Incidental Mutation 'R8374:Tatdn1'
ID 646595
Institutional Source Beutler Lab
Gene Symbol Tatdn1
Ensembl Gene ENSMUSG00000050891
Gene Name TatD DNase domain containing 1
Synonyms CDA11, 2310079P03Rik
MMRRC Submission 067742-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.157) question?
Stock # R8374 (G1)
Quality Score 225.009
Status Not validated
Chromosome 15
Chromosomal Location 58762004-58805587 bp(-) (GRCm39)
Type of Mutation critical splice donor site (1 bp from exon)
DNA Base Change (assembly) C to T at 58788000 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000105783 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000110155] [ENSMUST00000110155] [ENSMUST00000110155] [ENSMUST00000226707] [ENSMUST00000226835] [ENSMUST00000227540] [ENSMUST00000228538] [ENSMUST00000228787]
AlphaFold Q6P8M1
Predicted Effect probably null
Transcript: ENSMUST00000110155
SMART Domains Protein: ENSMUSP00000105783
Gene: ENSMUSG00000050891

DomainStartEndE-ValueType
Pfam:TatD_DNase 7 263 2.4e-51 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000110155
SMART Domains Protein: ENSMUSP00000105783
Gene: ENSMUSG00000050891

DomainStartEndE-ValueType
Pfam:TatD_DNase 7 263 2.4e-51 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000110155
SMART Domains Protein: ENSMUSP00000105783
Gene: ENSMUSG00000050891

DomainStartEndE-ValueType
Pfam:TatD_DNase 7 263 2.4e-51 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000226707
Predicted Effect probably benign
Transcript: ENSMUST00000226835
Predicted Effect probably benign
Transcript: ENSMUST00000227540
Predicted Effect probably benign
Transcript: ENSMUST00000228538
Predicted Effect probably benign
Transcript: ENSMUST00000228787
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts15 C T 9: 30,814,002 (GRCm39) G721E probably benign Het
Aip A T 19: 4,165,456 (GRCm39) M170K probably damaging Het
Alms1 T C 6: 85,585,973 (GRCm39) I276T probably benign Het
Arid1b C T 17: 5,392,919 (GRCm39) P2097S possibly damaging Het
Astn1 T G 1: 158,329,803 (GRCm39) N219K probably damaging Het
Cbx2 G T 11: 118,918,969 (GRCm39) R178L probably damaging Het
Clptm1 G A 7: 19,372,081 (GRCm39) P252S probably benign Het
Crebbp A G 16: 3,902,175 (GRCm39) S2355P probably damaging Het
D130043K22Rik C A 13: 25,041,962 (GRCm39) T297K probably benign Het
Ddx60 A G 8: 62,427,205 (GRCm39) D760G probably benign Het
Dgka T C 10: 128,557,112 (GRCm39) N621S probably benign Het
Ear10 A T 14: 44,160,645 (GRCm39) C61S probably damaging Het
F12 A T 13: 55,569,144 (GRCm39) C238S probably damaging Het
Fen1 A G 19: 10,177,824 (GRCm39) F207L probably benign Het
Fzr1 A G 10: 81,203,368 (GRCm39) L486P probably damaging Het
Gdnf A G 15: 7,864,176 (GRCm39) R196G probably benign Het
Gldc A C 19: 30,114,594 (GRCm39) F439V probably damaging Het
Gm3138 T C 14: 4,251,688 (GRCm38) M120T probably damaging Het
Gpi1 G A 7: 33,920,082 (GRCm39) A197V probably benign Het
Ighv1-4 T A 12: 114,450,899 (GRCm39) I70F probably benign Het
Il19 A T 1: 130,866,893 (GRCm39) L29Q probably damaging Het
Kank1 A T 19: 25,389,005 (GRCm39) I893F probably damaging Het
Kcnq5 G A 1: 21,549,648 (GRCm39) R360C probably damaging Het
Kif13b T C 14: 65,025,884 (GRCm39) S1414P probably damaging Het
Miga2 AAGAG AAG 2: 30,265,755 (GRCm39) probably null Het
Mosmo T A 7: 120,329,715 (GRCm39) M112K probably benign Het
Ntmt2 A T 1: 163,530,617 (GRCm39) M274K probably damaging Het
Or2d2b A G 7: 106,706,033 (GRCm39) F12L probably damaging Het
Or2h1b C A 17: 37,462,636 (GRCm39) V76F probably damaging Het
Or2w3b T A 11: 58,623,724 (GRCm39) D89V probably damaging Het
Pak6 G A 2: 118,524,477 (GRCm39) V497I probably benign Het
Ppargc1b G A 18: 61,443,564 (GRCm39) S549F probably damaging Het
Rassf8 T A 6: 145,760,863 (GRCm39) L63* probably null Het
Rptn G T 3: 93,303,602 (GRCm39) G312* probably null Het
Rsph14 T C 10: 74,797,481 (GRCm39) I169V probably benign Het
Sltm A G 9: 70,469,227 (GRCm39) D162G probably null Het
Tbx4 A C 11: 85,805,102 (GRCm39) E397A probably benign Het
Tdrd12 T C 7: 35,177,486 (GRCm39) D956G unknown Het
Tnr G A 1: 159,685,953 (GRCm39) V395I probably benign Het
Ugt1a2 A T 1: 88,129,107 (GRCm39) H250L possibly damaging Het
Vmn1r173 C T 7: 23,401,920 (GRCm39) H52Y probably damaging Het
Vps11 T C 9: 44,267,706 (GRCm39) D302G probably benign Het
Zfp398 T C 6: 47,836,468 (GRCm39) probably null Het
Other mutations in Tatdn1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01141:Tatdn1 APN 15 58,781,416 (GRCm39) intron probably benign
IGL03155:Tatdn1 APN 15 58,788,045 (GRCm39) intron probably benign
PIT4403001:Tatdn1 UTSW 15 58,777,596 (GRCm39) missense probably damaging 1.00
R0417:Tatdn1 UTSW 15 58,793,199 (GRCm39) missense probably benign 0.00
R1605:Tatdn1 UTSW 15 58,793,039 (GRCm39) intron probably benign
R1823:Tatdn1 UTSW 15 58,788,005 (GRCm39) missense probably damaging 1.00
R2267:Tatdn1 UTSW 15 58,777,601 (GRCm39) missense probably damaging 1.00
R3923:Tatdn1 UTSW 15 58,793,020 (GRCm39) missense possibly damaging 0.88
R6481:Tatdn1 UTSW 15 58,795,760 (GRCm39) missense possibly damaging 0.49
R6912:Tatdn1 UTSW 15 58,793,118 (GRCm39) splice site probably null
R7827:Tatdn1 UTSW 15 58,776,607 (GRCm39) missense probably benign 0.00
R8788:Tatdn1 UTSW 15 58,762,543 (GRCm39) makesense probably null
Predicted Primers PCR Primer
(F):5'- GCTTACTGCACAGTGGGAAAAG -3'
(R):5'- ATCCTGGTAAATGAAGCATCCC -3'

Sequencing Primer
(F):5'- TGGGAAAAGACGATTCACATTTG -3'
(R):5'- CCCTTTCTAAAAATTAAGTGGCAGG -3'
Posted On 2020-09-02