Incidental Mutation 'R8379:Denr'
ID 646850
Institutional Source Beutler Lab
Gene Symbol Denr
Ensembl Gene ENSMUSG00000023106
Gene Name density-regulated protein
Synonyms 1500003K04Rik
MMRRC Submission 067810-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R8379 (G1)
Quality Score 225.009
Status Validated
Chromosome 5
Chromosomal Location 124045309-124066705 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 124065124 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Lysine at position 159 (T159K)
Ref Sequence ENSEMBL: ENSMUSP00000023869 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023869] [ENSMUST00000094320] [ENSMUST00000165148] [ENSMUST00000166129] [ENSMUST00000166233]
AlphaFold Q9CQJ6
Predicted Effect possibly damaging
Transcript: ENSMUST00000023869
AA Change: T159K

PolyPhen 2 Score 0.593 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000023869
Gene: ENSMUSG00000023106
AA Change: T159K

DomainStartEndE-ValueType
Pfam:SUI1 111 184 3.1e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000094320
SMART Domains Protein: ENSMUSP00000091878
Gene: ENSMUSG00000061882

DomainStartEndE-ValueType
coiled coil region 61 197 N/A INTRINSIC
coiled coil region 241 297 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000165148
SMART Domains Protein: ENSMUSP00000127483
Gene: ENSMUSG00000061882

DomainStartEndE-ValueType
coiled coil region 61 197 N/A INTRINSIC
coiled coil region 241 297 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000166129
SMART Domains Protein: ENSMUSP00000143501
Gene: ENSMUSG00000105875

DomainStartEndE-ValueType
coiled coil region 16 109 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000166233
AA Change: T159K

PolyPhen 2 Score 0.593 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000126174
Gene: ENSMUSG00000023106
AA Change: T159K

DomainStartEndE-ValueType
Pfam:SUI1 108 183 4e-19 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.6%
Validation Efficiency 98% (61/62)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein whose expression was found to increase in cultured cells at high density but not during growth arrest. This gene was also shown to have increased expression in cells overexpressing HER-2/neu proto-oncogene. The protein contains an SUI1 domain. In budding yeast, SUI1 is a translation initiation factor that along with eIF-2 and the initiator tRNA-Met, directs the ribosome to the proper translation start site. Proteins similar to SUI have been found in mammals, insects, and plants. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aipl1 T C 11: 71,920,126 (GRCm39) D314G probably benign Het
Ankrd12 T G 17: 66,290,939 (GRCm39) E1498A probably benign Het
Appl1 A T 14: 26,647,372 (GRCm39) probably null Het
Auh A G 13: 53,063,349 (GRCm39) *116R probably null Het
Ccdc7a T A 8: 129,691,417 (GRCm39) H402L probably benign Het
Ccr4 T C 9: 114,321,235 (GRCm39) T277A probably benign Het
Col18a1 C T 10: 76,889,072 (GRCm39) V1302I probably benign Het
Csnk1a1 T C 18: 61,688,925 (GRCm39) I35T probably benign Het
Csnk1e T C 15: 79,304,882 (GRCm39) R374G possibly damaging Het
Ddx11 A G 17: 66,437,020 (GRCm39) R105G probably benign Het
Dmp1 C A 5: 104,359,571 (GRCm39) Y82* probably null Het
Dok3 A G 13: 55,671,833 (GRCm39) V246A probably benign Het
Endov A C 11: 119,382,723 (GRCm39) K57Q possibly damaging Het
Fam83a A G 15: 57,873,196 (GRCm39) T342A probably benign Het
Fbln1 G A 15: 85,116,773 (GRCm39) C275Y probably damaging Het
Fhip1b T C 7: 105,034,342 (GRCm39) N430D possibly damaging Het
Foxi1 A G 11: 34,157,530 (GRCm39) I165T possibly damaging Het
Gm14496 A T 2: 181,642,275 (GRCm39) I649F probably damaging Het
Grin2b A G 6: 135,899,967 (GRCm39) S305P probably damaging Het
Grm1 G A 10: 10,564,879 (GRCm39) T1143M possibly damaging Het
Ifi202b C A 1: 173,802,298 (GRCm39) probably null Het
Klhl32 A T 4: 24,629,194 (GRCm39) D491E probably damaging Het
Klk1b1 C T 7: 43,619,767 (GRCm39) R109C possibly damaging Het
Krt13 A G 11: 100,009,706 (GRCm39) L358P probably damaging Het
Limk2 G A 11: 3,321,162 (GRCm39) probably benign Het
Mdn1 A G 4: 32,756,453 (GRCm39) D4720G probably null Het
Mkln1 T A 6: 31,435,900 (GRCm39) Y286* probably null Het
Muc6 C A 7: 141,230,579 (GRCm39) E1143* probably null Het
Myh15 A G 16: 48,901,551 (GRCm39) I242M probably benign Het
Noc4l T G 5: 110,798,828 (GRCm39) K241Q probably damaging Het
Nup88 C A 11: 70,860,607 (GRCm39) L57F possibly damaging Het
Obsl1 G T 1: 75,480,501 (GRCm39) F374L possibly damaging Het
Or51aa2 A G 7: 103,188,183 (GRCm39) I86T possibly damaging Het
Orm1 A T 4: 63,264,355 (GRCm39) D137V probably damaging Het
Osbpl2 T A 2: 179,778,895 (GRCm39) D9E probably damaging Het
P4ha3 G T 7: 99,942,986 (GRCm39) D124Y probably damaging Het
Poteg T C 8: 27,943,354 (GRCm39) V208A probably benign Het
Ppfibp1 A G 6: 146,931,843 (GRCm39) D963G probably damaging Het
Prdx6 G T 1: 161,078,660 (GRCm39) D9E probably benign Het
Prrc2b C A 2: 32,104,666 (GRCm39) N1381K probably damaging Het
Ptpn14 T A 1: 189,565,598 (GRCm39) V222E possibly damaging Het
Rasal1 C T 5: 120,804,420 (GRCm39) R431C probably benign Het
Rexo5 A T 7: 119,433,508 (GRCm39) M422L probably benign Het
Rnf17 TG T 14: 56,661,999 (GRCm39) 132 probably null Het
Robo2 A T 16: 73,730,588 (GRCm39) I1008N probably damaging Het
Sidt1 T A 16: 44,106,755 (GRCm39) Y225F probably benign Het
Slc6a15 A T 10: 103,225,048 (GRCm39) E45D probably benign Het
Spata31d1a T G 13: 59,850,668 (GRCm39) M487L probably benign Het
St6galnac1 C A 11: 116,666,325 (GRCm39) probably benign Het
Tcp11l2 A G 10: 84,449,469 (GRCm39) Y478C probably damaging Het
Tdrd12 G T 7: 35,223,482 (GRCm39) C67* probably null Het
Tead2 G A 7: 44,867,505 (GRCm39) G78D probably damaging Het
Tfpi2 A T 6: 3,963,849 (GRCm39) N194K probably damaging Het
Timd2 A G 11: 46,568,027 (GRCm39) probably null Het
Tmem270 T C 5: 134,930,557 (GRCm39) T235A probably benign Het
Tnrc18 T C 5: 142,774,157 (GRCm39) D224G Het
Tsga10 G T 1: 37,840,959 (GRCm39) Q416K probably benign Het
Ulk1 C A 5: 110,935,531 (GRCm39) L911F probably damaging Het
Usp8 T C 2: 126,584,491 (GRCm39) S567P probably benign Het
Vmn2r-ps158 C T 7: 42,697,270 (GRCm39) P776S probably damaging Het
Zdhhc3 A C 9: 122,918,143 (GRCm39) C129G probably damaging Het
Other mutations in Denr
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01367:Denr APN 5 124,046,182 (GRCm39) missense probably benign 0.19
R0007:Denr UTSW 5 124,062,877 (GRCm39) missense probably damaging 1.00
R0007:Denr UTSW 5 124,062,877 (GRCm39) missense probably damaging 1.00
R0025:Denr UTSW 5 124,065,298 (GRCm39) unclassified probably benign
R0079:Denr UTSW 5 124,062,908 (GRCm39) missense probably damaging 1.00
R0567:Denr UTSW 5 124,046,221 (GRCm39) missense probably benign 0.01
R1818:Denr UTSW 5 124,055,283 (GRCm39) missense probably benign 0.00
R5125:Denr UTSW 5 124,065,144 (GRCm39) missense probably damaging 1.00
R6930:Denr UTSW 5 124,046,250 (GRCm39) missense probably benign 0.02
R7657:Denr UTSW 5 124,046,263 (GRCm39) missense probably damaging 0.96
R8970:Denr UTSW 5 124,055,279 (GRCm39) missense probably damaging 1.00
R9680:Denr UTSW 5 124,065,117 (GRCm39) missense possibly damaging 0.81
Predicted Primers PCR Primer
(F):5'- GCGGGAGGAGGTCATTAATACC -3'
(R):5'- TGTCGTCATCCACCTAGAAGAC -3'

Sequencing Primer
(F):5'- CGGGAGGAGGTCATTAATACCATCTG -3'
(R):5'- GTCATCCACCTAGAAGACACAGGTG -3'
Posted On 2020-09-02