benign 0.01
R1464:Vmn1r167 UTSW 7 23,204,681 (GRCm39) missense possibly damaging 0.62
R1464:Vmn1r167 UTSW 7 23,204,681 (GRCm39) missense possibly damaging 0.62
R1532:Vmn1r167 UTSW 7 23,204,204 (GRCm39) missense probably benign 0.01
R1937:Vmn1r167 UTSW 7 23,204,452 (GRCm39) missense probably benign 0.25
R2162:Vmn1r167 UTSW 7 23,204,224 (GRCm39) missense possibly damaging 0.91
R4639:Vmn1r167 UTSW 7 23,205,011 (GRCm39) missense probably benign 0.00
R4661:Vmn1r167 UTSW 7 23,204,117 (GRCm39) missense probably damaging 1.00
R4845:Vmn1r167 UTSW 7 23,204,158 (GRCm39) missense probably benign 0.01
R4868:Vmn1r167 UTSW 7 23,204,161 (GRCm39) missense probably benign
R4993:Vmn1r167 UTSW 7 23,204,653 (GRCm39) missense probably damaging 1.00
R5693:Vmn1r167 UTSW 7 23,204,646 (GRCm39) nonsense probably null
R6622:Vmn1r167 UTSW 7 23,205,014 (GRCm39) start codon destroyed probably null
R7800:Vmn1r167 UTSW 7 23,204,069 (GRCm39) makesense probably null
R8297:Vmn1r167 UTSW 7 23,204,215 (GRCm39) missense probably damaging 1.00
R8411:Vmn1r167 UTSW 7 23,204,981 (GRCm39) missense possibly damaging 0.86
R9667:Vmn1r167 UTSW 7 23,204,990 (GRCm39) missense probably benign 0.06
Predicted Primers PCR Primer
(F):5'- TTGGCCAAGAAACACGTTAAG -3'
(R):5'- GTCTCCATGGTAATTCTCCTGAAC -3'

Sequencing Primer
(F):5'- ACGTTAAGTGTATTCCCAGAAAATAG -3'
(R):5'- TGGTAATTCTCCTGAACAGACAC -3'
Posted On 2020-09-02