Incidental Mutation 'R0040:Zfp334'
ID 64655
Institutional Source Beutler Lab
Gene Symbol Zfp334
Ensembl Gene ENSMUSG00000017667
Gene Name zinc finger protein 334
Synonyms D2Ertd535e
MMRRC Submission 038334-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0040 (G1)
Quality Score 111
Status Validated
Chromosome 2
Chromosomal Location 165216184-165230179 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 165223492 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 184 (Y184H)
Ref Sequence ENSEMBL: ENSMUSP00000099373 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103084]
AlphaFold A2A4U6
Predicted Effect probably benign
Transcript: ENSMUST00000103084
AA Change: Y184H

PolyPhen 2 Score 0.449 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000099373
Gene: ENSMUSG00000017667
AA Change: Y184H

DomainStartEndE-ValueType
KRAB 8 68 5.91e-35 SMART
ZnF_C2H2 236 258 5.42e-2 SMART
ZnF_C2H2 264 286 1.2e-3 SMART
ZnF_C2H2 292 314 6.99e-5 SMART
ZnF_C2H2 320 342 1.22e-4 SMART
ZnF_C2H2 348 370 3.39e-3 SMART
ZnF_C2H2 376 398 7.15e-2 SMART
ZnF_C2H2 404 426 1.69e-3 SMART
ZnF_C2H2 432 454 1.92e-2 SMART
ZnF_C2H2 460 482 3.16e-3 SMART
ZnF_C2H2 543 565 1.82e-3 SMART
ZnF_C2H2 571 593 3.69e-4 SMART
ZnF_C2H2 599 621 1.58e-3 SMART
ZnF_C2H2 627 649 1.38e-3 SMART
ZnF_C2H2 655 677 3.89e-3 SMART
Meta Mutation Damage Score 0.0941 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.0%
  • 20x: 93.6%
Validation Efficiency 100% (88/88)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the C2H2 zinc finger family. The encoded protein contains a Krueppel-associated box, fourteen C2H2 zinc finger domains, and four C2H2-type/integrase DNA-binding domains. Decreased expression of this gene may be a marker for rheumatoid arthritis. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahrr G A 13: 74,431,143 (GRCm39) probably benign Het
Antxr2 G A 5: 98,086,284 (GRCm39) T441I possibly damaging Het
Apcs A G 1: 172,722,023 (GRCm39) Y108H probably benign Het
Atad5 A G 11: 79,988,840 (GRCm39) T666A probably benign Het
Atcay C T 10: 81,046,353 (GRCm39) probably null Het
Bahcc1 A G 11: 120,159,196 (GRCm39) D141G probably damaging Het
Ceacam10 A G 7: 24,477,689 (GRCm39) Y68C probably damaging Het
Cfap54 T A 10: 92,812,901 (GRCm39) Q1344L probably benign Het
Cyb5r4 A G 9: 86,948,795 (GRCm39) probably null Het
Cyp2b9 G T 7: 25,872,899 (GRCm39) S14I possibly damaging Het
Dusp12 A G 1: 170,708,226 (GRCm39) Y164H probably damaging Het
Eml2 T C 7: 18,930,539 (GRCm39) V373A possibly damaging Het
Fat1 A G 8: 45,479,441 (GRCm39) D2829G probably damaging Het
Fbxl13 T C 5: 21,691,371 (GRCm39) T671A probably damaging Het
Fbxo28 G T 1: 182,153,805 (GRCm39) probably benign Het
Fbxo44 A G 4: 148,243,152 (GRCm39) L89P probably damaging Het
Fndc3b T A 3: 27,610,266 (GRCm39) probably null Het
Gm9955 G T 18: 24,842,209 (GRCm39) probably benign Het
Gprc6a T A 10: 51,491,080 (GRCm39) K819* probably null Het
Gxylt1 A T 15: 93,152,436 (GRCm39) probably benign Het
Hspa12a T C 19: 58,788,056 (GRCm39) T589A probably benign Het
Idh2 A G 7: 79,747,570 (GRCm39) S317P probably damaging Het
Ifi30 T C 8: 71,216,421 (GRCm39) probably null Het
Ifna16 G A 4: 88,594,867 (GRCm39) A76V probably benign Het
Itpr2 C T 6: 146,246,638 (GRCm39) E1127K probably damaging Het
Kank4 A G 4: 98,667,457 (GRCm39) V330A probably benign Het
Kpna1 T A 16: 35,843,611 (GRCm39) D328E probably damaging Het
Krt71 T A 15: 101,646,868 (GRCm39) H280L possibly damaging Het
Lrrc37 G A 11: 103,433,816 (GRCm39) P942S probably damaging Het
Mapt A G 11: 104,196,224 (GRCm39) M446V probably damaging Het
Med1 C T 11: 98,057,081 (GRCm39) probably null Het
Mif T A 10: 75,695,614 (GRCm39) H63L probably damaging Het
Mycbp2 A G 14: 103,461,708 (GRCm39) V1447A probably benign Het
Myo1b A T 1: 51,821,148 (GRCm39) I451N probably damaging Het
Nme2 A T 11: 93,842,756 (GRCm39) probably null Het
Nubp1 A G 16: 10,238,981 (GRCm39) T199A probably damaging Het
Nup210l T A 3: 90,089,212 (GRCm39) V1165D probably damaging Het
Nup98 T A 7: 101,841,241 (GRCm39) T122S probably damaging Het
Or14a258 A T 7: 86,035,715 (GRCm39) L51Q probably benign Het
Or1n2 T C 2: 36,797,470 (GRCm39) F171L probably damaging Het
Or5j1 C T 2: 86,879,548 (GRCm39) E11K probably damaging Het
Or6c202 T A 10: 128,996,608 (GRCm39) I82L probably benign Het
Pard3b A T 1: 62,676,979 (GRCm39) Y1170F probably damaging Het
Pear1 T C 3: 87,661,665 (GRCm39) D536G probably damaging Het
Phrf1 G T 7: 140,823,770 (GRCm39) R196L probably damaging Het
Plxna2 G T 1: 194,326,204 (GRCm39) R46L probably benign Het
Rbm39 G A 2: 155,990,099 (GRCm39) T496I possibly damaging Het
Rpl14 C G 9: 120,401,167 (GRCm39) F3L possibly damaging Het
Rtf2 G A 2: 172,286,616 (GRCm39) S40N probably damaging Het
Runx2 G A 17: 44,919,141 (GRCm39) S481L possibly damaging Het
Sh3rf1 T A 8: 61,782,286 (GRCm39) Y143N possibly damaging Het
Siglec15 G A 18: 78,092,092 (GRCm39) probably benign Het
Slc4a8 T A 15: 100,687,727 (GRCm39) I288N probably damaging Het
Ttc38 C A 15: 85,725,690 (GRCm39) F184L probably damaging Het
Vmn1r28 T C 6: 58,242,879 (GRCm39) Y241H probably damaging Het
Vmn2r110 A T 17: 20,816,346 (GRCm39) V59D probably benign Het
Wdpcp A G 11: 21,661,638 (GRCm39) I303M probably damaging Het
Zc3h12d G A 10: 7,743,678 (GRCm39) A483T probably benign Het
Zfp106 C A 2: 120,362,094 (GRCm39) K1008N probably damaging Het
Zfp68 G A 5: 138,606,041 (GRCm39) T94I probably benign Het
Zkscan3 A T 13: 21,579,090 (GRCm39) probably null Het
Other mutations in Zfp334
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02097:Zfp334 APN 2 165,223,643 (GRCm39) nonsense probably null
IGL02185:Zfp334 APN 2 165,228,869 (GRCm39) utr 5 prime probably benign
IGL02415:Zfp334 APN 2 165,223,771 (GRCm39) missense possibly damaging 0.70
IGL02693:Zfp334 APN 2 165,222,433 (GRCm39) missense possibly damaging 0.80
ANU23:Zfp334 UTSW 2 165,223,017 (GRCm39) missense probably damaging 1.00
R1332:Zfp334 UTSW 2 165,222,776 (GRCm39) missense probably damaging 1.00
R1579:Zfp334 UTSW 2 165,223,719 (GRCm39) missense probably damaging 0.98
R2429:Zfp334 UTSW 2 165,222,432 (GRCm39) missense probably damaging 1.00
R5556:Zfp334 UTSW 2 165,222,504 (GRCm39) missense probably benign
R5579:Zfp334 UTSW 2 165,222,407 (GRCm39) nonsense probably null
R6891:Zfp334 UTSW 2 165,224,644 (GRCm39) missense probably benign
R6918:Zfp334 UTSW 2 165,223,799 (GRCm39) missense possibly damaging 0.46
R8360:Zfp334 UTSW 2 165,225,278 (GRCm39) missense probably benign 0.00
R8998:Zfp334 UTSW 2 165,223,408 (GRCm39) missense possibly damaging 0.80
R9481:Zfp334 UTSW 2 165,222,271 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CGAGTGAGGCTTGCCTTTATACGG -3'
(R):5'- ATGACCCTGGCGGAAATGGCTTAG -3'

Sequencing Primer
(F):5'- tctttctccggtatggattctc -3'
(R):5'- GCGGAAATGGCTTAGAAAATAACTC -3'
Posted On 2013-08-06