Incidental Mutation 'R8377:Or4k35'
ID 646721
Institutional Source Beutler Lab
Gene Symbol Or4k35
Ensembl Gene ENSMUSG00000074965
Gene Name olfactory receptor family 4 subfamily K member 35
Synonyms MOR248-11, Olfr1277, GA_x6K02T2Q125-72321818-72320907
MMRRC Submission 067745-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.075) question?
Stock # R8377 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 111099799-111100710 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 111099983 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Leucine at position 243 (H243L)
Ref Sequence ENSEMBL: ENSMUSP00000150703 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099619] [ENSMUST00000214760]
AlphaFold Q8VF41
Predicted Effect probably damaging
Transcript: ENSMUST00000099619
AA Change: H243L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000097214
Gene: ENSMUSG00000074965
AA Change: H243L

DomainStartEndE-ValueType
Pfam:7tm_4 31 303 5.5e-50 PFAM
Pfam:7tm_1 41 287 7.2e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214760
AA Change: H243L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acot3 C A 12: 84,105,561 (GRCm39) C251* probably null Het
Acsbg1 A G 9: 54,529,789 (GRCm39) C273R probably damaging Het
Adh6a A G 3: 138,031,884 (GRCm39) T259A probably damaging Het
Aknad1 A G 3: 108,689,255 (GRCm39) H639R possibly damaging Het
Alkal2 G T 12: 30,934,850 (GRCm39) G23V probably damaging Het
Ampd3 A G 7: 110,399,937 (GRCm39) R342G probably damaging Het
Arid5b G T 10: 67,933,217 (GRCm39) A895E probably damaging Het
BB014433 GCACACAGCTTTGGAGGTGTACACACCCGGGTTGGGGCCTCTACACACAGCTTTGGAGGTGTACACACCCGGGTTGGGGCCTCTGCACACAGCTTTGG GCACACAGCTTTGGAGGTGTACACACCCGGGTTGGGGCCTCTGCACACAGCTTTGG 8: 15,092,160 (GRCm39) probably benign Het
Bmp8a G T 4: 123,236,482 (GRCm39) P7Q unknown Het
Boll A C 1: 55,362,837 (GRCm39) V187G possibly damaging Het
Ccdc162 A T 10: 41,457,306 (GRCm39) C1544S probably benign Het
Cmss1 A C 16: 57,127,757 (GRCm39) M182R possibly damaging Het
Cntn3 T C 6: 102,186,254 (GRCm39) M578V probably benign Het
Dmxl2 A T 9: 54,286,032 (GRCm39) W2718R probably damaging Het
Dsg1a T A 18: 20,466,831 (GRCm39) I567N probably damaging Het
Epc2 T A 2: 49,412,527 (GRCm39) D168E probably damaging Het
Ern2 G A 7: 121,780,515 (GRCm39) Q162* probably null Het
F11r G T 1: 171,265,111 (GRCm39) probably benign Het
Fcgrt T C 7: 44,751,987 (GRCm39) Y59C probably damaging Het
Fmn2 G T 1: 174,436,011 (GRCm39) E661* probably null Het
Gbp4 T A 5: 105,266,328 (GRCm39) Q571L probably benign Het
Gm29106 A T 1: 118,126,593 (GRCm39) H95L probably damaging Het
Gphn G A 12: 78,711,280 (GRCm39) V621M probably damaging Het
Grwd1 T C 7: 45,480,036 (GRCm39) Y57C probably damaging Het
Insyn2b C A 11: 34,351,964 (GRCm39) A2D probably damaging Het
Irs2 G A 8: 11,054,848 (GRCm39) Q1195* probably null Het
Itpr1 G C 6: 108,487,699 (GRCm39) C2375S probably benign Het
Kcnmb4 A T 10: 116,282,290 (GRCm39) Y136N probably benign Het
Matn2 C T 15: 34,345,511 (GRCm39) P173S probably damaging Het
Med17 A C 9: 15,173,655 (GRCm39) D606E probably damaging Het
Mpl A G 4: 118,301,254 (GRCm39) V537A Het
Mrpl1 C G 5: 96,374,226 (GRCm39) A167G probably benign Het
Mrpl21 T C 19: 3,342,487 (GRCm39) F206S unknown Het
Msh6 T A 17: 88,292,598 (GRCm39) M451K probably damaging Het
Myo10 T C 15: 25,804,481 (GRCm39) I1592T possibly damaging Het
Naip1 A T 13: 100,562,374 (GRCm39) D930E possibly damaging Het
Necap2 T C 4: 140,795,534 (GRCm39) I242V probably benign Het
Nfya A G 17: 48,699,073 (GRCm39) V240A possibly damaging Het
Olfml2b A G 1: 170,496,353 (GRCm39) D328G probably damaging Het
Or10ak13 A T 4: 118,639,203 (GRCm39) M193K probably benign Het
Or5b24 T G 19: 12,912,399 (GRCm39) V99G probably benign Het
Or5p53 T G 7: 107,532,892 (GRCm39) L55R probably damaging Het
Phf8-ps C A 17: 33,286,038 (GRCm39) A255S probably benign Het
Pkd1l3 T C 8: 110,361,982 (GRCm39) V1018A probably benign Het
Plcg1 T C 2: 160,596,842 (GRCm39) L761P probably damaging Het
Ppp1r36 T C 12: 76,485,215 (GRCm39) S313P possibly damaging Het
Ptpru C A 4: 131,535,646 (GRCm39) G444C probably damaging Het
Rfxank A T 8: 70,587,960 (GRCm39) V149D probably damaging Het
Rimbp2 G A 5: 128,857,395 (GRCm39) H819Y probably damaging Het
Sgms1 T C 19: 32,101,821 (GRCm39) Y395C probably damaging Het
Siae G A 9: 37,542,901 (GRCm39) probably null Het
Slc46a2 T A 4: 59,914,713 (GRCm39) D70V probably damaging Het
Smpdl3a A C 10: 57,677,032 (GRCm39) L43F possibly damaging Het
Spcs1 T A 14: 30,722,103 (GRCm39) D146V possibly damaging Het
Srcin1 T C 11: 97,442,804 (GRCm39) D8G probably damaging Het
Stra6 G T 9: 58,056,488 (GRCm39) L373F probably damaging Het
Tacc1 A T 8: 25,672,299 (GRCm39) S310T possibly damaging Het
Tlr12 T C 4: 128,509,566 (GRCm39) S895G probably benign Het
Tnfaip3 A G 10: 18,887,258 (GRCm39) V89A probably damaging Het
Top1 C T 2: 160,488,009 (GRCm39) probably benign Het
Trappc13 T G 13: 104,297,509 (GRCm39) I132L probably benign Het
Trpt1 C T 19: 6,976,349 (GRCm39) Q249* probably null Het
Tsnaxip1 A C 8: 106,569,179 (GRCm39) K510Q probably damaging Het
Usp39 A T 6: 72,305,657 (GRCm39) N375K probably benign Het
Vldlr T A 19: 27,212,258 (GRCm39) C91S probably damaging Het
Vmn1r232 T A 17: 21,134,239 (GRCm39) L120F probably benign Het
Vmn2r71 T C 7: 85,264,707 (GRCm39) V13A probably benign Het
Wdr11 T A 7: 129,208,412 (GRCm39) V389E possibly damaging Het
Wsb2 A T 5: 117,514,766 (GRCm39) I321F possibly damaging Het
Zan A T 5: 137,389,949 (GRCm39) V4841E unknown Het
Zfy1 A T Y: 725,723 (GRCm39) F681I possibly damaging Het
Zpld1 C A 16: 55,067,017 (GRCm39) E179D probably benign Het
Other mutations in Or4k35
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01552:Or4k35 APN 2 111,100,257 (GRCm39) missense probably damaging 1.00
IGL02550:Or4k35 APN 2 111,100,349 (GRCm39) missense probably damaging 0.99
IGL02661:Or4k35 APN 2 111,099,811 (GRCm39) missense possibly damaging 0.56
IGL02940:Or4k35 APN 2 111,100,073 (GRCm39) missense probably damaging 0.99
R0121:Or4k35 UTSW 2 111,100,659 (GRCm39) missense probably benign 0.01
R0402:Or4k35 UTSW 2 111,100,208 (GRCm39) missense probably damaging 1.00
R0903:Or4k35 UTSW 2 111,100,701 (GRCm39) missense probably benign
R1804:Or4k35 UTSW 2 111,100,275 (GRCm39) missense probably benign
R1806:Or4k35 UTSW 2 111,100,622 (GRCm39) missense possibly damaging 0.65
R1965:Or4k35 UTSW 2 111,099,938 (GRCm39) missense probably damaging 1.00
R3718:Or4k35 UTSW 2 111,100,571 (GRCm39) missense probably benign
R4044:Or4k35 UTSW 2 111,099,927 (GRCm39) missense probably benign 0.01
R4401:Or4k35 UTSW 2 111,100,178 (GRCm39) missense probably damaging 1.00
R4518:Or4k35 UTSW 2 111,100,263 (GRCm39) missense probably benign
R5309:Or4k35 UTSW 2 111,100,655 (GRCm39) missense probably benign 0.00
R5312:Or4k35 UTSW 2 111,100,655 (GRCm39) missense probably benign 0.00
R5367:Or4k35 UTSW 2 111,100,235 (GRCm39) missense possibly damaging 0.81
R5727:Or4k35 UTSW 2 111,100,197 (GRCm39) nonsense probably null
R5772:Or4k35 UTSW 2 111,100,057 (GRCm39) nonsense probably null
R5827:Or4k35 UTSW 2 111,100,266 (GRCm39) missense probably damaging 1.00
R5882:Or4k35 UTSW 2 111,100,484 (GRCm39) missense probably damaging 0.99
R6036:Or4k35 UTSW 2 111,099,957 (GRCm39) missense probably damaging 1.00
R6036:Or4k35 UTSW 2 111,099,957 (GRCm39) missense probably damaging 1.00
R6728:Or4k35 UTSW 2 111,100,018 (GRCm39) missense probably benign 0.00
R7629:Or4k35 UTSW 2 111,100,221 (GRCm39) missense probably benign 0.00
R8870:Or4k35 UTSW 2 111,100,464 (GRCm39) missense possibly damaging 0.61
R9100:Or4k35 UTSW 2 111,100,094 (GRCm39) missense probably benign 0.35
R9668:Or4k35 UTSW 2 111,100,287 (GRCm39) missense probably benign 0.03
R9690:Or4k35 UTSW 2 111,099,822 (GRCm39) missense probably damaging 0.98
R9715:Or4k35 UTSW 2 111,100,623 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GCTAGCATTGTAATCTCTTCATAGCAG -3'
(R):5'- TGTAAATCTGCCCTTCTGTGG -3'

Sequencing Primer
(F):5'- AAACTTGTCCACCCAGGT -3'
(R):5'- CATTGGTAATCAAGCTAGCCTGC -3'
Posted On 2020-09-02