Incidental Mutation 'R8367:Zfp366'
ID 646227
Institutional Source Beutler Lab
Gene Symbol Zfp366
Ensembl Gene ENSMUSG00000050919
Gene Name zinc finger protein 366
Synonyms DC-SCRIPT
MMRRC Submission 067874-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.331) question?
Stock # R8367 (G1)
Quality Score 225.009
Status Validated
Chromosome 13
Chromosomal Location 99321331-99383540 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 99380551 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 549 (M549V)
Ref Sequence ENSEMBL: ENSMUSP00000060040 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056558]
AlphaFold Q6NS86
Predicted Effect possibly damaging
Transcript: ENSMUST00000056558
AA Change: M549V

PolyPhen 2 Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000060040
Gene: ENSMUSG00000050919
AA Change: M549V

DomainStartEndE-ValueType
low complexity region 159 175 N/A INTRINSIC
low complexity region 183 196 N/A INTRINSIC
ZnF_C2H2 250 272 1.18e-2 SMART
ZnF_C2H2 278 300 4.05e-1 SMART
ZnF_C2H2 306 328 1.79e-2 SMART
ZnF_C2H2 334 356 1.53e-1 SMART
ZnF_C2H2 362 384 1.89e-1 SMART
ZnF_C2H2 390 412 1.22e-4 SMART
ZnF_C2H2 418 440 1.36e-2 SMART
ZnF_C2H2 446 468 1.1e-2 SMART
ZnF_C2H2 474 496 8.34e-3 SMART
ZnF_C2H2 502 524 5.42e-2 SMART
ZnF_C2H2 530 553 2.4e-3 SMART
low complexity region 615 623 N/A INTRINSIC
Meta Mutation Damage Score 0.4406 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.0%
Validation Efficiency 100% (38/38)
MGI Phenotype PHENOTYPE: Mice homozygous for an ENU-induced mutation exhibit perimembranous and muscular ventricular septal defects (VSD), and overriding aorta. Short snout, micrognathia, micropthalmia, hypoplastic thymus, and hydronephrosis are also observed. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6820408C15Rik G A 2: 152,284,417 (GRCm39) probably null Het
8030423J24Rik A T 13: 71,032,096 (GRCm39) E56V unknown Het
Abcb1a A G 5: 8,736,221 (GRCm39) T205A probably benign Het
Aplp2 T C 9: 31,089,202 (GRCm39) E93G probably damaging Het
Arpin T A 7: 79,579,386 (GRCm39) N79I possibly damaging Het
Atg7 T A 6: 114,663,060 (GRCm39) D225E probably benign Het
Bltp3b T A 10: 89,641,239 (GRCm39) D803E probably damaging Het
Cc2d2b A G 19: 40,754,419 (GRCm39) M229V unknown Het
Cep295 C T 9: 15,245,826 (GRCm39) V877I probably benign Het
Clca3a2 A T 3: 144,523,508 (GRCm39) probably null Het
Cmip C T 8: 118,163,610 (GRCm39) P359L probably benign Het
Cyb5rl A G 4: 106,928,146 (GRCm39) Y94C probably benign Het
Cyp19a1 A G 9: 54,087,543 (GRCm39) I125T probably damaging Het
Cyp2c54 T G 19: 40,062,125 (GRCm39) Q44P probably damaging Het
Cyp2c67 A T 19: 39,627,118 (GRCm39) H237Q probably benign Het
Dlgap2 A T 8: 14,893,544 (GRCm39) Y953F probably benign Het
Hgfac G T 5: 35,202,790 (GRCm39) C430F probably damaging Het
Kdm4b T C 17: 56,662,875 (GRCm39) W149R probably damaging Het
Krt23 C T 11: 99,383,715 (GRCm39) W59* probably null Het
Lfng G A 5: 140,598,981 (GRCm39) E297K probably damaging Het
Lrrc7 T A 3: 157,908,007 (GRCm39) Q271L possibly damaging Het
Ltc4s C A 11: 50,127,511 (GRCm39) R108L possibly damaging Het
Mcm3ap T C 10: 76,313,693 (GRCm39) S596P possibly damaging Het
Myot A G 18: 44,470,166 (GRCm39) T48A probably benign Het
Mypn G C 10: 62,971,539 (GRCm39) P834A probably damaging Het
Or5d16 T C 2: 87,773,441 (GRCm39) N177S possibly damaging Het
Or8k30 C T 2: 86,339,025 (GRCm39) S74L probably damaging Het
Parp14 T C 16: 35,678,124 (GRCm39) K615E probably benign Het
Pramel6 A C 2: 87,340,814 (GRCm39) Q382P probably damaging Het
Prdx2 A G 8: 85,698,244 (GRCm39) D145G probably damaging Het
Prune1 A G 3: 95,172,837 (GRCm39) V76A probably benign Het
Sppl2b A T 10: 80,699,025 (GRCm39) H198L probably benign Het
Ttll9 C A 2: 152,836,068 (GRCm39) H271N probably benign Het
Vmn2r59 C A 7: 41,661,247 (GRCm39) R856M probably benign Het
Yeats2 C T 16: 20,041,575 (GRCm39) T1155I probably damaging Het
Zbbx A G 3: 74,989,034 (GRCm39) probably null Het
Zfp160 A G 17: 21,245,804 (GRCm39) D118G probably benign Het
Zp3r A G 1: 130,526,610 (GRCm39) S198P probably damaging Het
Other mutations in Zfp366
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00585:Zfp366 APN 13 99,383,080 (GRCm39) utr 3 prime probably benign
IGL01626:Zfp366 APN 13 99,364,920 (GRCm39) missense probably damaging 0.99
IGL02227:Zfp366 APN 13 99,370,696 (GRCm39) missense possibly damaging 0.85
IGL03074:Zfp366 APN 13 99,382,913 (GRCm39) missense probably benign
R0126:Zfp366 UTSW 13 99,365,129 (GRCm39) missense probably benign 0.14
R0145:Zfp366 UTSW 13 99,366,048 (GRCm39) missense probably damaging 1.00
R0234:Zfp366 UTSW 13 99,370,768 (GRCm39) missense probably damaging 1.00
R0234:Zfp366 UTSW 13 99,370,768 (GRCm39) missense probably damaging 1.00
R0376:Zfp366 UTSW 13 99,370,759 (GRCm39) missense probably benign 0.00
R0537:Zfp366 UTSW 13 99,365,786 (GRCm39) missense probably damaging 1.00
R0637:Zfp366 UTSW 13 99,365,474 (GRCm39) missense probably damaging 0.99
R0838:Zfp366 UTSW 13 99,365,118 (GRCm39) missense possibly damaging 0.73
R1386:Zfp366 UTSW 13 99,383,063 (GRCm39) missense probably damaging 0.98
R1422:Zfp366 UTSW 13 99,365,804 (GRCm39) missense probably damaging 1.00
R1669:Zfp366 UTSW 13 99,366,069 (GRCm39) missense probably damaging 0.99
R1839:Zfp366 UTSW 13 99,365,000 (GRCm39) missense probably damaging 0.98
R3751:Zfp366 UTSW 13 99,365,352 (GRCm39) missense probably damaging 1.00
R4782:Zfp366 UTSW 13 99,382,991 (GRCm39) missense probably damaging 1.00
R4908:Zfp366 UTSW 13 99,370,609 (GRCm39) missense possibly damaging 0.68
R4992:Zfp366 UTSW 13 99,366,003 (GRCm39) missense possibly damaging 0.62
R5040:Zfp366 UTSW 13 99,364,875 (GRCm39) missense probably damaging 1.00
R5086:Zfp366 UTSW 13 99,365,451 (GRCm39) missense probably benign 0.00
R5186:Zfp366 UTSW 13 99,382,676 (GRCm39) missense probably benign 0.00
R5249:Zfp366 UTSW 13 99,366,117 (GRCm39) missense probably damaging 1.00
R5450:Zfp366 UTSW 13 99,366,093 (GRCm39) missense probably damaging 1.00
R6838:Zfp366 UTSW 13 99,382,685 (GRCm39) missense possibly damaging 0.83
R6838:Zfp366 UTSW 13 99,365,015 (GRCm39) missense possibly damaging 0.93
R7250:Zfp366 UTSW 13 99,366,076 (GRCm39) missense probably damaging 1.00
R7378:Zfp366 UTSW 13 99,366,023 (GRCm39) missense probably damaging 1.00
R7571:Zfp366 UTSW 13 99,382,895 (GRCm39) missense probably benign 0.03
R7624:Zfp366 UTSW 13 99,382,804 (GRCm39) missense probably benign
R7653:Zfp366 UTSW 13 99,365,709 (GRCm39) missense probably damaging 1.00
R9510:Zfp366 UTSW 13 99,365,874 (GRCm39) missense probably damaging 1.00
R9658:Zfp366 UTSW 13 99,365,435 (GRCm39) missense probably benign 0.13
R9734:Zfp366 UTSW 13 99,365,352 (GRCm39) missense probably damaging 1.00
Z1176:Zfp366 UTSW 13 99,382,858 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TTCTGACACCCAGGTAGCAC -3'
(R):5'- TCGATGGGCAAGAATAACCC -3'

Sequencing Primer
(F):5'- CAGGGGGACATTGTCTTTAGAAG -3'
(R):5'- CCACCCCACCCTGAGAAGTG -3'
Posted On 2020-09-02