Mutagenetix > Incidental Mutation

Incidental Mutation 'R8377:Vmn1r232'

646777

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r232

Ensembl Gene

ENSMUSG00000062165

Gene Name

vomeronasal 1 receptor 232

Synonyms

V1re4

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.068) question?

Stock #

R8377 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

20913205-20914363 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 20913977 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Phenylalanine at position 120 (L120F)

Ref Sequence

ENSEMBL: ENSMUSP00000076261 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000077001]

AlphaFold

A2RTT5

Predicted Effect

probably benign
Transcript: ENSMUST00000077001
AA Change: L120F

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)

SMART Domains

Protein: ENSMUSP00000076261
Gene: ENSMUSG00000062165
AA Change: L120F

Domain	Start	End	E-Value	Type
Pfam:TAS2R	46	331	6.9e-7	PFAM
Pfam:7tm_1	70	324	1e-6	PFAM
Pfam:V1R	78	338	1.9e-29	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.1%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 72 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4921501E09Rik	C	A	17: 33,067,064	A255S	probably benign	Het
Acot3	C	A	12: 84,058,787	C251*	probably null	Het
Acsbg1	A	G	9: 54,622,505	C273R	probably damaging	Het
Adh6a	A	G	3: 138,326,123	T259A	probably damaging	Het
Aknad1	A	G	3: 108,781,939	H639R	possibly damaging	Het
Alkal2	G	T	12: 30,884,851	G23V	probably damaging	Het
Ampd3	A	G	7: 110,800,730	R342G	probably damaging	Het
Arid5b	G	T	10: 68,097,387	A895E	probably damaging	Het
BB014433	GCACACAGCTTTGGAGGTGTACACACCCGGGTTGGGGCCTCTACACACAGCTTTGGAGGTGTACACACCCGGGTTGGGGCCTCTGCACACAGCTTTGG	GCACACAGCTTTGGAGGTGTACACACCCGGGTTGGGGCCTCTGCACACAGCTTTGG	8: 15,042,160		probably benign	Het
Bmp8a	G	T	4: 123,342,689	P7Q	unknown	Het
Boll	A	C	1: 55,323,678	V187G	possibly damaging	Het
Ccdc162	A	T	10: 41,581,310	C1544S	probably benign	Het
Cmss1	A	C	16: 57,307,394	M182R	possibly damaging	Het
Cntn3	T	C	6: 102,209,293	M578V	probably benign	Het
Dmxl2	A	T	9: 54,378,748	W2718R	probably damaging	Het
Dsg1a	T	A	18: 20,333,774	I567N	probably damaging	Het
Epc2	T	A	2: 49,522,515	D168E	probably damaging	Het
Ern2	G	A	7: 122,181,292	Q162*	probably null	Het
F11r	G	T	1: 171,437,543		probably benign	Het
Fam196b	C	A	11: 34,401,964	A2D	probably damaging	Het
Fcgrt	T	C	7: 45,102,563	Y59C	probably damaging	Het
Fmn2	G	T	1: 174,608,445	E661*	probably null	Het
Gbp4	T	A	5: 105,118,462	Q571L	probably benign	Het
Gm29106	A	T	1: 118,198,863	H95L	probably damaging	Het
Gphn	G	A	12: 78,664,506	V621M	probably damaging	Het
Grwd1	T	C	7: 45,830,612	Y57C	probably damaging	Het
Irs2	G	A	8: 11,004,848	Q1195*	probably null	Het
Itpr1	G	C	6: 108,510,738	C2375S	probably benign	Het
Kcnmb4	A	T	10: 116,446,385	Y136N	probably benign	Het
Matn2	C	T	15: 34,345,365	P173S	probably damaging	Het
Med17	A	C	9: 15,262,359	D606E	probably damaging	Het
Mpl	A	G	4: 118,444,057	V537A		Het
Mrpl1	C	G	5: 96,226,367	A167G	probably benign	Het
Mrpl21	T	C	19: 3,292,487	F206S	unknown	Het
Msh6	T	A	17: 87,985,170	M451K	probably damaging	Het
Myo10	T	C	15: 25,804,395	I1592T	possibly damaging	Het
Naip1	A	T	13: 100,425,866	D930E	possibly damaging	Het
Necap2	T	C	4: 141,068,223	I242V	probably benign	Het
Nfya	A	G	17: 48,392,045	V240A	possibly damaging	Het
Olfml2b	A	G	1: 170,668,784	D328G	probably damaging	Het
Olfr1277	T	A	2: 111,269,638	H243L	probably damaging	Het
Olfr1337	A	T	4: 118,782,006	M193K	probably benign	Het
Olfr1449	T	G	19: 12,935,035	V99G	probably benign	Het
Olfr473	T	G	7: 107,933,685	L55R	probably damaging	Het
Pkd1l3	T	C	8: 109,635,350	V1018A	probably benign	Het
Plcg1	T	C	2: 160,754,922	L761P	probably damaging	Het
Ppp1r36	T	C	12: 76,438,441	S313P	possibly damaging	Het
Ptpru	C	A	4: 131,808,335	G444C	probably damaging	Het
Rfxank	A	T	8: 70,135,310	V149D	probably damaging	Het
Rimbp2	G	A	5: 128,780,331	H819Y	probably damaging	Het
Sgms1	T	C	19: 32,124,421	Y395C	probably damaging	Het
Siae	G	A	9: 37,631,605		probably null	Het
Slc46a2	T	A	4: 59,914,713	D70V	probably damaging	Het
Smpdl3a	A	C	10: 57,800,936	L43F	possibly damaging	Het
Spcs1	T	A	14: 31,000,146	D146V	possibly damaging	Het
Srcin1	T	C	11: 97,551,978	D8G	probably damaging	Het
Stra6	G	T	9: 58,149,205	L373F	probably damaging	Het
Tacc1	A	T	8: 25,182,283	S310T	possibly damaging	Het
Tlr12	T	C	4: 128,615,773	S895G	probably benign	Het
Tnfaip3	A	G	10: 19,011,510	V89A	probably damaging	Het
Top1	C	T	2: 160,646,089		probably benign	Het
Trappc13	T	G	13: 104,161,001	I132L	probably benign	Het
Trpt1	C	T	19: 6,998,981	Q249*	probably null	Het
Tsnaxip1	A	C	8: 105,842,547	K510Q	probably damaging	Het
Usp39	A	T	6: 72,328,674	N375K	probably benign	Het
Vldlr	T	A	19: 27,234,858	C91S	probably damaging	Het
Vmn2r71	T	C	7: 85,615,499	V13A	probably benign	Het
Wdr11	T	A	7: 129,606,688	V389E	possibly damaging	Het
Wsb2	A	T	5: 117,376,701	I321F	possibly damaging	Het
Zan	A	T	5: 137,391,687	V4841E	unknown	Het
Zfy1	A	T	Y: 725,723	F681I	possibly damaging	Het
Zpld1	C	A	16: 55,246,654	E179D	probably benign	Het

Other mutations in Vmn1r232

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00900:Vmn1r232	APN	17	20914132	missense	probably benign	0.07
IGL02576:Vmn1r232	APN	17	20913913	missense	probably benign	0.30
H8562:Vmn1r232	UTSW	17	20913394	missense	probably benign	0.29
R1182:Vmn1r232	UTSW	17	20913443	missense	possibly damaging	0.95
R2010:Vmn1r232	UTSW	17	20913339	missense	probably benign	0.00
R2088:Vmn1r232	UTSW	17	20913737	missense	possibly damaging	0.63
R2206:Vmn1r232	UTSW	17	20914203	missense	probably benign	0.29
R2207:Vmn1r232	UTSW	17	20914203	missense	probably benign	0.29
R2273:Vmn1r232	UTSW	17	20914203	missense	probably benign	0.29
R2274:Vmn1r232	UTSW	17	20914203	missense	probably benign	0.29
R2275:Vmn1r232	UTSW	17	20914203	missense	probably benign	0.29
R2443:Vmn1r232	UTSW	17	20913384	missense	probably damaging	1.00
R2516:Vmn1r232	UTSW	17	20914026	missense	possibly damaging	0.65
R3700:Vmn1r232	UTSW	17	20914203	missense	probably benign	0.29
R5256:Vmn1r232	UTSW	17	20913584	missense	probably damaging	1.00
R5418:Vmn1r232	UTSW	17	20914116	missense	possibly damaging	0.75
R5726:Vmn1r232	UTSW	17	20913339	missense	probably benign	0.00
R5833:Vmn1r232	UTSW	17	20913651	missense	probably damaging	1.00
R6528:Vmn1r232	UTSW	17	20914047	missense	probably benign	0.12
R7019:Vmn1r232	UTSW	17	20913285	missense	possibly damaging	0.76
R7600:Vmn1r232	UTSW	17	20913737	missense	possibly damaging	0.63
R8695:Vmn1r232	UTSW	17	20913847	missense	probably benign
R9000:Vmn1r232	UTSW	17	20913849	missense	probably damaging	1.00
R9512:Vmn1r232	UTSW	17	20914154	missense	probably damaging	0.99
Z1088:Vmn1r232	UTSW	17	20913838	missense	probably benign	0.38

Predicted Primers

PCR Primer
(F):5'- CGTCTTGGTAGATGTATACACAGG -3'
(R):5'- ATGGAGTCCAGGAACATGGC -3'

Sequencing Primer
(F):5'- ACACAGGGAAAAGCATATTTACTAAC -3'
(R):5'- GCAATAGGAGTAGGACTCTCACTTC -3'

Posted On

2020-09-02