Incidental Mutation 'R8381:Or51b6'
ID 646946
Institutional Source Beutler Lab
Gene Symbol Or51b6
Ensembl Gene ENSMUSG00000110259
Gene Name olfactory receptor family 51 subfamily B member 6
Synonyms MOR1-2, Olfr65, 5'[b]3, GA_x6K02T2PBJ9-6634906-6633983
MMRRC Submission 067748-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.142) question?
Stock # R8381 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 103555549-103556654 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 103556146 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 164 (F164L)
Ref Sequence ENSEMBL: ENSMUSP00000102477 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000106864] [ENSMUST00000209528] [ENSMUST00000214300]
AlphaFold A0A1B0GSF4
Predicted Effect
SMART Domains Protein: ENSMUSP00000102477
Gene: ENSMUSG00000110259
AA Change: F164L

DomainStartEndE-ValueType
Pfam:7tm_4 32 310 2.1e-113 PFAM
Pfam:7TM_GPCR_Srsx 36 300 5.6e-7 PFAM
Pfam:7tm_1 42 293 5.9e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000209528
AA Change: F167L

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
Predicted Effect
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930579F01Rik C T 3: 137,879,282 (GRCm39) probably null Het
Actrt3 A G 3: 30,651,985 (GRCm39) *370R probably null Het
Adam34 A G 8: 44,104,847 (GRCm39) I266T possibly damaging Het
Bhlhe40 TG TGG 6: 108,641,818 (GRCm39) 254 probably null Het
Celsr2 T C 3: 108,302,952 (GRCm39) N2507S probably damaging Het
E2f8 T C 7: 48,527,710 (GRCm39) D144G probably damaging Het
Eif4enif1 T C 11: 3,177,470 (GRCm39) S346P probably damaging Het
Fbln5 A G 12: 101,728,114 (GRCm39) F270S probably benign Het
Fnip2 T A 3: 79,373,000 (GRCm39) D1026V probably damaging Het
Fubp3 G A 2: 31,482,509 (GRCm39) probably null Het
Gjb6 T C 14: 57,361,919 (GRCm39) E114G probably benign Het
Gpr160 A G 3: 30,949,930 (GRCm39) M1V probably null Het
Hey2 A G 10: 30,709,986 (GRCm39) S256P probably damaging Het
Hnrnpll A T 17: 80,337,920 (GRCm39) H590Q probably damaging Het
Ice2 T A 9: 69,317,453 (GRCm39) H192Q probably damaging Het
Ighv1-20 T A 12: 114,687,501 (GRCm39) Q81L probably benign Het
Ighv5-2 T A 12: 113,542,325 (GRCm39) H51L probably benign Het
Jkampl A T 6: 73,445,895 (GRCm39) V218E probably damaging Het
Kif27 T C 13: 58,438,991 (GRCm39) D1190G probably benign Het
Klk1b1 C T 7: 43,619,767 (GRCm39) R109C possibly damaging Het
Mettl14 A G 3: 123,168,447 (GRCm39) Y198H probably damaging Het
Nlrp6 C T 7: 140,503,754 (GRCm39) A620V possibly damaging Het
Obsl1 G T 1: 75,480,501 (GRCm39) F374L possibly damaging Het
Or5h22 A G 16: 58,895,225 (GRCm39) S73P probably damaging Het
Or8h10 T C 2: 86,808,373 (GRCm39) I256V probably benign Het
Pcbp4 G A 9: 106,338,488 (GRCm39) A138T probably damaging Het
Pramel52-ps C T 5: 94,531,881 (GRCm39) T255I probably damaging Het
Rnf17 TG T 14: 56,661,999 (GRCm39) 132 probably null Het
Robo3 T A 9: 37,341,056 (GRCm39) D72V probably damaging Het
Slc16a5 A G 11: 115,360,716 (GRCm39) S300G probably benign Het
Smg6 C T 11: 74,822,566 (GRCm39) R670W probably damaging Het
Smok3c C T 5: 138,063,824 (GRCm39) T437I probably benign Het
Stk36 A G 1: 74,672,333 (GRCm39) I931V probably benign Het
Syk T C 13: 52,787,085 (GRCm39) Y383H probably benign Het
Tacc2 T A 7: 130,225,972 (GRCm39) S886T probably benign Het
Top1 A G 2: 160,545,594 (GRCm39) M321V probably null Het
Ttc17 A G 2: 94,132,166 (GRCm39) L598P probably damaging Het
Xdh T G 17: 74,219,456 (GRCm39) I648L probably benign Het
Zfhx4 A C 3: 5,447,676 (GRCm39) K1126T probably benign Het
Zfp729b T C 13: 67,739,617 (GRCm39) T883A possibly damaging Het
Other mutations in Or51b6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01079:Or51b6 APN 7 103,555,669 (GRCm39) missense probably benign
IGL02830:Or51b6 APN 7 103,555,651 (GRCm39) missense probably benign 0.32
IGL03238:Or51b6 APN 7 103,555,717 (GRCm39) missense probably benign
R0674:Or51b6 UTSW 7 103,556,462 (GRCm39) missense probably benign 0.01
R1711:Or51b6 UTSW 7 103,555,906 (GRCm39) missense probably damaging 1.00
R2018:Or51b6 UTSW 7 103,556,249 (GRCm39) missense possibly damaging 0.88
R2363:Or51b6 UTSW 7 103,556,267 (GRCm39) missense probably benign 0.19
R2968:Or51b6 UTSW 7 103,556,519 (GRCm39) missense probably benign 0.01
R2970:Or51b6 UTSW 7 103,556,519 (GRCm39) missense probably benign 0.01
R3746:Or51b6 UTSW 7 103,556,267 (GRCm39) missense probably benign 0.19
R4928:Or51b6 UTSW 7 103,555,879 (GRCm39) missense probably damaging 1.00
R5092:Or51b6 UTSW 7 103,556,406 (GRCm39) nonsense probably null
R5635:Or51b6 UTSW 7 103,555,845 (GRCm39) missense probably benign 0.05
R5881:Or51b6 UTSW 7 103,555,883 (GRCm39) missense probably damaging 0.98
R5963:Or51b6 UTSW 7 103,556,168 (GRCm39) missense probably benign 0.02
R5969:Or51b6 UTSW 7 103,556,117 (GRCm39) missense probably damaging 0.98
R6859:Or51b6 UTSW 7 103,555,908 (GRCm39) nonsense probably null
R7857:Or51b6 UTSW 7 103,555,817 (GRCm39) missense
R8065:Or51b6 UTSW 7 103,555,610 (GRCm39) start gained probably benign
R8067:Or51b6 UTSW 7 103,555,610 (GRCm39) start gained probably benign
R8501:Or51b6 UTSW 7 103,555,818 (GRCm39) missense
R8737:Or51b6 UTSW 7 103,555,913 (GRCm39) missense
R8796:Or51b6 UTSW 7 103,556,201 (GRCm39) missense
R9007:Or51b6 UTSW 7 103,556,165 (GRCm39) missense
R9455:Or51b6 UTSW 7 103,556,200 (GRCm39) missense
R9591:Or51b6 UTSW 7 103,556,470 (GRCm39) missense
X0065:Or51b6 UTSW 7 103,556,423 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATGGAGCCTGCTTCTCTCAG -3'
(R):5'- CAATGCCCATGACAGTCTTGAG -3'

Sequencing Primer
(F):5'- ACACTCTCTCTATTGTGGAGTCGG -3'
(R):5'- CATGACAGTCTTGAGAATCAAAACG -3'
Posted On 2020-09-02