Incidental Mutation 'R8377:Ccdc162'
ID 646760
Institutional Source Beutler Lab
Gene Symbol Ccdc162
Ensembl Gene ENSMUSG00000075225
Gene Name coiled-coil domain containing 162
Synonyms Gm29096, Gm6976, 5033413D22Rik
MMRRC Submission 067745-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # R8377 (G1)
Quality Score 225.009
Status Not validated
Chromosome 10
Chromosomal Location 41414838-41592586 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 41457306 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Serine at position 1544 (C1544S)
Ref Sequence ENSEMBL: ENSMUSP00000140774 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000019955] [ENSMUST00000099932] [ENSMUST00000179614] [ENSMUST00000189488] [ENSMUST00000219054]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000019955
SMART Domains Protein: ENSMUSP00000019955
Gene: ENSMUSG00000075225

DomainStartEndE-ValueType
coiled coil region 1 37 N/A INTRINSIC
low complexity region 116 138 N/A INTRINSIC
coiled coil region 177 217 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000095227
SMART Domains Protein: ENSMUSP00000092852
Gene: ENSMUSG00000075225

DomainStartEndE-ValueType
coiled coil region 140 179 N/A INTRINSIC
low complexity region 304 326 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000099932
AA Change: C81S

PolyPhen 2 Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000097516
Gene: ENSMUSG00000075225
AA Change: C81S

DomainStartEndE-ValueType
coiled coil region 327 366 N/A INTRINSIC
low complexity region 490 512 N/A INTRINSIC
coiled coil region 551 607 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000179614
AA Change: C271S

PolyPhen 2 Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000135966
Gene: ENSMUSG00000075225
AA Change: C271S

DomainStartEndE-ValueType
coiled coil region 517 556 N/A INTRINSIC
low complexity region 680 702 N/A INTRINSIC
coiled coil region 741 797 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000189488
AA Change: C1544S

PolyPhen 2 Score 0.076 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000140774
Gene: ENSMUSG00000075225
AA Change: C1544S

DomainStartEndE-ValueType
low complexity region 328 347 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000219054
AA Change: C271S

PolyPhen 2 Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acot3 C A 12: 84,105,561 (GRCm39) C251* probably null Het
Acsbg1 A G 9: 54,529,789 (GRCm39) C273R probably damaging Het
Adh6a A G 3: 138,031,884 (GRCm39) T259A probably damaging Het
Aknad1 A G 3: 108,689,255 (GRCm39) H639R possibly damaging Het
Alkal2 G T 12: 30,934,850 (GRCm39) G23V probably damaging Het
Ampd3 A G 7: 110,399,937 (GRCm39) R342G probably damaging Het
Arid5b G T 10: 67,933,217 (GRCm39) A895E probably damaging Het
BB014433 GCACACAGCTTTGGAGGTGTACACACCCGGGTTGGGGCCTCTACACACAGCTTTGGAGGTGTACACACCCGGGTTGGGGCCTCTGCACACAGCTTTGG GCACACAGCTTTGGAGGTGTACACACCCGGGTTGGGGCCTCTGCACACAGCTTTGG 8: 15,092,160 (GRCm39) probably benign Het
Bmp8a G T 4: 123,236,482 (GRCm39) P7Q unknown Het
Boll A C 1: 55,362,837 (GRCm39) V187G possibly damaging Het
Cmss1 A C 16: 57,127,757 (GRCm39) M182R possibly damaging Het
Cntn3 T C 6: 102,186,254 (GRCm39) M578V probably benign Het
Dmxl2 A T 9: 54,286,032 (GRCm39) W2718R probably damaging Het
Dsg1a T A 18: 20,466,831 (GRCm39) I567N probably damaging Het
Epc2 T A 2: 49,412,527 (GRCm39) D168E probably damaging Het
Ern2 G A 7: 121,780,515 (GRCm39) Q162* probably null Het
F11r G T 1: 171,265,111 (GRCm39) probably benign Het
Fcgrt T C 7: 44,751,987 (GRCm39) Y59C probably damaging Het
Fmn2 G T 1: 174,436,011 (GRCm39) E661* probably null Het
Gbp4 T A 5: 105,266,328 (GRCm39) Q571L probably benign Het
Gm29106 A T 1: 118,126,593 (GRCm39) H95L probably damaging Het
Gphn G A 12: 78,711,280 (GRCm39) V621M probably damaging Het
Grwd1 T C 7: 45,480,036 (GRCm39) Y57C probably damaging Het
Insyn2b C A 11: 34,351,964 (GRCm39) A2D probably damaging Het
Irs2 G A 8: 11,054,848 (GRCm39) Q1195* probably null Het
Itpr1 G C 6: 108,487,699 (GRCm39) C2375S probably benign Het
Kcnmb4 A T 10: 116,282,290 (GRCm39) Y136N probably benign Het
Matn2 C T 15: 34,345,511 (GRCm39) P173S probably damaging Het
Med17 A C 9: 15,173,655 (GRCm39) D606E probably damaging Het
Mpl A G 4: 118,301,254 (GRCm39) V537A Het
Mrpl1 C G 5: 96,374,226 (GRCm39) A167G probably benign Het
Mrpl21 T C 19: 3,342,487 (GRCm39) F206S unknown Het
Msh6 T A 17: 88,292,598 (GRCm39) M451K probably damaging Het
Myo10 T C 15: 25,804,481 (GRCm39) I1592T possibly damaging Het
Naip1 A T 13: 100,562,374 (GRCm39) D930E possibly damaging Het
Necap2 T C 4: 140,795,534 (GRCm39) I242V probably benign Het
Nfya A G 17: 48,699,073 (GRCm39) V240A possibly damaging Het
Olfml2b A G 1: 170,496,353 (GRCm39) D328G probably damaging Het
Or10ak13 A T 4: 118,639,203 (GRCm39) M193K probably benign Het
Or4k35 T A 2: 111,099,983 (GRCm39) H243L probably damaging Het
Or5b24 T G 19: 12,912,399 (GRCm39) V99G probably benign Het
Or5p53 T G 7: 107,532,892 (GRCm39) L55R probably damaging Het
Phf8-ps C A 17: 33,286,038 (GRCm39) A255S probably benign Het
Pkd1l3 T C 8: 110,361,982 (GRCm39) V1018A probably benign Het
Plcg1 T C 2: 160,596,842 (GRCm39) L761P probably damaging Het
Ppp1r36 T C 12: 76,485,215 (GRCm39) S313P possibly damaging Het
Ptpru C A 4: 131,535,646 (GRCm39) G444C probably damaging Het
Rfxank A T 8: 70,587,960 (GRCm39) V149D probably damaging Het
Rimbp2 G A 5: 128,857,395 (GRCm39) H819Y probably damaging Het
Sgms1 T C 19: 32,101,821 (GRCm39) Y395C probably damaging Het
Siae G A 9: 37,542,901 (GRCm39) probably null Het
Slc46a2 T A 4: 59,914,713 (GRCm39) D70V probably damaging Het
Smpdl3a A C 10: 57,677,032 (GRCm39) L43F possibly damaging Het
Spcs1 T A 14: 30,722,103 (GRCm39) D146V possibly damaging Het
Srcin1 T C 11: 97,442,804 (GRCm39) D8G probably damaging Het
Stra6 G T 9: 58,056,488 (GRCm39) L373F probably damaging Het
Tacc1 A T 8: 25,672,299 (GRCm39) S310T possibly damaging Het
Tlr12 T C 4: 128,509,566 (GRCm39) S895G probably benign Het
Tnfaip3 A G 10: 18,887,258 (GRCm39) V89A probably damaging Het
Top1 C T 2: 160,488,009 (GRCm39) probably benign Het
Trappc13 T G 13: 104,297,509 (GRCm39) I132L probably benign Het
Trpt1 C T 19: 6,976,349 (GRCm39) Q249* probably null Het
Tsnaxip1 A C 8: 106,569,179 (GRCm39) K510Q probably damaging Het
Usp39 A T 6: 72,305,657 (GRCm39) N375K probably benign Het
Vldlr T A 19: 27,212,258 (GRCm39) C91S probably damaging Het
Vmn1r232 T A 17: 21,134,239 (GRCm39) L120F probably benign Het
Vmn2r71 T C 7: 85,264,707 (GRCm39) V13A probably benign Het
Wdr11 T A 7: 129,208,412 (GRCm39) V389E possibly damaging Het
Wsb2 A T 5: 117,514,766 (GRCm39) I321F possibly damaging Het
Zan A T 5: 137,389,949 (GRCm39) V4841E unknown Het
Zfy1 A T Y: 725,723 (GRCm39) F681I possibly damaging Het
Zpld1 C A 16: 55,067,017 (GRCm39) E179D probably benign Het
Other mutations in Ccdc162
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01013:Ccdc162 APN 10 41,457,335 (GRCm39) missense probably benign 0.01
IGL01366:Ccdc162 APN 10 41,456,302 (GRCm39) missense possibly damaging 0.49
IGL01924:Ccdc162 APN 10 41,445,883 (GRCm39) missense probably damaging 1.00
IGL02504:Ccdc162 APN 10 41,428,384 (GRCm39) missense probably damaging 1.00
IGL02678:Ccdc162 APN 10 41,437,151 (GRCm39) missense probably damaging 0.99
IGL02955:Ccdc162 APN 10 41,437,123 (GRCm39) missense probably damaging 1.00
beeswax UTSW 10 41,437,222 (GRCm39) missense possibly damaging 0.57
honeycomb UTSW 10 41,520,637 (GRCm39) missense probably benign 0.35
FR4304:Ccdc162 UTSW 10 41,432,117 (GRCm39) missense possibly damaging 0.49
R0432:Ccdc162 UTSW 10 41,417,856 (GRCm39) missense probably benign 0.01
R0585:Ccdc162 UTSW 10 41,462,375 (GRCm39) missense probably benign 0.03
R0645:Ccdc162 UTSW 10 41,462,407 (GRCm39) splice site probably benign
R0731:Ccdc162 UTSW 10 41,455,139 (GRCm39) missense probably damaging 1.00
R1426:Ccdc162 UTSW 10 41,429,178 (GRCm39) missense possibly damaging 0.89
R1447:Ccdc162 UTSW 10 41,456,243 (GRCm39) missense probably damaging 1.00
R1712:Ccdc162 UTSW 10 41,415,427 (GRCm39) missense probably benign 0.35
R2138:Ccdc162 UTSW 10 41,457,293 (GRCm39) missense probably benign 0.15
R2351:Ccdc162 UTSW 10 41,431,968 (GRCm39) critical splice donor site probably null
R2394:Ccdc162 UTSW 10 41,445,894 (GRCm39) missense probably damaging 1.00
R2431:Ccdc162 UTSW 10 41,445,841 (GRCm39) missense probably benign
R2571:Ccdc162 UTSW 10 41,428,393 (GRCm39) missense probably damaging 1.00
R2873:Ccdc162 UTSW 10 41,531,095 (GRCm39) missense possibly damaging 0.68
R2926:Ccdc162 UTSW 10 41,437,203 (GRCm39) start gained probably benign
R2999:Ccdc162 UTSW 10 41,456,286 (GRCm39) missense probably benign 0.00
R3412:Ccdc162 UTSW 10 41,415,545 (GRCm39) splice site probably benign
R3712:Ccdc162 UTSW 10 41,463,375 (GRCm39) missense probably benign
R3736:Ccdc162 UTSW 10 41,465,564 (GRCm39) splice site probably null
R4112:Ccdc162 UTSW 10 41,532,324 (GRCm39) missense possibly damaging 0.77
R4557:Ccdc162 UTSW 10 41,463,384 (GRCm39) missense probably benign 0.01
R4580:Ccdc162 UTSW 10 41,437,136 (GRCm39) missense probably benign 0.02
R4685:Ccdc162 UTSW 10 41,557,682 (GRCm39) missense possibly damaging 0.89
R4837:Ccdc162 UTSW 10 41,549,863 (GRCm39) missense probably benign 0.00
R5155:Ccdc162 UTSW 10 41,455,147 (GRCm39) missense probably damaging 1.00
R5155:Ccdc162 UTSW 10 41,429,576 (GRCm39) splice site probably null
R5645:Ccdc162 UTSW 10 41,428,352 (GRCm39) missense probably benign 0.06
R5656:Ccdc162 UTSW 10 41,445,930 (GRCm39) missense probably benign 0.26
R5682:Ccdc162 UTSW 10 41,432,799 (GRCm39) nonsense probably null
R5808:Ccdc162 UTSW 10 41,531,500 (GRCm39) missense possibly damaging 0.62
R5909:Ccdc162 UTSW 10 41,437,111 (GRCm39) missense probably damaging 1.00
R6000:Ccdc162 UTSW 10 41,437,159 (GRCm39) missense possibly damaging 0.75
R6057:Ccdc162 UTSW 10 41,510,037 (GRCm39) missense possibly damaging 0.72
R6211:Ccdc162 UTSW 10 41,506,141 (GRCm39) nonsense probably null
R6264:Ccdc162 UTSW 10 41,570,464 (GRCm39) missense probably benign 0.31
R6329:Ccdc162 UTSW 10 41,539,147 (GRCm39) missense possibly damaging 0.76
R6349:Ccdc162 UTSW 10 41,570,396 (GRCm39) missense probably damaging 0.97
R6398:Ccdc162 UTSW 10 41,503,145 (GRCm39) missense probably damaging 1.00
R6453:Ccdc162 UTSW 10 41,426,821 (GRCm39) missense probably damaging 1.00
R6602:Ccdc162 UTSW 10 41,491,976 (GRCm39) missense probably benign 0.00
R6627:Ccdc162 UTSW 10 41,539,181 (GRCm39) missense probably damaging 1.00
R6722:Ccdc162 UTSW 10 41,520,637 (GRCm39) missense probably benign 0.35
R6750:Ccdc162 UTSW 10 41,437,222 (GRCm39) missense possibly damaging 0.57
R6968:Ccdc162 UTSW 10 41,549,840 (GRCm39) missense possibly damaging 0.55
R6970:Ccdc162 UTSW 10 41,491,954 (GRCm39) missense probably benign 0.03
R6989:Ccdc162 UTSW 10 41,457,349 (GRCm39) missense probably damaging 0.99
R7008:Ccdc162 UTSW 10 41,428,411 (GRCm39) missense probably damaging 1.00
R7135:Ccdc162 UTSW 10 41,549,855 (GRCm39) missense probably benign 0.00
R7139:Ccdc162 UTSW 10 41,542,717 (GRCm39) missense possibly damaging 0.49
R7224:Ccdc162 UTSW 10 41,437,187 (GRCm39) missense probably damaging 1.00
R7230:Ccdc162 UTSW 10 41,554,809 (GRCm39) missense probably damaging 1.00
R7256:Ccdc162 UTSW 10 41,431,997 (GRCm39) missense probably damaging 0.99
R7261:Ccdc162 UTSW 10 41,437,136 (GRCm39) missense probably benign 0.02
R7390:Ccdc162 UTSW 10 41,510,044 (GRCm39) missense probably benign
R7712:Ccdc162 UTSW 10 41,503,223 (GRCm39) missense possibly damaging 0.56
R7726:Ccdc162 UTSW 10 41,429,071 (GRCm39) missense probably benign 0.00
R7754:Ccdc162 UTSW 10 41,463,371 (GRCm39) missense probably damaging 1.00
R7764:Ccdc162 UTSW 10 41,566,109 (GRCm39) missense possibly damaging 0.95
R8053:Ccdc162 UTSW 10 41,520,577 (GRCm39) missense probably benign
R8088:Ccdc162 UTSW 10 41,499,410 (GRCm39) missense possibly damaging 0.68
R8094:Ccdc162 UTSW 10 41,488,864 (GRCm39) missense probably benign 0.02
R8097:Ccdc162 UTSW 10 41,510,115 (GRCm39) missense probably benign 0.03
R8321:Ccdc162 UTSW 10 41,510,029 (GRCm39) missense probably damaging 0.98
R8399:Ccdc162 UTSW 10 41,415,517 (GRCm39) missense probably damaging 1.00
R8669:Ccdc162 UTSW 10 41,428,352 (GRCm39) missense probably benign 0.06
R8772:Ccdc162 UTSW 10 41,506,033 (GRCm39) missense probably damaging 0.99
R8810:Ccdc162 UTSW 10 41,542,737 (GRCm39) missense probably benign 0.41
R8903:Ccdc162 UTSW 10 41,531,440 (GRCm39) critical splice donor site probably null
R8928:Ccdc162 UTSW 10 41,462,245 (GRCm39) splice site probably benign
R8950:Ccdc162 UTSW 10 41,474,507 (GRCm39) missense probably benign 0.00
R8960:Ccdc162 UTSW 10 41,429,178 (GRCm39) missense probably damaging 0.96
R8985:Ccdc162 UTSW 10 41,432,102 (GRCm39) missense probably damaging 1.00
R9071:Ccdc162 UTSW 10 41,457,174 (GRCm39) nonsense probably null
R9254:Ccdc162 UTSW 10 41,488,944 (GRCm39) critical splice acceptor site probably null
R9297:Ccdc162 UTSW 10 41,506,110 (GRCm39) missense probably benign
R9318:Ccdc162 UTSW 10 41,506,110 (GRCm39) missense probably benign
R9518:Ccdc162 UTSW 10 41,465,572 (GRCm39) missense probably damaging 1.00
R9525:Ccdc162 UTSW 10 41,559,222 (GRCm39) missense probably damaging 0.99
R9539:Ccdc162 UTSW 10 41,463,407 (GRCm39) missense possibly damaging 0.54
R9638:Ccdc162 UTSW 10 41,437,159 (GRCm39) missense probably benign 0.01
Z1176:Ccdc162 UTSW 10 41,530,993 (GRCm39) missense possibly damaging 0.84
Z1176:Ccdc162 UTSW 10 41,481,104 (GRCm39) missense possibly damaging 0.84
Z1176:Ccdc162 UTSW 10 41,429,127 (GRCm39) missense probably benign 0.00
Z1176:Ccdc162 UTSW 10 41,566,088 (GRCm39) missense probably benign 0.00
Z1177:Ccdc162 UTSW 10 41,559,191 (GRCm39) missense probably benign 0.00
Predicted Primers
Posted On 2020-09-02