Incidental Mutation 'R8373:Zfp704'
ID 646531
Institutional Source Beutler Lab
Gene Symbol Zfp704
Ensembl Gene ENSMUSG00000040209
Gene Name zinc finger protein 704
Synonyms Gig1
MMRRC Submission 067741-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8373 (G1)
Quality Score 225.009
Status Not validated
Chromosome 3
Chromosomal Location 9427020-9610085 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) G to A at 9609442 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Threonine to Methionine at position 93 (T93M)
Ref Sequence ENSEMBL: ENSMUSP00000041242 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000041124]
AlphaFold Q9ERQ3
Predicted Effect unknown
Transcript: ENSMUST00000041124
AA Change: T93M
SMART Domains Protein: ENSMUSP00000041242
Gene: ENSMUSG00000040209
AA Change: T93M

DomainStartEndE-ValueType
low complexity region 12 94 N/A INTRINSIC
low complexity region 98 129 N/A INTRINSIC
low complexity region 267 290 N/A INTRINSIC
ZnF_C2H2 346 371 3.58e-2 SMART
c-clamp 536 566 1.55e-13 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.8%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a reporter (null) allele are viable and fertile with no obvious developmental defects. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2210010C04Rik T G 6: 41,031,688 (GRCm38) T231P possibly damaging Het
Adgrg6 T C 10: 14,467,334 (GRCm38) T290A probably benign Het
Aff4 C T 11: 53,400,267 (GRCm38) Q685* probably null Het
Ankmy1 A G 1: 92,896,094 (GRCm38) M150T probably damaging Het
Armc1 T C 3: 19,149,567 (GRCm38) Y65C probably damaging Het
Armc8 A G 9: 99,527,099 (GRCm38) V222A probably benign Het
Bcar1 A T 8: 111,715,738 (GRCm38) Y228* probably null Het
Cct2 T C 10: 117,060,824 (GRCm38) D158G possibly damaging Het
Cul1 T A 6: 47,515,063 (GRCm38) C426S possibly damaging Het
Deup1 G T 9: 15,592,375 (GRCm38) L297M possibly damaging Het
Dpp10 A G 1: 123,854,229 (GRCm38) S74P possibly damaging Het
Epha4 A G 1: 77,507,079 (GRCm38) Y98H possibly damaging Het
Epn3 T G 11: 94,492,936 (GRCm38) D296A probably damaging Het
Eri2 A C 7: 119,772,597 (GRCm38) I252S probably benign Het
Gm14025 T A 2: 129,038,171 (GRCm38) I612F Het
Gp9 C T 6: 87,779,012 (GRCm38) T3I probably benign Het
H2-Q5 T A 17: 35,394,456 (GRCm38) V55E Het
Kif3c G T 12: 3,366,089 (GRCm38) V37L probably benign Het
Lct A T 1: 128,303,840 (GRCm38) N757K probably damaging Het
Lhx8 A C 3: 154,324,658 (GRCm38) N112K probably damaging Het
Loxl3 T A 6: 83,048,891 (GRCm38) S373R possibly damaging Het
Mettl4 G A 17: 94,733,649 (GRCm38) T359I probably damaging Het
Mpp7 A G 18: 7,444,096 (GRCm38) S109P probably damaging Het
Nckap5 A G 1: 126,026,295 (GRCm38) V840A probably benign Het
Ncoa4 T A 14: 32,176,936 (GRCm38) L571Q probably damaging Het
Olfr453 T C 6: 42,744,346 (GRCm38) F103S probably damaging Het
Olfr46 A T 7: 140,610,295 (GRCm38) Y35F possibly damaging Het
Phgdh G A 3: 98,321,245 (GRCm38) T204I probably damaging Het
Pla2g4d C T 2: 120,277,499 (GRCm38) V310M probably null Het
Psmd12 C T 11: 107,497,624 (GRCm38) P421L probably damaging Het
Ptch1 A G 13: 63,541,168 (GRCm38) Y432H probably damaging Het
Rapgef1 G A 2: 29,710,231 (GRCm38) G655S probably damaging Het
Rilpl2 C A 5: 124,478,034 (GRCm38) A18S probably damaging Het
Srsf7 T C 17: 80,205,386 (GRCm38) R88G probably benign Het
St6galnac1 T C 11: 116,769,233 (GRCm38) K85E possibly damaging Het
Trip12 A T 1: 84,795,767 (GRCm38) S49R probably damaging Het
Wdr48 A G 9: 119,905,494 (GRCm38) T160A probably damaging Het
Other mutations in Zfp704
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00848:Zfp704 APN 3 9,565,239 (GRCm38) missense possibly damaging 0.61
IGL03288:Zfp704 APN 3 9,439,891 (GRCm38) splice site probably benign
R0265:Zfp704 UTSW 3 9,565,157 (GRCm38) missense probably damaging 1.00
R0524:Zfp704 UTSW 3 9,609,364 (GRCm38) missense unknown
R1466:Zfp704 UTSW 3 9,447,348 (GRCm38) missense possibly damaging 0.94
R1466:Zfp704 UTSW 3 9,447,348 (GRCm38) missense possibly damaging 0.94
R1647:Zfp704 UTSW 3 9,471,039 (GRCm38) missense probably damaging 1.00
R1648:Zfp704 UTSW 3 9,471,039 (GRCm38) missense probably damaging 1.00
R1865:Zfp704 UTSW 3 9,474,491 (GRCm38) splice site probably benign
R1912:Zfp704 UTSW 3 9,609,358 (GRCm38) missense unknown
R2109:Zfp704 UTSW 3 9,474,525 (GRCm38) missense probably damaging 1.00
R2566:Zfp704 UTSW 3 9,609,493 (GRCm38) missense unknown
R3551:Zfp704 UTSW 3 9,474,525 (GRCm38) missense probably damaging 1.00
R4495:Zfp704 UTSW 3 9,471,077 (GRCm38) missense probably benign 0.01
R6165:Zfp704 UTSW 3 9,443,886 (GRCm38) missense probably benign 0.00
R6682:Zfp704 UTSW 3 9,565,193 (GRCm38) missense probably benign 0.11
R7057:Zfp704 UTSW 3 9,470,917 (GRCm38) missense probably damaging 1.00
R7348:Zfp704 UTSW 3 9,474,598 (GRCm38) missense probably damaging 1.00
R7758:Zfp704 UTSW 3 9,444,222 (GRCm38) missense possibly damaging 0.90
R7858:Zfp704 UTSW 3 9,444,157 (GRCm38) critical splice donor site probably null
R8104:Zfp704 UTSW 3 9,565,241 (GRCm38) missense probably benign 0.03
R8877:Zfp704 UTSW 3 9,609,356 (GRCm38) missense unknown
R9136:Zfp704 UTSW 3 9,444,264 (GRCm38) missense probably benign 0.03
Z1176:Zfp704 UTSW 3 9,471,044 (GRCm38) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCTGAGCACCGACAGGCC -3'
(R):5'- CGGTGAAGACACGACACAA -3'

Sequencing Primer
(F):5'- CTGAGCCGCAGTTCCGC -3'
(R):5'- GCACCGGGAAGCTGGAG -3'
Posted On 2020-09-02